PL2379592T3 - Przeciwciała przeciwko ludzkiej Angiopoetynie 2 - Google Patents
Przeciwciała przeciwko ludzkiej Angiopoetynie 2Info
- Publication number
- PL2379592T3 PL2379592T3 PL09793471T PL09793471T PL2379592T3 PL 2379592 T3 PL2379592 T3 PL 2379592T3 PL 09793471 T PL09793471 T PL 09793471T PL 09793471 T PL09793471 T PL 09793471T PL 2379592 T3 PL2379592 T3 PL 2379592T3
- Authority
- PL
- Poland
- Prior art keywords
- antibodies against
- against human
- human angiopoietin
- angiopoietin
- antibodies
- Prior art date
Links
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 title 1
- 102000047825 human ANGPT2 Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08021835 | 2008-12-16 | ||
| PCT/EP2009/008930 WO2010069532A1 (en) | 2008-12-16 | 2009-12-14 | Antibodies against human angiopoietin 2 |
| EP09793471.5A EP2379592B1 (en) | 2008-12-16 | 2009-12-14 | Antibodies against human angiopoietin 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2379592T3 true PL2379592T3 (pl) | 2015-07-31 |
Family
ID=40585738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09793471T PL2379592T3 (pl) | 2008-12-16 | 2009-12-14 | Przeciwciała przeciwko ludzkiej Angiopoetynie 2 |
Country Status (34)
| Country | Link |
|---|---|
| US (12) | US8133979B2 (pl) |
| EP (1) | EP2379592B1 (pl) |
| JP (2) | JP5559191B2 (pl) |
| KR (2) | KR101445518B1 (pl) |
| CN (3) | CN102746400B (pl) |
| AR (2) | AR074756A1 (pl) |
| AU (1) | AU2009328613B2 (pl) |
| BR (2) | BR122013022089B1 (pl) |
| CA (2) | CA2916481C (pl) |
| CL (2) | CL2011001285A1 (pl) |
| CR (2) | CR20110321A (pl) |
| CY (1) | CY1116264T1 (pl) |
| DK (1) | DK2379592T3 (pl) |
| EC (2) | ECSP11011139A (pl) |
| ES (1) | ES2534635T3 (pl) |
| HK (2) | HK1172349A1 (pl) |
| HR (1) | HRP20150439T1 (pl) |
| HU (1) | HUE024545T2 (pl) |
| IL (2) | IL213039A (pl) |
| MA (1) | MA32876B1 (pl) |
| MX (1) | MX2011005908A (pl) |
| MY (2) | MY155654A (pl) |
| NZ (2) | NZ592856A (pl) |
| PE (2) | PE20120551A1 (pl) |
| PH (1) | PH12013502192A1 (pl) |
| PL (1) | PL2379592T3 (pl) |
| PT (1) | PT2379592E (pl) |
| RU (2) | RU2569461C2 (pl) |
| SG (1) | SG172216A1 (pl) |
| SI (1) | SI2379592T1 (pl) |
| TW (2) | TWI396549B (pl) |
| UA (2) | UA103912C2 (pl) |
| WO (1) | WO2010069532A1 (pl) |
| ZA (2) | ZA201103990B (pl) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| WO2009088805A2 (en) | 2008-01-03 | 2009-07-16 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| US8133979B2 (en) | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| KR101431318B1 (ko) | 2009-04-02 | 2014-08-20 | 로슈 글리카트 아게 | 전장 항체 및 단일쇄 ｆａｂ 단편을 포함하는 다중특이성 항체 |
| US20120189635A1 (en) | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| JO3182B1 (ar) * | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| US8980268B2 (en) | 2009-07-29 | 2015-03-17 | Regeneron Pharamceuticals, Inc. | Methods for treating cancer by administering an anti-Ang-2 antibody |
| SG10201408401RA (en) | 2009-09-16 | 2015-01-29 | Genentech Inc | Coiled coil and/or tether containing protein complexes and uses thereof |
| AR080793A1 (es) * | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| JP5758004B2 (ja) | 2010-08-24 | 2015-08-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ジスルフィドによって安定化されたＦｖ断片を含む二重特異性抗体 |
| JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
| CN102221615A (zh) * | 2011-03-31 | 2011-10-19 | 广州华灿医药科技有限公司 | 一种基于Angiogenin检测的双抗夹心ELISA方法 |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| US9512220B2 (en) | 2011-04-05 | 2016-12-06 | Neopharm Co., Ltd. | Antibodies against angiopoietins 1 and 2, and their use |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| DK2760471T3 (en) | 2011-09-30 | 2017-05-08 | Dana Farber Cancer Inst Inc | THERAPEUTIC PEPTIDES |
| EP2812357B1 (en) | 2012-02-10 | 2020-11-04 | F.Hoffmann-La Roche Ag | Single-chain antibodies and other heteromultimers |
| JP2015520168A (ja) * | 2012-05-24 | 2015-07-16 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 多重特異性抗体 |
| MX354862B (es) | 2012-06-27 | 2018-03-23 | Hoffmann La Roche | Método para la producción de entidades dirigidas altamente selectivas hechas a la medida y biespecíficas que contienen dos entidades de unión diferentes. |
| CA2871882A1 (en) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| MY183712A (en) | 2012-07-13 | 2021-03-09 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| KR101967345B1 (ko) | 2012-10-18 | 2019-04-09 | 삼성전자주식회사 | 안지오포이에틴-2와 인테그린 간의 결합을 저해하는 펩타이드 및 그 용도 |
| WO2014108854A1 (en) * | 2013-01-09 | 2014-07-17 | Fusimab Ltd. | Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies |
| MX2015013163A (es) | 2013-03-15 | 2016-04-04 | Zyngenia Inc | Complejos multiespecificos multivalente y monovalentes y sus usos. |
| AU2014236867A1 (en) | 2013-03-15 | 2015-09-24 | Amgen Inc. | Methods and compositions relating to anti-CCR7 antigen binding proteins |
| NZ629816A (en) | 2013-03-15 | 2017-07-28 | Dana Farber Cancer Inst Inc | Therapeutic peptides |
| KR102131371B1 (ko) | 2013-07-02 | 2020-07-08 | 삼성전자주식회사 | Ang-2 특이적 항체 및 그의 용도 |
| EP2832746B1 (en) | 2013-07-29 | 2018-07-18 | Samsung Electronics Co., Ltd | Anti-Ang2 antibody |
| KR102146845B1 (ko) | 2013-07-30 | 2020-08-21 | 삼성전자주식회사 | 앤지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도 |
| KR102196450B1 (ko) | 2013-09-17 | 2020-12-30 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제 |
| PE20160753A1 (es) * | 2013-12-20 | 2016-08-01 | Hoffmann La Roche | Terapia combinada con un anticuerpo anti-ang2 y un agonista de cd40 |
| KR102206029B1 (ko) | 2014-01-27 | 2021-01-20 | 삼성전자주식회사 | Ang-2에 특이적으로 결합하는 항체 및 그의 용도 |
| CA3124243A1 (en) | 2014-03-14 | 2015-09-17 | Dana-Farber Cancer Institute, Inc. | Vaccine compositions and methods for restoring nkg2d pathway function against cancers |
| US9957333B2 (en) * | 2014-04-17 | 2018-05-01 | Case Western Reserve University | Anti-CEP antibody or fragment thereof |
| AR100270A1 (es) * | 2014-05-19 | 2016-09-21 | Lilly Co Eli | Anticuerpos ang2 |
| KR102349370B1 (ko) | 2014-05-26 | 2022-01-10 | 삼성전자주식회사 | 인간화 또는 친화도 성숙된 항 앤지오포이에틴-2 항체 및 그의 용도 |
| CA2963091A1 (en) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
| AU2015331602A1 (en) * | 2014-10-17 | 2017-04-27 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies |
| KR20170082594A (ko) * | 2014-11-10 | 2017-07-14 | 에프. 호프만-라 로슈 아게 | 항-ang2 항체 및 사용 방법 |
| CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| KR20170105609A (ko) | 2015-01-28 | 2017-09-19 | 피어이스 파마슈티컬즈 게엠베하 | 신생혈관형성에 특이적인 신규한 단백질 |
| JP6901400B2 (ja) * | 2015-04-03 | 2021-07-14 | ゾーマ テクノロジー リミテッド | ＴＧＦ−β及びＰＤ−１の阻害物質を使用する癌の治療法 |
| CA2992788A1 (en) | 2015-08-14 | 2017-02-23 | Allergan, Inc. | Heavy chain only antibodies to pdgf |
| PE20181363A1 (es) | 2015-09-23 | 2018-08-27 | Genentech Inc | Variantes optimizadas de anticuerpos anti-vegf |
| EA035586B1 (ru) | 2015-11-30 | 2020-07-10 | Пиерис Острелиа Пти Лтд. | Новые антиангиогенные слитые белки |
| WO2018114728A1 (en) | 2016-12-20 | 2018-06-28 | F. Hoffmann-La Roche Ag | Combination therapy with a bispecific anti-ang2/vegf antibody and a bispecific anti-her2 antibody |
| KR102143132B1 (ko) * | 2016-12-26 | 2020-08-10 | 기초과학연구원 | 항 Ang2 항체를 포함하는 안구질환 예방 및 치료용 조성물 |
| SG10202107829YA (en) | 2017-03-22 | 2021-08-30 | Genentech Inc | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| WO2018175752A1 (en) | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Optimized antibody compositions for treatment of ocular disorders |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| WO2019164219A1 (en) * | 2018-02-20 | 2019-08-29 | Institute For Basic Science | Anti-angiopoietin-2 antibodies and uses thereof |
| KR102497171B1 (ko) | 2018-02-20 | 2023-02-08 | 기초과학연구원 | 항-안지오포이에틴-2(Ang2) 항체 및 그의 용도 |
| TW202027794A (zh) | 2018-10-03 | 2020-08-01 | 瑞士商諾華公司 | 血管生成素樣３多肽之持續遞送 |
| CA3131250A1 (en) * | 2019-02-25 | 2020-09-03 | Pharmabcine Inc. | Anti-ang2 antibody and use thereof |
| TW202115112A (zh) * | 2019-06-27 | 2021-04-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗-angpt2抗體 |
| PE20230252A1 (es) | 2020-03-13 | 2023-02-07 | Genentech Inc | Anticuerpos anti-interleucina-33 y sus usos de estos |
| MX2022011752A (es) | 2020-03-24 | 2022-10-18 | Genentech Inc | Agentes de fijacion a tie2 y metodos de uso. |
| WO2021259200A1 (zh) * | 2020-06-22 | 2021-12-30 | 信达生物制药(苏州)有限公司 | 抗ang-2抗体及其用途 |
| CA3198668A1 (en) | 2020-10-15 | 2022-04-21 | Genentech, Inc. | Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics |
| WO2024064640A2 (en) * | 2022-09-19 | 2024-03-28 | Sonoma Biotherapeutics, Inc. | Citrullinated antigen-specific chimeric antigen receptors for targeting regulatory t cells to treat hidradenitis suppurativa |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5814464A (en) * | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7138370B2 (en) * | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| RU2277411C1 (ru) * | 2004-12-15 | 2006-06-10 | Ольга Алексеевна Кост | Фармацевтическая композиция для лечения глазных болезней, связанных с нарушением микроциркуляции и/или воспалительными процессами |
| SI1838733T1 (sl) | 2004-12-21 | 2011-12-30 | Medimmune Ltd | Protitelesa usmerjena na angiopoietin-2 in njih uporaba |
| CA2799802A1 (en) * | 2004-12-21 | 2006-06-29 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
| EP2377554A1 (en) * | 2005-07-22 | 2011-10-19 | Amgen, Inc | Concentrated protein lyophilates, methods and uses |
| WO2007033216A2 (en) | 2005-09-12 | 2007-03-22 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state |
| EP3168234A1 (en) | 2005-12-15 | 2017-05-17 | Medimmune Limited | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer |
| AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| CN103232540A (zh) * | 2006-02-01 | 2013-08-07 | 赛法隆澳大利亚控股有限公司 | 结构域抗体构建体 |
| RU2509085C2 (ru) * | 2008-01-28 | 2014-03-10 | Медиммун Лимитед | Стабилизированные антитела против ангиопоэтина-2 и их применение |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| US8268314B2 (en) * | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| US8133979B2 (en) * | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| US8703132B2 (en) * | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| MY183712A (en) * | 2012-07-13 | 2021-03-09 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
-
2009
- 2009-12-11 US US12/635,825 patent/US8133979B2/en active Active
- 2009-12-14 MY MYPI2011002743A patent/MY155654A/en unknown
- 2009-12-14 UA UAA201108713A patent/UA103912C2/uk unknown
- 2009-12-14 PT PT97934715T patent/PT2379592E/pt unknown
- 2009-12-14 SI SI200931184T patent/SI2379592T1/sl unknown
- 2009-12-14 KR KR1020137023369A patent/KR101445518B1/ko active IP Right Grant
- 2009-12-14 HU HUE09793471A patent/HUE024545T2/hu unknown
- 2009-12-14 NZ NZ592856A patent/NZ592856A/en not_active IP Right Cessation
- 2009-12-14 WO PCT/EP2009/008930 patent/WO2010069532A1/en active Application Filing
- 2009-12-14 PL PL09793471T patent/PL2379592T3/pl unknown
- 2009-12-14 UA UAA201310603A patent/UA105151C2/uk unknown
- 2009-12-14 MX MX2011005908A patent/MX2011005908A/es active IP Right Grant
- 2009-12-14 CA CA2916481A patent/CA2916481C/en active Active
- 2009-12-14 JP JP2011539960A patent/JP5559191B2/ja active Active
- 2009-12-14 PE PE2011001109A patent/PE20120551A1/es active IP Right Grant
- 2009-12-14 CN CN201210237207.1A patent/CN102746400B/zh active Active
- 2009-12-14 KR KR1020117013735A patent/KR101381012B1/ko active IP Right Grant
- 2009-12-14 NZ NZ600005A patent/NZ600005A/xx unknown
- 2009-12-14 CN CN200980150647XA patent/CN102257008A/zh not_active Withdrawn
- 2009-12-14 CA CA2744624A patent/CA2744624C/en not_active Expired - Fee Related
- 2009-12-14 SG SG2011044344A patent/SG172216A1/en unknown
- 2009-12-14 RU RU2013140625/10A patent/RU2569461C2/ru active
- 2009-12-14 AU AU2009328613A patent/AU2009328613B2/en not_active Ceased
- 2009-12-14 BR BR122013022089-5A patent/BR122013022089B1/pt active IP Right Grant
- 2009-12-14 PE PE2013002135A patent/PE20140814A1/es active IP Right Grant
- 2009-12-14 EP EP09793471.5A patent/EP2379592B1/en active Active
- 2009-12-14 CN CN201410024638.9A patent/CN103739709B/zh active Active
- 2009-12-14 BR BRPI0923434A patent/BRPI0923434A2/pt not_active Application Discontinuation
- 2009-12-14 DK DK09793471T patent/DK2379592T3/en active
- 2009-12-14 ES ES09793471.5T patent/ES2534635T3/es active Active
- 2009-12-14 RU RU2011129204/10A patent/RU2569107C2/ru not_active IP Right Cessation
- 2009-12-15 AR ARP090104876A patent/AR074756A1/es active IP Right Grant
- 2009-12-15 TW TW098142952A patent/TWI396549B/zh not_active IP Right Cessation
- 2009-12-15 TW TW102107374A patent/TWI482631B/zh active
-
2011
- 2011-05-19 IL IL213039A patent/IL213039A/en active IP Right Grant
- 2011-05-30 ZA ZA2011/03990A patent/ZA201103990B/en unknown
