PT82649B - Processo para a preparacao de derivados de dioxidos de benzotiazina - Google Patents

Processo para a preparacao de derivados de dioxidos de benzotiazina

Info

Publication number
PT82649B
PT82649B PT82649A PT8264986A PT82649B PT 82649 B PT82649 B PT 82649B PT 82649 A PT82649 A PT 82649A PT 8264986 A PT8264986 A PT 8264986A PT 82649 B PT82649 B PT 82649B
Authority
PT
Portugal
Prior art keywords
methyl
ethyl
amino
methylpyridinium
pyridyl
Prior art date
Application number
PT82649A
Other languages
English (en)
Other versions
PT82649A (en
Inventor
Joseph George Lombardino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT82649A publication Critical patent/PT82649A/pt
Publication of PT82649B publication Critical patent/PT82649B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Dental Preparations (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT82649A 1985-05-29 1986-05-27 Processo para a preparacao de derivados de dioxidos de benzotiazina PT82649B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/738,805 US4623486A (en) 1985-05-29 1985-05-29 [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity

Publications (2)

Publication Number Publication Date
PT82649A PT82649A (en) 1986-06-01
PT82649B true PT82649B (pt) 1988-08-17

Family

ID=24969564

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82649A PT82649B (pt) 1985-05-29 1986-05-27 Processo para a preparacao de derivados de dioxidos de benzotiazina

Country Status (25)

Country Link
US (1) US4623486A (pt)
EP (1) EP0208404B1 (pt)
JP (1) JPS61277683A (pt)
KR (1) KR870000913B1 (pt)
CN (1) CN1004628B (pt)
AT (1) ATE56010T1 (pt)
AU (1) AU557396B1 (pt)
CA (1) CA1270485A (pt)
DD (1) DD247451A5 (pt)
DE (1) DE3673710D1 (pt)
DK (1) DK249086A (pt)
EG (1) EG17811A (pt)
ES (1) ES8707211A1 (pt)
FI (1) FI86065C (pt)
GR (1) GR861389B (pt)
HU (2) HU200178B (pt)
IL (1) IL78912A (pt)
NO (1) NO165240C (pt)
NZ (1) NZ216310A (pt)
PH (1) PH23146A (pt)
PL (1) PL147843B1 (pt)
PT (1) PT82649B (pt)
SU (2) SU1538896A3 (pt)
YU (1) YU44576B (pt)
ZA (1) ZA863986B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2650589A1 (fr) * 1989-08-04 1991-02-08 Esteve Labor Dr Derives benzothiaziniques, leur preparation et leurs applications comme medicaments ou comme intermediaires de synthese de medicaments
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
FR2795412B1 (fr) * 1999-06-23 2001-07-13 Adir Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0031107D0 (en) * 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
FR2818641B1 (fr) * 2000-12-21 2004-03-05 Servier Lab Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent
GB0202873D0 (en) 2002-02-07 2002-03-27 Novartis Ag Organic compounds
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
WO2008024829A2 (en) * 2006-08-23 2008-02-28 Board Of Regents, The University Of Texas System Radiohaloimatinibs and methods of their synthesis and use in pet imaging of cancers
CN103980228B (zh) * 2006-10-11 2020-03-17 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
CN101522692A (zh) * 2006-10-11 2009-09-02 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
KR20090061068A (ko) * 2006-10-26 2009-06-15 시코르, 인크. 이매티닙의 제조 방법
US8466154B2 (en) 2006-10-27 2013-06-18 The Board Of Regents Of The University Of Texas System Methods and compositions related to wrapping of dehydrons
JP5235423B2 (ja) * 2007-01-25 2013-07-10 株式会社 資生堂 皮膚外用組成物
JP2010529101A (ja) * 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
MX362949B (es) 2008-12-04 2019-02-27 Yu Chongxi Composiciones de alta penetracion y sus aplicaciones.
CN101665472B (zh) * 2009-06-15 2011-08-24 威海迪素制药有限公司 2-甲基-3，4-二氢-4-氧代-2h-1，2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法
US8609842B2 (en) 2010-04-23 2013-12-17 Fujian South Pharmaceutical Co., Ltd. Method for synthesizing Imatinib
WO2013008242A1 (en) 2011-07-12 2013-01-17 Natco Pharma Limited A process for the preparation of highly pure 4-(4-methyl piperazinomethyl) benzoic acid dihydrochloride
WO2013035102A1 (en) 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH93438A (de) * 1921-02-24 1922-04-01 Hoffmann La Roche Verfahren zur Darstellung des p-Dimethylaminomethylbenzoesäurebenzylesters.
CH93751A (de) * 1921-02-24 1922-04-01 Hoffmann La Roche Verfahren zur Darstellung des p-Diäthylaminomethylbenzoesäurebenzylesters.
US2406627A (en) * 1942-04-16 1946-08-27 American Cyanamid Co Alkamine derivatives of para aminomethyl benzoic acid
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
JPS4810078U (pt) * 1971-06-17 1973-02-03
US3788324A (en) * 1972-05-05 1974-01-29 P Lim External catheter device
JPS5070888A (pt) * 1973-10-27 1975-06-12
US3925371A (en) * 1974-09-23 1975-12-09 Mcneilab Inc Benzothiazine-1,1-dioxides
US3900470A (en) * 1974-09-23 1975-08-19 Mcneilab Inc Esters of benzothiazine-1,1-dioxides derivatives
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
IT1126509B (it) * 1979-12-07 1986-05-21 Medea Res Srl Benzimidi ad attivita' anestetica locale e antiaritmica,processo per la loro preparazione e composizioni farmaceutiche che le contengono
JPS5714589A (en) * 1980-06-27 1982-01-25 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation and drug composition
JPS5770888A (en) * 1980-10-18 1982-05-01 Shinichi Ito Benzothiazine derivative, its preparation and medicinal composition
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
US4434164A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Crystalline benzothiazine dioxide salts
IT1168064B (it) * 1981-11-12 1987-05-20 Prodotti Antibiotici Spa Composto ad azione antinfiammatoria
IT8219486A0 (it) * 1982-02-05 1982-02-05 Chiesi Farma Spa Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche.
JPS59193879A (ja) * 1983-03-31 1984-11-02 Fujisawa Pharmaceut Co Ltd トロポン誘導体
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
JPS60184077A (ja) * 1984-02-23 1985-09-19 フアイザー・インコーポレーテツド 抗炎症性オキシム前駆薬

