CY1112337T1 - Καινοφανης ενωση αλφα-(ν-σουλφοναμιδο) ακεταμιδιου ως αναστολεας της παραγωγης του βητα αμυλοειδους πεπτιδιου - Google Patents
Καινοφανης ενωση αλφα-(ν-σουλφοναμιδο) ακεταμιδιου ως αναστολεας της παραγωγης του βητα αμυλοειδους πεπτιδιουInfo
- Publication number
- CY1112337T1 CY1112337T1 CY20111100570T CY111100570T CY1112337T1 CY 1112337 T1 CY1112337 T1 CY 1112337T1 CY 20111100570 T CY20111100570 T CY 20111100570T CY 111100570 T CY111100570 T CY 111100570T CY 1112337 T1 CY1112337 T1 CY 1112337T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sulfonamido
- acetamide
- amyloid peptide
- inhibitor
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει καινοφανή ένωση άλφα-(Ν-σουλφοναμιδο)ακεταμιδίου, την φαρμακευτική σύνθεση αυτής, τις διεργασίες εξ αυτής και μέθοδο για την αγωγή της νόσου του Αλτσχάιμερ και άλλων καταστάσεων που συσχετίζονται με το β-αμυλοειδές πεπτίδιο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98411807P | 2007-10-31 | 2007-10-31 | |
EP08843687A EP2205575B1 (en) | 2007-10-31 | 2008-10-14 | A novel alpha-(n-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112337T1 true CY1112337T1 (el) | 2015-12-09 |
Family
ID=40193955
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100570T CY1112337T1 (el) | 2007-10-31 | 2011-06-15 | Καινοφανης ενωση αλφα-(ν-σουλφοναμιδο) ακεταμιδιου ως αναστολεας της παραγωγης του βητα αμυλοειδους πεπτιδιου |
CY20121100889T CY1113346T1 (el) | 2007-10-31 | 2012-09-28 | Καινοφανη ενδιαμεσα προϊοντα χρησιμα στην παρασκευη της ενωσης του αλφα-(ν-σουλφοναμιδο)ακεταμιδιου |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100889T CY1113346T1 (el) | 2007-10-31 | 2012-09-28 | Καινοφανη ενδιαμεσα προϊοντα χρησιμα στην παρασκευη της ενωσης του αλφα-(ν-σουλφοναμιδο)ακεταμιδιου |
Country Status (29)
Country | Link |
---|---|
US (2) | US8084477B2 (el) |
EP (3) | EP2471769A1 (el) |
JP (1) | JP5460605B2 (el) |
KR (1) | KR20100075575A (el) |
CN (2) | CN101910141B (el) |
AR (1) | AR069135A1 (el) |
AT (1) | ATE502022T1 (el) |
AU (1) | AU2008319122A1 (el) |
BR (1) | BRPI0818837A2 (el) |
CA (1) | CA2704360A1 (el) |
CL (1) | CL2008003271A1 (el) |
CO (1) | CO6270332A2 (el) |
CY (2) | CY1112337T1 (el) |
DE (1) | DE602008005636D1 (el) |
DK (2) | DK2295417T3 (el) |
EA (2) | EA201171439A1 (el) |
ES (2) | ES2390042T3 (el) |
HK (2) | HK1141801A1 (el) |
HR (2) | HRP20110219T1 (el) |
IL (1) | IL205406A0 (el) |
MX (1) | MX2010004319A (el) |
NZ (1) | NZ584545A (el) |
PE (1) | PE20091394A1 (el) |
PL (2) | PL2295417T3 (el) |
PT (2) | PT2205575E (el) |
SG (2) | SG174044A1 (el) |
SI (2) | SI2205575T1 (el) |
TW (1) | TW200927099A (el) |
WO (1) | WO2009058552A1 (el) |
Families Citing this family (25)
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BR0215182A (pt) | 2001-12-20 | 2004-10-19 | Bristol Myers Squibb Co | Derivados de (alfa)- (n-sulfonamido) acetamida como inibidores de (beta)-amilóide |
US8093276B2 (en) * | 2007-10-31 | 2012-01-10 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
MX2011009271A (es) * | 2009-03-19 | 2011-09-26 | Bristol Myers Squibb Co | Nuevo compuesto de alfa-(n-sulfonamido)acetamida como inhibidor de la produccion del peptido beta amiloide. |
US8044077B2 (en) * | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
US7977362B2 (en) | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
US8252821B2 (en) * | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
TW201043269A (en) * | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
