DK2767292T3 - Vedvarende lokalbedøvelsessammensætning indeholdende saib - Google Patents
Vedvarende lokalbedøvelsessammensætning indeholdende saib Download PDFInfo
- Publication number
- DK2767292T3 DK2767292T3 DK14167954.8T DK14167954T DK2767292T3 DK 2767292 T3 DK2767292 T3 DK 2767292T3 DK 14167954 T DK14167954 T DK 14167954T DK 2767292 T3 DK2767292 T3 DK 2767292T3
- Authority
- DK
- Denmark
- Prior art keywords
- composition
- bupivacaine
- anesthetic
- present
- amount
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Detergent Compositions (AREA)
- Optical Communication System (AREA)
- Amplifiers (AREA)
- Selective Calling Equipment (AREA)
Claims (15)
1. Flydende sammensætning til tilvejebringelse af vedvarende lokalbedøvelse efter administration til et individ, hvilken sammensætning omfatter bupivacain som et bedøvelsesmiddel, sucroseacetatisobutyrat som en farmaceutisk acceptabel ikke-polymerbærer og benzylalkohol som et opløsningsmiddel for bæreren, hvor bupivacain er til stede i en mængde fra 30 til 5 vægt-% i forhold til sammensætningens samlede vægt
2. Sammensætning ifølge krav 1, hvor bupivacain er til stede i form af fri base.
3. Sammensætning ifølge krav 1 eller 2, hvor bæreren er til stede i en mængde fra 75 til 25 vægt-% i forhold til sammensætningens samlede vægt.
4. Sammensætning ifølge et hvilket som helst af de foregående krav, hvor opløsningsmidlet er til stede i en mængde fra 55 til 10 vægt-% i forhold til sammensætningens samlede vægt.
5. Sammensætning ifølge krav 4, hvor opløsningsmidlet er til stede i en mængde fra 50 til 15 vægt-% i forhold til sammensætningens samlede vægt.
6. Sammensætning ifølge et hvilket som helst af de foregående krav, hvor bupivacain er til stede i en mængde på fra 25 til 5 vægt-% i forhold til sammensætningens samlede vægt eller i en mængde på fra 20 til 5 vægt-% i forhold til sammensætningens samlede vægt.
7. Anvendelse af bupivacain som et bedøvelsesmiddel, sucroseacetatisobutyrat som en farmaceutisk acceptabel ikke-polymerbærer og benzylalkohol som et opløsningsmiddel for bæreren til fremstilling af en flydende sammensætning til tilvejebringelse af vedvarende lokalbedøvelse efter administration til et individ, hvor bupivacain er til stede i en mængde fra 30 til 5 vægt-% i forhold til sammensætningens samlede vægt.
8. Anvendelse ifølge krav 7, hvor sammensætningen administreres til et operationssår, og fortrinsvis hvor sammensætningen administreres i og/eller i umiddelbar nærhed af såret.
9. Anvendelse ifølge krav 7 eller 8, hvor sammensætningen administreres ved hældning.
10. Anvendelse ifølge et hvilket som helst af kravene 7 til 9, hvor individet er en menneskepatient, der opereres for lyskebrok.
11. Anvendelse ifølge et hvilket som helst af kravene 7 til 10, hvor sammensætningen anvendes til at behandle postoperativ smerte i forbindelse med en medicinsk behandling, hvor den medicinske behandling fortrinsvis er en appendektomi.
12. Anvendelse ifølge et hvilket som helst af kravene 7 til 11, hvor bupivacain er til stede i form af fri base.
13. Anvendelse ifølge et hvilket som helst af kravene 7 til 12, hvor bæreren er til stede i en mængde fra 75 til 25 vægt-% i forhold til sammensætningens samlede vægt.
14. Anvendelse ifølge et hvilket som helst af kravene 7 til 13, hvor opløsningsmidlet er til stede i en mængde fra 55 til 10 vægt-% i forhold til sammensætningens samlede vægt eller i en mængde fra 50 til 15 vægt-% i forhold til sammensætningens samlede vægt.
