DK2295417T3 - Nye mellemprodukter, som kan anvendes til fremstilling af alpha-(n-sulfonamid)acetamidforbindelse - Google Patents

Nye mellemprodukter, som kan anvendes til fremstilling af alpha-(n-sulfonamid)acetamidforbindelse

Info

Publication number
DK2295417T3
DK2295417T3 DK10190591.7T DK10190591T DK2295417T3 DK 2295417 T3 DK2295417 T3 DK 2295417T3 DK 10190591 T DK10190591 T DK 10190591T DK 2295417 T3 DK2295417 T3 DK 2295417T3
Authority
DK
Denmark
Prior art keywords
sulfonamide
novel intermediates
acetamide compound
prepare alpha
alpha
Prior art date
Application number
DK10190591.7T
Other languages
English (en)
Inventor
John E Starrett Jr
Kevin W Gillman
Richard E Olson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40193955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2295417(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK2295417T3 publication Critical patent/DK2295417T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK10190591.7T 2007-10-31 2008-10-14 Nye mellemprodukter, som kan anvendes til fremstilling af alpha-(n-sulfonamid)acetamidforbindelse DK2295417T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98411807P 2007-10-31 2007-10-31
EP08843687A EP2205575B1 (en) 2007-10-31 2008-10-14 A novel alpha-(n-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production

Publications (1)

Publication Number Publication Date
DK2295417T3 true DK2295417T3 (da) 2012-10-15

Family

ID=40193955

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10190591.7T DK2295417T3 (da) 2007-10-31 2008-10-14 Nye mellemprodukter, som kan anvendes til fremstilling af alpha-(n-sulfonamid)acetamidforbindelse
DK08843687.8T DK2205575T3 (da) 2007-10-31 2008-10-14 Ny alpha-(n-sulfonamid)acetamid-forbindelse som inhibitor af betaamyloidpeptid-produktion

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK08843687.8T DK2205575T3 (da) 2007-10-31 2008-10-14 Ny alpha-(n-sulfonamid)acetamid-forbindelse som inhibitor af betaamyloidpeptid-produktion

Country Status (29)

Country Link
US (2) US8084477B2 (da)
EP (3) EP2205575B1 (da)
JP (1) JP5460605B2 (da)
KR (1) KR20100075575A (da)
CN (2) CN101910141B (da)
AR (1) AR069135A1 (da)
AT (1) ATE502022T1 (da)
AU (1) AU2008319122A1 (da)
BR (1) BRPI0818837A2 (da)
CA (1) CA2704360A1 (da)
CL (1) CL2008003271A1 (da)
CO (1) CO6270332A2 (da)
CY (2) CY1112337T1 (da)
DE (1) DE602008005636D1 (da)
DK (2) DK2295417T3 (da)
EA (2) EA016447B1 (da)
ES (2) ES2390042T3 (da)
HK (2) HK1141801A1 (da)
HR (2) HRP20110219T1 (da)
IL (1) IL205406A0 (da)
MX (1) MX2010004319A (da)
NZ (1) NZ584545A (da)
PE (1) PE20091394A1 (da)
PL (2) PL2295417T3 (da)
PT (2) PT2205575E (da)
SG (2) SG174043A1 (da)
SI (2) SI2295417T1 (da)
TW (1) TW200927099A (da)
WO (1) WO2009058552A1 (da)

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BR0215182A (pt) 2001-12-20 2004-10-19 Bristol Myers Squibb Co Derivados de (alfa)- (n-sulfonamido) acetamida como inibidores de (beta)-amilóide
US8093276B2 (en) * 2007-10-31 2012-01-10 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8044077B2 (en) * 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
ES2406363T3 (es) * 2009-03-19 2013-06-06 Bristol-Myers Squibb Company Compuesto de alfa-(N-sulfonamido)acetamida como un inhibidor de la producción de péptido beta amiloide
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US8252821B2 (en) * 2009-04-14 2012-08-28 Bristol-Myers Squibb Company Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound
TW201043269A (en) * 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound
WO2011111831A1 (ja) 2010-03-12 2011-09-15 日本曹達株式会社 ピリジン環含有化合物、及びハロゲン化ピコリン誘導体及びテトラゾリルオキシム誘導体の製造方法
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
EP2643299B1 (en) 2010-11-22 2016-06-22 Noscira, S.A. Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions
CN104822677A (zh) 2012-09-21 2015-08-05 百时美施贵宝公司 氟烷基-1,4-苯并二氮杂*酮化合物
WO2014047369A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Substituted 1,5-benzodiazepinone compounds
CN104854094A (zh) 2012-09-21 2015-08-19 百时美施贵宝公司 氟烷基二苯并二氮杂*酮化合物
EP2897960B1 (en) 2012-09-21 2016-08-03 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds as notch inhibitors
CN103058913B (zh) * 2012-12-13 2015-09-30 江苏弘和药物研发有限公司 5-氯异吲哚酮的合成方法
CN104163784B (zh) * 2014-06-20 2019-01-08 湖南天地恒一制药有限公司 一种奥拉西坦的合成工艺
RU2757276C2 (ru) 2016-12-16 2021-10-12 Пайплайн Терапьютикс, Инк. Способы лечения кохлеарной синаптопатии
US20200055948A1 (en) 2017-04-28 2020-02-20 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
EP3615068A1 (en) 2017-04-28 2020-03-04 Novartis AG Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
CN107935957B (zh) * 2017-12-02 2020-08-21 江苏仁明生物科技有限公司 一种合成高纯度沙坦侧链ttbb的方法
CN112384531B (zh) 2018-06-01 2024-05-14 诺华股份有限公司 针对bcma的结合分子及其用途
CN108640886A (zh) * 2018-08-01 2018-10-12 余锋 一种作为β-淀粉样肽产生的抑制剂BMS-708163的合成方法
TW202115114A (zh) 2019-06-24 2021-04-16 瑞士商諾華公司 針對靶向ｂ細胞成熟抗原的多特異抗體之給藥方案及組合療法
CN113466367B (zh) * 2021-06-25 2023-04-14 深圳万乐药业有限公司 乌苯美司原料药中α-苯乙胺杂质检测方法
CN113816874B (zh) * 2021-10-30 2024-01-26 大连双硼医药化工有限公司 一种合成4-氰基-2-氟苄醇的工艺方法

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US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
DK0874836T3 (da) * 1995-11-17 2003-02-10 Warner Lambert Co Sulfonamidinhibitorer af matrix metalloproteinaser
JP2000515153A (ja) 1996-07-22 2000-11-14 モンサント カンパニー チオールスルホンアミド メタロプロテアーゼインヒビター
JPH11343279A (ja) 1998-03-16 1999-12-14 Shionogi & Co Ltd スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤
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US6313123B1 (en) * 1999-01-27 2001-11-06 American Cyanamid Company Acetylenic sulfonamide thiol tace inhibitors
MXPA01008606A (es) 1999-02-26 2003-05-05 Merck & Co Inc Compuestos de sulfonamida novedosos y uso de los mismos.
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BR0215182A (pt) * 2001-12-20 2004-10-19 Bristol Myers Squibb Co Derivados de (alfa)- (n-sulfonamido) acetamida como inibidores de (beta)-amilóide
NZ535591A (en) * 2002-02-28 2006-07-28 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
ES2286345T3 (es) * 2003-03-20 2007-12-01 Santhera Pharmaceuticals (Schweiz) Ag Derivados de piperidina y piperazina substituidos como moduladores del receptor de melanocortina-4.
US7300951B2 (en) * 2003-03-31 2007-11-27 Wyeth Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
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CA2637615A1 (en) * 2006-02-17 2007-08-30 Wyeth Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
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WO2009005688A2 (en) 2007-06-29 2009-01-08 Trustees Of Columbia University In The City Of New York Activating mutations in notch-1
US8093276B2 (en) 2007-10-31 2012-01-10 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8044077B2 (en) * 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production

Also Published As

Publication number Publication date
US8084477B2 (en) 2011-12-27
JP2011502153A (ja) 2011-01-20
IL205406A0 (en) 2010-12-30
CY1113346T1 (el) 2016-06-22
WO2009058552A1 (en) 2009-05-07
AU2008319122A1 (en) 2009-05-07
MX2010004319A (es) 2010-04-30
SG174044A1 (en) 2011-09-29
EA016447B1 (ru) 2012-05-30
CN101910141A (zh) 2010-12-08
AR069135A1 (es) 2009-12-30
PE20091394A1 (es) 2009-09-25
HK1155161A1 (en) 2012-05-11
SI2205575T1 (sl) 2011-07-29
EP2471769A1 (en) 2012-07-04
PT2295417E (pt) 2012-09-26
ATE502022T1 (de) 2011-04-15
BRPI0818837A2 (pt) 2015-04-22
CY1112337T1 (el) 2015-12-09
PL2295417T3 (pl) 2012-11-30
EP2205575A1 (en) 2010-07-14
NZ584545A (en) 2011-04-29
EP2295417B1 (en) 2012-07-04
US8350084B2 (en) 2013-01-08
CL2008003271A1 (es) 2009-07-10
CN102718689A (zh) 2012-10-10
HRP20120703T1 (hr) 2012-09-30
ES2390042T3 (es) 2012-11-06
EA201000714A1 (ru) 2010-10-29
CO6270332A2 (es) 2011-04-20
PL2205575T3 (pl) 2011-09-30
CA2704360A1 (en) 2009-05-07
SG174043A1 (en) 2011-09-29
KR20100075575A (ko) 2010-07-02
EA201171439A1 (ru) 2012-05-30
JP5460605B2 (ja) 2014-04-02
CN101910141B (zh) 2012-12-19
HK1141801A1 (en) 2010-11-19
ES2361283T3 (es) 2011-06-15
US20090111858A1 (en) 2009-04-30
TW200927099A (en) 2009-07-01
DE602008005636D1 (de) 2011-04-28
DK2205575T3 (da) 2011-07-11
SI2295417T1 (sl) 2012-11-30
EP2205575B1 (en) 2011-03-16
US20120088925A1 (en) 2012-04-12
EP2295417A1 (en) 2011-03-16
PT2205575E (pt) 2011-05-23
HRP20110219T1 (hr) 2011-04-30

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