IL91778A - A method for reducing the heterogeneity of monoclonal antibodies - Google Patents
A method for reducing the heterogeneity of monoclonal antibodiesInfo
- Publication number
- IL91778A IL91778A IL9177889A IL9177889A IL91778A IL 91778 A IL91778 A IL 91778A IL 9177889 A IL9177889 A IL 9177889A IL 9177889 A IL9177889 A IL 9177889A IL 91778 A IL91778 A IL 91778A
- Authority
- IL
- Israel
- Prior art keywords
- antibodies
- incubation
- heterogeneity
- culture
- hours
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25078788A | 1988-09-28 | 1988-09-28 | |
| US25078688A | 1988-09-28 | 1988-09-28 | |
| US25078888A | 1988-09-28 | 1988-09-28 | |
| US07/364,056 US5126250A (en) | 1988-09-28 | 1989-06-09 | Method for the reduction of heterogeneity of monoclonal antibodies |
| CA000613379A CA1332367C (en) | 1988-09-28 | 1989-09-26 | Method for the reduction of heterogeneity of monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL91778A true IL91778A (en) | 1994-10-07 |
Family
ID=27508376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9177889A IL91778A (en) | 1988-09-28 | 1989-09-26 | A method for reducing the heterogeneity of monoclonal antibodies |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0361902B1 (es) |
| JP (1) | JP2925181B2 (es) |
| CN (1) | CN1041392A (es) |
| AR (1) | AR242986A1 (es) |
| AT (1) | ATE101876T1 (es) |
| AU (1) | AU615576B2 (es) |
| BG (1) | BG60017B2 (es) |
| CA (1) | CA1332367C (es) |
| DE (1) | DE68913251T2 (es) |
| DK (1) | DK475389A (es) |
| ES (1) | ES2049332T3 (es) |
| IE (1) | IE63562B1 (es) |
| IL (1) | IL91778A (es) |
| MX (1) | MX170441B (es) |
| NZ (1) | NZ230786A (es) |
| PL (1) | PL162260B1 (es) |
| RO (1) | RO105652B1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| EP2031064A1 (de) * | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| EP4368721A2 (en) | 2007-09-26 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| US9688762B2 (en) | 2007-09-26 | 2017-06-27 | Chugai Sciyaku Kabushiki Kaisha | Modified antibody constant region |
| NO2708559T3 (es) | 2008-04-11 | 2018-08-25 | ||
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| TWI646193B (zh) | 2009-03-19 | 2019-01-01 | 中外製藥股份有限公司 | 抗體恆定區域改變體 |
| EP2409991B1 (en) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| AU2011337704B2 (en) | 2010-11-30 | 2017-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| CN103282509A (zh) * | 2010-12-28 | 2013-09-04 | 中外制药株式会社 | 动物细胞的培养方法 |
| EP3333183B1 (en) | 2012-04-30 | 2023-02-22 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
| PL2970512T3 (pl) | 2013-03-12 | 2019-03-29 | Biocon Limited | Immunomodulujące białka fuzyjne i sposoby ich otrzymywania |
| US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
| PL3263132T3 (pl) | 2015-02-27 | 2024-04-15 | Chugai Seiyaku Kabushiki Kaisha | Kompozycja do leczenia chorób związanych z il-6 |
| JP6875683B2 (ja) | 2015-05-19 | 2021-05-26 | 国立研究開発法人国立精神・神経医療研究センター | 多発性硬化症（ｍｓ）患者の新規治療適用判断方法 |
| EA201990593A1 (ru) * | 2016-10-17 | 2019-10-31 | Непрерывный способ для снижения гетерогенности терапевтического белка | |
| US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
| KR20200074160A (ko) | 2017-10-20 | 2020-06-24 | 가꼬우호우징 효고 이카다이가쿠 | 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물 |
-
1989
- 1989-09-26 RO RO141765A patent/RO105652B1/ro unknown
- 1989-09-26 BG BG089846A patent/BG60017B2/bg unknown
- 1989-09-26 AR AR89310004A patent/AR242986A1/es active
- 1989-09-26 NZ NZ230786A patent/NZ230786A/xx unknown
- 1989-09-26 CA CA000613379A patent/CA1332367C/en not_active Expired - Fee Related
