DK2379592T3 - Antistoffer mod humant angiopoietin 2 - Google Patents
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- DK2379592T3 DK2379592T3 DK09793471T DK09793471T DK2379592T3 DK 2379592 T3 DK2379592 T3 DK 2379592T3 DK 09793471 T DK09793471 T DK 09793471T DK 09793471 T DK09793471 T DK 09793471T DK 2379592 T3 DK2379592 T3 DK 2379592T3
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Claims (13)
1. Antistof eller antistoffragment der specifikt binder til humant angiopoietin-2 (ANG-2), kendetegnet ved at a) det tungkæde variable domæne omfatter en CDR3 region ifølge SEQ ID NO: 1, en CDR2-region ifølge SEQ ID NO: 2, og en CDRl-region ifølge SEQ ID NO: 3, og b) det letkæde variable domæne omfatter en CDR3-region ifølge SEQ ID NO: 4, en CDR2-region ifølge SEQ ID NO: 5, og en CDRl-region ifølge SEQ ID NO: 6.
2. Antistoffet eller antistoffragment ifølge krav 1, kendetegnet ved at det omfatter a) det tungkæde variable domæne ifølge SEQ ID NO: 7; og b) det letkæde variable domæne ifølge SEQ ID NO: 8.
3. Antistoffet eller antistoffragment ifølge krav 1 eller krav 2, kendetegnet ved at antistoffet ikke binder til humant angiopoietin 1 (ANG-1).
4. Antistoffet eller antistoffragment ifølge et hvilket som helst af kravene 1 til 3, kendetegnet ved at antistoffet er af human IgG4-underklasse eller er af human IgGl-underklasse.
5. Farmaceutisk sammensætning kendetegnet ved at det omfatter antistof eller antistoffragment ifølge et hvilket som helst af kravene 1 til 4.
6. Antistoffet eller antistoffragment ifølge et hvilket som helst af kravene 1 til 4, til anvendelse i terapi.
7. Antistoffet eller antistoffragment ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til forebyggelse af metastaser.
8. Antistoffet eller antistoffragment ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling af cancer.
9. Antistoffet eller antistoffragment ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling af vaskulære sygdomme.
10. Antistoffet eller antistoffragment ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling af retinopati.
11. Nukleinsyre der koder for en tungkæde og en letkæde af et antistof der specifikt binder til humant angiopoietin-2 (ANG-2), kendetegnet ved at antistoffet omfatter et tungkæde variabelt domæne og et letkæde variabelt domæne ifølge krav 1.
12. Ekspressionsvektor kendetegnet ved at det omfatter en nukleinsyre ifølge krav 11 til ekspression af et antistof der specifikt binder til humant angiopoietin-2 (ANG-2) i en prokaryot eller eukaryot værtscelle.
13. Prokaryot eller eukaryot værtscelle omfattende en vektor ifølge krav 12.
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PCT/EP2009/008930 WO2010069532A1 (en) | 2008-12-16 | 2009-12-14 | Antibodies against human angiopoietin 2 |
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DK09793471T DK2379592T3 (da) | 2008-12-16 | 2009-12-14 | Antistoffer mod humant angiopoietin 2 |
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