15. Anvendelse ifølge et hvilket som helst af kravene 7 til 14, hvor bupivacain er til stede i en mængde på fra 25 til 5 vægt-% i forhold til sammensætningens samlede vægt eller i en mængde på fra 20 til 5 vægt-% i forhold til sammensætningens samlede vægt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61079704P | 2004-09-17 | 2004-09-17 | |
| US69139505P | 2005-06-17 | 2005-06-17 | |
| EP20110187311 EP2415484B1 (en) | 2004-09-17 | 2005-09-15 | Sustained local anesthetic composition containing SAIB |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2767292T3 true DK2767292T3 (da) | 2016-12-19 |
Family
ID=35949130
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11187311T DK2415484T3 (da) | 2004-09-17 | 2005-09-15 | Sammensætning indeholdende saib til vedvarende lokalbedøvelse |
| DK05812735.8T DK1809329T3 (da) | 2004-09-17 | 2005-09-15 | Vedvarende lokalanæstesisammensætning indeholdende saib |
| DK14167954.8T DK2767292T3 (da) | 2004-09-17 | 2005-09-15 | Vedvarende lokalbedøvelsessammensætning indeholdende saib |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11187311T DK2415484T3 (da) | 2004-09-17 | 2005-09-15 | Sammensætning indeholdende saib til vedvarende lokalbedøvelse |
| DK05812735.8T DK1809329T3 (da) | 2004-09-17 | 2005-09-15 | Vedvarende lokalanæstesisammensætning indeholdende saib |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US8753665B2 (da) |
| EP (4) | EP2767292B1 (da) |
| JP (2) | JP5285275B2 (da) |
| KR (2) | KR101492361B1 (da) |
| AT (1) | ATE537844T1 (da) |
| AU (1) | AU2005287175B2 (da) |
| BR (1) | BRPI0515372B8 (da) |
| CA (1) | CA2581287C (da) |
| CY (2) | CY1112625T1 (da) |
| DK (3) | DK2415484T3 (da) |
| EA (2) | EA201001885A1 (da) |
| ES (3) | ES2602273T3 (da) |
| GE (1) | GEP20094831B (da) |
| HK (1) | HK1201437A1 (da) |
| HR (1) | HRP20120254T1 (da) |
| HU (1) | HUE032040T2 (da) |
| IL (1) | IL181474A (da) |
| LT (1) | LT2767292T (da) |
| MX (1) | MX2007002962A (da) |
| NO (1) | NO342596B1 (da) |
| NZ (1) | NZ553369A (da) |
| PL (2) | PL2415484T3 (da) |
| PT (3) | PT2767292T (da) |
| RS (1) | RS52198B (da) |
| SI (2) | SI2767292T1 (da) |
| WO (1) | WO2006033948A2 (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7833543B2 (en) * | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| SI2767292T1 (sl) | 2004-09-17 | 2017-01-31 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
| WO2006039336A2 (en) * | 2004-10-01 | 2006-04-13 | Ramscor, Inc. | Conveniently implantable sustained release drug compositions |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| ES2388355T3 (es) * | 2006-11-03 | 2012-10-11 | Durect Corporation | Sistemas de suministro transdémico que comprenden bupivacaína |
| PL3085363T3 (pl) * | 2007-03-28 | 2019-08-30 | Innocoll Pharmaceuticals Limited | Urządzenie dostarczające lek dla zapewnienia miejscowej analgezji, miejscowego znieczulenia lub blokady nerwowej |
| EP2244679A4 (en) * | 2008-02-08 | 2013-10-09 | Qps Llc | NON-POLYMERIC COMPOSITIONS FOR CONTROLLED MEDICINAL PRODUCTION |
| WO2010077732A2 (en) * | 2008-12-09 | 2010-07-08 | Aether Medical Llc | Implantable analgesic |
| US9045600B2 (en) | 2009-05-13 | 2015-06-02 | Keraplast Technologies, Ltd. | Biopolymer materials |
| MX347014B (es) * | 2010-11-24 | 2017-04-07 | Durect Corp | Composición para administración de fármaco biodegradable. |
| US10828272B2 (en) * | 2012-05-16 | 2020-11-10 | Chardon Group B.V. | Means to facilitate food intake and food retention |
| WO2014143635A1 (en) | 2013-03-15 | 2014-09-18 | Heron Therapeutics, Inc. | Compositions of a polyorthoester and an aprotic solvent |
| CA2913100C (en) * | 2013-05-24 | 2021-10-26 | Danmarks Tekniske Universitet | Gel formulations for guiding radiotherapy |
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| WO2015123734A1 (en) * | 2014-02-21 | 2015-08-27 | The University Of Sydney | Liquid carrier materials |
| EP3509601A1 (en) | 2014-04-21 | 2019-07-17 | Heron Therapeutics, Inc. | A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam |
| CN106535886A (zh) | 2014-04-21 | 2017-03-22 | 赫伦治疗有限公司 | 长效聚合物输送系统 |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| KR20170025011A (ko) | 2015-08-27 | 2017-03-08 | 고려대학교 산학협력단 | 통증완화약물의 지속성 방출을 위한 약학적 조성물 및 그 투여를 위한 투여 장치 |
| WO2017193066A1 (en) * | 2016-05-05 | 2017-11-09 | Liquidia Technologies, Inc. | Precision controlled load and release particles for post-operative pain |
| US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
| US10668011B2 (en) * | 2016-06-30 | 2020-06-02 | Durect Corporation | Depot formulations |
| US11000487B2 (en) * | 2016-12-26 | 2021-05-11 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
| PL3486233T3 (pl) * | 2017-03-27 | 2021-06-28 | Fruithy Holdings Limited | Słabo rozpuszczalny kompleks lub jego solwat, kompozycja farmaceutyczna i jej zastosowanie |
| CA3078555A1 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | Implantable depots for the controlled release of therapeutic agents |
| RU2674025C1 (ru) * | 2017-10-25 | 2018-12-04 | Общество с ограниченной ответственностью "Научно-производственная фирма "ЭЛЕСТ" (ООО "НПФ "ЭЛЕСТ") | Лекарственное средство на основе порфиринового фотосенсибилизатора копропорфирина для лечения рака кожи методом фотодинамической терапии |
| EP4087540A4 (en) * | 2020-01-06 | 2024-01-10 | Pacira Pharmaceuticals, Inc. | TREATMENT OF PAIN ASSOCIATED WITH CESAREON SECTION USING SUSTAINED RELEASE LIPOSOMAL ANESTHETICS COMPOSITION |
| CN115297854A (zh) | 2020-01-10 | 2022-11-04 | 帕西拉制药股份有限公司 | 通过蛛网膜下腔给予缓释脂质体麻醉组合物治疗疼痛 |
| EP4087568A4 (en) | 2020-01-10 | 2024-01-17 | Pacira Pharmaceuticals, Inc. | TREATMENT OF PAIN BY ADMINISTRATION OF SUSTAINED-RELEASE LIPOSOMAL ANESTHESIC COMPOSITIONS |
| CN115666621A (zh) * | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 |
| CA3168712A1 (en) * | 2020-02-25 | 2021-09-02 | The University Of North Carolina At Chapel Hill | Eutectic based anesthetic compositions and applications thereof |
| US11918688B2 (en) | 2021-01-11 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of hip pain with sustained-release liposomal anesthetic compositions |
| CN115068414B (zh) * | 2021-03-16 | 2023-07-21 | 湖南慧泽生物医药科技有限公司 | 供注射用罗哌卡因长效溶液制剂及其制备方法 |
| CN117320696A (zh) | 2021-03-19 | 2023-12-29 | 帕西拉制药股份有限公司 | 通过给予缓释脂质体麻醉组合物治疗儿科患者的疼痛 |
| CN115414324A (zh) * | 2021-05-31 | 2022-12-02 | 中国科学院过程工程研究所 | 一种载局部麻醉药的乳剂及其制备方法 |
| IL314565A (en) | 2022-01-28 | 2024-09-01 | Rebel Medicine Inc | Pharmaceutical preparations for pain treatment |
| US11918565B1 (en) | 2022-11-03 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions |
Family Cites Families (147)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US556450A (en) * | 1896-03-17 | Antifriction-bearing | ||
| US2931802A (en) | 1958-04-30 | 1960-04-05 | Eastman Kodak Co | Mixed esters of glucose and sucrose |
| GB1088992A (en) | 1963-09-19 | 1967-10-25 | Squibb & Sons Inc | Protective dressings |
| US4411890A (en) | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US3743398A (en) | 1971-03-22 | 1973-07-03 | Eastman Kodak Co | Motion picture projector |
