MX170441B - Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales - Google Patents

Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales

Info

Publication number
MX170441B
MX170441B MX017721A MX1772189A MX170441B MX 170441 B MX170441 B MX 170441B MX 017721 A MX017721 A MX 017721A MX 1772189 A MX1772189 A MX 1772189A MX 170441 B MX170441 B MX 170441B
Authority
MX
Mexico
Prior art keywords
heterogeneity
reducing
monoclonal antibodies
antibody
elimination
Prior art date
Application number
MX017721A
Other languages
English (en)
Inventor
James Patrick Mc Donough
Richard Mark Bartholomew
Thomas Charles Furman
Rodney Alan Jue
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/364,056 external-priority patent/US5126250A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX170441B publication Critical patent/MX170441B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un metodo de reducción de la heterogeneidad de anticuerpos secretados por celulas productoras de anticuerpo, caracterizado porque consiste en la eliminación o la adición de un aminoácido o varios aminoácidos al extremo carboxi de una o de las dos cadenas pesadas del anticuerpo.
MX017721A 1988-09-28 1989-09-27 Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales MX170441B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25078888A 1988-09-28 1988-09-28
US25078788A 1988-09-28 1988-09-28
US25078688A 1988-09-28 1988-09-28
US07/364,056 US5126250A (en) 1988-09-28 1989-06-09 Method for the reduction of heterogeneity of monoclonal antibodies
CA000613379A CA1332367C (en) 1988-09-28 1989-09-26 Method for the reduction of heterogeneity of monoclonal antibodies

Publications (1)

Publication Number Publication Date
MX170441B true MX170441B (es) 1993-08-23

Family

ID=27508376

Family Applications (1)

Application Number Title Priority Date Filing Date
MX017721A MX170441B (es) 1988-09-28 1989-09-27 Metodo para la reduccion de la heterogeneidad de anticuerpos monoclonales

Country Status (17)

Country Link
EP (1) EP0361902B1 (es)
JP (1) JP2925181B2 (es)
CN (1) CN1041392A (es)
AR (1) AR242986A1 (es)
AT (1) ATE101876T1 (es)
AU (1) AU615576B2 (es)
BG (1) BG60017B2 (es)
CA (1) CA1332367C (es)
DE (1) DE68913251T2 (es)
DK (1) DK475389A (es)
ES (1) ES2049332T3 (es)
IE (1) IE63562B1 (es)
IL (1) IL91778A (es)
MX (1) MX170441B (es)
NZ (1) NZ230786A (es)
PL (1) PL162260B1 (es)
RO (1) RO105652B1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN10515A (es) 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
EP1878747A1 (en) 2006-07-11 2008-01-16 greenovation Biotech GmbH Glyco-engineered antibodies
EP2031064A1 (de) * 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
DK3059246T3 (en) 2007-09-26 2018-10-01 Chugai Pharmaceutical Co Ltd Modified constant region of an antibody
MX336725B (es) 2007-09-26 2016-01-28 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
TWI700293B (zh) 2008-04-11 2020-08-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗體
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
EP2409991B1 (en) 2009-03-19 2017-05-03 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
JP5787446B2 (ja) 2009-03-19 2015-09-30 中外製薬株式会社 抗体定常領域改変体
KR102568454B1 (ko) 2010-11-30 2023-08-18 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자
MX345399B (es) * 2010-12-28 2017-01-30 Chugai Pharmaceutical Co Ltd Metodo de cultivo de celulas animales.
MY174248A (en) 2012-04-30 2020-04-01 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same
CN105121474B9 (zh) 2013-03-12 2020-06-19 比奥孔有限公司 融合免疫调节蛋白及其制备方法
WO2014200018A1 (ja) 2013-06-11 2014-12-18 独立行政法人 国立精神・神経医療研究センター 再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法
EP3263132B1 (en) 2015-02-27 2023-12-06 Chugai Seiyaku Kabushiki Kaisha Composition for treating il-6-related diseases
US10697883B2 (en) 2015-05-19 2020-06-30 National Center Of Neurology And Psychiatry Method for determining application of therapy to multiple sclerosis (MS) patient
JP6976343B2 (ja) * 2016-10-17 2021-12-08 エンゼン・バイオサイエンシズ・リミテッドEnzene Biosciences Limited 治療用タンパク質の不均質性を低減するための連続的方法
EP3620531A4 (en) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
CN115697404A (zh) 2020-05-29 2023-02-03 中外制药株式会社 含有抗体的制剂

Also Published As

Publication number Publication date
DE68913251D1 (de) 1994-03-31
DE68913251T2 (de) 1994-06-23
AU4234389A (en) 1990-04-05
NZ230786A (en) 1991-11-26
ES2049332T3 (es) 1994-04-16
AR242986A1 (es) 1993-06-30
EP0361902A2 (en) 1990-04-04
EP0361902B1 (en) 1994-02-23
IE63562B1 (en) 1995-05-17
PL162260B1 (pl) 1993-09-30
BG60017B2 (bg) 1993-06-30
IE893094L (en) 1990-03-28
CA1332367C (en) 1994-10-11
JPH02163096A (ja) 1990-06-22
DK475389A (da) 1990-03-29
RO105652B1 (ro) 1992-11-30
ATE101876T1 (de) 1994-03-15
EP0361902A3 (en) 1990-08-16
CN1041392A (zh) 1990-04-18
JP2925181B2 (ja) 1999-07-28
DK475389D0 (da) 1989-09-27
AU615576B2 (en) 1991-10-03
IL91778A (en) 1994-10-07

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