DK2475372T4 - Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse - Google Patents
Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse Download PDFInfo
- Publication number
- DK2475372T4 DK2475372T4 DK10757747.0T DK10757747T DK2475372T4 DK 2475372 T4 DK2475372 T4 DK 2475372T4 DK 10757747 T DK10757747 T DK 10757747T DK 2475372 T4 DK2475372 T4 DK 2475372T4
- Authority
- DK
- Denmark
- Prior art keywords
- rna
- micro
- preparation
- therapeutic use
- therapeutic
- Prior art date
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- 108091070501 miRNA Proteins 0.000 title 1
- 239000002679 microRNA Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
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- Bioinformatics & Cheminformatics (AREA)
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- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
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- Biomedical Technology (AREA)
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- Molecular Biology (AREA)
- Epidemiology (AREA)
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- Immunology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09169937 | 2009-09-10 | ||
| PCT/EP2010/063313 WO2011029903A1 (en) | 2009-09-10 | 2010-09-10 | Method for the preparation of micro-rna and its therapeutic application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2475372T3 DK2475372T3 (en) | 2017-10-23 |
| DK2475372T4 true DK2475372T4 (da) | 2020-11-30 |
Family
ID=42147287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10757747.0T DK2475372T4 (da) | 2009-09-10 | 2010-09-10 | Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9078914B2 (enExample) |
| EP (1) | EP2475372B2 (enExample) |
| JP (1) | JP5902088B2 (enExample) |
| CN (1) | CN102573856B (enExample) |
| AU (1) | AU2010294197C9 (enExample) |
| CA (1) | CA2773619C (enExample) |
| DK (1) | DK2475372T4 (enExample) |
| WO (1) | WO2011029903A1 (enExample) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| EP2475372B2 (en) | 2009-09-10 | 2020-10-21 | Velin-Pharma A/S | Method for the preparation of micro-rna and its therapeutic application |
| EP2354246A1 (en) | 2010-02-05 | 2011-08-10 | febit holding GmbH | miRNA in the diagnosis of ovarian cancer |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US8716258B2 (en) | 2010-06-04 | 2014-05-06 | The Board Of Regents, The University Of Texas System | Regulation of metabolism by miR-378 |
| US10385314B2 (en) * | 2010-08-16 | 2019-08-20 | Exostem Biotec Ltd. | Methods of generating oligodendrocytes and cell populations comprising same |
| US8642751B2 (en) | 2010-12-15 | 2014-02-04 | Miragen Therapeutics | MicroRNA inhibitors comprising locked nucleotides |
| US9771617B2 (en) | 2011-06-27 | 2017-09-26 | Eisai R&D Management Co., Ltd. | Microrna biomarkers indicative of alzheimer's disease |
| CN102296112B (zh) * | 2011-08-09 | 2013-06-05 | 南京医科大学 | 人类非梗阻性无精子症相关的精浆微小核糖核酸标志物及其应用 |
| US20140274789A1 (en) * | 2011-08-11 | 2014-09-18 | Andreas Keller | Complex sets of mirnas as non-invasive biomarkers for psoriasis |
| US20140302068A1 (en) * | 2011-09-09 | 2014-10-09 | The Regents Of The University Of Colorado | MicroRNA Biomarkers for Diagnosing Parkinson's Disease |
| US9428749B2 (en) | 2011-10-06 | 2016-08-30 | The Board Of Regents, The University Of Texas System | Control of whole body energy homeostasis by microRNA regulation |
| CN104080911A (zh) * | 2011-11-30 | 2014-10-01 | 不来梅大学 | miRNA在胎盘组织中的表达 |
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| WO2013170146A1 (en) | 2012-05-10 | 2013-11-14 | Uab Research Foundation | Methods and compositions for modulating mir-204 activity |
| EP2861238A4 (en) | 2012-06-05 | 2016-03-16 | Capricor Inc | OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY |
| JP6208228B2 (ja) | 2012-06-21 | 2017-10-04 | ミラゲン セラピューティクス, インコーポレイテッド | ロックド核酸モチーフを含むオリゴヌクレオチドベースの阻害剤 |
| CN102727909B (zh) * | 2012-06-28 | 2014-06-04 | 中国人民解放军总医院 | 一种抑制原发性肝癌生长和转移的新方法 |
| CN102787117A (zh) * | 2012-07-20 | 2012-11-21 | 苏州大学 | 微小rna用于调控b7-h2基因表达 |
| US9828603B2 (en) | 2012-08-13 | 2017-11-28 | Cedars Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| CN103667282A (zh) * | 2012-08-30 | 2014-03-26 | 苏州博泰安生物科技有限公司 | 前列腺癌分子标志物miR-628-3P及其应用 |
