DK2768986T3 - Plasma-mikrorna til detektionen af tidlig kolorektal cancer - Google Patents
Plasma-mikrorna til detektionen af tidlig kolorektal cancer Download PDFInfo
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- DK2768986T3 DK2768986T3 DK12852462.6T DK12852462T DK2768986T3 DK 2768986 T3 DK2768986 T3 DK 2768986T3 DK 12852462 T DK12852462 T DK 12852462T DK 2768986 T3 DK2768986 T3 DK 2768986T3
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- DK
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- Prior art keywords
- colorectal
- micrornas
- plasma
- sample
- cancer
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Claims (7)
1. Fremgangsmåde til at diagnosticere eller detektere kolorektal neoplasi hos et menneskeligt individ omfattende trinnene: a. at opnå en biologisk prøve valgt fra listen bestående af en plasmaprøve, en serumprøve og en blodprøve fra individet mistænkt for at lide af kolorektal neoplasi; b. at måle et overordnet ekspressionsmønster eller -niveau af en microRNA's biosignatur omfattende mindst microRNA miR15b opnået fra den/de biologisk(e) prøve(r) af individet; og c. at sammenligne det overordnede ekspressionsmønster af microRNA-biosignaturen fra den biologiske prøve af individet mistænkt for at lide af kolorektal neoplasi med det overordnede ekspressionsmønster af microRNA-biosignaturen fra en biologisk prøve af et normalt individ, hvor det normale individ er et sundt individ, som ikke lider af kolorektal neoplasi, og hvor overekspression af mindst miR15b indikerer kolorektal cancer.
2. Fremgangsmåden ifølge krav 1, yderligere omfattende analysen af mindst en af miR29a, miR19a, miR19b eller miR335 sammenlignet med ekspression fra det normale individ, hvor overekspression af miRNA miR15b i kombination med mindst en af miR29a, miR19a, miR19b eller miR335 indikerer kolorektal neoplasi.
3. Fremgangsmåden ifølge et hvilket som helst af kravene 1 eller 2, hvor fremgangsmåden er i stand til at detektere tidlig CRC (I-II) lige så akkurat som fremskreden CRC (stadie II-III), tumorer i højre side og læsioner i venstre side.
4. Fremgangsmåde til at stratificere en patient til en undergruppe i risiko for at lide af kolorektal neoplasi under anvendelse af fremgangsmåden ifølge et hvilket som helst af kravene 1 til 3.
5. Fremgangsmåde til at bestemme resistens over for eller modtagelighed for en kolorektal neoplasi terapeutisk plan under anvendelse af fremgangsmåden ifølge et hvilket som helst af kravene 1-3.
6. In v/fro-anvendelse af et kit til en diagnose af kolorektal neoplasi omfattende biomarkør-detekterende reagenser til at bestemme et differentieret ekspressionsniveau af mindst miR15b i en plasmaprøve, en serumprøve eller en blodprøve.
7. In v/fro-anvendelse af kittet ifølge krav 6, hvilket yderligere omfatter værktøjer, beholdere og reagenser nødvendige til at opnå prøver fra et individ valgt fra gruppen bestående afen plasmaprøve, en serumprøve eller en blodprøve.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550148P | 2011-10-21 | 2011-10-21 | |
| PCT/IB2012/003035 WO2013093635A2 (en) | 2011-10-21 | 2012-10-20 | Plasma micrornas for the detection of early colorectal cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2768986T3 true DK2768986T3 (da) | 2018-09-10 |
Family
ID=48136439
