DK2354124T3 - Heteroarylpyrrolidinyl og piperidinylketonderivater - Google Patents

Heteroarylpyrrolidinyl og piperidinylketonderivater

Info

Publication number
DK2354124T3
DK2354124T3 DK10190446.4T DK10190446T DK2354124T3 DK 2354124 T3 DK2354124 T3 DK 2354124T3 DK 10190446 T DK10190446 T DK 10190446T DK 2354124 T3 DK2354124 T3 DK 2354124T3
Authority
DK
Denmark
Prior art keywords
garyl
heter
pyrrolidinyl
ketone derivatives
piperidinyl ketone
Prior art date
Application number
DK10190446.4T
Other languages
Danish (da)
English (en)
Inventor
Pravin Iyer
Clara Jeou Jen Lin
Matthew C Lucas
Stephen M Lynch
Ann Marie Madera
Kerem Erol Ozboya
Ryan Craig Schoenfeld
Robert James Weikert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39262542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2354124(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK2354124T3 publication Critical patent/DK2354124T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Seasonings (AREA)
DK10190446.4T 2006-12-19 2007-12-11 Heteroarylpyrrolidinyl og piperidinylketonderivater DK2354124T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87596906P 2006-12-19 2006-12-19
US99956107P 2007-10-19 2007-10-19
EP07848060A EP2102157B1 (en) 2006-12-19 2007-12-11 Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives

Publications (1)

Publication Number Publication Date
DK2354124T3 true DK2354124T3 (da) 2013-03-11

Family

ID=39262542

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10190446.4T DK2354124T3 (da) 2006-12-19 2007-12-11 Heteroarylpyrrolidinyl og piperidinylketonderivater

Country Status (30)

Country Link
US (2) US8084623B2 (enExample)
EP (3) EP2684871B1 (enExample)
JP (1) JP5394252B2 (enExample)
KR (1) KR101054189B1 (enExample)
CN (1) CN101563319B (enExample)
AR (1) AR064397A1 (enExample)
AT (1) ATE513808T1 (enExample)
BR (1) BRPI0720742B8 (enExample)
CA (1) CA2671378C (enExample)
CL (1) CL2007003672A1 (enExample)
CO (1) CO6190531A2 (enExample)
CR (1) CR10809A (enExample)
CY (1) CY1113916T1 (enExample)
DK (1) DK2354124T3 (enExample)
EC (1) ECSP099442A (enExample)
ES (2) ES2401129T3 (enExample)
HR (1) HRP20130362T1 (enExample)
IL (1) IL198879A0 (enExample)
MA (1) MA31142B1 (enExample)
MX (1) MX2009006334A (enExample)
MY (1) MY186650A (enExample)
NO (1) NO20092058L (enExample)
NZ (1) NZ577114A (enExample)
PE (2) PE20121151A1 (enExample)
PL (1) PL2354124T3 (enExample)
PT (1) PT2354124E (enExample)
RU (1) RU2479575C2 (enExample)
SG (1) SG170054A1 (enExample)
TW (1) TWI377202B (enExample)
WO (1) WO2008074703A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101209373B1 (ko) * 2008-03-20 2012-12-06 에프. 호프만-라 로슈 아게 피롤리디닐 유도체 및 이의 용도
EP2297096A2 (en) * 2008-06-18 2011-03-23 F. Hoffmann-La Roche AG Aryl ketone as mri
EP2974724A1 (en) * 2009-02-09 2016-01-20 Sunovion Pharmaceuticals Inc. Pyrrolidine triple reuptake inhibitors
JP5992192B2 (ja) * 2012-03-30 2016-09-14 三井金属鉱業株式会社 パラジウム触媒
EP2841418B1 (en) 2012-04-25 2017-03-08 F. Hoffmann-La Roche AG (3,4-dichloro-phenyl)-((s)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes
CN105102448B (zh) 2013-02-28 2018-03-06 百时美施贵宝公司 作为rock1和rock2抑制剂的苯基吡唑衍生物
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
CN110642880B (zh) * 2019-10-11 2021-12-31 长沙麓兴生物科技有限公司 一种氮未取代吡唑和吲唑类硼酸的制备方法
CN114014792B (zh) * 2021-12-15 2024-01-26 沈阳海诺威医药科技有限公司 一种7-(4-溴苯甲酰基)-1,3-二氢-2h-吲哚-2-酮的制备方法
WO2023161533A1 (en) 2022-02-28 2023-08-31 Noema Pharma Ag Triple uptake inhibitor for the treatment of atypical depression
CN116751157B (zh) * 2023-06-21 2025-09-12 上海再启生物技术有限公司 一种2-(2-氨基-5-溴-苯甲酰基)吡啶的放大制备方法
TW202525282A (zh) 2023-08-28 2025-07-01 瑞士商諾埃瑪製藥公司 使用三重再攝取抑制劑治療行為免疫-代謝叢集病症或疾病之方法
TW202515540A (zh) * 2023-08-30 2025-04-16 瑞士商諾埃瑪製藥公司 使用三重再攝取抑制劑治療睡眠障礙之方法
WO2025106383A1 (en) * 2023-11-17 2025-05-22 Merck Sharp & Dohme Llc Pyrrolidinyl derivatives useful as hcn1/hcn 2 modulators
WO2025146469A1 (en) * 2024-01-05 2025-07-10 Noema Pharma Ag Treatment for the symptoms of menopause and perimenopause

