DK2701695T3 - Neurodegenerative lidelser og muskelsygdomme, der involverer polyumættede fedtsyrer - Google Patents
Neurodegenerative lidelser og muskelsygdomme, der involverer polyumættede fedtsyrer Download PDFInfo
- Publication number
- DK2701695T3 DK2701695T3 DK12776294.6T DK12776294T DK2701695T3 DK 2701695 T3 DK2701695 T3 DK 2701695T3 DK 12776294 T DK12776294 T DK 12776294T DK 2701695 T3 DK2701695 T3 DK 2701695T3
- Authority
- DK
- Denmark
- Prior art keywords
- fatty acids
- polyunsaturated fatty
- neurodegenerative disorders
- diseases involving
- muscle diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161479269P | 2011-04-26 | 2011-04-26 | |
US201161479270P | 2011-04-26 | 2011-04-26 | |
PCT/US2012/034832 WO2012148926A2 (en) | 2011-04-26 | 2012-04-24 | Neurodegenerative disorders and muscle diseases implicating pufas |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2701695T3 true DK2701695T3 (da) | 2019-06-17 |
Family
ID=47073020
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12776294.6T DK2701695T3 (da) | 2011-04-26 | 2012-04-24 | Neurodegenerative lidelser og muskelsygdomme, der involverer polyumættede fedtsyrer |
Country Status (9)
Country | Link |
---|---|
US (3) | US10154983B2 (da) |
EP (1) | EP2701695B1 (da) |
JP (4) | JP6106157B2 (da) |
KR (2) | KR102020611B1 (da) |
AU (1) | AU2012249917B2 (da) |
CA (1) | CA2834274C (da) |
DK (1) | DK2701695T3 (da) |
IL (1) | IL229016B (da) |
WO (1) | WO2012148926A2 (da) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5934102B2 (ja) | 2009-10-30 | 2016-06-15 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | Pufa誘導体による酸化ストレス障害の緩和 |
KR102014526B1 (ko) | 2011-04-26 | 2019-08-26 | 레트로토프 인코포레이티드 | Pufa 산화와 관련된 장애 |
JP6106158B2 (ja) | 2011-04-26 | 2017-03-29 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | 酸化的網膜疾患 |
EP3730135A1 (en) | 2011-04-26 | 2020-10-28 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
EP2701695B1 (en) | 2011-04-26 | 2019-04-03 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating pufas |
WO2013071281A1 (en) * | 2011-11-13 | 2013-05-16 | Blanchette Rockefeller Neurosciences Institute | Esters of dcpla and methods of treatment using the same |
EP2767532B1 (en) * | 2012-12-21 | 2016-07-13 | National Institutes for Quantum and Radiological Science and Technology | Novel compound for imaging tau protein accumulated in the brain |
EP3943081A1 (en) | 2014-03-13 | 2022-01-26 | Retrotope, Inc. | Optic neuropathy treatment and reduction of steroid- induced oxidative stress with stabilized polyunsaturated substances |
EP3950649A1 (en) | 2015-11-23 | 2022-02-09 | Retrotope, Inc. | Site-specific isotopic labeling of 1, 4-diene systems |
JP7132630B2 (ja) * | 2016-11-17 | 2022-09-07 | レトロトップ、 インコーポレイテッド | 同位体修飾成分及びその治療上の使用 |
WO2019195467A1 (en) * | 2018-04-04 | 2019-10-10 | Retrotope, Inc. | Isotopically modified composition and therapeutic uses thereof |
AU2019255739A1 (en) * | 2018-04-20 | 2020-11-12 | Biojiva Llc | Stabilized polyunsaturated compounds and uses thereof |
CN111072451B (zh) * | 2018-10-19 | 2021-04-02 | 上虞新和成生物化工有限公司 | 一种格氏反应金属有机产物的水解工艺 |
CA3117216A1 (en) * | 2018-11-15 | 2020-05-22 | Retrotope, Inc. | Deuterated compounds, compositions, and uses |
