GR880100409A - Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids - Google Patents
Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acidsInfo
- Publication number
- GR880100409A GR880100409A GR88100409A GR880100409A GR880100409A GR 880100409 A GR880100409 A GR 880100409A GR 88100409 A GR88100409 A GR 88100409A GR 880100409 A GR880100409 A GR 880100409A GR 880100409 A GR880100409 A GR 880100409A
- Authority
- GR
- Greece
- Prior art keywords
- cyclopropyl
- dihydro
- oxo
- fluoro
- quinoline
- Prior art date
Links
Abstract
A method of preparation is described for 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-chloro-kinolin-3-carboxylic acid: [chemical formula] as well as the reaction process of the acid (I) with piperazine, or its derivatives of the formula: [chemical formula], where R = methyl, ethyl, benzyl, pyridyl, hydrogen. Transformations of these new piperazinic derivatives to acidic additive salts are distinguished for their antibacterial properties and are pharmaceutically useful.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR88100409 | 1988-06-23 |
Publications (2)
Publication Number | Publication Date |
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GR880100409A true GR880100409A (en) | 1990-05-11 |
GR1000201B GR1000201B (en) | 1992-03-20 |
Family
ID=10938767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR880100409A GR1000201B (en) | 1988-06-23 | 1988-06-23 | Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1000201B (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0078362A2 (en) * | 1981-10-29 | 1983-05-11 | Bayer Ag | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, process for their preparation and antibacterial agents containing them |
EP0113091A1 (en) * | 1982-12-29 | 1984-07-11 | Bayer Ag | Microbiocidal agents based on quinolone-carboxylic acids |
ES8602674A1 (en) * | 1985-02-07 | 1985-12-01 | Inst Investigacion Desarrollo | Quinoline carboxylic acid derivs. |
ES8606284A1 (en) * | 1985-10-30 | 1986-04-16 | Lafarquim | Prepn. of quinoline-3-carboxylic acid and salts |
-
1988
- 1988-06-23 GR GR880100409A patent/GR1000201B/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0078362A2 (en) * | 1981-10-29 | 1983-05-11 | Bayer Ag | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, process for their preparation and antibacterial agents containing them |
EP0113091A1 (en) * | 1982-12-29 | 1984-07-11 | Bayer Ag | Microbiocidal agents based on quinolone-carboxylic acids |
ES8602674A1 (en) * | 1985-02-07 | 1985-12-01 | Inst Investigacion Desarrollo | Quinoline carboxylic acid derivs. |
ES8606284A1 (en) * | 1985-10-30 | 1986-04-16 | Lafarquim | Prepn. of quinoline-3-carboxylic acid and salts |
Non-Patent Citations (3)
Title |
---|
CHEMICAL ABSTRACTS, vol. 105, 1986, page 774, abstract no. 226392c, Columbus Ohio, US; & ES-A1-8602674 (INSTITUTO DE INVESTIGACION Y DESARROLLO QUIMICO Y BIOLOGICO S.A.) 16-03-1986 * |
CHEMICAL ABSTRACTS, vol. 107, 1987, page 708, abstract no. 39864n, Columbus, Ohio, US; & ES-A1-8606284 (LABORATORIO FARMACEUTICO QUIMICO-LAFARQUIM S.A.) 01-10-1986 * |
CLAIMS SEARCHED: ALL * |
Also Published As
Publication number | Publication date |
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GR1000201B (en) | 1992-03-20 |
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