CN101563319B - 杂芳基吡咯烷基和哌啶基甲酮衍生物 - Google Patents
杂芳基吡咯烷基和哌啶基甲酮衍生物 Download PDFInfo
- Publication number
- CN101563319B CN101563319B CN2007800471648A CN200780047164A CN101563319B CN 101563319 B CN101563319 B CN 101563319B CN 2007800471648 A CN2007800471648 A CN 2007800471648A CN 200780047164 A CN200780047164 A CN 200780047164A CN 101563319 B CN101563319 B CN 101563319B
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- China
- Prior art keywords
- methanone
- pyrrolidin
- phenyl
- propyl
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CCC*C([C@](C1C(C(C)(*)N(*)C2)=C1)(C=C(*)C2(C)*#C)I)=O Chemical compound CCC*C([C@](C1C(C(C)(*)N(*)C2)=C1)(C=C(*)C2(C)*#C)I)=O 0.000 description 2
- GBBSAMQTQCPOBF-UHFFFAOYSA-N CB1OB(C)OB(C)O1 Chemical compound CB1OB(C)OB(C)O1 GBBSAMQTQCPOBF-UHFFFAOYSA-N 0.000 description 1
- LDPIPPINNOCUOR-UHFFFAOYSA-N CC(C)(C)CCC1(CNCC1)C(c(cc1Oc2ccccc2)ccc1Cl)=O Chemical compound CC(C)(C)CCC1(CNCC1)C(c(cc1Oc2ccccc2)ccc1Cl)=O LDPIPPINNOCUOR-UHFFFAOYSA-N 0.000 description 1
- FIZPJPVIFIKKIJ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CC1(Cc1ccccc1)C(c(cc1)cc2c1[nH]cc2)=O)=O Chemical compound CC(C)(C)OC(N(CC1)CC1(Cc1ccccc1)C(c(cc1)cc2c1[nH]cc2)=O)=O FIZPJPVIFIKKIJ-UHFFFAOYSA-N 0.000 description 1
- FYPOFTWQPZTWHJ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CC1(Cc1ccccc1)C(c(cc1)cc2c1[n](C)cc2)=O)=O Chemical compound CC(C)(C)OC(N(CC1)CC1(Cc1ccccc1)C(c(cc1)cc2c1[n](C)cc2)=O)=O FYPOFTWQPZTWHJ-UHFFFAOYSA-N 0.000 description 1
- OHXOQELCMRNMRS-UHFFFAOYSA-N CC(C)(CC1(CNCC1)C(c(cc1)cc(Cl)c1Cl)=O)OC Chemical compound CC(C)(CC1(CNCC1)C(c(cc1)cc(Cl)c1Cl)=O)OC OHXOQELCMRNMRS-UHFFFAOYSA-N 0.000 description 1
- DNENFXLPANCRIW-UHFFFAOYSA-N CCCC(C1)C1OC(N(CC1)CC1(CCC)C=O)=O Chemical compound CCCC(C1)C1OC(N(CC1)CC1(CCC)C=O)=O DNENFXLPANCRIW-UHFFFAOYSA-N 0.000 description 1
- WKARYNYJQMZOIM-UHFFFAOYSA-N CCCC(CC1)(CN1C(OC(C)(C)C)=O)C(c([s]1)cc(Cl)c1Cl)O Chemical compound CCCC(CC1)(CN1C(OC(C)(C)C)=O)C(c([s]1)cc(Cl)c1Cl)O WKARYNYJQMZOIM-UHFFFAOYSA-N 0.000 description 1
- DXWBRTONQPMSDK-UHFFFAOYSA-N CCCCOC(N(CC1)CC1(CCC)C(c1cc(Cl)c(C)[s]1)=O)=O Chemical compound CCCCOC(N(CC1)CC1(CCC)C(c1cc(Cl)c(C)[s]1)=O)=O DXWBRTONQPMSDK-UHFFFAOYSA-N 0.000 description 1
- ZYARGIYESWZMMI-UHFFFAOYSA-N CCOCC(CCC1)(C(OC)=O)N1C(OC(C)(C)C)=O Chemical compound CCOCC(CCC1)(C(OC)=O)N1C(OC(C)(C)C)=O ZYARGIYESWZMMI-UHFFFAOYSA-N 0.000 description 1
- PHPCBAXLCUMORS-UHFFFAOYSA-N CCOCC(CCC1)(C=O)N1C(OC(C)(C)C)=O Chemical compound CCOCC(CCC1)(C=O)N1C(OC(C)(C)C)=O PHPCBAXLCUMORS-UHFFFAOYSA-N 0.000 description 1