| NO139560C (no) | 1972-04-29 | 1979-04-04 | Takeda Chemical Industries Ltd | Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater |
| DE2451841A1 (de) | 1973-11-01 | 1975-05-07 | Wellcome Found | Biologisch aktive amide, verfahren zu ihrer herstellung und ihre verwendung |
| DE2438352A1 (de) | 1974-08-09 | 1976-02-26 | Hoechst Ag | Peptidcyclopropylamide mit lh-rh/fshrh-wirkung |
| DE2438350C3 (de) | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
| JPS55154991A (en) | 1979-05-23 | 1980-12-02 | Hisamitsu Pharmaceut Co Inc | Beta-d-fructopyranoside derivative |
| NZ194405A (en) | 1979-08-02 | 1982-05-25 | Dut Pty Ltd | Producing liquid hydrocarbon streams by hydrogenation of fossil-based feedstock |
| US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| DE3716302C2 (de) | 1987-05-15 | 1996-02-01 | Henkel Kgaa | Verbesserte resorbierbare Knochenwachse und ihre Verwendung |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| JPS59210024A (ja) | 1983-05-13 | 1984-11-28 | Taiyo Kagaku Kk | トコフエロ−ル乳化物 |
| US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| JPS607418U (ja) | 1983-06-28 | 1985-01-19 | 株式会社デンソー | 歯付スラストワツシヤをもつ軸受装置 |
| US4891225A (en) | 1984-05-21 | 1990-01-02 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| US4630019A (en) | 1984-09-28 | 1986-12-16 | Westinghouse Electric Corp. | Molded case circuit breaker with calibration adjusting means for a bimetal |
| US4725852A (en) | 1985-05-09 | 1988-02-16 | Burlington Industries, Inc. | Random artificially perturbed liquid apparatus and method |
| US4780320A (en) | 1986-04-29 | 1988-10-25 | Pharmetrix Corp. | Controlled release drug delivery system for the periodontal pocket |
| ATE107857T1 (de) | 1986-06-10 | 1994-07-15 | Euro Celtique Sa | Zusammensetzung mit kontrollierter freisetzung von dihydrocodein. |
| US4970075A (en) | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| GB8626098D0 (en) | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
| US5234520A (en) | 1987-03-20 | 1993-08-10 | Morgan Adhesives Co. | Method of making an adhesive construction |
| US5391381A (en) | 1987-06-25 | 1995-02-21 | Alza Corporation | Dispenser capable of delivering plurality of drug units |
| US4795641A (en) | 1987-08-20 | 1989-01-03 | Eastman Kodak Company | Polymer blends having reverse phase morphology for controlled delivery of bioactive agents |
| US5350741A (en) | 1988-07-30 | 1994-09-27 | Kanji Takada | Enteric formulations of physiologically active peptides and proteins |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US4987893A (en) | 1988-10-12 | 1991-01-29 | Rochal Industries, Inc. | Conformable bandage and coating material |
| US5324520A (en) | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| GB8926612D0 (en) | 1989-11-24 | 1990-01-17 | Erba Farmitalia | Pharmaceutical compositions |
| IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
| US5110685A (en) | 1990-05-18 | 1992-05-05 | Exxon Chemical Patents, Inc. | Low friction, abrasion resistant polymer coating |
| US5149543A (en) | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| WO1992017900A1 (en) | 1991-04-03 | 1992-10-15 | Eastman Kodak Company | HIGH DURABILITY MASK FOR DRY ETCHING OF GaAs |
| JP3313124B2 (ja) | 1991-07-31 | 2002-08-12 | 森下仁丹株式会社 | 親水性物質を内容物とするシームレスカプセルおよびその製法 |
| DE69231536T2 (de) | 1991-08-26 | 2001-06-13 | Abbott Laboratories, Abbott Park | Verbindungen und methoden zur sublingualen oder buccalen verabreichung von therapeutischen agentien |
| US5487898A (en) | 1991-08-26 | 1996-01-30 | Abbott Laboratories | Compositions and method for the sublingual or buccal administration therapeutic agents |
| IL103275A0 (en) | 1991-10-01 | 1993-02-21 | Lilly Co Eli | Injectable extended release formulations and methods |
| YU87892A (sh) | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
| AU2605592A (en) | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| JP3313113B2 (ja) | 1991-10-21 | 2002-08-12 | ペプテック リミテッド | 雌馬の排卵制御用生体適合性インプラント |
| US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
| US5656295A (en) | 1991-11-27 | 1997-08-12 | Euro-Celtique, S.A. | Controlled release oxycodone compositions |
| DE69212497T2 (de) | 1991-12-05 | 1996-12-12 | Mallinckrodt Veterinary, Inc., Mundelein, Ill. | Glasartige kohlenhydratenmatrize zur verabreichung von heilmitteln mit verzögerter wirkstoffabgabe |
| EP0616526A1 (en) | 1991-12-11 | 1994-09-28 | The Procter & Gamble Company | Cetylpyridinium chloride and domiphen bromide in organic solvent |
| US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5540912A (en) | 1992-03-30 | 1996-07-30 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
| US5922340A (en) * | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| ES2170074T3 (es) | 1992-09-10 | 2002-08-01 | Childrens Medical Center | Matrices de polimero biodegradables para la liberacion prolongada de agentes anestesicos locales. |
| CA2150574A1 (en) | 1993-01-06 | 1994-07-21 | Shalaby W. Shalaby | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| US5340572A (en) | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
| AU679510B2 (en) | 1993-03-17 | 1997-07-03 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing a diol-diacid derived dispersing aid |
| DE69413955T2 (de) | 1993-03-17 | 1999-04-01 | Minnesota Mining And Mfg. Co., Saint Paul, Minn. | Aerosolzusammensetzung enthaltend einen aus ester-, amid- oder merkaptoester- derivat dispergiermittel |
| DK44193D0 (da) | 1993-04-20 | 1993-04-20 | Euromed I S | Saarforbinding og klaebemiddel til en saarforbinding eller lignende |
| IL110014A (en) | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| JP3257750B2 (ja) | 1993-07-20 | 2002-02-18 | エチコン・インコーポレーテツド | ε−カプロラクトンおよびラクチドの液状コポリマー |
| US5879705A (en) | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
| JPH07112940A (ja) | 1993-08-26 | 1995-05-02 | Takeda Chem Ind Ltd | 徐放性非経口投与製剤およびその製造方法 |
| AU5895994A (en) | 1993-10-04 | 1995-05-01 | Mark Chasin | Controlled release microspheres |
| CA2180260A1 (en) | 1993-12-29 | 1995-07-06 | Dennis M. Brown | Methods and compositions for the treatment of a host with a cellular proliferative disease |
| JP4259610B2 (ja) | 1994-04-08 | 2009-04-30 | キューエルティー・ユーエスエイ・インコーポレーテッド | 液体デリバリー組成物 |
| US5633000A (en) | 1994-06-23 | 1997-05-27 | Axxia Technologies | Subcutaneous implant |
| PT782569E (pt) | 1994-09-23 | 2002-09-30 | Darwin Discovery Ltd | Processo de racemizacao utilizado no fabrico de levobupivacaina e seus analogos |
| US5599852A (en) | 1994-10-18 | 1997-02-04 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
| DE69531356T2 (de) | 1994-10-25 | 2004-05-27 | Darwin Discovery Ltd., Slough | Kristallisierung von levobupivacaine und deren analogen |
| ES2203645T3 (es) | 1994-10-25 | 2004-04-16 | Darwin Discovery Limited | Procedimiento para la preparacion de levobupivacaina y analogos de losmismos. |
| GB9501071D0 (en) | 1995-01-18 | 1995-03-08 | Chiroscience Ltd | Racemisation |