AU2011225122B8 (en) | 2010-03-12 | 2013-12-12 | Nippon Soda Co., Ltd. | Compound containing pyridine ring and method for producing halogenated picoline derivative and tetrazolyloxime derivative |
WO2012040444A2 (en) * | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Treatment of patients with incipient alzheimer's disease |
US9284296B2 (en) | 2010-11-22 | 2016-03-15 | Aubergine Pharmaceuticals Llc | Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions |
US9133139B2 (en) | 2012-09-21 | 2015-09-15 | Bristol-Myers Squibb Company | Fluoroalkyl-1,4-benzodiazepinone compounds |
JP2015529250A (ja) | 2012-09-21 | 2015-10-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | フルオロアルキルジベンゾジアゼピノン化合物 |
US9187434B2 (en) | 2012-09-21 | 2015-11-17 | Bristol-Myers Squibb Company | Substituted 1,5-benzodiazepinones compounds |
WO2014047390A1 (en) | 2012-09-21 | 2014-03-27 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds as notch inhibitors |
CN103058913B (zh) * | 2012-12-13 | 2015-09-30 | 江苏弘和药物研发有限公司 | 5-氯异吲哚酮的合成方法 |
CN104163784B (zh) * | 2014-06-20 | 2019-01-08 | 湖南天地恒一制药有限公司 | 一种奥拉西坦的合成工艺 |
KR20190098998A (ko) | 2016-12-16 | 2019-08-23 | 파이프라인 테라퓨틱스, 아이엔씨. | 달팽이관 시냅스질환의 치료 방법 |
US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
CN107935957B (zh) * | 2017-12-02 | 2020-08-21 | 江苏仁明生物科技有限公司 | 一种合成高纯度沙坦侧链ttbb的方法 |
EP3802611A2 (en) | 2018-06-01 | 2021-04-14 | Novartis AG | Binding molecules against bcma and uses thereof |
CN108640886A (zh) * | 2018-08-01 | 2018-10-12 | 余锋 | 一种作为β-淀粉样肽产生的抑制剂BMS-708163的合成方法 |
JP2022538237A (ja) | 2019-06-24 | 2022-09-01 | ノバルティス アーゲー | B細胞成熟抗原を標的にする多重特異性抗体のための投与計画及び組み合わせ治療 |
CN113466367B (zh) * | 2021-06-25 | 2023-04-14 | 深圳万乐药业有限公司 | 乌苯美司原料药中α-苯乙胺杂质检测方法 |
CN113816874B (zh) * | 2021-10-30 | 2024-01-26 | 大连双硼医药化工有限公司 | 一种合成4-氰基-2-氟苄醇的工艺方法 |
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US5274094A (en) | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
GB9202791D0 (en) | 1992-02-11 | 1992-03-25 | British Bio Technology | Compounds |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
ES2184893T3 (es) | 1995-11-17 | 2003-04-16 | Warner Lambert Co | Inhibidores de sulfonamida de lasd metaloproteinasas matricales. |
PL331338A1 (en) | 1996-07-22 | 1999-07-05 | Monsanto Co | Thiosulphonamidic metaloprotease inhibitors |
JPH11343279A (ja) | 1998-03-16 | 1999-12-14 | Shionogi & Co Ltd | スルホンアミド誘導体およびそれらを含有するTNF―α産生抑制剤 |
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BR0215182A (pt) | 2001-12-20 | 2004-10-19 | Bristol Myers Squibb Co | Derivados de (alfa)- (n-sulfonamido) acetamida como inibidores de (beta)-amilóide |
MXPA04008273A (es) * | 2002-02-28 | 2004-11-10 | Astrazeneca Ab | Derivados de oxazolidinona, procesos para su preparacion, y composiciones farmaceuticas que los contienen. |
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KR20060002908A (ko) | 2003-03-31 | 2006-01-09 | 와이어쓰 | 베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체 |
US7144894B2 (en) | 2004-09-23 | 2006-12-05 | Bristol-Myers Squibb Company | Sulfonamide bicyclic compounds |
BRPI0707741A2 (pt) | 2006-02-17 | 2011-05-10 | Wyeth Corp | mÉtodos para preparar um amino Álcool, ou sal do mesmo, e um Álcool substituÍdo por sulfonamida |
US7838550B2 (en) | 2006-02-17 | 2010-11-23 | Wyeth Llc | Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols |
WO2008112249A1 (en) | 2007-03-13 | 2008-09-18 | Trustees Of Columbia University In The City Of New York | Synergistic interaction of notch-1 inhibitors with glucocorticoids |
WO2009005688A2 (en) | 2007-06-29 | 2009-01-08 | Trustees Of Columbia University In The City Of New York | Activating mutations in notch-1 |
US8093276B2 (en) | 2007-10-31 | 2012-01-10 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
US8044077B2 (en) * | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
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2008
- 2008-10-10 US US12/249,180 patent/US8084477B2/en active Active
- 2008-10-14 ES ES10190591T patent/ES2390042T3/es active Active
- 2008-10-14 PL PL10190591T patent/PL2295417T3/pl unknown
- 2008-10-14 PT PT08843687T patent/PT2205575E/pt unknown
- 2008-10-14 PT PT10190591T patent/PT2295417E/pt unknown
- 2008-10-14 CN CN2008801240109A patent/CN101910141B/zh not_active Expired - Fee Related
- 2008-10-14 PL PL08843687T patent/PL2205575T3/pl unknown
- 2008-10-14 JP JP2010532118A patent/JP5460605B2/ja not_active Expired - Fee Related
- 2008-10-14 BR BRPI0818837 patent/BRPI0818837A2/pt not_active IP Right Cessation
- 2008-10-14 KR KR1020107009453A patent/KR20100075575A/ko not_active Application Discontinuation
- 2008-10-14 DK DK10190591.7T patent/DK2295417T3/da active
- 2008-10-14 ES ES08843687T patent/ES2361283T3/es active Active
- 2008-10-14 WO PCT/US2008/079798 patent/WO2009058552A1/en active Application Filing
- 2008-10-14 SG SG2011056454A patent/SG174044A1/en unknown
- 2008-10-14 EP EP12159802A patent/EP2471769A1/en not_active Withdrawn
- 2008-10-14 CA CA2704360A patent/CA2704360A1/en not_active Abandoned
- 2008-10-14 AT AT08843687T patent/ATE502022T1/de active
- 2008-10-14 EA EA201171439A patent/EA201171439A1/ru unknown
- 2008-10-14 AU AU2008319122A patent/AU2008319122A1/en not_active Abandoned
- 2008-10-14 EP EP10190591A patent/EP2295417B1/en not_active Not-in-force
- 2008-10-14 SI SI200830183T patent/SI2205575T1/sl unknown
- 2008-10-14 SI SI200830775T patent/SI2295417T1/sl unknown
- 2008-10-14 EA EA201000714A patent/EA016447B1/ru not_active IP Right Cessation
- 2008-10-14 EP EP08843687A patent/EP2205575B1/en not_active Not-in-force
- 2008-10-14 SG SG2011056447A patent/SG174043A1/en unknown
- 2008-10-14 DE DE602008005636T patent/DE602008005636D1/de active Active
- 2008-10-14 CN CN201210178082XA patent/CN102718689A/zh active Pending
- 2008-10-14 MX MX2010004319A patent/MX2010004319A/es active IP Right Grant
- 2008-10-14 DK DK08843687.8T patent/DK2205575T3/da active
- 2008-10-14 NZ NZ584545A patent/NZ584545A/en not_active IP Right Cessation
- 2008-10-30 CL CL2008003271A patent/CL2008003271A1/es unknown
- 2008-10-30 AR ARP080104770A patent/AR069135A1/es unknown
- 2008-10-31 PE PE2008001866A patent/PE20091394A1/es not_active Application Discontinuation
- 2008-10-31 TW TW097142279A patent/TW200927099A/zh unknown
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2010
- 2010-04-27 CO CO10049723A patent/CO6270332A2/es not_active Application Discontinuation
- 2010-04-28 IL IL205406A patent/IL205406A0/en unknown
- 2010-08-30 HK HK10108238.3A patent/HK1141801A1/xx not_active IP Right Cessation
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2011
- 2011-03-28 HR HR20110219T patent/HRP20110219T1/hr unknown
- 2011-06-15 CY CY20111100570T patent/CY1112337T1/el unknown
- 2011-09-05 HK HK11109371.7A patent/HK1155161A1/xx not_active IP Right Cessation
- 2011-11-18 US US13/299,703 patent/US8350084B2/en active Active
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2012
- 2012-09-04 HR HRP20120703AT patent/HRP20120703T1/hr unknown
- 2012-09-28 CY CY20121100889T patent/CY1113346T1/el unknown
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