- SAHJMWFRKFDFOZ-UHFFFAOYSA-N C[n](cc1)c(cc2)c1cc2C(C1(Cc2ccccc2)CNCC1)=O Chemical compound C[n](cc1)c(cc2)c1cc2C(C1(Cc2ccccc2)CNCC1)=O SAHJMWFRKFDFOZ-UHFFFAOYSA-N 0.000 description 1
- LVNVLQIXMBTMPH-UHFFFAOYSA-N Clc(cc[s]1)c1Cl Chemical compound Clc(cc[s]1)c1Cl LVNVLQIXMBTMPH-UHFFFAOYSA-N 0.000 description 1
- OOWSDISYPCDYPH-UHFFFAOYSA-N O=C(C1(CC2CCCC2)CNCC1)c(cc1Cl)ccc1Cl Chemical compound O=C(C1(CC2CCCC2)CNCC1)c(cc1Cl)ccc1Cl OOWSDISYPCDYPH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87596906P | 2006-12-19 | 2006-12-19 | |
| US60/875,969 | 2006-12-19 | ||
| US99956107P | 2007-10-19 | 2007-10-19 | |
| US60/999,561 | 2007-10-19 | ||
| PCT/EP2007/063736 WO2008074703A1 (en) | 2006-12-19 | 2007-12-11 | Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101563319A CN101563319A (zh) | 2009-10-21 |
| CN101563319B true CN101563319B (zh) | 2012-09-05 |
Family
ID=39262542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800471648A Active CN101563319B (zh) | 2006-12-19 | 2007-12-11 | 杂芳基吡咯烷基和哌啶基甲酮衍生物 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8084623B2 (enExample) |
| EP (3) | EP2684871B1 (enExample) |
| JP (1) | JP5394252B2 (enExample) |
| KR (1) | KR101054189B1 (enExample) |
| CN (1) | CN101563319B (enExample) |
| AR (1) | AR064397A1 (enExample) |
| AT (1) | ATE513808T1 (enExample) |
| BR (1) | BRPI0720742B8 (enExample) |
| CA (1) | CA2671378C (enExample) |
| CL (1) | CL2007003672A1 (enExample) |
| CO (1) | CO6190531A2 (enExample) |
| CR (1) | CR10809A (enExample) |
| CY (1) | CY1113916T1 (enExample) |
| DK (1) | DK2354124T3 (enExample) |
| EC (1) | ECSP099442A (enExample) |
| ES (2) | ES2401129T3 (enExample) |
| HR (1) | HRP20130362T1 (enExample) |
| IL (1) | IL198879A0 (enExample) |
| MA (1) | MA31142B1 (enExample) |
| MX (1) | MX2009006334A (enExample) |
| MY (1) | MY186650A (enExample) |
| NO (1) | NO20092058L (enExample) |
| NZ (1) | NZ577114A (enExample) |
| PE (2) | PE20121151A1 (enExample) |
| PL (1) | PL2354124T3 (enExample) |
| PT (1) | PT2354124E (enExample) |
| RU (1) | RU2479575C2 (enExample) |
| SG (1) | SG170054A1 (enExample) |
| TW (1) | TWI377202B (enExample) |
| WO (1) | WO2008074703A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101209373B1 (ko) * | 2008-03-20 | 2012-12-06 | 에프. 호프만-라 로슈 아게 | 피롤리디닐 유도체 및 이의 용도 |
| EP2297096A2 (en) * | 2008-06-18 | 2011-03-23 | F. Hoffmann-La Roche AG | Aryl ketone as mri |
| EP2974724A1 (en) * | 2009-02-09 | 2016-01-20 | Sunovion Pharmaceuticals Inc. | Pyrrolidine triple reuptake inhibitors |