TWI759962B (zh) | 2019-11-13 | 2022-04-01 | 香港商新旭生技股份有限公司 | 用於降解tau蛋白聚集體的化合物及其用途 |
WO2021163580A1 (en) * | 2020-02-14 | 2021-08-19 | Retrotope, Inc. | Methods for treating tauopathy |
EP4107163A4 (en) | 2020-02-21 | 2024-06-19 | Retrotope, Inc. | PROCESS FOR ISOTOPIC MODIFICATION OF POLYUNSATURATED FATTY ACIDS AND THEIR DERIVATIVES |
US20220249442A1 (en) * | 2021-02-05 | 2022-08-11 | Retrotope, Inc. | Synergistic combination therapy for treating als |
WO2022170136A1 (en) * | 2021-02-05 | 2022-08-11 | Retrotope, Inc. | Methods for assessing a patient's response to treatment of a neurodegenerative disease with deuterated arachidonic acid |
US20230301956A1 (en) * | 2021-12-21 | 2023-09-28 | Biojiva Llc | Methods and compositions for treatment of inflammatory disease |
US20230333087A1 (en) * | 2022-02-11 | 2023-10-19 | Biojiva Llc | Methods for monitoring patient response to treatment of retinal oxidative diseases |
WO2023220058A1 (en) * | 2022-05-09 | 2023-11-16 | Retrotope, Inc. | Therapeutic methods for treating als |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3520872A (en) | 1967-03-24 | 1970-07-21 | Upjohn Co | Process for labelling purine and pyrimidine containing compounds |
US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
AU620929B2 (en) * | 1988-10-27 | 1992-02-27 | Bar-Ilan University | Method and compositions for treating alzheimer's disease, related dementias and epilepsy |
DK0455783T3 (da) | 1989-11-30 | 1996-04-01 | Croda Int Plc | Anvendelse af nervonsyre og langkædede fedtsyrer til behandlingen af demyeliniserende sygdomme |
ES2033193B1 (es) | 1990-10-30 | 1994-01-16 | Ganadera Union Ind Agro | Mezcla grasa para nutricion infantil y de adultos. |
US5436269A (en) | 1991-11-14 | 1995-07-25 | Sagami Chemical Research Center | Method for treating hepatitis |
FR2721518B3 (fr) | 1994-06-28 | 1996-04-12 | Gattefosse Ets Sa | Compositions cosmétiques, pharmaceutiques, diététiques, vétérinaires contenant de l'eau. |
GB9423625D0 (en) | 1994-11-23 | 1995-01-11 | Scotia Holdings Plc | Fortified fruit juice |
JPH08268885A (ja) | 1995-03-30 | 1996-10-15 | Oyo Seikagaku Kenkyusho | 過酸化脂質増量抑制剤 |
US5578334A (en) | 1995-04-07 | 1996-11-26 | Brandeis University | Increasing the HDL level and the HDL/LDL ratio in human serum with fat blends |
CN1114878A (zh) | 1995-06-09 | 1996-01-17 | 郑州铁路局中心医院 | 一种防治心血管系统疾病的制剂 |
JPH09143492A (ja) | 1995-11-17 | 1997-06-03 | Katsumasa Koike | 酸化脂質の確認方法及び酸化脂質の生成方法 |
JPH10291955A (ja) | 1997-04-22 | 1998-11-04 | Sagami Chem Res Center | 13c標識ドコサヘキサエン酸及びその製造方法 |
US20030013772A1 (en) | 2000-02-23 | 2003-01-16 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
US6111066A (en) | 1997-09-02 | 2000-08-29 | Martek Biosciences Corporation | Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains |
ATE423130T1 (de) | 1997-10-08 | 2009-03-15 | Isotechnika Inc | Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien |
US20030069208A1 (en) | 1997-11-25 | 2003-04-10 | University Of Otago | Mitochondrially targeted antioxidants |
US6331532B1 (en) | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
US6270974B1 (en) | 1998-03-13 | 2001-08-07 | Promega Corporation | Exogenous nucleic acid detection |
JP2002513911A (ja) | 1998-05-06 | 2002-05-14 | アイソテクニカ、インコーポレーテッド | 糖尿病症状の診断及び血糖コントロール監視用13cグルコース呼気試験 |