| US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
| ATE287673T1 (de) | 1995-06-07 | 2005-02-15 | Southern Biosystems Inc | Kontrolliertes zuführsystem mit einer flüssigkeit von hoher viskosität |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US6413536B1 (en) * | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US5968542A (en) | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| CA2195119C (en) | 1995-06-09 | 2001-09-11 | Mark Chasin | Formulations and methods for providing prolonged local anesthesia |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| ATE303792T1 (de) | 1996-02-02 | 2005-09-15 | Alza Corp | Implantierbares system mit verzögerter wirkstofffreisetzung |
| US6245351B1 (en) | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
| EP0954301A4 (en) | 1996-06-24 | 2006-03-08 | Euro Celtique Sa | SAFE METHODS OF LOCAL ANESTHESIA |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| US6046187A (en) * | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| US5747051A (en) | 1996-09-27 | 1998-05-05 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid |
| US6479074B2 (en) | 1996-10-24 | 2002-11-12 | Pharmaceutical Applications Associates Llc | Methods and transdermal compositions for pain relief |
| US6572880B2 (en) | 1996-10-24 | 2003-06-03 | Pharmaceutical Applications Associates Llc | Methods and transdermal compositions for pain relief |
| ATE318580T1 (de) | 1996-12-20 | 2006-03-15 | Alza Corp | Gelzusammensetzungen und verfahren |
| US6203813B1 (en) | 1997-01-13 | 2001-03-20 | Lance L. Gooberman | Pharmaceutical delivery device and method of preparation therefor |
| US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| DE19714765A1 (de) | 1997-04-10 | 1998-10-15 | Merck Patent Gmbh | Verwendung von niedermolekularen, oligomeren Estern von alpha-Hydroxysäuren und/oder aromatischen o-Hydroxysäuren in kosmetischen Formulierungen |
| US5919473A (en) | 1997-05-12 | 1999-07-06 | Elkhoury; George F. | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| US6051558A (en) | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
| CN100408100C (zh) | 1997-07-29 | 2008-08-06 | 阿尔康实验室公司 | 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物 |
| BR9814883A (pt) | 1997-11-19 | 2000-10-03 | Darwin Discovery Ltd | Formulação anestésica |
| RU2180557C2 (ru) * | 1998-06-26 | 2002-03-20 | Казахский Государственный национальный университет им. Аль-Фараби | Анестезирующий состав пролонгированного действия |
| PL345216A1 (en) | 1998-06-29 | 2001-12-03 | Pharmaceuticals Applic Asociat | Methods and transdermal compositions for pain relief |
| US6312717B1 (en) | 1998-07-07 | 2001-11-06 | Bristol-Myers Squibb Company | Method for treatment of anxiety and depression |
| DE19858891A1 (de) | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Verbesserte Knochensiegel |
| US6498153B1 (en) | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
| US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
| NZ515644A (en) * | 1999-06-04 | 2004-12-24 | Skyepharma Inc | Oil-core compositions for the sustained release of hydrophobic drugs |
| WO2000078335A1 (en) | 1999-06-18 | 2000-12-28 | Southern Biosystems, Inc. | COMPOSITIONS FOR CONTROLLED RELEASE OF THE HORMONE GnRH AND ITS ANALOGS |
| DZ3227A1 (fr) * | 1999-12-23 | 2001-07-05 | Pfizer Prod Inc | Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees |
| PT1248596E (pt) | 2000-01-11 | 2007-06-21 | Bertex Pharma Gmbh | Kit para implantações contendo uma fase de veículo e um solvente |
| BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| US6992065B2 (en) | 2000-04-19 | 2006-01-31 | Genentech, Inc. | Sustained release formulations |
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| WO2002010436A2 (en) | 2000-07-28 | 2002-02-07 | The Brigham And Women's Hospital, Inc. | Prognostic classification of breast cancer |
| FR2814308B1 (fr) | 2000-09-15 | 2003-03-14 | France Telecom | Procede de gestion de l'usage d'une ligne de telecommunication et systeme de mise en oeuvre |
| JP2004512354A (ja) | 2000-10-30 | 2004-04-22 | ユーロ−セルティーク，エス．エイ． | ヒドロコドン放出制御製剤 |
| WO2002058670A1 (en) * | 2001-01-25 | 2002-08-01 | Euroceltique S.A. | Local anesthetic, and method of use |
| ES2554106T3 (es) | 2001-06-21 | 2015-12-16 | Genentech, Inc. | Formulación de liberación sostenida |
| ATE507816T1 (de) * | 2001-11-14 | 2011-05-15 | Durect Corp | Injizierbare depotzusammensetzungen und deren verwendung |
| FR2838349B1 (fr) | 2002-04-15 | 2004-06-25 | Laurence Paris | Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication |
| WO2003101358A1 (en) | 2002-05-31 | 2003-12-11 | Titan Pharmaceuticals, Inc. | Implantable polymeric device for sustained release of buprenorphine |
| US20040109893A1 (en) | 2002-06-25 | 2004-06-10 | Guohua Chen | Sustained release dosage forms of anesthetics for pain management |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| JP4417039B2 (ja) | 2002-06-28 | 2010-02-17 | 太陽化学株式会社 | 水中油滴型乳化組成物 |
| JP4712380B2 (ja) | 2002-07-26 | 2011-06-29 | 三笠製薬株式会社 | 外用剤 |
| AU2003267763A1 (en) | 2002-10-25 | 2004-05-13 | Pfizer Products Inc. | Depot formulations of arylheterocyclic active agents in the form of a suspension |
| AU2003267788A1 (en) | 2002-10-25 | 2004-05-13 | Pfizer Products Inc. | Novel injectable depot formulations |
| CN101797221B (zh) | 2002-12-13 | 2013-06-12 | 杜雷科特公司 | 包含高粘度液体载体材料的口服递药系统 |
| BR0317421A (pt) | 2002-12-19 | 2005-11-08 | Alza Corp | Géis de fase única não-aquosa estável e formulações destes para liberação a partir de um dispositivo implantável |
| DE10312346A1 (de) | 2003-03-20 | 2004-09-30 | Bayer Healthcare Ag | Kontrolliertes Freisetzungssystem |
| DE10322469A1 (de) | 2003-05-19 | 2004-12-16 | Bayer Healthcare Ag | Heterocyclische Verbindungen |
| US20050106304A1 (en) | 2003-11-14 | 2005-05-19 | Cook Phillip M. | Sucrose acetate isobutyrate formulation |
| US20050171052A1 (en) | 2003-11-14 | 2005-08-04 | Cook Phillip M. | Sucrose acetate isobutyrate formulation |
| US20050232876A1 (en) | 2004-04-19 | 2005-10-20 | Robin Lynn Minga | Skin care compositions |
| US20080023261A1 (en) | 2004-05-14 | 2008-01-31 | Yanmar Co., Ltd. | Noise Proof Structure of Cabin |
| US20050266087A1 (en) | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| SI2767292T1 (sl) | 2004-09-17 | 2017-01-31 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
| WO2006084141A2 (en) | 2005-02-03 | 2006-08-10 | Intarcia Therapeutics, Inc | Suspension formulation of interferon |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| JP5194273B2 (ja) | 2007-09-20 | 2013-05-08 | 三菱電機株式会社 | 半導体装置 |
| SE531980C2 (sv) | 2008-01-17 | 2009-09-22 | Avtech Sweden Ab | Flygstyrningsförfarande samt datorprogram och datorprogramprodukt för att genomföra förfarandet |
-
2005
- 2005-09-15 SI SI200532112A patent/SI2767292T1/sl unknown
- 2005-09-15 EP EP14167954.8A patent/EP2767292B1/en not_active Not-in-force
- 2005-09-15 DK DK11187311T patent/DK2415484T3/da active
- 2005-09-15 AT AT05812735T patent/ATE537844T1/de active
- 2005-09-15 PT PT141679548T patent/PT2767292T/pt unknown
