DK2044121T3 - Glyco-konstruerede antistoffer - Google Patents

Glyco-konstruerede antistoffer

Info

Publication number
DK2044121T3
DK2044121T3 DK07801422.2T DK07801422T DK2044121T3 DK 2044121 T3 DK2044121 T3 DK 2044121T3 DK 07801422 T DK07801422 T DK 07801422T DK 2044121 T3 DK2044121 T3 DK 2044121T3
Authority
DK
Denmark
Prior art keywords
engineered antibodies
glyco
glyco engineered
antibodies
engineered
Prior art date
Application number
DK07801422.2T
Other languages
English (en)
Inventor
Manfred Schuster
Ralf Kircheis
Andreas Nechansky
Wolfgang Jost
Gilbert Gorr
Original Assignee
Greenovation Biotech Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37635723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2044121(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Greenovation Biotech Gmbh filed Critical Greenovation Biotech Gmbh
Application granted granted Critical
Publication of DK2044121T3 publication Critical patent/DK2044121T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK07801422.2T 2006-07-11 2007-07-11 Glyco-konstruerede antistoffer DK2044121T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06450095A EP1878747A1 (en) 2006-07-11 2006-07-11 Glyco-engineered antibodies
PCT/EP2007/006123 WO2008006554A2 (en) 2006-07-11 2007-07-11 Glyco-engineered antibodies

Publications (1)

Publication Number Publication Date
DK2044121T3 true DK2044121T3 (da) 2013-10-07

Family

ID=37635723

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11163178.4T DK2368913T3 (da) 2006-07-11 2007-07-11 Glyco-modificerede antistoffer
DK07801422.2T DK2044121T3 (da) 2006-07-11 2007-07-11 Glyco-konstruerede antistoffer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11163178.4T DK2368913T3 (da) 2006-07-11 2007-07-11 Glyco-modificerede antistoffer

Country Status (12)

Country Link
US (2) US9051577B2 (da)
EP (3) EP1878747A1 (da)
JP (1) JP5424878B2 (da)
KR (1) KR101565949B1 (da)
CN (1) CN101495514A (da)
CA (1) CA2657605C (da)
DK (2) DK2368913T3 (da)
ES (2) ES2428875T3 (da)
IL (1) IL196022A (da)
PL (2) PL2044121T3 (da)
PT (1) PT2368913E (da)
WO (1) WO2008006554A2 (da)

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US8637435B2 (en) 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
EP2263089B1 (en) 2008-03-03 2015-01-28 GlycoFi, Inc. Surface display of recombinant proteins in lower eukaryotes
CA2723197C (en) * 2008-05-02 2017-09-19 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
EP2379598B1 (en) 2009-01-19 2015-03-11 Innate Pharma Anti-kir3d antibodies
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US20140120555A1 (en) 2011-06-20 2014-05-01 Pierre Fabre Medicament Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer
US10323081B2 (en) * 2011-07-06 2019-06-18 Genmag A/S Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains
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PL3677591T3 (pl) 2013-04-29 2023-06-26 Teva Pharmaceuticals Australia Pty Ltd Przeciwciała anty-cd38 i fuzje z interferonem alfa-2b o osłabionej aktywności
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
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CA2965414C (en) 2014-10-29 2024-01-09 Teva Pharmaceuticals Australia Pty Ltd Interferon .alpha.2.beta. variants
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RU2694903C1 (ru) 2015-10-12 2019-07-18 АПРОДЖЕН КейАйСи ИНК. Антитела к CD43 и их применение для лечения рака
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WO2021101351A2 (ko) * 2019-11-21 2021-05-27 (주)지플러스 생명과학 비푸코실화된 담배를 이용하여 생산한 항체 및 이의 용도
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Also Published As

Publication number Publication date
CA2657605A1 (en) 2008-01-17
PL2368913T3 (pl) 2015-05-29
KR101565949B1 (ko) 2015-11-06
US9051577B2 (en) 2015-06-09
US20150284461A1 (en) 2015-10-08
ES2529769T3 (es) 2015-02-25
EP2368913A3 (en) 2011-11-23
PL2044121T3 (pl) 2014-01-31
CA2657605C (en) 2018-11-06
DK2368913T3 (da) 2015-02-16
KR20090039756A (ko) 2009-04-22
CN101495514A (zh) 2009-07-29
IL196022A0 (en) 2011-08-01
EP2368913A2 (en) 2011-09-28
US10253098B2 (en) 2019-04-09
EP2368913B1 (en) 2014-12-24
IL196022A (en) 2015-01-29
EP2044121A2 (en) 2009-04-08
US20090291078A1 (en) 2009-11-26
PT2368913E (pt) 2015-03-17
JP5424878B2 (ja) 2014-02-26
WO2008006554A3 (en) 2008-04-24
ES2428875T3 (es) 2013-11-12
WO2008006554A2 (en) 2008-01-17
EP1878747A1 (en) 2008-01-16
JP2009542750A (ja) 2009-12-03
EP2044121B1 (en) 2013-08-21
WO2008006554A8 (en) 2008-03-13

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