RO105652B1 - Procedeu de reducere a heterogenitatii anticorpilor monoclonali - Google Patents

Procedeu de reducere a heterogenitatii anticorpilor monoclonali

Info

Publication number
RO105652B1
RO105652B1 RO141765A RO14176589A RO105652B1 RO 105652 B1 RO105652 B1 RO 105652B1 RO 141765 A RO141765 A RO 141765A RO 14176589 A RO14176589 A RO 14176589A RO 105652 B1 RO105652 B1 RO 105652B1
Authority
RO
Romania
Prior art keywords
heterogeneity
monoclonal antibodies
reduction process
reduction
monoclonal
Prior art date
Application number
RO141765A
Other languages
English (en)
Inventor
Richard Mark Batholomew
Charles Furman Thomas
Alan Jue Rodney
Patrick Mcdonough James
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/364,056 external-priority patent/US5126250A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of RO105652B1 publication Critical patent/RO105652B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RO141765A 1988-09-28 1989-09-26 Procedeu de reducere a heterogenitatii anticorpilor monoclonali RO105652B1 (ro)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25078788A 1988-09-28 1988-09-28
US25078888A 1988-09-28 1988-09-28
US25078688A 1988-09-28 1988-09-28
US07/364,056 US5126250A (en) 1988-09-28 1989-06-09 Method for the reduction of heterogeneity of monoclonal antibodies
CA000613379A CA1332367C (en) 1988-09-28 1989-09-26 Method for the reduction of heterogeneity of monoclonal antibodies

Publications (1)

Publication Number Publication Date
RO105652B1 true RO105652B1 (ro) 1992-11-30

Family

ID=27508376

Family Applications (1)

Application Number Title Priority Date Filing Date
RO141765A RO105652B1 (ro) 1988-09-28 1989-09-26 Procedeu de reducere a heterogenitatii anticorpilor monoclonali

Country Status (17)

Country Link
EP (1) EP0361902B1 (ro)
JP (1) JP2925181B2 (ro)
CN (1) CN1041392A (ro)
AR (1) AR242986A1 (ro)
AT (1) ATE101876T1 (ro)
AU (1) AU615576B2 (ro)
BG (1) BG60017B2 (ro)
CA (1) CA1332367C (ro)
DE (1) DE68913251T2 (ro)
DK (1) DK475389A (ro)
ES (1) ES2049332T3 (ro)
IE (1) IE63562B1 (ro)
IL (1) IL91778A (ro)
MX (1) MX170441B (ro)
NZ (1) NZ230786A (ro)
PL (1) PL162260B1 (ro)
RO (1) RO105652B1 (ro)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN10515A (ro) 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
EP1878747A1 (en) 2006-07-11 2008-01-16 greenovation Biotech GmbH Glyco-engineered antibodies
EP2031064A1 (de) * 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
ES2687808T3 (es) 2007-09-26 2018-10-29 Chugai Seiyaku Kabushiki Kaisha Región constante de anticuerpo modificado
MX369784B (es) 2007-09-26 2019-11-21 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
PT2708559T (pt) 2008-04-11 2018-05-16 Chugai Pharmaceutical Co Ltd Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
US20120071634A1 (en) 2009-03-19 2012-03-22 Chugai Seiyaku Kabushiki Kaisha Antibody Constant Region Variant
JP5717624B2 (ja) 2009-03-19 2015-05-13 中外製薬株式会社 抗体定常領域改変体
TWI654204B (zh) 2010-11-30 2019-03-21 中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
EP2660328A4 (en) * 2010-12-28 2016-07-13 Chugai Pharmaceutical Co Ltd ANIMAL CELL CULTURE METHOD
NZ714549A (en) 2012-04-30 2016-10-28 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same
PL2970512T3 (pl) 2013-03-12 2019-03-29 Biocon Limited Immunomodulujące białka fuzyjne i sposoby ich otrzymywania
EP3009518B1 (en) 2013-06-11 2020-08-12 National Center of Neurology and Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
CA2972393A1 (en) 2015-02-27 2016-09-01 Chugai Seiyaku Kabushiki Kaisha Composition for treating il-6-related diseases
US10697883B2 (en) 2015-05-19 2020-06-30 National Center Of Neurology And Psychiatry Method for determining application of therapy to multiple sclerosis (MS) patient
JP6976343B2 (ja) * 2016-10-17 2021-12-08 エンゼン・バイオサイエンシズ・リミテッドEnzene Biosciences Limited 治療用タンパク質の不均質性を低減するための連続的方法
JP7185884B2 (ja) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
KR102771895B1 (ko) 2017-10-20 2025-02-21 가꼬우호우징 효고 이카다이가쿠 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물

Also Published As

Publication number Publication date
IE893094L (en) 1990-03-28
IL91778A (en) 1994-10-07
JPH02163096A (ja) 1990-06-22
AU4234389A (en) 1990-04-05
ATE101876T1 (de) 1994-03-15
CA1332367C (en) 1994-10-11
AU615576B2 (en) 1991-10-03
AR242986A1 (es) 1993-06-30
DE68913251T2 (de) 1994-06-23
ES2049332T3 (es) 1994-04-16
DE68913251D1 (de) 1994-03-31
NZ230786A (en) 1991-11-26
EP0361902A3 (en) 1990-08-16
PL162260B1 (pl) 1993-09-30
JP2925181B2 (ja) 1999-07-28
MX170441B (es) 1993-08-23
IE63562B1 (en) 1995-05-17
BG60017B2 (bg) 1993-06-30
CN1041392A (zh) 1990-04-18
EP0361902B1 (en) 1994-02-23
DK475389A (da) 1990-03-29
DK475389D0 (da) 1989-09-27
EP0361902A2 (en) 1990-04-04

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