- 2011-05-31 CL CL2011001285A patent/CL2011001285A1/es unknown
- 2011-06-02 MA MA33908A patent/MA32876B1/fr unknown
- 2011-06-09 CR CR20110321A patent/CR20110321A/es unknown
- 2011-06-14 MY MYPI2013003828A patent/MY158438A/en unknown
- 2011-06-16 EC EC2011011139A patent/ECSP11011139A/es unknown
-
2012
- 2012-01-26 US US13/358,831 patent/US8399626B2/en active Active
- 2012-01-26 US US13/358,813 patent/US8361747B2/en active Active
- 2012-07-13 US US13/548,244 patent/US9109027B2/en active Active - Reinstated
- 2012-10-30 CL CL2012003054A patent/CL2012003054A1/es unknown
- 2012-12-04 US US13/693,085 patent/US9340609B2/en active Active
- 2012-12-18 HK HK12113037.4A patent/HK1172349A1/zh unknown
-
2013
- 2013-02-06 US US13/760,118 patent/US9073986B2/en active Active
- 2013-05-13 IL IL226350A patent/IL226350A/en active IP Right Grant
- 2013-08-28 CR CR20130418A patent/CR20130418A/es unknown
- 2013-08-30 JP JP2013179932A patent/JP5814317B2/ja active Active
- 2013-09-09 AR ARP130103201A patent/AR092487A2/es unknown
- 2013-09-30 ZA ZA2013/07297A patent/ZA201307297B/en unknown
- 2013-10-23 PH PH12013502192A patent/PH12013502192A1/en unknown
- 2013-10-25 EC ECSP13011139 patent/ECSP13011139A/es unknown
-
2014
- 2014-07-08 HK HK14106922.4A patent/HK1195775A1/zh unknown
-
2015
- 2015-04-22 HR HRP20150439TT patent/HRP20150439T1/hr unknown
- 2015-05-07 CY CY20151100399T patent/CY1116264T1/el unknown
- 2015-06-04 US US14/731,277 patent/US20150284457A1/en not_active Abandoned
-
2016
- 2016-04-12 US US15/097,097 patent/US20170029493A1/en not_active Abandoned
-
2018
- 2018-02-28 US US15/907,836 patent/US20180282404A1/en not_active Abandoned
-
2019
- 2019-09-26 US US16/583,839 patent/US20200262904A1/en not_active Abandoned
-
2021
- 2021-04-05 US US17/222,776 patent/US20210388071A1/en not_active Abandoned
-
2023
- 2023-03-31 US US18/193,889 patent/US20230227543A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201307297B (en) | Antibodies against human angiopoietin 2 | |
| PL2949666T3 (pl) | Ludzkie przeciwciała przeciwko alfa-synukleinie | |
| ZA201103723B (en) | Human antibodies against human tissue factor | |
| EP2207803A4 (en) | CD9-SPECIFIC HUMAN ANTIBODIES | |
| ZA201102004B (en) | Antibodies against human il 17 and uses thereof | |
| IL212795A0 (en) | Fully human antibodies against n-cadherin | |
| GB0815788D0 (en) | Therapeutic antibodies | |
| EP2344533A4 (en) | SPECIFIC HUMAN ANTIBODY OF TMPRSS4 | |
| EP2324059A4 (en) | THERAPEUTIC ANTI-PAMP ANTIBODIES | |
| GB0812080D0 (en) | Human propeeled boat | |
| HRP20190159T1 (hr) | Antitijela humanog anti-alfa-sinukleina | |
| SG10202006468XA (en) | Human antibodies against human tissue factor | |
| GB0819010D0 (en) | Medical uses | |
| GB0809339D0 (en) | Medical uses | |
| GB0809333D0 (en) | Medical uses | |
| GB0811536D0 (en) | 4 Transmembrane protein | |
| GB0808545D0 (en) | Note 200009 | |
| GB0808544D0 (en) | Note 200010 | |
| GB0805897D0 (en) | Note 10001 | |
| GB0808546D0 (en) | Note 200008 | |
| GB0808547D0 (en) | Note 200007 | |
| GB0808548D0 (en) | Note 200005 | |
| GB0808549D0 (en) | Note 200004 | |
| GB0808550D0 (en) | Note 200003 | |
| GB0808551D0 (en) | Note 200002 |