| EP2916853B1 (en) * | 2012-11-09 | 2020-05-06 | Velin-Pharma A/S | Compositions for pulmonary delivery |
| WO2014086243A1 (zh) * | 2012-12-07 | 2014-06-12 | 中国科学院上海生命科学研究院 | 负向调控I型干扰素通路的miRNA分子及其应用 |
| CN103173448A (zh) * | 2013-02-07 | 2013-06-26 | 上海市胸科医院 | 早期肺腺癌miRNA特异表达谱及其反转录引物和用途 |
| US9675633B2 (en) | 2013-03-14 | 2017-06-13 | Board Of Regents, The University Of Texas System | miRNA for treating cancer and for use with adoptive immunotherapies |
| US20160017326A1 (en) * | 2013-03-14 | 2016-01-21 | The Trustees Of Princeton University | Micrornas as functional mediators and biomarkers of bone metastasis |
| CN103157117B (zh) * | 2013-03-19 | 2014-07-02 | 广州中国科学院先进技术研究所 | 一种调控肿瘤对trail耐受性的药物 |
| JP6137894B2 (ja) * | 2013-03-22 | 2017-05-31 | 国立大学法人京都大学 | リポソーム−エキソソームハイブリッドベシクル及びその調製法 |
| CN103194542B (zh) * | 2013-04-28 | 2014-03-26 | 夏彦恺 | 人类胎儿生长受限相关的血清微小核糖核酸标志物及其应用 |
| CN103205430B (zh) * | 2013-04-28 | 2015-04-15 | 夏彦恺 | 人类重度子痫前期发生相关的血清微小核糖核酸标志物及其应用 |
| WO2014189850A1 (en) | 2013-05-20 | 2014-11-27 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Detection and treatment of irritable bowel syndrome |
| US9879260B2 (en) | 2013-08-20 | 2018-01-30 | The Board Of Regents Of The University Of Texas System | Micro-RNA regulation of bone loss |
| WO2015042435A1 (en) * | 2013-09-20 | 2015-03-26 | Academia Sinica | Treating diseases associated with pgc1-alpha by modulating micrornas mir-130a and mir-130b |
| US20160289763A1 (en) * | 2013-11-13 | 2016-10-06 | The Texas A&M University System | Micro-rnas that modulate lymphangiogenesis and inflammatory pathways in lymphatic vessel cells |
| WO2015081263A1 (en) | 2013-11-26 | 2015-06-04 | Central Biomedia, Inc. | Method and diet for immune enhanced donor blood |
| CN103623431B (zh) * | 2013-12-05 | 2015-04-22 | 南京大学 | miR181s在制备治疗急性肠炎药物中的应用 |
| RU2548816C1 (ru) * | 2013-12-16 | 2015-04-20 | Мамонтова Марина Васильевна | Способ выделения микрорнк из биологических жидкостей |
| WO2015091892A1 (en) * | 2013-12-19 | 2015-06-25 | Comprehensive Biomarker Center Gmbh | Mirnas as non-invasive biomarkers for parkinson's disease |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| WO2015095794A1 (en) | 2013-12-20 | 2015-06-25 | Advanced ReGen Medical Technologies, LLC | Compositions for cellular restoration and methods of making and using same |
| ES2760263T3 (es) * | 2014-03-21 | 2020-05-13 | Genzyme Corp | Tratamiento génico de la retinitis pigmentaria |
| KR101667650B1 (ko) * | 2014-03-31 | 2016-10-20 | 숙명여자대학교산학협력단 | miR-192, miR-215 또는 miR-194를 포함하는 인간 상염색체 우성 다낭신 치료용 약학 조성물 |
| CN103937826B (zh) * | 2014-04-04 | 2016-04-06 | 东华大学 | 一种中枢神经系统中特异表达miR-505的载体的制备方法 |
| WO2015189345A2 (en) * | 2014-06-13 | 2015-12-17 | Universität Für Bodenkultur Wien | Compositions and methods for the diagnosis and treatment of bone fractures and disorders |
| JP6566612B2 (ja) * | 2014-06-27 | 2019-08-28 | 国立大学法人北海道大学 | 免疫体質又は免疫応答型を判定するためのバイオマーカー及び免疫応答型制御剤 |
| JP6385732B2 (ja) * | 2014-06-27 | 2018-09-05 | 国立大学法人北海道大学 | 免疫応答制御剤 |
| CN105368822A (zh) * | 2014-08-29 | 2016-03-02 | 香港大学 | 一种miRNA标记物、其方法和应用 |
| CN105457039A (zh) * | 2014-09-10 | 2016-04-06 | 洪挺祯 | 促进伤口愈合的制剂及其制备方法及使用方法 |
| CN104306988B (zh) * | 2014-09-25 | 2017-02-15 | 中国医学科学院基础医学研究所 | miR‑431在制备治疗肌肉疾病的药物中的用途 |
| US11357799B2 (en) | 2014-10-03 | 2022-06-14 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| CN104491878A (zh) * | 2014-12-19 | 2015-04-08 | 青岛大学 | 一种含有miRNA-324的药物组合物及其用途 |
| EP3247716A4 (en) | 2015-01-20 | 2018-10-17 | Miragen Therapeutics, Inc. | Mir-92 inhibitors and uses thereof |
| CN104830858A (zh) * | 2015-03-05 | 2015-08-12 | 中国人民解放军第四军医大学 | 一种与浆液性卵巢癌发生发展机制相关的microRNA分子及其应用 |
| CN105647919A (zh) * | 2015-04-01 | 2016-06-08 | 四川大学华西医院 | 一种microRNA-129-5p的检测试剂盒和检测方法 |
| CN104940954B (zh) * | 2015-06-23 | 2017-12-26 | 同济大学 | MicroRNA‑7在制备抗胶质化药物中的应用 |
| US10441601B2 (en) * | 2015-06-30 | 2019-10-15 | St. Jude Children's Research Hospital, Inc. | Method for treating schizophrenia |
| WO2017004526A1 (en) * | 2015-07-02 | 2017-01-05 | University Of Louisville Research Foundation, Inc. | EDIBLE PLANT-DERIVED MICROVESICLE COMPOSITIONS FOR DELIVERY OF miRNA AND METHODS FOR TREATMENT OF CANCER |
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