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15158185.7T DK2944700T3 (da) | 2011-10-21 | 2012-10-20 | Plasma-mikroRNA til detektionen af kolorektal cancer på tidligt stadie |
| DK12852462.6T DK2768986T3 (da) | 2011-10-21 | 2012-10-20 | Plasma-mikrorna til detektionen af tidlig kolorektal cancer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15158185.7T DK2944700T3 (da) | 2011-10-21 | 2012-10-20 | Plasma-mikroRNA til detektionen af kolorektal cancer på tidligt stadie |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US20130102487A1 (da) |
| EP (2) | EP2768986B1 (da) |
| JP (2) | JP6159727B2 (da) |
| KR (2) | KR101900872B1 (da) |
| CN (2) | CN104145024A (da) |
| AU (1) | AU2012356317B2 (da) |
| BR (2) | BR112014009643B1 (da) |
| CA (1) | CA2852850C (da) |
| DK (2) | DK2944700T3 (da) |
| ES (2) | ES2688693T3 (da) |
| HU (2) | HUE039522T2 (da) |
| IN (1) | IN2015DN01855A (da) |
| MX (2) | MX357550B (da) |
| NO (1) | NO3051026T3 (da) |
| PL (2) | PL2944700T3 (da) |
| PT (2) | PT2768986T (da) |
| RU (2) | RU2611189C2 (da) |
| WO (1) | WO2013093635A2 (da) |
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| EP2668295A4 (en) | 2011-01-26 | 2016-01-13 | Cepheid | METHODS OF DETECTING LUNG CANCER |
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| WO2014039556A1 (en) | 2012-09-04 | 2014-03-13 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP3087204B1 (en) | 2013-12-28 | 2018-02-14 | Guardant Health, Inc. | Methods and systems for detecting genetic variants |
| CA2939343A1 (en) | 2014-02-18 | 2015-08-27 | Baylor Research Institute | Mir-320e and colorectal cancer |
| EP3971299A3 (en) | 2014-06-13 | 2022-06-29 | Toray Industries, Inc. | Colorectal cancer detection kit or device, and detection method |
| WO2016034715A2 (fr) * | 2014-09-05 | 2016-03-10 | Prestizia | Methode de prediction de l'evolution clinique du cancer colorectal |
| CN104313142B (zh) * | 2014-10-16 | 2016-02-03 | 上海交通大学医学院附属仁济医院 | miRNA-30a作为标记分子在制备诊断试剂中的用途 |
| CN104388541B (zh) * | 2014-10-21 | 2017-07-04 | 复旦大学附属肿瘤医院 | miR‑1914*和miR‑1915的用途 |
| CN104372004B (zh) * | 2014-12-04 | 2018-04-27 | 广东医学院 | 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用 |
| EP3147370A1 (en) * | 2015-09-28 | 2017-03-29 | Rheinische Friedrich-Wilhelms-Universität Bonn | Exosomal microrna in serum as an indicator for the activation of brown and beige fat tissue (bat) |
| EP3390668A4 (en) | 2015-12-17 | 2020-04-01 | Guardant Health, Inc. | METHODS OF DETERMINING THE NUMBER OF TUMOR GENE COPIES BY ACELLULAR DNA ANALYSIS |
| US20190185945A1 (en) * | 2016-08-18 | 2019-06-20 | University Of Technology Sydney | Biomarkers of Oral, Pharyngeal and Laryngeal Cancers |
| EP3327135A1 (en) * | 2016-11-28 | 2018-05-30 | Advanced Marker Discovery, S.L. | In vitro method for identifying colorectal adenomas or colorectal cancer |
| CN106950370A (zh) * | 2017-01-25 | 2017-07-14 | 上海市第十人民医院 | 血液微小核酸大肠癌诊断分子组合 |
| CN107254522A (zh) * | 2017-06-09 | 2017-10-17 | 中山大学附属第三医院 | miR‑664a‑5p的检测试剂在制备肝癌诊断试剂/试剂盒中的应用 |
| CN107236799B (zh) * | 2017-06-15 | 2020-06-09 | 昆明医科大学第六附属医院 | 一种肾纤维化miRNA标记物 |
| CN107326092B (zh) * | 2017-08-25 | 2021-07-20 | 深圳市恩普电子技术有限公司 | 大肠癌相关的miRNA作为生物标志物的应用及大肠癌检测试剂盒 |
| CN107746886B (zh) * | 2017-09-11 | 2019-10-01 | 朱伟 | 一种与结直肠癌辅助诊断相关的血浆miRNA标志物及其应用 |
| WO2019144183A1 (en) * | 2018-01-23 | 2019-08-01 | La Trobe University | Biomarkers of colorectal cancer |
| US11976332B2 (en) | 2018-02-14 | 2024-05-07 | Dermtech, Inc. | Gene classifiers and uses thereof in non-melanoma skin cancers |
| CN110205367B (zh) * | 2018-02-28 | 2022-06-21 | 伽蓝（集团）股份有限公司 | 一种筛选保护皮肤细胞端粒的活性物的方法 |
| CA3099275A1 (en) * | 2018-05-09 | 2019-11-14 | Dermtech, Inc. | Novel gene classifiers and uses thereof in autoimmune diseases |
| CN108753974B (zh) * | 2018-06-27 | 2022-05-06 | 深圳华大生命科学研究院 | 一种结直肠癌肿瘤标志物及其检测方法与装置 |
| CN109557311B (zh) * | 2018-12-13 | 2022-02-15 | 中南大学湘雅医院 | 结直肠癌诊断标志物及结直肠癌的检测产品及其应用 |
| KR102275465B1 (ko) * | 2019-01-18 | 2021-07-09 | 사회복지법인 삼성생명공익재단 | 전이성 대장암 치료물질 스크리닝 방법 |
| CN112041463B (zh) * | 2019-03-11 | 2024-07-23 | 香港中文大学 | 结肠直肠癌的miRNA标志物 |
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| JPWO2023032452A1 (da) * | 2021-08-31 | 2023-03-09 | ||
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2009
- 2009-04-01 NO NO16160669A patent/NO3051026T3/no unknown
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2012
- 2012-10-20 JP JP2014536355A patent/JP6159727B2/ja active Active
- 2012-10-20 ES ES12852462.6T patent/ES2688693T3/es active Active
- 2012-10-20 CN CN201280064096.7A patent/CN104145024A/zh active Pending
- 2012-10-20 EP EP12852462.6A patent/EP2768986B1/en active Active
- 2012-10-20 HU HUE12852462A patent/HUE039522T2/hu unknown
- 2012-10-20 KR KR1020147013663A patent/KR101900872B1/ko active IP Right Grant
- 2012-10-20 DK DK15158185.7T patent/DK2944700T3/da active
- 2012-10-20 IN IN1855DEN2015 patent/IN2015DN01855A/en unknown
- 2012-10-20 AU AU2012356317A patent/AU2012356317B2/en active Active
- 2012-10-20 MX MX2014004810A patent/MX357550B/es active IP Right Grant
- 2012-10-20 BR BR112014009643-0A patent/BR112014009643B1/pt active IP Right Grant
- 2012-10-20 WO PCT/IB2012/003035 patent/WO2013093635A2/en active Application Filing
- 2012-10-20 PL PL15158185T patent/PL2944700T3/pl unknown
- 2012-10-20 RU RU2014120427A patent/RU2611189C2/ru active
- 2012-10-20 MX MX2015002910A patent/MX357119B/es unknown
- 2012-10-20 PT PT12852462T patent/PT2768986T/pt unknown
- 2012-10-20 KR KR1020157005756A patent/KR101912731B1/ko active IP Right Grant
- 2012-10-20 HU HUE15158185A patent/HUE035614T2/en unknown
- 2012-10-20 BR BR122015004941-5A patent/BR122015004941B1/pt active IP Right Grant
- 2012-10-20 PT PT151581857T patent/PT2944700T/pt unknown
- 2012-10-20 DK DK12852462.6T patent/DK2768986T3/da active
- 2012-10-20 ES ES15158185.7T patent/ES2662401T3/es active Active
- 2012-10-20 PL PL12852462T patent/PL2768986T3/pl unknown
- 2012-10-20 CA CA2852850A patent/CA2852850C/en active Active
- 2012-10-20 US US13/656,690 patent/US20130102487A1/en not_active Abandoned
- 2012-10-20 EP EP15158185.7A patent/EP2944700B1/en active Active
- 2012-10-20 RU RU2015108970A patent/RU2662975C1/ru active
- 2012-10-20 CN CN201510098369.5A patent/CN104651521B/zh active Active
- 2012-10-20 US US14/352,462 patent/US20150087525A1/en not_active Abandoned
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2015
- 2015-03-05 US US14/639,539 patent/US20150176082A1/en not_active Abandoned
- 2015-03-05 JP JP2015043433A patent/JP6203209B2/ja active Active
-
2016
- 2016-06-14 US US15/181,578 patent/US20160289771A1/en not_active Abandoned
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2018
- 2018-06-28 US US16/022,597 patent/US20180346996A1/en active Pending
- 2018-08-08 US US16/058,940 patent/US20180355439A1/en active Pending
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