DK2432802T3 - Bifunctional polypeptides - Google Patents
Bifunctional polypeptides Download PDFInfo
- Publication number
- DK2432802T3 DK2432802T3 DK10720803.5T DK10720803T DK2432802T3 DK 2432802 T3 DK2432802 T3 DK 2432802T3 DK 10720803 T DK10720803 T DK 10720803T DK 2432802 T3 DK2432802 T3 DK 2432802T3
- Authority
- DK
- Denmark
- Prior art keywords
- tcr
- antibody
- polypeptide
- chain
- seq
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0908613.3A GB0908613D0 (en) | 2009-05-20 | 2009-05-20 | T Cell Reseptors |
| PCT/GB2010/000988 WO2010133828A1 (fr) | 2009-05-20 | 2010-05-19 | Polypeptides bifonctionnels |
Publications (1)
| Publication Number | Publication Date |
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| DK2432802T3 true DK2432802T3 (en) | 2017-02-13 |
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| DK10720803.5T DK2432802T3 (en) | 2009-05-20 | 2010-05-19 | Bifunctional polypeptides |
| DK16176249.7T DK3112377T3 (en) | 2009-05-20 | 2010-05-19 | BIFUNCTIONAL POLYPEPTIDES |
| DK16176246.3T DK3112376T3 (en) | 2009-05-20 | 2010-05-19 | BIFUNCTIONAL POLYPEPTIDES |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
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| DK16176249.7T DK3112377T3 (en) | 2009-05-20 | 2010-05-19 | BIFUNCTIONAL POLYPEPTIDES |
| DK16176246.3T DK3112376T3 (en) | 2009-05-20 | 2010-05-19 | BIFUNCTIONAL POLYPEPTIDES |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US10130721B2 (fr) |
| EP (3) | EP3112377B1 (fr) |
| JP (4) | JP5667171B2 (fr) |
| CN (1) | CN102439034B (fr) |
| AU (1) | AU2010250951B2 (fr) |
| BR (1) | BRPI1013029A2 (fr) |
| CA (2) | CA2762604C (fr) |
| CY (3) | CY1118405T1 (fr) |
| DK (3) | DK2432802T3 (fr) |
| EA (1) | EA020841B1 (fr) |
| ES (3) | ES2608653T3 (fr) |
| GB (1) | GB0908613D0 (fr) |
| HR (3) | HRP20170086T1 (fr) |
| HU (3) | HUE043245T2 (fr) |
| LT (3) | LT3112377T (fr) |
| MX (1) | MX340168B (fr) |
| PL (3) | PL3112377T3 (fr) |
| PT (3) | PT3112377T (fr) |
| SI (3) | SI3112376T1 (fr) |
| TR (2) | TR201905437T4 (fr) |
| WO (1) | WO2010133828A1 (fr) |
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| GB0908613D0 (en) * | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| US9133244B2 (en) | 2011-01-18 | 2015-09-15 | Bioniz, Llc | Compositions and methods for modulating gamma-c-cytokine activity |
| CA2848209C (fr) * | 2011-09-15 | 2021-06-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recepteurs des lymphocytes t reconnaissant un gene mage restreint par hla-a1 ou hla-cw7 |
| WO2013048243A1 (fr) * | 2011-09-29 | 2013-04-04 | Apo-T B.V. | Molécules de liaison multispécifiques ciblant des cellules aberrantes |
| US20130273089A1 (en) | 2011-11-03 | 2013-10-17 | Tolera Therapeutics, Inc. | Antibody and methods for selective inhibition of t-cell responses |
| BR112014010532A2 (pt) | 2011-11-03 | 2017-04-18 | Tolera Therapeutics Inc | anticorpo e métodos para inibição seletiva de respostas de célula-t |
| SG10201705698PA (en) | 2012-01-13 | 2017-08-30 | Apo-T B V | Aberrant Cell-Restricted Immunoglobulins Provided With A Toxic Moiety |
| GB201223172D0 (en) | 2012-12-21 | 2013-02-06 | Immunocore Ltd | Method |
| GB201313377D0 (en) * | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| WO2015136072A1 (fr) | 2014-03-14 | 2015-09-17 | Immunocore Limited | Banques de tcr |
| US10526391B2 (en) | 2014-07-22 | 2020-01-07 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| CN107223133B (zh) | 2014-11-07 | 2021-01-29 | 广东香雪精准医疗技术有限公司 | 一种可溶的异质二聚t细胞受体及其制法和应用 |
| GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516275D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516274D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| GB201516270D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516265D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516269D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| CN108350032A (zh) | 2015-10-09 | 2018-07-31 | 比奥尼斯有限责任公司 | 调节γC-细胞因子活性 |
| GB201520558D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
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| GB201607534D0 (en) | 2016-04-29 | 2016-06-15 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| WO2017089786A1 (fr) | 2015-11-23 | 2017-06-01 | Immunocore Limited | Peptides |
| GB201520570D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
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| GB201520579D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| WO2018083505A1 (fr) | 2016-11-07 | 2018-05-11 | Immunocore Limited | Peptides |
| GB201520566D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
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| GB201522592D0 (en) * | 2015-12-22 | 2016-02-03 | Immunocore Ltd | T cell receptors |
| DK3430037T3 (da) * | 2016-03-16 | 2022-11-21 | Immatics Biotechnologies Gmbh | Transficerede t-celler og t-cellereceptorer til anvendelse i immunterapi mod cancere |
| GB201604953D0 (en) | 2016-03-23 | 2016-05-04 | Immunocore Ltd | T cell receptors |
| HUE059159T2 (hu) | 2016-04-08 | 2022-10-28 | Immunocore Ltd | T-sejt-receptorok |
| WO2017192536A1 (fr) | 2016-05-02 | 2017-11-09 | University Of Kansas | Élimination de la restriction par le cmh du récepteur de lymphocyte t en tant que stratégie d'immunothérapie |
| AU2017273147A1 (en) | 2016-06-02 | 2019-01-03 | Immunocore Limited | Dosing regimen for GP100-specific TCR - anti-CD3 SCFV fusion protein |
| EP3532078A4 (fr) * | 2016-10-31 | 2020-06-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cellules présentatrices d'antigène artificielles utilisées pour l'expansion de cellules immunitaires pour l'immunothérapie |
| CN108203459A (zh) * | 2016-12-19 | 2018-06-26 | 广东香雪精准医疗技术有限公司 | 源自于prame的肿瘤抗原短肽 |
| GB201709866D0 (en) | 2017-06-20 | 2017-08-02 | Immunocore Ltd | T cell receptors |
| CN112424230A (zh) | 2018-05-14 | 2021-02-26 | 英美偌科有限公司 | 双功能结合多肽 |
| GB201815041D0 (en) | 2018-09-14 | 2018-10-31 | Scancell Ltd | Epitopes |
| AU2020208110A1 (en) * | 2019-01-14 | 2021-07-15 | Nanjing Legend Biotech Co., Ltd. | Chimeric receptor polypeptides and uses thereof |
| CA3126611A1 (fr) | 2019-01-17 | 2020-07-23 | Immunocore Limited | Formulations |
| GB201901306D0 (en) | 2019-01-30 | 2019-03-20 | Immunocore Ltd | Multi-domain binding molecules |
| GB201901305D0 (en) | 2019-01-30 | 2019-03-20 | Immunocore Ltd | Specific binding molecules |
| JP2022519649A (ja) | 2019-02-08 | 2022-03-24 | ジェネンテック， インコーポレイテッド | がんの診断および治療方法 |
| GB201902277D0 (en) | 2019-02-19 | 2019-04-03 | King S College London | Therapeutic agents |
| CN113906140A (zh) | 2019-03-18 | 2022-01-07 | 路德维格癌症研究院 | A2/ny-eso-1特异性t细胞受体及其用途 |
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| GB202006629D0 (en) | 2020-05-05 | 2020-06-17 | Immunocore Ltd | Specific binding molecules |
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| EP4196612A1 (fr) | 2020-08-12 | 2023-06-21 | Genentech, Inc. | Méthodes diagnostiques et thérapeutiques pour le cancer |
| WO2022184805A1 (fr) | 2021-03-03 | 2022-09-09 | Immatics Biotechnologies Gmbh | Protéines de liaison à l'antigène se liant spécifiquement à des peptides antigéniques du sars-cov-2 en un complexe avec une protéine du complexe majeur d'histocompatibilité |