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3073829A (en) * 1963-01-15 Certificate of correction
US2248018A (en) * 1939-03-30 1941-07-01 Winthrop Chem Co Inc 4-aryl-piperidine-ketones and a process of preparing them
US3056795A (en) * 1958-04-30 1962-10-02 Sterling Drug Inc 3-aryl-3-(aroyl or alkanoyl)tropanes and preparation thereof
NL130088C (enExample) * 1960-03-14
US4341698A (en) * 1979-06-21 1982-07-27 Richardson-Merrell Inc. Enkaphalin derivatives
GB2060937A (en) 1979-10-12 1981-05-07 Rolls Royce Fluid-flow restrictor assembly
ZA806501B (en) * 1979-10-27 1981-10-28 Richardson Merrell Inc 4-(4-alkyl-aroyl-1-piperidino)butyrophenone antipsychotic agents
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
CA1228867A (en) 1984-05-03 1987-11-03 G. Paull Torrence Methanol carbonylation process
WO1991009594A1 (en) 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
FR2735127B1 (fr) 1995-06-09 1997-08-22 Pf Medicament Nouvelles piperazines heteroaromatiques utiles comme medicaments.
GB9523583D0 (en) * 1995-11-17 1996-01-17 Merck Sharp & Dohme Therapeutic agents
FR2758327B1 (fr) 1997-01-15 1999-04-02 Pf Medicament Nouvelles arylpiperazines derivees de piperidine
TR200002466T2 (tr) * 1998-02-26 2000-12-21 Akzo Nobel N.V. Azetidin ve pirolidin türevleri
AU6936500A (en) 1999-08-24 2001-03-19 Regents Of The University Of California, The Non-quinoline inhibitors of malaria parasites
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
WO2001021577A2 (en) * 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
WO2001022964A1 (en) * 1999-09-27 2001-04-05 Georgetown University Dopamine transporter inhibitors and their use
AU2001290873B2 (en) 2000-09-11 2006-07-27 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)
JP4544820B2 (ja) 2001-03-09 2010-09-15 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 複素環化合物
US6569887B2 (en) * 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US20040034019A1 (en) 2002-08-08 2004-02-19 Ronald Tomlinson Piperazine and piperidine derivatives
WO2004022712A2 (en) 2002-09-03 2004-03-18 Scios Inc. INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE
WO2004024720A1 (en) * 2002-09-11 2004-03-25 Merck & Co., Inc. Piperazine urea derivatives as melanocortin-4 receptor agonists
US20050256159A1 (en) 2002-10-11 2005-11-17 Astrazeneca Ab 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors
WO2004080925A2 (en) 2003-03-12 2004-09-23 The University Of Western Ontario Synthesis of tetrahydro-1,2-oxazines by the cycloaddition of nitrones with cyclopropanes
US20060014987A1 (en) 2003-07-07 2006-01-19 Lan Huang Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof
JP2005057154A (ja) * 2003-08-07 2005-03-03 Canon Inc 露光装置
WO2005040129A2 (en) 2003-10-24 2005-05-06 F. Hoffmann-La Roche Ag Ccr3 receptor antagonists
GB0325745D0 (en) 2003-11-05 2003-12-10 Astrazeneca Ab Chemical compounds
WO2005047253A1 (en) * 2003-11-12 2005-05-26 Lg Life Sciences Ltd. Melanocortin receptor agonists
CA2557276A1 (en) 2004-02-26 2005-09-09 Kyowa Hakko Kogyo Co., Ltd. Preventive and/or therapeutic agent for neutrophilic inflammatory diseases
DK1761519T3 (da) 2004-06-21 2008-07-21 Hoffmann La Roche Indolderivater som histaminreceptorantagonister
WO2006003147A1 (en) 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
JP5149009B2 (ja) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
US20060167044A1 (en) * 2004-12-20 2006-07-27 Arnaiz Damian O Piperidine derivatives and their use as anti-inflammatory agents
DE102004061934A1 (de) 2004-12-22 2006-07-13 Siemens Ag Verfahren zur Datenübertragung zwischen einer sendenden und einer empfangenden Einheit in einem Bluetooth-Funkkommunikationssystem
KR20070097590A (ko) 2005-01-25 2007-10-04 에픽스 델라웨어, 인코포레이티드 치환된 아릴아민 화합물 및 5―ｈｔ6 조절제로서의 이의용도
WO2006086609A2 (en) 2005-02-10 2006-08-17 Axys Pharmaceuticals, Inc. Inhibitors of tryptase
CA2631853C (en) 2005-12-12 2015-11-24 Nerviano Medical Sciences S.R.L. Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors
US7544698B2 (en) 2006-04-07 2009-06-09 Janssen Pharmaceutica, N.V. Indoles and benzoimidazoles as modulators of the histamine H4 receptor

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Publication number Publication date
EP2354124A3 (en) 2011-09-14
PT2354124E (pt) 2013-04-09
US8513425B2 (en) 2013-08-20
AR064397A1 (es) 2009-04-01
SG170054A1 (en) 2011-04-29
PE20121151A1 (es) 2012-08-27
JP5394252B2 (ja) 2014-01-22
CN101563319B (zh) 2012-09-05
CL2007003672A1 (es) 2008-07-25
BRPI0720742B8 (pt) 2021-05-25
EP2354124A2 (en) 2011-08-10
NO20092058L (no) 2009-09-17
PL2354124T3 (pl) 2013-07-31
JP2010513379A (ja) 2010-04-30
CN101563319A (zh) 2009-10-21
ATE513808T1 (de) 2011-07-15
BRPI0720742A2 (pt) 2014-01-28
US20080146607A1 (en) 2008-06-19
PE20081831A1 (es) 2008-12-27
CA2671378A1 (en) 2008-06-26
BRPI0720742B1 (pt) 2021-02-09
EP2102157A1 (en) 2009-09-23
TWI377202B (en) 2012-11-21
IL198879A0 (en) 2010-02-17
RU2479575C2 (ru) 2013-04-20
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US8084623B2 (en) 2011-12-27
MY186650A (en) 2021-08-03
ES2401129T3 (es) 2013-04-17
ES2366980T3 (es) 2011-10-27
EP2684871A1 (en) 2014-01-15
KR20090091194A (ko) 2009-08-26
NZ577114A (en) 2011-12-22
CR10809A (es) 2009-06-25
CA2671378C (en) 2015-10-20
RU2009122666A (ru) 2011-01-27
KR101054189B1 (ko) 2011-08-03
ECSP099442A (es) 2009-07-31
EP2102157B1 (en) 2011-06-22
WO2008074703A1 (en) 2008-06-26
EP2354124B1 (en) 2013-02-13
MA31142B1 (fr) 2010-02-01
EP2684871B1 (en) 2016-05-04
US20120065225A1 (en) 2012-03-15
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