DK2567709T3 - Molekyler og fremgangsmåder til modulering af lav-densitets-lipoprotein receptor-beslægtet protein 6 (LRP6) - Google Patents

Molekyler og fremgangsmåder til modulering af lav-densitets-lipoprotein receptor-beslægtet protein 6 (LRP6) Download PDF

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Publication number
DK2567709T3
DK2567709T3 DK12188230.2T DK12188230T DK2567709T3 DK 2567709 T3 DK2567709 T3 DK 2567709T3 DK 12188230 T DK12188230 T DK 12188230T DK 2567709 T3 DK2567709 T3 DK 2567709T3
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lrp6
antibody
binding
antigen
human
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DK12188230.2T
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Feng Cong
Shamina M Rangwala
Seth Ettenberg
Sabine Guth
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Novartis Ag
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Claims (10)

1. Monoklonalt antistof eller et antigen-bindende fragment deraf der specifikt binder til human lav-densitets-lipoprotein receptor-beslægtet protein 6 polypeptid (LRP6) med aminosyresekvensen af SEQ ID NO:l, er i stand til at antagonisere 5 Wnt-signaleringsvejen, og inhiberer Wnt3- og Wnt3a-specifik signaleringsaktivitet, hvor den antigen-bindende del binder til en epitop af humant LRP6 inde i aminosyrerne 631-932 af SEQ ID NO:l som vist i tabel 1.
2. Monoklonalt antistof eller antigen-bindende fragment ifolge krav 1, hvor den 10 antigen-bindende del er i stand til at binde til og inhibere phosphoryleret-LRP6 (phospho-LRP6).
3. Monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som helst af de foregâende krav, hvor fragmentet er et Fab-fragment, et Fab'-fragment, et 15 F(ab')2-, eller et Fv-fragment af antistoffet.
4. Monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som helst af de foregâende krav, hvor den antigen-bindende del binder til LRP6 med en Kd lig med eller mindre end 1 nM. 20
5. Monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som helst af kravene 1-4, hvor den antigen-bindende del er en antigen-bindende del af et humant antistof.
6. Monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som helst af kravene 1-4, hvor antistoffet er et humant eller humaniseret antistof.
7. Monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som helst af kravene 1-5, hvor antistoffet er et kimært antistof. 30
8. Monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som helst af de foregâende krav, hvor antistoffet er et af folgende isotyper: IgGl, IgG2, IgG3 eller IgG4.
9. Farmaceutisk sammensætning omfattende monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som helst af de foregâende krav.
10. Monoklonalt antistof eller antigen-bindende fragment ifolge et hvilket som 5 helst af kravene 1 til 8 eller den farmaceutiske sammensætning ifolge krav 9 til anvendelse i behandling af cancer, hvor anvendelsen omfatter administration af antistoffet, det antigen-bindende fragment, eller den farmaceutiske sammensætning til et individ der lider af eller er ramt af cancer. 10
DK12188230.2T 2007-11-02 2008-10-31 Molekyler og fremgangsmåder til modulering af lav-densitets-lipoprotein receptor-beslægtet protein 6 (LRP6) DK2567709T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98482707P 2007-11-02 2007-11-02
EP08844924.4A EP2209491B1 (en) 2007-11-02 2008-10-31 Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (lrp6)

Publications (1)

Publication Number Publication Date
DK2567709T3 true DK2567709T3 (da) 2018-03-12

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DK12188230.2T DK2567709T3 (da) 2007-11-02 2008-10-31 Molekyler og fremgangsmåder til modulering af lav-densitets-lipoprotein receptor-beslægtet protein 6 (LRP6)

Country Status (15)

Country Link
US (1) US20100254980A1 (da)
EP (3) EP2209491B1 (da)
JP (1) JP5764329B2 (da)
KR (1) KR20100091170A (da)
CN (1) CN101951954A (da)
AU (1) AU2008320823B2 (da)
BR (1) BRPI0820327A2 (da)
CA (1) CA2700433A1 (da)
DK (1) DK2567709T3 (da)
EA (1) EA201000718A1 (da)
ES (2) ES2663077T3 (da)
HK (1) HK1252539A1 (da)
MX (1) MX2010004761A (da)
PL (1) PL2567709T3 (da)
WO (1) WO2009056634A2 (da)

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