CO6190531A2 - Derivados de heteroaril-pirrolidinil- y-piperidinil-cetona - Google Patents
Derivados de heteroaril-pirrolidinil- y-piperidinil-cetonaInfo
- Publication number
- CO6190531A2 CO6190531A2 CO09053154A CO09053154A CO6190531A2 CO 6190531 A2 CO6190531 A2 CO 6190531A2 CO 09053154 A CO09053154 A CO 09053154A CO 09053154 A CO09053154 A CO 09053154A CO 6190531 A2 CO6190531 A2 CO 6190531A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- alkyl
- alkoxy
- cycloalkyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
1.- Un compuesto de la fórmula I:o una sal farmacéuticamente aceptable del mismo, en la que: m es un número de 0 a 3; n es un número de 0 a 2; Ar es: indolilo opcionalmente sustituido; indazolilo opcionalmente sustituido; azaindolilo opcionalmente sustituido; azaindazolilo opcionalmente sustituido; 2, 3-dihidro-indolilo opcionalmente sustituido; 1,3-dihidro-indol-2-on-ilo opcionalmente sustituido; benzotiofenilo opcionalmente sustituido; bencimidazolilo opcionalmente sustituido; benzoxazolilo opcionalmente sustituido; bencisoxazolilo opcionalmente sustituido; benzotiazolilo opcionalmente sustituido; bencisotiazolilo opcionalmente sustituido; quinolinilo opcionalmente sustituido; 1,2,3,4-tetrahidroquinolinilo opcionalmente sustituido; quinolin-2-on-ilo opcionalmente sustituido; isoquinolinilo opcionalmente sustituido; naftalenilo opcionalmente sustituido; piridinilo opcionalmente sustituido; tiofenilo opcionalmente sustituido; R1 es: alquilo C1-6; alquenilo C2-6; alquinilo C2-6; hetero-alquilo C1-6; halo-alquilo C1-6; halo-alquenilo C2-6; cicloalquilo C3-7; (cicloalquil C3-7) -alquilo C1-6; (alquil C1-6) - (cicloalquil C3-6) -alquilo C1-6; alcoxi C1-6; alquilsulfonilo C1-6; alquilsulfanilo C1-6; arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; heterociclil-alquilo C1-6; aril-alquilo C1-3, cuya porción arilo está opcionalmente sustituida; heteroaril-alquilo C1-3, cuya porción heteroarilo está opcionalmente sustituida; ariloxi; aril-alcoxi C1-6; heteroariloxi; o heteroaril-alcoxi C1-6; R2 es: hidrógeno; o alquilo C1-6; y Ra y Rb con independencia entre sí son: hidrógeno; alquilo C1-6; alcoxi C1-6; halógeno; hidroxi; o oxo; o Ra y Rb forman, juntos, un alquileno C1-2; con la condición de que cuando m es 1, n es 2 y Ar es fenilo opcionalmente sustituido, entonces R1 no sea metilo ni etilo, y en donde opcionalmente sustituidos significa uno a cuatro sustituyentes, seleccionados de alquilo, cicloalquilo, alcoxi, halógeno, haloalquilo, haloalcoxi, ciano, nitro, heteroalquilo, amino, acilamino, mono-alquilamino, di-alquilamino, hidroxialquilo, alcoxialquilo, benciloxi, cicloalquilalquilo, cicloalcoxi, cicloalquilalcoxi, alquilsulfoniloxi, tiofenilo, pirazolilo, piridinilo, morfolinocarbonilo, -(CH2)q-S(O)rRf; -(CH2)qNRgRh; -(CH2)q-C(=O)-NRgRh; -(CH2)q-C(=O)-C(=O)-NRgRh; -(CH2)q-SO2-NRgRh; -(CH2)q-N(Rf)-C(=O)-Ri; -(CH2)q-C(=O)-Ri; o -(CH2)q-N(Rf)-SO2-Rg, donde q es 0 o 1, r es de 0 a 2, Rf, Rg y Rh cada uno es independientemente hidrógeno o alquilo, y cada R1 es independientemente hidrógeno, alquilo, hidroxi o alcoxi.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87596906P | 2006-12-19 | 2006-12-19 | |
US99956107P | 2007-10-19 | 2007-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6190531A2 true CO6190531A2 (es) | 2010-08-19 |
Family
ID=39262542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09053154A CO6190531A2 (es) | 2006-12-19 | 2009-05-22 | Derivados de heteroaril-pirrolidinil- y-piperidinil-cetona |
Country Status (30)
Country | Link |
---|---|
US (2) | US8084623B2 (es) |
EP (3) | EP2102157B1 (es) |
JP (1) | JP5394252B2 (es) |
KR (1) | KR101054189B1 (es) |
CN (1) | CN101563319B (es) |
AR (1) | AR064397A1 (es) |
AT (1) | ATE513808T1 (es) |
BR (1) | BRPI0720742B8 (es) |
CA (1) | CA2671378C (es) |
CL (1) | CL2007003672A1 (es) |
CO (1) | CO6190531A2 (es) |
CR (1) | CR10809A (es) |
CY (1) | CY1113916T1 (es) |
DK (1) | DK2354124T3 (es) |
EC (1) | ECSP099442A (es) |
ES (2) | ES2366980T3 (es) |
HR (1) | HRP20130362T1 (es) |
IL (1) | IL198879A0 (es) |
MA (1) | MA31142B1 (es) |
MX (1) | MX2009006334A (es) |
MY (1) | MY186650A (es) |
NO (1) | NO20092058L (es) |
NZ (1) | NZ577114A (es) |
PE (2) | PE20081831A1 (es) |
PL (1) | PL2354124T3 (es) |
PT (1) | PT2354124E (es) |
RU (1) | RU2479575C2 (es) |
SG (1) | SG170054A1 (es) |
TW (1) | TWI377202B (es) |
WO (1) | WO2008074703A1 (es) |
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EP2257545B1 (en) * | 2008-03-20 | 2011-08-31 | F. Hoffmann-La Roche AG | Pyrrolidinyl derivatives and uses thereof |
CN102066320A (zh) * | 2008-06-18 | 2011-05-18 | 弗·哈夫曼-拉罗切有限公司 | 作为mri的芳基甲酮 |
EP2393357B1 (en) | 2009-02-09 | 2015-08-26 | Sunovion Pharmaceuticals Inc. | Pyrrolidine triple reuptake inhibitors |
JP5992192B2 (ja) * | 2012-03-30 | 2016-09-14 | 三井金属鉱業株式会社 | パラジウム触媒 |
MX2014011419A (es) | 2012-04-25 | 2014-11-25 | Hoffmann La Roche | Clorhidrato de (3,4-dicloro-fenil)-((s)-3-propil-pirrolidin-3-il)- metanona y procesos de manufacturacion. |
WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效rock1及rock2抑制劑之苯基吡唑衍生物 |
CN110642880B (zh) * | 2019-10-11 | 2021-12-31 | 长沙麓兴生物科技有限公司 | 一种氮未取代吡唑和吲唑类硼酸的制备方法 |
CN114014792B (zh) * | 2021-12-15 | 2024-01-26 | 沈阳海诺威医药科技有限公司 | 一种7-(4-溴苯甲酰基)-1,3-二氢-2h-吲哚-2-酮的制备方法 |
WO2023161533A1 (en) | 2022-02-28 | 2023-08-31 | Noema Pharma Ag | Triple uptake inhibitor for the treatment of atypical depression |
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