DK2799427T3 - Terapeutiske forbindelser - Google Patents

Terapeutiske forbindelser Download PDF

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DK2799427T3
DK2799427T3 DK14173039.0T DK14173039T DK2799427T3 DK 2799427 T3 DK2799427 T3 DK 2799427T3 DK 14173039 T DK14173039 T DK 14173039T DK 2799427 T3 DK2799427 T3 DK 2799427T3
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mmol
mhz
amino
benzoic acid
alkyne
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DK14173039.0T
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Spencer John Williams
David Stapleton
Steven Zammit
Darren James Kelly
Richard Ernest Gilbert
Henry Krum
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Fibrotech Therapeutics Pty Ltd
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
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  • Pyridine Compounds (AREA)

Claims (11)

1. Forbindelse med formel 2:
formel II til anvendelse i behandlingen af fokal segmental glomerulosclerose; hvor Ri og R2, der kan være den samme eller forskellig, er valgt fra gruppen bestående af Ci til C10 alkyl, C3 til C10 cycloalkyl, C3 til C10 cycloalkylmethyl, C3 til C10 alken, C3 til C10 alkyn og en kæde indeholdende en heterocyklisk eller kondenseret ring, der hver eventuelt kan være substitueret; Xi og X2 er den samme eller forskellig og er valgt fra gruppen bestående af en binding, O, N og S; T er en enkelt- eller dobbeltbinding; R3 er valgt fra gruppen bestående af H, C3 til C10 alken, C3 til C10 alkyn og en kæde indeholdende en heterocyklisk eller kondenseret ring, der hver eventuelt kan være substitueret; R4 er valgt fra gruppen bestående af H, OH, OR6, NHR6 og NR6R7; R5 er valgt fra gruppen bestående af H, NHR6, NR6R7, ORs, halogen, C3 til C10 alken, C3 til C10 alkyn og en kæde bestående af en heterocyklisk eller kondenseret ring, der hver eventuelt kan være substitueret; R6 og R7, der kan være den samme eller forskellig, er valgt fra gruppen bestående af H, Ci til C10 alkyl, C3 til C10 cycloalkyl, C3 til C10 cycloalkylmethyl, C3 til C10 alken, C3 til C10 alkyn, aryl, Cs til C20 alkaryl, og en carbonhydridkæde indeholdende en heterocyklisk eller kondenseret ring, der hver eventuelt kan være substitueret;
Rs er valgt fra gruppen bestående af H, Ci til Cio alkyl, C3 til Cio cycloalkyl, C3 til Cio cycloalkylmethyl, C3 til Cio alken, C3 til Cio alkyn, aryl, Cs til C20 alkaryl, og en carbonhydridkæde indeholdende en heterocyklisk eller kondenseret ring, der hver eventuelt kan være substitueret; og n er et heltal mellem 0 og 4; eller farmaceutisk acceptable salte deraf; med det forbehold at når Xi og X2 begge er O eller en binding, og ét af Ri eller R2 er Ci til C4 alkyl, er den anden af Ri eller R2 C4 til Cio alkyl, C3 til Cio cycloalkyl, C3 til Cio cycloalkylmethyl, C3 til Cio alkyn, eller en kæde indeholdende en heterocyklisk eller kondenseret ring; and med det forbehold at forbindelsen ikke er Tranilast.
2. Forbindelse til anvendelse ifølge krav 1 med formlen 3:
formel III hvor R9 eller Rio, der kan være den samme eller forskellig, er valgt fra gruppen bestående af Ci til Cio alkyl, C3 til Cs terminal eller ikke-terminal alkyn, cyclopentyl, cyclohexyl, cyclohexylmethyl, og cyclopentylmethyl; eller farmaceutisk acceptable salte deraf; med det forbehold at når én af R9 eller Rio er Ci til C4 alkyl, er den anden af R9 eller Rio C4 til Cio alkyl, C3 til Cio cycloalkyl, C3 til Cio cycloalkylmethyl, C3 til Cio alkyn eller og en kæde indeholdende en heterocyklisk eller kondenseret ring, hvilke som helst eventuelt er substitueret; og med det forbehold at forbindelsen ikke er Tranilast.
3. Forbindelsen til anvendelse ifølge krav 1, hvor Xi og X2 er O.
4. Forbindelsen til anvendelse ifølge krav 3, hvor Ri eller R2 er methyl.
5. Forbindelsen til anvendelse ifølge krav 4, hvor R3 er H.
6. Forbindelsen til anvendelse ifølge krav 3, hvor Ri eller R2 er en alkyn eller en kæde indeholdende triazol.
7. Forbindelse til anvendelse ifølge krav 1 med formlen 4 eller formel 5:
formel 4 eller v
formel 5 hvor p er et heltal mellem 1 og 10; og R er valgt fra gruppen bestående af H og Ci til C10 alkyl; eller farmaceutisk acceptable salte deraf.
8. Forbindelse til anvendelse ifølge krav 1 med formlen 6 eller Formlen 7
formel 6 eller
formel 7 hvor G er en cyclopentylring, en cyclohexylring eller en 1,4-disubstituteret 1,2,3-triazolring; og
q er et heltal mellem O og 6; eller farmaceutisk acceptable salte deraf.
9. Forbindelse til anvendelse ifølge krav 1, valgt fra gruppen bestående af
eller farmaceutisk acceptable salte deraf.
10. Forbindelse til anvendelse ifølge krav 1, valgt fra gruppen bestående af
eller farmaceutisk acceptable salte deraf.
11. Forbindelse til anvendelse ifølge krav 1, hvor forbindelsen har formlen:
eller farmaceutisk acceptabel salt deraf.
DK14173039.0T 2006-07-05 2007-07-05 Terapeutiske forbindelser DK2799427T3 (da)

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PT2035369E (pt) 2014-09-30
ES2689484T3 (es) 2018-11-14
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CA2656851C (en) 2013-12-10
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AU2007271734A1 (en) 2008-01-10
US9561201B2 (en) 2017-02-07
WO2008003141A1 (en) 2008-01-10
KR20150067400A (ko) 2015-06-17
AU2007271734B2 (en) 2012-03-29

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