DK249086A - 4-(p-aminomethylbenzoyloxy)-2-methyl-n-heteroaryl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og farmaceutiske praeparater indeholdende disse - Google Patents
4-(p-aminomethylbenzoyloxy)-2-methyl-n-heteroaryl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og farmaceutiske praeparater indeholdende disse Download PDFInfo
- Publication number
- DK249086A DK249086A DK249086A DK249086A DK249086A DK 249086 A DK249086 A DK 249086A DK 249086 A DK249086 A DK 249086A DK 249086 A DK249086 A DK 249086A DK 249086 A DK249086 A DK 249086A
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- ethyl
- amino
- methylpyridinium
- pyridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Dental Preparations (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/738,805 US4623486A (en) | 1985-05-29 | 1985-05-29 | [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DK249086D0 DK249086D0 (da) | 1986-05-28 |
DK249086A true DK249086A (da) | 1986-11-30 |
Family
ID=24969564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK249086A DK249086A (da) | 1985-05-29 | 1986-05-28 | 4-(p-aminomethylbenzoyloxy)-2-methyl-n-heteroaryl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og farmaceutiske praeparater indeholdende disse |
Country Status (25)
Country | Link |
---|---|
US (1) | US4623486A (fr) |
EP (1) | EP0208404B1 (fr) |
JP (1) | JPS61277683A (fr) |
KR (1) | KR870000913B1 (fr) |
CN (1) | CN1004628B (fr) |
AT (1) | ATE56010T1 (fr) |
AU (1) | AU557396B1 (fr) |
CA (1) | CA1270485A (fr) |
DD (1) | DD247451A5 (fr) |
DE (1) | DE3673710D1 (fr) |
DK (1) | DK249086A (fr) |
EG (1) | EG17811A (fr) |
ES (1) | ES8707211A1 (fr) |
FI (1) | FI86065C (fr) |
GR (1) | GR861389B (fr) |
HU (2) | HU200178B (fr) |
IL (1) | IL78912A (fr) |
NO (1) | NO165240C (fr) |
NZ (1) | NZ216310A (fr) |
PH (1) | PH23146A (fr) |
PL (1) | PL147843B1 (fr) |
PT (1) | PT82649B (fr) |
SU (2) | SU1538896A3 (fr) |
YU (1) | YU44576B (fr) |
ZA (1) | ZA863986B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2650589A1 (fr) * | 1989-08-04 | 1991-02-08 | Esteve Labor Dr | Derives benzothiaziniques, leur preparation et leurs applications comme medicaments ou comme intermediaires de synthese de medicaments |
JPH069600A (ja) * | 1992-05-06 | 1994-01-18 | Bristol Myers Squibb Co | タクソールのベンゾエート誘導体 |
FR2795412B1 (fr) * | 1999-06-23 | 2001-07-13 | Adir | Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB0031107D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
FR2818641B1 (fr) * | 2000-12-21 | 2004-03-05 | Servier Lab | Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent |
GB0202873D0 (en) | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
US20090221703A1 (en) * | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
WO2008024829A2 (fr) * | 2006-08-23 | 2008-02-28 | Board Of Regents, The University Of Texas System | Radiohaloimatinibes, procédés de synthèse de ceux-ci et leur utilisation dans l'imagerie de cancers par tomographie à émission de positrons |
EP2084165B1 (fr) * | 2006-10-11 | 2013-06-12 | Techfields Biochem Co. Ltd | Pro-médicaments d'oxicams solubles dans l'eau et chargés positivement et composés apparentés avec une vitesse de pénétration de la peau très élevée |
CN103980228B (zh) * | 2006-10-11 | 2020-03-17 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药 |
JP2009514988A (ja) * | 2006-10-26 | 2009-04-09 | シコール インコーポレイティド | イマチニブ塩基及びイマチニブメシレート、及びそれらの調製方法 |
US8466154B2 (en) | 2006-10-27 | 2013-06-18 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to wrapping of dehydrons |
JP5235423B2 (ja) * | 2007-01-25 | 2013-07-10 | 株式会社 資生堂 | 皮膚外用組成物 |
KR20190091378A (ko) * | 2007-06-04 | 2019-08-05 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도 |
KR20210123406A (ko) | 2008-12-04 | 2021-10-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
CN101665472B (zh) * | 2009-06-15 | 2011-08-24 | 威海迪素制药有限公司 | 2-甲基-3,4-二氢-4-氧代-2h-1,2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法 |
US8609842B2 (en) | 2010-04-23 | 2013-12-17 | Fujian South Pharmaceutical Co., Ltd. | Method for synthesizing Imatinib |
WO2013008242A1 (fr) | 2011-07-12 | 2013-01-17 | Natco Pharma Limited | Procédé de préparation d'un dichlorhydrate d'acide 4-(4-méthylpipérazino- méthyl)benzoïque très pur |
