DK0430114T3 - Hexahydro-1H-quino 4,3,2-ef 1,4 -benzoxazepiner og beslægtede forbindelser, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler - Google Patents

Hexahydro-1H-quino 4,3,2-ef 1,4 -benzoxazepiner og beslægtede forbindelser, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number
DK0430114T3
DK0430114T3 DK90122456.8T DK90122456T DK0430114T3 DK 0430114 T3 DK0430114 T3 DK 0430114T3 DK 90122456 T DK90122456 T DK 90122456T DK 0430114 T3 DK0430114 T3 DK 0430114T3
Authority
DK
Denmark
Prior art keywords
benzoxazepines
quino
hexahydro
intermediates
preparation
Prior art date
Application number
DK90122456.8T
Other languages
English (en)
Inventor
Kevin James Kapples
Gregory Michael Shutske
John Dick Tomer Iv
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0430114T3 publication Critical patent/DK0430114T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DK90122456.8T 1989-11-28 1990-11-26 Hexahydro-1H-quino 4,3,2-ef 1,4 -benzoxazepiner og beslægtede forbindelser, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler DK0430114T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/443,288 US4994452A (en) 1989-11-28 1989-11-28 Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds

Publications (1)

Publication Number Publication Date
DK0430114T3 true DK0430114T3 (da) 1996-06-17

Family

ID=23760195

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90122456.8T DK0430114T3 (da) 1989-11-28 1990-11-26 Hexahydro-1H-quino 4,3,2-ef 1,4 -benzoxazepiner og beslægtede forbindelser, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler

Country Status (21)

Country Link
US (1) US4994452A (da)
EP (1) EP0430114B1 (da)
JP (1) JP2600019B2 (da)
KR (1) KR100190782B1 (da)
AT (1) ATE133953T1 (da)
AU (2) AU633382B2 (da)
CA (1) CA2030715C (da)
CZ (1) CZ283943B6 (da)
DE (1) DE69025274T2 (da)
DK (1) DK0430114T3 (da)
ES (1) ES2083416T3 (da)
FI (1) FI905813A (da)
GR (1) GR3019089T3 (da)
HU (1) HU207326B (da)
IE (1) IE72154B1 (da)
IL (1) IL96467A (da)
NO (1) NO905128L (da)
PL (1) PL287958A1 (da)
PT (1) PT96017B (da)
YU (1) YU224890A (da)
ZA (1) ZA909513B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10004572A1 (de) 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318896A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
US3329676A (en) * 1964-11-09 1967-07-04 American Home Prod Fused 1, 4-diazepine ring systems
US3580915A (en) * 1968-09-16 1971-05-25 American Home Prod 1,2,3,4-tetrahydrobenzol(b)(1,6)naphthyridine derivatives
ES431307A1 (es) * 1973-11-16 1976-09-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos derivados de quinoleina.
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4816456A (en) * 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
EP0282959A3 (en) * 1987-03-17 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments
US4743601A (en) * 1987-07-13 1988-05-10 Hoechst-Roussel Pharmaceuticals Inc. Dihydro-1,4-oxazino(2,3-C)quinolines
MX13270A (es) * 1987-10-05 1993-06-01 Pfizer Procedimiento para la preparacion de derivados de 4-aminopiridina
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US4927820A (en) * 1988-11-25 1990-05-22 Hoechst Roussel Pharmaceuticals Inc. Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine

Also Published As

Publication number Publication date
JPH03209383A (ja) 1991-09-12
AU2856092A (en) 1993-02-11
JP2600019B2 (ja) 1997-04-16
DE69025274T2 (de) 1996-08-22
IL96467A0 (en) 1991-08-16
IL96467A (en) 1999-08-17
PT96017A (pt) 1991-09-13
PL287958A1 (en) 1992-08-24
YU224890A (en) 1999-11-22
IE72154B1 (en) 1997-03-26
CZ283943B6 (cs) 1998-07-15
EP0430114B1 (en) 1996-02-07
FI905813A (fi) 1991-05-29
PT96017B (pt) 1998-02-27
ZA909513B (en) 1991-08-28
ES2083416T3 (es) 1996-04-16
NO905128L (no) 1991-05-29
EP0430114A3 (en) 1992-01-29
NO905128D0 (no) 1990-11-27
CZ588790A3 (cs) 1998-02-18
HUT61026A (en) 1992-11-30
US4994452A (en) 1991-02-19
AU6696290A (en) 1991-06-06
AU633382B2 (en) 1993-01-28
HU907667D0 (en) 1991-06-28
ATE133953T1 (de) 1996-02-15
CA2030715A1 (en) 1991-05-29
CA2030715C (en) 2003-02-11
IE904279A1 (en) 1991-06-05
KR910009666A (ko) 1991-06-28
GR3019089T3 (en) 1996-05-31
EP0430114A2 (en) 1991-06-05
DE69025274D1 (de) 1996-03-21
HU207326B (en) 1993-03-29
FI905813A0 (fi) 1990-11-26
KR100190782B1 (ko) 1999-06-01

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