DE69935995T3 (de) * | 1998-10-15 | 2011-02-10 | Dsm Ip Assets B.V. | Polyungesättigen fettsäuren nährungsergänzung |
IT1304406B1 (it) | 1998-10-21 | 2001-03-19 | Danital Italia S R L | Preparazione per la veicolazione di principi attivi basata su acidigrassi polinsaturi del gruppo omega 3. |
US20060229278A1 (en) | 1998-11-25 | 2006-10-12 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
US20080275005A1 (en) | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
US20070270381A1 (en) | 2000-05-25 | 2007-11-22 | Antipodean Pharmaceuticals, Inc. | Mitochondrially targeted antioxidants |
US6503478B2 (en) | 1999-01-13 | 2003-01-07 | Lightouch Medical, Inc. | Chemically specific imaging of tissue |
US7271315B2 (en) | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
JP2000290291A (ja) | 1999-03-31 | 2000-10-17 | Nippon Sanso Corp | 安定同位体標識オリゴヌクレオチド及びオリゴヌクレオチド検出方法 |
ITMI991894A1 (it) | 1999-09-09 | 2001-03-09 | Carlo Ghisalberti | Acido linoleico coniugato e trigliceride nuovi metodi di sintesi e d'uso |
JP3432778B2 (ja) | 1999-11-19 | 2003-08-04 | 森澤 紳勝 | 活性酸素消去剤の濃縮液、その製造方法および活性酸素消去剤パウダー |
GB9929897D0 (en) | 1999-12-18 | 2000-02-09 | Slabas Antoni R | Improvements in or relating to conjugated fatty acids and related compounds |
JP2001270832A (ja) | 2000-03-27 | 2001-10-02 | Ito En Ltd | 網膜障害予防剤 |
GB2368339B (en) | 2000-10-26 | 2002-09-18 | Yissum Res Dev Co | Complex incorporating a plurality of antioxidants |
US20040043013A1 (en) | 2000-12-28 | 2004-03-04 | Mccleary Edward Larry | Metabolic uncoupling therapy |
PL364093A1 (en) | 2001-05-30 | 2004-12-13 | Laxdale Limited | Coenzyme q (ubiquinone) and eicosapentaenoic acid (epa) |
GB0113348D0 (en) | 2001-06-01 | 2001-07-25 | Mars Uk Ltd | Skin diet |
NZ513547A (en) | 2001-08-13 | 2002-09-27 | Antipodean Biotechnology Ltd | Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone) |
US20030091553A1 (en) | 2001-10-19 | 2003-05-15 | Gehlsen Kurt R. | Use of histamine to treat liver disease |
US6870077B2 (en) | 2002-01-30 | 2005-03-22 | Edward O. Kenaschuk | High linolenic acid flax |
JP2004081156A (ja) | 2002-08-28 | 2004-03-18 | Shigeo Ota | 糖尿病および糖尿病関連疾患の予測のためのマーカーおよび個体分類方法 |
JPWO2004029254A1 (ja) | 2002-09-30 | 2006-01-26 | 味の素株式会社 | 安定同位体標識タンパク質の製造方法 |
JP2006504701A (ja) | 2002-09-30 | 2006-02-09 | マーク・エー・バビザイェフ | 眼疾患の局所的治療方法、並びに、その治療用組成物及び治療用手段 |
BR0317026A (pt) | 2002-12-06 | 2005-10-25 | Alcon Inc | Mìmicos de superóxido dismutase para o tratamento de distúrbios e doenças oculares |
US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
JP4648319B2 (ja) | 2003-08-22 | 2011-03-09 | アンティポディーン ファーマシューティカルズ インコーポレイティド | ミトコンドリアを標的とする抗酸化剤として使用されるミトキノン誘導体 |
US7514461B2 (en) | 2003-09-19 | 2009-04-07 | Edison Pharmaceuticals, Inc. | Chroman derivatives |
KR20050029582A (ko) * | 2003-09-23 | 2005-03-28 | 주식회사 리포젠 | 알지닌 공액리놀레인산 복합체를 포함하는 항산화 조성물 |
IL158552A0 (en) | 2003-10-22 | 2004-05-12 | Enzymotec Ltd | Lipids containing omega-3 fatty acids |
AU2005208832A1 (en) | 2004-01-19 | 2005-08-11 | Martek Biosciences Corporation | Reelin deficiency or dysfunction and methods related thereto |
US20050164908A1 (en) | 2004-01-23 | 2005-07-28 | Ginsberg Myron D. | Neuroprotective complex for treatment of cerebral ischemia and injury |
CA2582385A1 (en) | 2004-06-18 | 2005-12-18 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
CN101035594B (zh) | 2004-08-09 | 2013-10-23 | 酶学技术有限公司 | 用于糖尿病患者的食品 |
JP2006053100A (ja) | 2004-08-13 | 2006-02-23 | Institute Of Physical & Chemical Research | 動物の代謝解析方法、ラベル動物の製造方法、ラベル動物、および、動物のnmr測定方法 |
AU2005306320B2 (en) | 2004-11-19 | 2011-09-08 | Martek Biosciences Corporation | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
WO2006073147A1 (ja) | 2005-01-04 | 2006-07-13 | Mochida Pharmaceutical Co., Ltd. | 脂肪毒性の改善剤 |
US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
ES2617577T3 (es) | 2005-07-08 | 2017-06-19 | Dsm Ip Assets B.V. | Ácidos grasos poliinsaturados para el tratamiento de la demencia y afecciones relacionadas con la pre-demencia |
ES2823728T3 (es) | 2005-09-15 | 2021-05-10 | Ptc Therapeutics Inc | Variantes de cola de agentes terapéuticos con actividad redox para el tratamiento de enfermedades mitocondriales y otras afecciones y la modulación de biomarcadores de energía |
JP2009525948A (ja) * | 2005-12-20 | 2009-07-16 | シラメッド・インコーポレーテッド | 高親油性スルフヒドリル化合物の製薬組成物及び使用方法 |
WO2007081773A2 (en) | 2006-01-05 | 2007-07-19 | Reliant Pharmaceuticals, Inc | Treatment of fatty liver |
GB0604647D0 (en) * | 2006-03-08 | 2006-04-19 | Shchepinov Mikhail | Stabilized food supplements and their derivatives |
US20100048705A1 (en) | 2006-11-09 | 2010-02-25 | Children's Medical Center Corporation | Methods of treating and preventing neovascularization with omega-3 polyunsaturated fatty acids |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
EP1961311A1 (en) | 2007-02-23 | 2008-08-27 | Belovo S.A., Egg Science & Technology | Food comprising polyunsaturated fatty acids for the prevention of chronic diseases |
AU2008224869A1 (en) * | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
US20080234197A1 (en) | 2007-03-19 | 2008-09-25 | Undurti N Das | Method(s) of stabilizing and potentiating the actions and administration of brain-derived neurotrophic factor (BDNF) |
RU2460526C2 (ru) | 2007-05-25 | 2012-09-10 | Сантен Фармасьютикал Ко., Лтд. | Профилактическое или терапевтическое средство для возрастной дегенерации желтого пятна |
SI2182981T1 (sl) | 2007-08-02 | 2013-05-31 | Gilead Biologics, Inc. | Postopki in sestavki za zdravljenje in diagnozo fibroze |
US20090069354A1 (en) | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched gemcitabine |
CA2708961C (en) | 2008-01-08 | 2017-03-28 | Edison Pharmaceuticals, Inc. | (het)aryl-p-quinone derivatives for treatment of mitochondrial diseases |
WO2009097331A1 (en) | 2008-01-28 | 2009-08-06 | The Board Of Regents Of The University Of Oklahoma | Very long chain polyunsaturated fatty acids, methods of production, and uses |
EP2268604B1 (en) | 2008-03-14 | 2017-02-15 | Retrotope, Inc. | Therapies for cancer using isotopically substituted lysine |
EP2276774B1 (en) | 2008-03-14 | 2016-08-17 | Retrotope, Inc. | Therapeutic substances that modulate genome methylation |
EP2110027A1 (en) | 2008-04-01 | 2009-10-21 | Nestec S.A. | Long-chain polyunsaturated fatty acids (LC-PUFA) in maternal nutrition during pregnancy and lactation |
MX2010010713A (es) | 2008-04-01 | 2011-02-21 | Antipodean Pharmaceuticals Inc | Composiciones y metodos para el cuidado de la piel. |
US8461348B2 (en) | 2008-04-04 | 2013-06-11 | Takeda Pharmaceutical Company Limited | Heterocyclic derivative and use thereof |
DK2280928T3 (da) | 2008-05-01 | 2018-11-05 | Complexa Inc | Vinylsubstituerede fedtsyrer |
US20110092592A1 (en) | 2008-06-13 | 2011-04-21 | Takashi Yano | Diagnosis and treatment of hepatic disorder |
GB0813599D0 (en) | 2008-07-24 | 2008-09-03 | Pharma Marine As | Method |
US8163800B2 (en) | 2008-07-28 | 2012-04-24 | Blanchette Rockefeller Neurosciences Institute | PKC-activating compounds for the treatment of neurodegenerative diseases |
US20100029706A1 (en) | 2008-07-30 | 2010-02-04 | Edison Parmaceuticals, Inc. a Delaware Corporation | HYDROGENATED PYRIDO[4,3-b]INDOLES FOR THE TREATMENT OF OXIDATIVE STRESS |
CA2747235C (en) * | 2008-12-11 | 2021-02-09 | Biovista, Inc. | Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles |
ES2345241B1 (es) | 2009-03-16 | 2011-09-08 | Lipopharma Therapeutics | Uso de 2-hidroxiderivados de acidos grasos poliinsaturados como medicamentos. |
US20120046363A1 (en) | 2009-05-11 | 2012-02-23 | University Of Maryland, Baltimore | Docosahexaenoic acid for the treatment of heart failure |
WO2010143053A1 (en) | 2009-06-10 | 2010-12-16 | Energy4Life Ag | Methods and compositions for treating insulin resistance, diabetes mellitus type 2, metabolic syndrome and related disorders |
EP2483233A4 (en) | 2009-10-02 | 2013-08-14 | Complexa Inc | HETEROATOMA CONTAINING SUBSTITUTED FATTY ACIDS |
JP5934102B2 (ja) | 2009-10-30 | 2016-06-15 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | Pufa誘導体による酸化ストレス障害の緩和 |
WO2011097273A1 (en) | 2010-02-02 | 2011-08-11 | Martek Biosciences Corporation | Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine |
US9012500B2 (en) | 2010-11-16 | 2015-04-21 | Nishizaki Bioinformation Research Institute | PKC-ε activator |
EP3730135A1 (en) | 2011-04-26 | 2020-10-28 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
JP6106158B2 (ja) | 2011-04-26 | 2017-03-29 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | 酸化的網膜疾患 |
EP2701695B1 (en) * | 2011-04-26 | 2019-04-03 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating pufas |
KR102014526B1 (ko) | 2011-04-26 | 2019-08-26 | 레트로토프 인코포레이티드 | Pufa 산화와 관련된 장애 |
WO2012174262A2 (en) | 2011-06-14 | 2012-12-20 | Cenestra Llc | Formulations and methods of treating subjects having central nervous system, endocrine, inflammatory or cardiovascular disorders or at-risk thereof with highly purified omega-3 fatty acid formulations |
-
2012
- 2012-04-24 EP EP12776294.6A patent/EP2701695B1/en active Active
- 2012-04-24 JP JP2014508486A patent/JP6106157B2/ja active Active
- 2012-04-24 DK DK12776294.6T patent/DK2701695T3/da active
- 2012-04-24 AU AU2012249917A patent/AU2012249917B2/en active Active
- 2012-04-24 KR KR1020137031179A patent/KR102020611B1/ko active IP Right Grant
- 2012-04-24 KR KR1020197026028A patent/KR102111997B1/ko active IP Right Grant
- 2012-04-24 CA CA2834274A patent/CA2834274C/en active Active
- 2012-04-24 US US14/113,542 patent/US10154983B2/en active Active
- 2012-04-24 WO PCT/US2012/034832 patent/WO2012148926A2/en active Application Filing
-
2013
- 2013-10-22 IL IL229016A patent/IL229016B/en active IP Right Grant
-
2017
- 2017-03-03 JP JP2017040094A patent/JP6518708B2/ja active Active
-
2018
- 2018-10-26 US US16/171,901 patent/US11241409B2/en active Active
-
2019
- 2019-04-22 JP JP2019080922A patent/JP6890842B2/ja active Active
-
2021
- 2021-05-19 JP JP2021084443A patent/JP7331037B2/ja active Active
-
2022
- 2022-02-04 US US17/665,436 patent/US20220378734A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20190107157A (ko) | 2019-09-18 |
WO2012148926A8 (en) | 2013-12-12 |
IL229016A0 (en) | 2013-12-31 |
JP2017125045A (ja) | 2017-07-20 |
JP2021121614A (ja) | 2021-08-26 |
KR102020611B1 (ko) | 2019-09-10 |
EP2701695B1 (en) | 2019-04-03 |
US10154983B2 (en) | 2018-12-18 |
CA2834274A1 (en) | 2012-11-01 |
JP6518708B2 (ja) | 2019-05-22 |
CA2834274C (en) | 2021-08-03 |
US20220378734A1 (en) | 2022-12-01 |
AU2012249917B2 (en) | 2017-06-15 |
JP2014513098A (ja) | 2014-05-29 |
JP2019135256A (ja) | 2019-08-15 |
WO2012148926A2 (en) | 2012-11-01 |
EP2701695A4 (en) | 2014-10-29 |
US11241409B2 (en) | 2022-02-08 |
AU2012249917A1 (en) | 2013-12-12 |
JP6890842B2 (ja) | 2021-06-18 |
KR102111997B1 (ko) | 2020-05-18 |
EP2701695A2 (en) | 2014-03-05 |
KR20140032408A (ko) | 2014-03-14 |
US20190231733A1 (en) | 2019-08-01 |
US20140147428A1 (en) | 2014-05-29 |
JP7331037B2 (ja) | 2023-08-22 |
IL229016B (en) | 2020-09-30 |
JP6106157B2 (ja) | 2017-03-29 |
WO2012148926A3 (en) | 2013-01-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2701695T3 (da) | Neurodegenerative lidelser og muskelsygdomme, der involverer polyumættede fedtsyrer | |
CO6940374A2 (es) | Composiciones, usos y métodos para tratamiento de trastornos y enfermedades metabólicas | |
CO6852065A2 (es) | Galleta saludable | |
DK3491915T3 (da) | Fremgangsmåde til at inducere en målrettet translokation i en plante | |
HK1201452A1 (en) | Methods of reducing risk of cardiovascular disease | |
CO6920257A2 (es) | Protéinas de fusión para tratar trastornos metabólicos | |
BR112013007678A2 (pt) | método para tratamento de doenças alérgicas | |
DK2701697T3 (da) | Oxidative nethindesygdomme | |
EP2763540A4 (en) | COMPOSITIONS AND METHODS FOR EVALUATION AND TREATMENT OF DISEASES AND INFLAMMATORY DISORDERS | |
HK1198909A1 (en) | Compositions and methods for the treatment of hepatic diseases and disorders | |
IL229019B (en) | Disorders involving the oxidation of polyunsaturated fatty acids | |
EP2882429A4 (en) | METHOD FOR TREATING NEURODEEGENERATIVE ILLNESSES | |
EP2809317A4 (en) | FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS | |
BR112013022766A2 (pt) | método de administração de d-pirfenidona e kit | |
ZA201306521B (en) | Method for inducing resistance to diseases in plants | |
BR112014013694A2 (pt) | método para tratar uma doença, e, kit | |
CO6880064A2 (es) | Métodos terapéuticos | |
BR112015015258A2 (pt) | métodos para tratar distúrbios do trato gastrintestinal | |
BR112014005614A2 (pt) | método para produzir chocolate, e, chocolate | |
DK3351554T3 (da) | Glutenrelaterede forstyrrelser | |
BR112013023537A2 (pt) | método para tratar distúrbios da pele | |
PL2726161T3 (pl) | Samodzielne urządzenie do treningu terapeutycznego | |
GB201201062D0 (en) | Radiofluorination method | |
FR2980728B1 (fr) | Composition de fondant et procede de soudage | |
BR112013022530A2 (pt) | método terapêutico homeopático e composições |