WO2013035102A1 (fr) | 2011-09-05 | 2013-03-14 | Natco Pharma Limited | Procédés pour la préparation d'imatinib sous forme de base et leurs intermédiaires |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH93438A (de) * | 1921-02-24 | 1922-04-01 | Hoffmann La Roche | Verfahren zur Darstellung des p-Dimethylaminomethylbenzoesäurebenzylesters. |
CH93751A (de) * | 1921-02-24 | 1922-04-01 | Hoffmann La Roche | Verfahren zur Darstellung des p-Diäthylaminomethylbenzoesäurebenzylesters. |
US2406627A (en) * | 1942-04-16 | 1946-08-27 | American Cyanamid Co | Alkamine derivatives of para aminomethyl benzoic acid |
US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
US3787324A (en) * | 1971-03-01 | 1974-01-22 | Warner Lambert Co | 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production |
JPS4810078U (fr) * | 1971-06-17 | 1973-02-03 | ||
US3788324A (en) * | 1972-05-05 | 1974-01-29 | P Lim | External catheter device |
JPS5070888A (fr) * | 1973-10-27 | 1975-06-12 | ||
US3925371A (en) * | 1974-09-23 | 1975-12-09 | Mcneilab Inc | Benzothiazine-1,1-dioxides |
US3900470A (en) * | 1974-09-23 | 1975-08-19 | Mcneilab Inc | Esters of benzothiazine-1,1-dioxides derivatives |
AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
IT1126509B (it) * | 1979-12-07 | 1986-05-21 | Medea Res Srl | Benzimidi ad attivita' anestetica locale e antiaritmica,processo per la loro preparazione e composizioni farmaceutiche che le contengono |
JPS5714589A (en) * | 1980-06-27 | 1982-01-25 | Mitsui Toatsu Chem Inc | Benzothiazine derivative, its preparation and drug composition |
JPS5770888A (en) * | 1980-10-18 | 1982-05-01 | Shinichi Ito | Benzothiazine derivative, its preparation and medicinal composition |
US4309427A (en) * | 1981-01-15 | 1982-01-05 | Pfizer Inc. | Benzothiazine dioxide derivatives |
US4434164A (en) * | 1981-06-01 | 1984-02-28 | Pfizer Inc. | Crystalline benzothiazine dioxide salts |
IT1168064B (it) * | 1981-11-12 | 1987-05-20 | Prodotti Antibiotici Spa | Composto ad azione antinfiammatoria |
IT8219486A0 (it) * | 1982-02-05 | 1982-02-05 | Chiesi Farma Spa | Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche. |
JPS59193879A (ja) * | 1983-03-31 | 1984-11-02 | Fujisawa Pharmaceut Co Ltd | トロポン誘導体 |
US4551452A (en) * | 1983-12-21 | 1985-11-05 | Pfizer Inc. | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
JPS60184077A (ja) * | 1984-02-23 | 1985-09-19 | フアイザー・インコーポレーテツド | 抗炎症性オキシム前駆薬 |
-
1985
- 1985-05-29 US US06/738,805 patent/US4623486A/en not_active Expired - Lifetime
-
1986
- 1986-05-26 IL IL78912A patent/IL78912A/xx unknown
- 1986-05-27 AT AT86304017T patent/ATE56010T1/de not_active IP Right Cessation
- 1986-05-27 PT PT82649A patent/PT82649B/pt not_active IP Right Cessation
- 1986-05-27 ES ES555374A patent/ES8707211A1/es not_active Expired
- 1986-05-27 EP EP86304017A patent/EP0208404B1/fr not_active Expired - Lifetime
- 1986-05-27 NZ NZ216310A patent/NZ216310A/xx unknown
- 1986-05-27 DE DE8686304017T patent/DE3673710D1/de not_active Expired - Fee Related
- 1986-05-27 PL PL1986259740A patent/PL147843B1/pl unknown
- 1986-05-27 CA CA000510033A patent/CA1270485A/fr not_active Expired - Fee Related
- 1986-05-28 SU SU864027578A patent/SU1538896A3/ru active
- 1986-05-28 GR GR861389A patent/GR861389B/el unknown
- 1986-05-28 YU YU906/86A patent/YU44576B/xx unknown
- 1986-05-28 KR KR1019860004181A patent/KR870000913B1/ko not_active IP Right Cessation
- 1986-05-28 PH PH33823A patent/PH23146A/en unknown
- 1986-05-28 DD DD86290676A patent/DD247451A5/de not_active IP Right Cessation
- 1986-05-28 FI FI862252A patent/FI86065C/fi not_active IP Right Cessation
- 1986-05-28 DK DK249086A patent/DK249086A/da not_active Application Discontinuation
- 1986-05-28 CN CN86103603.4A patent/CN1004628B/zh not_active Expired
- 1986-05-28 AU AU58013/86A patent/AU557396B1/en not_active Ceased
- 1986-05-28 HU HU862250A patent/HU200178B/hu not_active IP Right Cessation
- 1986-05-28 ZA ZA863986A patent/ZA863986B/xx unknown
- 1986-05-28 HU HU872418A patent/HU199839B/hu unknown
- 1986-05-28 EG EG318/86A patent/EG17811A/xx active
- 1986-05-28 JP JP61123215A patent/JPS61277683A/ja active Granted
- 1986-05-28 NO NO862124A patent/NO165240C/no not_active IP Right Cessation
-
1987
- 1987-04-24 SU SU874202427A patent/SU1531855A3/ru active
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |