IL91778A - שיטה להקטנת ההטרוגניות של נוגדנים מונוקלונליים - Google Patents

שיטה להקטנת ההטרוגניות של נוגדנים מונוקלונליים

Info

Publication number
IL91778A
IL91778A IL9177889A IL9177889A IL91778A IL 91778 A IL91778 A IL 91778A IL 9177889 A IL9177889 A IL 9177889A IL 9177889 A IL9177889 A IL 9177889A IL 91778 A IL91778 A IL 91778A
Authority
IL
Israel
Prior art keywords
antibodies
incubation
heterogeneity
culture
hours
Prior art date
Application number
IL9177889A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/364,056 external-priority patent/US5126250A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL91778A publication Critical patent/IL91778A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL9177889A 1988-09-28 1989-09-26 שיטה להקטנת ההטרוגניות של נוגדנים מונוקלונליים IL91778A (he)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25078788A 1988-09-28 1988-09-28
US25078888A 1988-09-28 1988-09-28
US25078688A 1988-09-28 1988-09-28
US07/364,056 US5126250A (en) 1988-09-28 1989-06-09 Method for the reduction of heterogeneity of monoclonal antibodies
CA000613379A CA1332367C (en) 1988-09-28 1989-09-26 Method for the reduction of heterogeneity of monoclonal antibodies

Publications (1)

Publication Number Publication Date
IL91778A true IL91778A (he) 1994-10-07

Family

ID=27508376

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9177889A IL91778A (he) 1988-09-28 1989-09-26 שיטה להקטנת ההטרוגניות של נוגדנים מונוקלונליים

Country Status (17)

Country Link
EP (1) EP0361902B1 (he)
JP (1) JP2925181B2 (he)
CN (1) CN1041392A (he)
AR (1) AR242986A1 (he)
AT (1) ATE101876T1 (he)
AU (1) AU615576B2 (he)
BG (1) BG60017A3 (he)
CA (1) CA1332367C (he)
DE (1) DE68913251T2 (he)
DK (1) DK475389A (he)
ES (1) ES2049332T3 (he)
IE (1) IE63562B1 (he)
IL (1) IL91778A (he)
MX (1) MX170441B (he)
NZ (1) NZ230786A (he)
PL (1) PL162260B1 (he)
RO (1) RO105652B1 (he)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5624276B2 (ja) 2006-03-31 2014-11-12 中外製薬株式会社 抗体の血中動態を制御する方法
EP1878747A1 (en) * 2006-07-11 2008-01-16 greenovation Biotech GmbH Glyco-engineered antibodies
EP2031064A1 (de) * 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
JP5334319B2 (ja) 2007-09-26 2013-11-06 中外製薬株式会社 Ｃｄｒのアミノ酸置換により抗体の等電点を改変する方法
KR102225009B1 (ko) 2007-09-26 2021-03-08 추가이 세이야쿠 가부시키가이샤 항체 정상영역 개변체
KR20220162801A (ko) 2008-04-11 2022-12-08 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
EP2409991B1 (en) 2009-03-19 2017-05-03 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
EP2409990A4 (en) 2009-03-19 2013-01-23 Chugai Pharmaceutical Co Ltd VARIANT OF A CONSTANT ANTIBODY REGION
EP2647706B1 (en) 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
MY163081A (en) * 2010-12-28 2017-08-15 Chugai Pharmaceutical Co Ltd Animal cell culturing method
CA2902830C (en) 2013-03-12 2023-09-19 Biocon Ltd. Fusion immunomodulatory proteins and methods for making same
EP3009518B1 (en) 2013-06-11 2020-08-12 National Center of Neurology and Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
EP4269440A3 (en) 2015-02-27 2024-02-28 Chugai Seiyaku Kabushiki Kaisha Composition for treating il-6-related diseases
WO2016186154A1 (ja) 2015-05-19 2016-11-24 国立研究開発法人国立精神・神経医療研究センター 多発性硬化症（ｍｓ）患者の新規治療適用判断方法
PL3500586T3 (pl) * 2016-10-17 2021-09-27 Enzene Biosciences Ltd. Sposób ciągły zmniejszania heterogeniczności białka terapeutycznego
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
KR20200074160A (ko) 2017-10-20 2020-06-24 가꼬우호우징 효고 이카다이가쿠 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물

Also Published As

Publication number Publication date
NZ230786A (en) 1991-11-26
EP0361902A3 (en) 1990-08-16
CA1332367C (en) 1994-10-11
DE68913251D1 (de) 1994-03-31
EP0361902B1 (en) 1994-02-23
MX170441B (es) 1993-08-23
CN1041392A (zh) 1990-04-18
IE63562B1 (en) 1995-05-17
IE893094L (en) 1990-03-28
JPH02163096A (ja) 1990-06-22
BG60017A3 (en) 1993-06-15
PL162260B1 (pl) 1993-09-30
ES2049332T3 (es) 1994-04-16
DK475389D0 (da) 1989-09-27
RO105652B1 (ro) 1992-11-30
AU4234389A (en) 1990-04-05
DE68913251T2 (de) 1994-06-23
EP0361902A2 (en) 1990-04-04
JP2925181B2 (ja) 1999-07-28
AR242986A1 (es) 1993-06-30
ATE101876T1 (de) 1994-03-15
DK475389A (da) 1990-03-29
AU615576B2 (en) 1991-10-03

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Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees