MX170441B - Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales - Google Patents

Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales

Info

Publication number
MX170441B
MX170441B MX017721A MX1772189A MX170441B MX 170441 B MX170441 B MX 170441B MX 017721 A MX017721 A MX 017721A MX 1772189 A MX1772189 A MX 1772189A MX 170441 B MX170441 B MX 170441B
Authority
MX
Mexico
Prior art keywords
heterogeneity
reducing
monoclonal antibodies
antibody
elimination
Prior art date
Application number
MX017721A
Other languages
English (en)
Inventor
James Patrick Mc Donough
Richard Mark Bartholomew
Thomas Charles Furman
Rodney Alan Jue
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/364,056 external-priority patent/US5126250A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX170441B publication Critical patent/MX170441B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un metodo de reducción de la heterogeneidad de anticuerpos secretados por celulas productoras de anticuerpo, caracterizado porque consiste en la eliminación o la adición de un aminoácido o varios aminoácidos al extremo carboxi de una o de las dos cadenas pesadas del anticuerpo.
MX017721A 1988-09-28 1989-09-27 Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales MX170441B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25078788A 1988-09-28 1988-09-28
US25078688A 1988-09-28 1988-09-28
US25078888A 1988-09-28 1988-09-28
US07/364,056 US5126250A (en) 1988-09-28 1989-06-09 Method for the reduction of heterogeneity of monoclonal antibodies
CA000613379A CA1332367C (en) 1988-09-28 1989-09-26 Method for the reduction of heterogeneity of monoclonal antibodies

Publications (1)

Publication Number Publication Date
MX170441B true MX170441B (es) 1993-08-23

Family

ID=27508376

Family Applications (1)

Application Number Title Priority Date Filing Date
MX017721A MX170441B (es) 1988-09-28 1989-09-27 Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales

Country Status (17)

Country Link
EP (1) EP0361902B1 (es)
JP (1) JP2925181B2 (es)
CN (1) CN1041392A (es)
AR (1) AR242986A1 (es)
AT (1) ATE101876T1 (es)
AU (1) AU615576B2 (es)
BG (1) BG60017B2 (es)
CA (1) CA1332367C (es)
DE (1) DE68913251T2 (es)
DK (1) DK475389A (es)
ES (1) ES2049332T3 (es)
IE (1) IE63562B1 (es)
IL (1) IL91778A (es)
MX (1) MX170441B (es)
NZ (1) NZ230786A (es)
PL (1) PL162260B1 (es)
RO (1) RO105652B1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
EP1878747A1 (en) 2006-07-11 2008-01-16 greenovation Biotech GmbH Glyco-engineered antibodies
EP2031064A1 (de) * 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
MX369784B (es) 2007-09-26 2019-11-21 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
PH12018501459A1 (en) 2007-09-26 2019-11-11 Chugai Pharmaceutical Co Ltd Modified antibody constant region
DK2708559T3 (en) 2008-04-11 2018-06-14 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of repeatedly binding two or more antigen molecules
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
JP5717624B2 (ja) 2009-03-19 2015-05-13 中外製薬株式会社 抗体定常領域改変体
JP5787446B2 (ja) 2009-03-19 2015-09-30 中外製薬株式会社 抗体定常領域改変体
CN108715614A (zh) 2010-11-30 2018-10-30 中外制药株式会社 与多分子的抗原重复结合的抗原结合分子
EP2660328A4 (en) * 2010-12-28 2016-07-13 Chugai Pharmaceutical Co Ltd ANIMAL CELL CULTURE METHOD
PL2970512T3 (pl) * 2013-03-12 2019-03-29 Biocon Limited Immunomodulujące białka fuzyjne i sposoby ich otrzymywania
US10782290B2 (en) 2013-06-11 2020-09-22 National Center Of Neurology And Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy
TWI805046B (zh) 2015-02-27 2023-06-11 日商中外製藥股份有限公司 Il-6受體抗體用於製備醫藥組成物的用途
PL3299810T3 (pl) 2015-05-19 2021-12-13 National Center Of Neurology And Psychiatry Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm)
JP6976343B2 (ja) * 2016-10-17 2021-12-08 エンゼン・バイオサイエンシズ・リミテッドEnzene Biosciences Limited 治療用タンパク質の不均質性を低減するための連続的方法
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
KR20200074160A (ko) 2017-10-20 2020-06-24 가꼬우호우징 효고 이카다이가쿠 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물

Also Published As

Publication number Publication date
AU615576B2 (en) 1991-10-03
AU4234389A (en) 1990-04-05
AR242986A1 (es) 1993-06-30
DE68913251D1 (de) 1994-03-31
ES2049332T3 (es) 1994-04-16
IE63562B1 (en) 1995-05-17
EP0361902A2 (en) 1990-04-04
RO105652B1 (ro) 1992-11-30
JPH02163096A (ja) 1990-06-22
NZ230786A (en) 1991-11-26
ATE101876T1 (de) 1994-03-15
DK475389A (da) 1990-03-29
DK475389D0 (da) 1989-09-27
CN1041392A (zh) 1990-04-18
CA1332367C (en) 1994-10-11
DE68913251T2 (de) 1994-06-23
BG60017B2 (en) 1993-06-30
IL91778A (en) 1994-10-07
EP0361902B1 (en) 1994-02-23
PL162260B1 (pl) 1993-09-30
EP0361902A3 (en) 1990-08-16
IE893094L (en) 1990-03-28
JP2925181B2 (ja) 1999-07-28

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