| JP5992192B2 (ja) * | 2012-03-30 | 2016-09-14 | 三井金属鉱業株式会社 | パラジウム触媒 |
| EP2841418B1 (en) | 2012-04-25 | 2017-03-08 | F. Hoffmann-La Roche AG | (3,4-dichloro-phenyl)-((s)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes |
| CN105102448B (zh) | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| CN110642880B (zh) * | 2019-10-11 | 2021-12-31 | 长沙麓兴生物科技有限公司 | 一种氮未取代吡唑和吲唑类硼酸的制备方法 |
| CN114014792B (zh) * | 2021-12-15 | 2024-01-26 | 沈阳海诺威医药科技有限公司 | 一种7-(4-溴苯甲酰基)-1,3-二氢-2h-吲哚-2-酮的制备方法 |
| WO2023161533A1 (en) | 2022-02-28 | 2023-08-31 | Noema Pharma Ag | Triple uptake inhibitor for the treatment of atypical depression |
| CN116751157B (zh) * | 2023-06-21 | 2025-09-12 | 上海再启生物技术有限公司 | 一种2-(2-氨基-5-溴-苯甲酰基)吡啶的放大制备方法 |
| TW202525282A (zh) | 2023-08-28 | 2025-07-01 | 瑞士商諾埃瑪製藥公司 | 使用三重再攝取抑制劑治療行為免疫-代謝叢集病症或疾病之方法 |
| TW202515540A (zh) * | 2023-08-30 | 2025-04-16 | 瑞士商諾埃瑪製藥公司 | 使用三重再攝取抑制劑治療睡眠障礙之方法 |
| WO2025106383A1 (en) * | 2023-11-17 | 2025-05-22 | Merck Sharp & Dohme Llc | Pyrrolidinyl derivatives useful as hcn1/hcn 2 modulators |
| WO2025146469A1 (en) * | 2024-01-05 | 2025-07-10 | Noema Pharma Ag | Treatment for the symptoms of menopause and perimenopause |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2248018A (en) * | 1939-03-30 | 1941-07-01 | Winthrop Chem Co Inc | 4-aryl-piperidine-ketones and a process of preparing them |
| BE601228A (nl) * | 1960-03-14 | 1961-07-03 | Paul Adriaan Jan Janssen | Nieuwe 1-aroylalkyl-4-arylpiperidine-carboxamiden en werkwijzen ter bereiding daarvan |
| WO1997019073A1 (en) * | 1995-11-17 | 1997-05-29 | Merck Sharp & Dohme Limited | Piperidine and tetrahydropyridine derivatives |
| WO2004024720A1 (en) * | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
| WO2005047253A1 (en) * | 2003-11-12 | 2005-05-26 | Lg Life Sciences Ltd. | Melanocortin receptor agonists |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3073829A (en) * | 1963-01-15 | Certificate of correction | ||
| US3056795A (en) * | 1958-04-30 | 1962-10-02 | Sterling Drug Inc | 3-aryl-3-(aroyl or alkanoyl)tropanes and preparation thereof |
| US4341698A (en) * | 1979-06-21 | 1982-07-27 | Richardson-Merrell Inc. | Enkaphalin derivatives |
| GB2060937A (en) | 1979-10-12 | 1981-05-07 | Rolls Royce | Fluid-flow restrictor assembly |
| ZA806501B (en) * | 1979-10-27 | 1981-10-28 | Richardson Merrell Inc | 4-(4-alkyl-aroyl-1-piperidino)butyrophenone antipsychotic agents |
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