Also Published As

Publication number Publication date
GR861389B (en) 1986-09-17
US4623486A (en) 1986-11-18
ES555374A0 (es) 1987-07-16
CN1004628B (zh) 1989-06-28
DK249086D0 (da) 1986-05-28
NO165240C (no) 1991-01-16
ZA863986B (en) 1988-01-27
DE3673710D1 (de) 1990-10-04
EP0208404B1 (en) 1990-08-29
EP0208404A2 (en) 1987-01-14
KR870000913B1 (ko) 1987-05-06
SU1531855A3 (ru) 1989-12-23
ATE56010T1 (de) 1990-09-15
HUT43597A (en) 1987-11-30
CA1270485A (en) 1990-06-19
DK249086A (da) 1986-11-30
FI862252A (fi) 1986-11-30
AU557396B1 (en) 1986-12-18
FI86065C (fi) 1992-07-10
NZ216310A (en) 1988-10-28
YU44576B (en) 1990-10-31
PL147843B1 (en) 1989-08-31
NO165240B (no) 1990-10-08
ES8707211A1 (es) 1987-07-16
JPS61277683A (ja) 1986-12-08
PH23146A (en) 1989-05-11
HU200178B (en) 1990-04-28
KR860009012A (ko) 1986-12-19
PT82649A (en) 1986-06-01
NO862124L (no) 1986-12-01
CN86103603A (zh) 1987-01-21
EG17811A (en) 1990-08-30
FI862252A0 (fi) 1986-05-28
FI86065B (fi) 1992-03-31
DD247451A5 (de) 1987-07-08
EP0208404A3 (en) 1987-04-15
IL78912A (en) 1990-07-12
HU199839B (en) 1990-03-28
JPH0575754B2 (pt) 1993-10-21
SU1538896A3 (ru) 1990-01-23
YU90686A (en) 1987-10-31

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Effective date: 20000831