DK2586313T3 - Fermentation process using yeast cells with interrupted conversion pathway from dihydroxyacetone phosphate to glycerol - Google Patents

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Publication number

DK2586313T3

DK2586313T3 DK12196287.2T DK12196287T DK2586313T3 DK 2586313 T3 DK2586313 T3 DK 2586313T3 DK 12196287 T DK12196287 T DK 12196287T DK 2586313 T3 DK2586313 T3 DK 2586313T3

Authority

DK

Denmark

Prior art keywords

ala

leu

val

lys

gly

Prior art date

2006-03-13

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• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title claims description 274
• 238000000855 fermentation Methods 0.000 title claims description 92
• 230000004151 fermentation Effects 0.000 title claims description 92
• GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 title claims description 56
• 210000005253 yeast cell Anatomy 0.000 title description 23
• 238000006243 chemical reaction Methods 0.000 title description 13
• 230000037361 pathway Effects 0.000 title description 13
• 238000012217 deletion Methods 0.000 claims description 78
• 230000037430 deletion Effects 0.000 claims description 78
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 55
• 239000008103 glucose Substances 0.000 claims description 55
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 53
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 42
• 241000235645 Pichia kudriavzevii Species 0.000 claims description 36
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 25
• 229910052799 carbon Inorganic materials 0.000 claims description 25
• 108010041921 Glycerolphosphate Dehydrogenase Proteins 0.000 claims description 24
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• 150000007524 organic acids Chemical class 0.000 claims description 15
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• AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 11
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