- 1989-09-26 IL IL9177889A patent/IL91778A/en not_active IP Right Cessation
- 1989-09-27 MX MX017721A patent/MX170441B/es unknown
- 1989-09-27 AT AT89309851T patent/ATE101876T1/de not_active IP Right Cessation
- 1989-09-27 DK DK475389A patent/DK475389A/da not_active Application Discontinuation
- 1989-09-27 AU AU42343/89A patent/AU615576B2/en not_active Ceased
- 1989-09-27 ES ES89309851T patent/ES2049332T3/es not_active Expired - Lifetime
- 1989-09-27 DE DE68913251T patent/DE68913251T2/de not_active Expired - Fee Related
- 1989-09-27 IE IE309489A patent/IE63562B1/en not_active IP Right Cessation
- 1989-09-27 EP EP89309851A patent/EP0361902B1/en not_active Expired - Lifetime
- 1989-09-27 PL PL89281598A patent/PL162260B1/pl unknown
- 1989-09-28 CN CN89107508.9A patent/CN1041392A/zh active Pending
- 1989-09-28 JP JP1256890A patent/JP2925181B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IE63562B1 (en) | 1995-05-17 |
| AU615576B2 (en) | 1991-10-03 |
| EP0361902B1 (en) | 1994-02-23 |
| CN1041392A (zh) | 1990-04-18 |
| EP0361902A2 (en) | 1990-04-04 |
| EP0361902A3 (en) | 1990-08-16 |
| JPH02163096A (ja) | 1990-06-22 |
| CA1332367C (en) | 1994-10-11 |
| DK475389A (da) | 1990-03-29 |
| IE893094L (en) | 1990-03-28 |
| AU4234389A (en) | 1990-04-05 |
| JP2925181B2 (ja) | 1999-07-28 |
| ATE101876T1 (de) | 1994-03-15 |
| RO105652B1 (ro) | 1992-11-30 |
| DE68913251D1 (de) | 1994-03-31 |
| PL162260B1 (pl) | 1993-09-30 |
| NZ230786A (en) | 1991-11-26 |
| MX170441B (es) | 1993-08-23 |
| AR242986A1 (es) | 1993-06-30 |
| BG60017B2 (bg) | 1993-06-30 |
| DK475389D0 (da) | 1989-09-27 |
| ES2049332T3 (es) | 1994-04-16 |
| DE68913251T2 (de) | 1994-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5126250A (en) | Method for the reduction of heterogeneity of monoclonal antibodies | |
| EP0361902B1 (en) | Method for the reduction of heterogeneity of monoclonal antibodies | |
| RU2252961C2 (ru) | Способ получения амидированного пептида | |
| US4954437A (en) | Cell encoding recombinant human erythropoietin | |
| EP0732404A1 (en) | Novel expression screening vector | |
| WO1986004336A1 (en) | Monoclonal antibodies against core proteins of lymphadenopathy-associated-viruses | |
| EP0162034B1 (en) | Method of isolating monoclonal antibodies from hybridoma cultures | |
| EP0169239A1 (en) | HUMAN ERYTHROPOIETIN cDNA CLONES | |
| EP0816504A2 (en) | Platelet activating factor acetylhdrolase, and gene thereof | |
| EP0132021B1 (en) | Tgf polypeptides, antigenic oligopeptides derived therefrom and antibodies produced therefrom | |
| EP0519728A2 (en) | Anti-TCF-II monoclonal antibodies and method for the measurement of TCF-II by applying the antibodies | |
| JPH10226700A (ja) | Ｍｉａの検出のためのイムノアッセイ | |
| JPH09235300A (ja) | ヒトｔｉｍｐ−３及び抗ヒトｔｉｍｐ−３モノクローナル抗体並びにその用途 | |
| Inagami | Purification of renin and prorenin. | |
| Ishizuka et al. | Characterization of monoclonal antibodies against human prorenin profragment and identification of active prorenins in plasma | |
| JP4361579B2 (ja) | コンドロイチナーゼａｂｃに対するモノクローナル抗体 | |
| JP4090486B2 (ja) | コンドロイチン硫酸リアーゼｉｉに対するモノクローナル抗体 | |
| EP0559428B1 (en) | Novel polypeptides and DNAs encoding them | |
| JPS61221128A (ja) | プラスミノ−ゲン活性化因子に対するモノクロ−ナル抗体とその調製方法及び該モノクロ−ナル抗体の使用方法 | |
| JP4361578B2 (ja) | コンドロイチン硫酸リアーゼｉｉに対するモノクローナル抗体 | |
| EP0542287A2 (en) | Anti-human ornithine decarboxylase antibody | |
| AU752369B2 (en) | TNF-alpha converting enzyme | |
| JP4090487B2 (ja) | コンドロイチナーゼａｂｃに対するモノクローナル抗体 | |
| EP0420151A1 (en) | Anti-rhodopsin monoclonal antibody and use thereof | |
| JPS63253098A (ja) | ヒト抗体に対するモノクロ−ナル抗体、その製法及び用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |