DK2065471T3 - Fremgangsmåde til fremstilling af basisk aminosyre - Google Patents
Fremgangsmåde til fremstilling af basisk aminosyre Download PDFInfo
- Publication number
- DK2065471T3 DK2065471T3 DK09001098.4T DK09001098T DK2065471T3 DK 2065471 T3 DK2065471 T3 DK 2065471T3 DK 09001098 T DK09001098 T DK 09001098T DK 2065471 T3 DK2065471 T3 DK 2065471T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- basic amino
- fermentation
- medium
- culture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/141—Feedstock
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (8)
1. Fermenteringsmedium, der indeholder en basisk aminosyre, der kan opnås ved dyrkning afen mikroorganisme, der har en evne til at producere den basiske aminosyre i et væskeformigt medium underen aerob betingelse, eller et koncentrat deraf, hvor fermenteringsmediet og koncentratet deraf indeholder hydrogencarbonat-ioner og/eller carbonat-ioner som modioner af kationer hovedsageligt bestående af den basiske aminosyre i et normalitetsforhold på 5 % til 80 %, hvilket forhold udregnes i henhold til den følgende ligning: normalitetsforhold = [normalitet af hydrogencarbonat-ioner og/eller carbonat-ioner] / [normalitet af kationer hovedsageligt bestående af basisk aminosyre] x 100.
2. Fermenteringsmediet, der indeholder en basisk aminosyre eller koncentratet deraf ifølge krav 1, hvor den basiske aminosyre består af en eller flere typer af aminosyrer valgt fra L-lysin, L-arginin og L-histidin.
3. Fermenteringsmediet, der indeholder en basisk aminosyre eller koncentratet deraf ifølge et hvilket som helst af kravene 1 og 2, hvor mikroorganismen er coryneform-bakterie eller Escherichia coli.
4. Fermenteringsmediet, der indeholder en basisk aminosyre eller koncentratet deraf ifølge krav 3, hvor coryneform-bakterien er Corynebacterium glutamicum.
5. Fremgangsmåde til fremstilling af fermenteringsmediet, der indeholder en basisk aminosyre ifølge et hvilket som helst af kravene 1 til 4 ved fermentering, omfattende trinnet at dyrke en mikroorganisme, der har en evne til at producere den basiske aminosyre i et væskeformigt medium under en aerob betingelse for at producere og akkumulere den basiske aminosyre i mediet, hvor: pH af mediet reguleres til at være 6,5-9,0 under dyrkningen, og 7,2-9,0 ved afslutningen af dyrkningen, og en dyrkningsperiode, hvor 2 g/L eller mere af hydrogencarbonat-ioner og/eller carbonat-ioner findes i mediet, sikres under dyrkningen ved at regulere trykket i en fermenteringstank til at være et positivt tryk under fermenteringen eller ved at tilføre carbondioxidgas eller en blandet gas, der indeholder carbondioxidgas, til mediet, hvor trykket i fermenteringstanken er 0,03-0,2 MPa, således at hydrogencarbonat-ionerne og/eller carbonat-ionerne fungerer som modioner af kationer hovedsageligt bestående af den basiske aminosyre.
6. Fremgangsmåden ifølge krav 5, hvor den basiske aminosyre består af en eller flere typer af aminosyrer valgt fra L-lysin, L-arginin og L-histidin.
7. Fremgangsmåden ifølge et hvilket som helst af kravene 5 og 6, hvor mikroorganismen er coryneform-bakterie eller Escherichia coli.
8. Fremgangsmåden ifølge krav 7, hvor coryneform-bakterien er Corynebacterium glutamicum.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000253692A JP4362959B2 (ja) | 2000-08-24 | 2000-08-24 | 塩基性アミノ酸の製造方法 |
| EP01120248A EP1182261B1 (en) | 2000-08-24 | 2001-08-23 | Method for producing basic amino acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2065471T3 true DK2065471T3 (da) | 2017-09-25 |
Family
ID=18742744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01120248.8T DK1182261T3 (da) | 2000-08-24 | 2001-08-23 | Fremgangsmåde til frembringelse af basisk aminosyre |
| DK09001098.4T DK2065471T3 (da) | 2000-08-24 | 2001-08-23 | Fremgangsmåde til fremstilling af basisk aminosyre |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01120248.8T DK1182261T3 (da) | 2000-08-24 | 2001-08-23 | Fremgangsmåde til frembringelse af basisk aminosyre |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20020025564A1 (da) |
| EP (2) | EP1182261B1 (da) |
| JP (1) | JP4362959B2 (da) |
| KR (1) | KR100858828B1 (da) |
| CN (2) | CN1982465B (da) |
| AU (1) | AU782303B2 (da) |
| BR (1) | BR0103636B1 (da) |
| CA (1) | CA2355492C (da) |
| DE (1) | DE60144083D1 (da) |
| DK (2) | DK1182261T3 (da) |
| HU (1) | HUP0103445A2 (da) |
| MX (1) | MXPA01008569A (da) |
| TW (1) | TWI311587B (da) |
| ZA (1) | ZA200106984B (da) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003219807A (ja) * | 2002-01-25 | 2003-08-05 | Ajinomoto Co Inc | Ｌ−リジンを主成分とする造粒乾燥物 |
| ES2941685T3 (es) | 2004-10-07 | 2023-05-24 | Ajinomoto Kk | Método para producción de una substancia básica |
| JP2007089506A (ja) * | 2005-09-29 | 2007-04-12 | Bio Energy Kk | コリネバクテリウム属微生物を用いるバイオマスからのアミノ酸の直接生産 |
| JP2007185184A (ja) * | 2005-12-16 | 2007-07-26 | Ajinomoto Co Inc | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| EP1979486B1 (en) | 2006-01-30 | 2013-04-17 | Ajinomoto Co., Inc. | L-amino acid producing bacterium and method of producing l-amino acid |
| JP2009118740A (ja) * | 2006-03-03 | 2009-06-04 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| WO2007105790A1 (ja) * | 2006-03-15 | 2007-09-20 | Kyowa Hakko Kogyo Co., Ltd. | アミノ酸の精製方法 |
| JP2009060791A (ja) | 2006-03-30 | 2009-03-26 | Ajinomoto Co Inc | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| JP2009165355A (ja) | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法 |
| JP2010017081A (ja) * | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| BRPI0703692B1 (pt) * | 2006-12-25 | 2016-12-27 | Ajinomoto Kk | método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores |
| BRPI0806790B1 (pt) | 2007-01-22 | 2017-02-14 | Ajinomoto Kk | microorganismo, e, método para produzir um l-aminoácido |
| EP2192170B1 (en) | 2007-09-04 | 2017-02-15 | Ajinomoto Co., Inc. | Amino acid-producing microorganism and method of producing amino acid |
| JP2011067095A (ja) | 2008-01-10 | 2011-04-07 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
| BRPI0906795A2 (pt) | 2008-01-23 | 2015-08-18 | Ajinomoto Kk | Método para produzir um l-aminoácido |
| JP5488467B2 (ja) | 2008-09-05 | 2014-05-14 | 味の素株式会社 | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| CN102177246B (zh) | 2008-09-08 | 2015-02-11 | 味之素株式会社 | 生产l-氨基酸的微生物和l-氨基酸的生产方法 |
| JP2012029565A (ja) | 2008-11-27 | 2012-02-16 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| JP2010142200A (ja) | 2008-12-22 | 2010-07-01 | Ajinomoto Co Inc | Ｌ−リジンの製造法 |
| WO2010084995A2 (en) | 2009-01-23 | 2010-07-29 | Ajinomoto Co.,Inc. | A method for producing an l-amino acid |
| BRPI1014661B1 (pt) | 2009-07-29 | 2020-12-15 | Ajinomoto Co., Inc. | Método para produzir um l-aminoácido |
| JP2012196144A (ja) | 2009-08-03 | 2012-10-18 | Ajinomoto Co Inc | ビブリオ属細菌を用いたｌ−リジンの製造法 |
| JP2012223092A (ja) | 2009-08-28 | 2012-11-15 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| JP2013013329A (ja) | 2009-11-06 | 2013-01-24 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| JP2013074795A (ja) | 2010-02-08 | 2013-04-25 | Ajinomoto Co Inc | 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法 |
| CN102344889A (zh) * | 2010-07-29 | 2012-02-08 | 凯洛斯环球有限公司 | 循环培养光合作用微藻的方法 |
| JP2014036576A (ja) | 2010-12-10 | 2014-02-27 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| EP2868745B1 (en) | 2013-05-13 | 2017-06-21 | Ajinomoto Co., Inc. | Method for manufacturing an L-amino acid |
| CN106459857B (zh) | 2013-10-02 | 2019-04-19 | 味之素株式会社 | 氨控制装置及氨控制方法 |
| BR112015005215B1 (pt) | 2013-10-21 | 2022-12-13 | Ajinomoto Co., Inc | Métodos para a produção de um l-aminoácido e para a produção de l-lisina |
| BR112016008830B1 (pt) | 2013-10-23 | 2023-02-23 | Ajinomoto Co., Inc | Método para produzir uma substância alvo |
| CN103926130B (zh) * | 2014-05-06 | 2016-09-07 | 山东师范大学 | 以糖蜜为原料提取生物素的方法及检测方法 |
| JP2019062742A (ja) * | 2016-02-24 | 2019-04-25 | 味の素株式会社 | Ｌ−アミノ酸の製造法 |
| BR112021010719A2 (pt) * | 2018-12-07 | 2021-08-31 | Cj Cheiljedang Corporation | Aditivo alimentício granular |
| CN110484575A (zh) * | 2019-07-24 | 2019-11-22 | 南京高新工大生物技术研究院有限公司 | 一种发酵制备氨基酸碳酸盐的方法 |
| CN110437087B (zh) * | 2019-07-24 | 2022-06-03 | 南京高新工大生物技术研究院有限公司 | 一种从发酵液中分离氨基酸碳酸盐的方法 |
| KR102457998B1 (ko) * | 2020-03-13 | 2022-10-24 | 씨제이제일제당 주식회사 | 과립형 사료 첨가제의 제조 방법 |
| CN116583605A (zh) | 2020-10-28 | 2023-08-11 | 味之素株式会社 | L-氨基酸的制造方法 |
| US20240117393A1 (en) | 2022-09-30 | 2024-04-11 | Ajinomoto Co., Inc. | Method for producing l-amino acid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3839151A (en) | 1969-10-23 | 1974-10-01 | Kyowa Hakko Kogyo Kk | Process for producing l-lysine by fermentation |
| NL175617C (nl) * | 1973-05-07 | 1984-12-03 | Stamicarbon | Werkwijze voor de optische splitsing van racemisch lysinesulfanilaat. |
| JPS52102498A (en) * | 1976-02-20 | 1977-08-27 | Ajinomoto Co Inc | Preparation of l-lysine |
| JPS559783A (en) * | 1978-07-10 | 1980-01-23 | Ajinomoto Co Inc | Preparation of l-lysine by fermentation |
| DD290213A5 (de) * | 1987-11-16 | 1991-05-23 | Zi Fuer Mikrobiologie Und Experimentelle Therapie,De | Verfahren zur herstellung von l-lysin auf fermentativem wege |
| BR9100618A (pt) * | 1990-02-15 | 1991-10-29 | Ajinomoto Kk | Processo para fermentacao concorrente de um l-amino-acido basico e um l-amino-acido acido |
| JP2876739B2 (ja) * | 1990-08-03 | 1999-03-31 | 味の素株式会社 | 発酵法によるｌ―リジンの製造法 |