| EP4113120A1 (fr) | 2021-06-28 | 2023-01-04 | Immatics Biotechnologies GmbH | Procédé de caractérisation des caractéristiques de liaison entre un peptide d'intérêt et des molécules du cmh |
| US20230024554A1 (en) | 2021-06-28 | 2023-01-26 | Immatics Biotechnologies Gmbh | Method of characterizing the binding characteristics between a peptide of interest and mhc molecules |
| WO2023288203A2 (fr) | 2021-07-12 | 2023-01-19 | Ludwig Institute For Cancer Research Ltd | Récepteurs de lymphocytes t spécifiques pour des antigènes associés aux tumeurs et leurs procédés d'utilisation |
| CN115724988B (zh) * | 2021-08-26 | 2023-11-17 | 瑅安生物医药（杭州）有限公司 | 一种接近天然分子的多肽融合分子 |
| EP4198052A1 (fr) | 2021-12-15 | 2023-06-21 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Peptides et protéines de liaison d'antigène pour utilisation dans l'immunothérapie contre le carcinome hépatocellulaire fibrolamellaire (fl-hcc) et autres cancers |
| WO2023156663A1 (fr) | 2022-02-20 | 2023-08-24 | Immunocore Limited | Molécules de liaison spécifiques au vih et tcr |
| WO2024038183A1 (fr) | 2022-08-18 | 2024-02-22 | Immunocore Limited | Molécules de liaison à domaines multiples |
| WO2024038193A1 (fr) | 2022-08-18 | 2024-02-22 | Immunocore Limited | Molécules de liaison à domaines multiples |
| WO2024038198A1 (fr) | 2022-08-18 | 2024-02-22 | Immunocore Limited | Molécules de liaison à domaines multiples |
| WO2024067821A1 (fr) * | 2022-09-30 | 2024-04-04 | 瑅安生物医药（杭州）有限公司 | Cellule modifiée et son utilisation |
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| JP4124480B2 (ja) * | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
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| JP4467188B2 (ja) * | 1998-10-21 | 2010-05-26 | アルター・バイオサイエンス・コーポレーション | 多重特異的結合分子とその使用 |
| JP2004501364A (ja) | 2000-05-25 | 2004-01-15 | スノル・モレキュラー・コーポレーション | Ｔ−細胞レセプター相互作用のモジュレーション |
| WO2001093913A2 (fr) * | 2000-06-05 | 2001-12-13 | Sunol Molecular Corporation | Fusions et conjugues de recepteurs de lymphocytes t et procedes d'utilisation correspondants |
| US20030017134A1 (en) * | 2001-06-19 | 2003-01-23 | Technion Research And Development Foundation Ltd. | Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer |
| PT1421115E (pt) | 2001-08-31 | 2005-07-29 | Avidex Ltd | Receptor de celulas t soluvel |
| JP2005533486A (ja) * | 2002-02-20 | 2005-11-10 | ダイアックス、コープ | Ｍｈｃ−ペプチド複合体結合リガンド |
| US7569664B2 (en) | 2002-10-09 | 2009-08-04 | Immunocore Limited | Single chain recombinant T cell receptors |
| GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| NZ550810A (en) | 2004-05-19 | 2009-05-31 | Immunocore Ltd | High affinity NY-ESO T cell receptor |
| AU2005247950B2 (en) * | 2004-05-27 | 2012-02-02 | Receptor Logic, Inc. | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| US20090042285A1 (en) | 2004-05-27 | 2009-02-12 | Weidanz Jon A | Antibodies at T cell receptor mimics, methods of production and uses thereof |
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| JP2008514685A (ja) * | 2004-10-01 | 2008-05-08 | メディジーン リミテッド | 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター |
| DK1976880T3 (en) * | 2005-12-21 | 2016-09-26 | Amgen Res (Munich) Gmbh | Pharmaceutical compositions with resistance to soluble cea |
| EP1981532A4 (fr) * | 2005-12-21 | 2010-06-30 | Medimmune Llc | Molecules epha2 bite et leur utilisation |
| GB0708585D0 (en) | 2007-05-03 | 2007-06-13 | Queen Mary & Westfield College | Novel antibody and use in diagnosis and therapy of arthropathies |
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| GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| GB0911566D0 (en) * | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
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