- 2005-09-15 GE GEAP20059991A patent/GEP20094831B/en unknown
- 2005-09-15 ES ES14167954.8T patent/ES2602273T3/es active Active
- 2005-09-15 EA EA201001885A patent/EA201001885A1/ru unknown
- 2005-09-15 PT PT11187311T patent/PT2415484E/pt unknown
- 2005-09-15 ES ES05812735T patent/ES2378671T3/es active Active
- 2005-09-15 US US11/663,125 patent/US8753665B2/en active Active
- 2005-09-15 EP EP20110187311 patent/EP2415484B1/en not_active Not-in-force
- 2005-09-15 KR KR1020137031550A patent/KR101492361B1/ko active IP Right Grant
- 2005-09-15 PT PT05812735T patent/PT1809329E/pt unknown
- 2005-09-15 KR KR1020077008645A patent/KR101351771B1/ko active IP Right Grant
- 2005-09-15 BR BRPI0515372A patent/BRPI0515372B8/pt not_active IP Right Cessation
- 2005-09-15 HU HUE14167954A patent/HUE032040T2/en unknown
- 2005-09-15 CA CA2581287A patent/CA2581287C/en active Active
- 2005-09-15 ES ES11187311.3T patent/ES2496765T3/es active Active
- 2005-09-15 EP EP05812735A patent/EP1809329B1/en active Active
- 2005-09-15 PL PL11187311T patent/PL2415484T3/pl unknown
- 2005-09-15 PL PL05812735T patent/PL1809329T3/pl unknown
- 2005-09-15 SI SI200531885T patent/SI2415484T1/sl unknown
- 2005-09-15 DK DK05812735.8T patent/DK1809329T3/da active
- 2005-09-15 LT LTEP14167954.8T patent/LT2767292T/lt unknown
- 2005-09-15 EP EP16178709.8A patent/EP3103477A1/en not_active Withdrawn
- 2005-09-15 NZ NZ553369A patent/NZ553369A/en not_active IP Right Cessation
- 2005-09-15 AU AU2005287175A patent/AU2005287175B2/en not_active Ceased
- 2005-09-15 WO PCT/US2005/032863 patent/WO2006033948A2/en active Application Filing
- 2005-09-15 DK DK14167954.8T patent/DK2767292T3/da active
- 2005-09-15 JP JP2007532447A patent/JP5285275B2/ja not_active Expired - Fee Related
- 2005-09-15 MX MX2007002962A patent/MX2007002962A/es active IP Right Grant
- 2005-09-15 RS RS20120121A patent/RS52198B/en unknown
- 2005-09-15 EA EA200700653A patent/EA014852B1/ru not_active IP Right Cessation
-
2007
- 2007-02-21 IL IL181474A patent/IL181474A/en active IP Right Grant
- 2007-04-16 NO NO20071914A patent/NO342596B1/no not_active IP Right Cessation
- 2007-07-31 US US11/888,648 patent/US8153661B2/en active Active
- 2007-07-31 US US11/888,658 patent/US8153149B2/en active Active
-
2008
- 2008-09-30 JP JP2008252115A patent/JP5285374B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-12 CY CY20121100253T patent/CY1112625T1/el unknown
- 2012-03-20 HR HR20120254T patent/HRP20120254T1/hr unknown
-
2013
- 2013-03-07 US US13/789,416 patent/US8846072B2/en active Active
-
2014
- 2014-08-20 US US14/464,624 patent/US20150111924A1/en not_active Abandoned
-
2015
- 2015-02-13 HK HK15101685.1A patent/HK1201437A1/xx not_active IP Right Cessation
-
2016
- 2016-01-25 US US15/005,937 patent/US20160235726A1/en not_active Abandoned
- 2016-11-24 CY CY20161101218T patent/CY1118360T1/el unknown
-
2017
- 2017-01-09 US US15/402,011 patent/US20170216267A1/en not_active Abandoned
-
2018
- 2018-01-12 US US15/870,745 patent/US20180256553A1/en not_active Abandoned
-
2019
- 2019-02-20 US US16/281,026 patent/US20190231762A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2767292T3 (da) | Vedvarende lokalbedøvelsessammensætning indeholdende saib | |
| RU2429882C2 (ru) | Система контролируемой доставки | |
| AU2012201226B2 (en) | Sustained local anesthetic composition containing preferably a sugar ester such as SAIB | |
| AU2017228714A1 (en) | Sustained local anesthetic composition containing preferably a sugar ester such as SAIB |