| BE1008008A3 (fr) * | 1990-11-30 | 1995-12-12 | Ajinomoto Kk | Procede et appareil pour regler la concentration en source de carbone dans la culture aerobie d'un micro-organisme. |
| DE4130867A1 (de) | 1991-09-17 | 1993-03-18 | Degussa | Verfahren zur fermentativen herstellung von aminosaeuren |
| DE4130868C2 (de) * | 1991-09-17 | 1994-10-13 | Degussa | Tierfuttermittelsupplement auf der Basis einer Aminosäure und Verfahren zu dessen Herstellung |
| ATE139451T1 (de) * | 1992-04-06 | 1996-07-15 | Baxter Int | Wässrige peritonealdialyse-lösung |
| JP3880636B2 (ja) * | 1994-01-10 | 2007-02-14 | 味の素株式会社 | 発酵法によるｌ−グルタミン酸の製造法 |
| JP4032441B2 (ja) * | 1995-08-30 | 2008-01-16 | 味の素株式会社 | Ｌ−アミノ酸の製造方法 |
| DE19621930C1 (de) * | 1996-05-31 | 1997-12-11 | Degussa | Verfahren zur Herstellung eines Tierfuttermittel-Zusatzes auf Fermentationsbrühe-Basis |
| US6359056B1 (en) | 2000-01-27 | 2002-03-19 | Kodak Polychrome Graphics Llc | Printing plate and method to prepare a printing plate |
-
2000
- 2000-08-24 JP JP2000253692A patent/JP4362959B2/ja not_active Expired - Lifetime
-
2001
- 2001-08-21 CA CA002355492A patent/CA2355492C/en not_active Expired - Lifetime
- 2001-08-22 AU AU63589/01A patent/AU782303B2/en not_active Expired
- 2001-08-23 US US09/934,633 patent/US20020025564A1/en not_active Abandoned
- 2001-08-23 DK DK01120248.8T patent/DK1182261T3/da active
- 2001-08-23 BR BRPI0103636-0B1A patent/BR0103636B1/pt active IP Right Grant
- 2001-08-23 EP EP01120248A patent/EP1182261B1/en not_active Expired - Lifetime
- 2001-08-23 TW TW090120764A patent/TWI311587B/zh active
- 2001-08-23 DE DE60144083T patent/DE60144083D1/de not_active Expired - Lifetime
- 2001-08-23 MX MXPA01008569A patent/MXPA01008569A/es active IP Right Grant
- 2001-08-23 KR KR1020010050917A patent/KR100858828B1/ko active IP Right Grant
- 2001-08-23 ZA ZA200106984A patent/ZA200106984B/xx unknown
- 2001-08-23 EP EP09001098.4A patent/EP2065471B1/en not_active Expired - Lifetime
- 2001-08-23 DK DK09001098.4T patent/DK2065471T3/da active
- 2001-08-24 CN CN2007100016118A patent/CN1982465B/zh not_active Expired - Lifetime
- 2001-08-24 HU HU0103445A patent/HUP0103445A2/hu not_active Application Discontinuation
- 2001-08-24 CN CNB011407786A patent/CN1303215C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60144083D1 (de) | 2011-04-07 |
| JP4362959B2 (ja) | 2009-11-11 |
| AU6358901A (en) | 2002-02-28 |
| CN1348009A (zh) | 2002-05-08 |
| CA2355492A1 (en) | 2002-02-24 |
| MXPA01008569A (es) | 2003-05-19 |
| KR20020016544A (ko) | 2002-03-04 |
| BR0103636A (pt) | 2002-04-16 |
| CN1982465A (zh) | 2007-06-20 |
| CA2355492C (en) | 2010-02-02 |
| ZA200106984B (en) | 2002-03-04 |
| EP1182261B1 (en) | 2011-02-23 |
| HU0103445D0 (en) | 2001-10-28 |
| EP1182261A1 (en) | 2002-02-27 |
| HUP0103445A2 (en) | 2002-09-28 |
| EP2065471B1 (en) | 2017-08-16 |
| JP2002065287A (ja) | 2002-03-05 |
| US20020025564A1 (en) | 2002-02-28 |
| EP2065471A1 (en) | 2009-06-03 |
| CN1982465B (zh) | 2012-07-11 |
| TWI311587B (en) | 2009-07-01 |
| DK1182261T3 (da) | 2011-05-16 |
| BR0103636B1 (pt) | 2013-11-19 |
| AU782303B2 (en) | 2005-07-14 |
| CN1303215C (zh) | 2007-03-07 |
| KR100858828B1 (ko) | 2008-09-17 |
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