DE68913251D1 - Verfahren zur Verringerung der Heterogenität von monoklonalen Antikörpern. - Google Patents

Verfahren zur Verringerung der Heterogenität von monoklonalen Antikörpern.

Info

Publication number
DE68913251D1
DE68913251D1 DE89309851T DE68913251T DE68913251D1 DE 68913251 D1 DE68913251 D1 DE 68913251D1 DE 89309851 T DE89309851 T DE 89309851T DE 68913251 T DE68913251 T DE 68913251T DE 68913251 D1 DE68913251 D1 DE 68913251D1
Authority
DE
Germany
Prior art keywords
monoclonal antibodies
reducing heterogeneity
heterogeneity
reducing
monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89309851T
Other languages
English (en)
Other versions
DE68913251T2 (de
Inventor
Richard Mark Bartholomew
Thomas Charles Furman
Rodney Alan Jue
James Patrick Mcdonough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/364,056 external-priority patent/US5126250A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE68913251D1 publication Critical patent/DE68913251D1/de
Application granted granted Critical
Publication of DE68913251T2 publication Critical patent/DE68913251T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68913251T 1988-09-28 1989-09-27 Verfahren zur Verringerung der Heterogenität von monoklonalen Antikörpern. Expired - Fee Related DE68913251T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25078788A 1988-09-28 1988-09-28
US25078688A 1988-09-28 1988-09-28
US25078888A 1988-09-28 1988-09-28
US07/364,056 US5126250A (en) 1988-09-28 1989-06-09 Method for the reduction of heterogeneity of monoclonal antibodies
CA000613379A CA1332367C (en) 1988-09-28 1989-09-26 Method for the reduction of heterogeneity of monoclonal antibodies

Publications (2)

Publication Number Publication Date
DE68913251D1 true DE68913251D1 (de) 1994-03-31
DE68913251T2 DE68913251T2 (de) 1994-06-23

Family

ID=27508376

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68913251T Expired - Fee Related DE68913251T2 (de) 1988-09-28 1989-09-27 Verfahren zur Verringerung der Heterogenität von monoklonalen Antikörpern.

Country Status (17)

Country Link
EP (1) EP0361902B1 (de)
JP (1) JP2925181B2 (de)
CN (1) CN1041392A (de)
AR (1) AR242986A1 (de)
AT (1) ATE101876T1 (de)
AU (1) AU615576B2 (de)
BG (1) BG60017B2 (de)
CA (1) CA1332367C (de)
DE (1) DE68913251T2 (de)
DK (1) DK475389A (de)
ES (1) ES2049332T3 (de)
IE (1) IE63562B1 (de)
IL (1) IL91778A (de)
MX (1) MX170441B (de)
NZ (1) NZ230786A (de)
PL (1) PL162260B1 (de)
RO (1) RO105652B1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
EP1878747A1 (de) 2006-07-11 2008-01-16 greenovation Biotech GmbH Glyco-hergestellte Antikörper
EP2031064A1 (de) * 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
MX369784B (es) 2007-09-26 2019-11-21 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
PH12018501459A1 (en) 2007-09-26 2019-11-11 Chugai Pharmaceutical Co Ltd Modified antibody constant region
DK2708559T3 (en) 2008-04-11 2018-06-14 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of repeatedly binding two or more antigen molecules
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
JP5717624B2 (ja) 2009-03-19 2015-05-13 中外製薬株式会社 抗体定常領域改変体
JP5787446B2 (ja) 2009-03-19 2015-09-30 中外製薬株式会社 抗体定常領域改変体
CN108715614A (zh) 2010-11-30 2018-10-30 中外制药株式会社 与多分子的抗原重复结合的抗原结合分子
EP2660328A4 (de) * 2010-12-28 2016-07-13 Chugai Pharmaceutical Co Ltd Tierzellen-kultivierungsverfahren
PL2970512T3 (pl) * 2013-03-12 2019-03-29 Biocon Limited Immunomodulujące białka fuzyjne i sposoby ich otrzymywania
US10782290B2 (en) 2013-06-11 2020-09-22 National Center Of Neurology And Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy
TWI805046B (zh) 2015-02-27 2023-06-11 日商中外製藥股份有限公司 Il-6受體抗體用於製備醫藥組成物的用途
PL3299810T3 (pl) 2015-05-19 2021-12-13 National Center Of Neurology And Psychiatry Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm)
JP6976343B2 (ja) * 2016-10-17 2021-12-08 エンゼン・バイオサイエンシズ・リミテッドEnzene Biosciences Limited 治療用タンパク質の不均質性を低減するための連続的方法
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
KR20200074160A (ko) 2017-10-20 2020-06-24 가꼬우호우징 효고 이카다이가쿠 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물

Also Published As

Publication number Publication date
AU615576B2 (en) 1991-10-03
AU4234389A (en) 1990-04-05
AR242986A1 (es) 1993-06-30
ES2049332T3 (es) 1994-04-16
IE63562B1 (en) 1995-05-17
EP0361902A2 (de) 1990-04-04
RO105652B1 (ro) 1992-11-30
JPH02163096A (ja) 1990-06-22
NZ230786A (en) 1991-11-26
ATE101876T1 (de) 1994-03-15
DK475389A (da) 1990-03-29
DK475389D0 (da) 1989-09-27
CN1041392A (zh) 1990-04-18
CA1332367C (en) 1994-10-11
DE68913251T2 (de) 1994-06-23
BG60017B2 (en) 1993-06-30
IL91778A (en) 1994-10-07
MX170441B (es) 1993-08-23
EP0361902B1 (de) 1994-02-23
PL162260B1 (pl) 1993-09-30
EP0361902A3 (en) 1990-08-16
IE893094L (en) 1990-03-28
JP2925181B2 (ja) 1999-07-28

Similar Documents

Publication Publication Date Title
DE3585147D1 (de) Verfahren zur reinigung von proteinen.
DE3587360D1 (de) Verfahren zur herstellung von chimaerischen monoklonalen antikoerpern.
DE3861783D1 (de) Verfahren zur gasphasensilylierung von photoresisten.
DE3485206D1 (de) Verfahren zur hydroraffination von kohlenwasserstoff-einsatzmaterial.
DE69116921D1 (de) Verfahren zur Reinigung von monoklonalen Antikörpern
DE68913251D1 (de) Verfahren zur Verringerung der Heterogenität von monoklonalen Antikörpern.
DE68907407D1 (de) Verfahren zur sequenzanalyse von dna.
ATE89255T1 (de) Verfahren zur isomerisierung von gesaettigten fluorkohlenwasserstoffen.
DE3784374D1 (de) Verfahren zur rueckgewinnung von kohlenwasserstoffdaempfen.
DE3774360D1 (de) Verfahren zur hydroraffinierung von kohlenwasserstoff enthaltenden einsaetzen.
DE3483344D1 (de) Verfahren zur reinigung von lpf-ha.
DE3763186D1 (de) Verfahren zur umstrukturierung von olefinen.
DE3486207D1 (de) Verfahren zur Abtrennung von 2-Chlor-m-xylol.
DE68904815D1 (de) Verfahren zur rueckgewinnung von methacrolein.
DE58901598D1 (de) Verfahren zur gewinnung von rohargon.
DE3871898D1 (de) Verfahren zur selektiven monohydroformylierung von diolefinen.
DE3763468D1 (de) Verfahren zur feinreinigung von spaltmolybdaen.
DE3586999D1 (de) Verfahren zur bestimmung von leucinaminopeptidase (lap).
ATA154783A (de) Verfahren zur deponierung von sonderabfaellen
DE3586448D1 (de) Verfahren zur zubereitung von reisware.
DE3865439D1 (de) Verfahren zur gewinnung von alkansulfonamiden.
DE3879570D1 (de) Verfahren zur selektiven reduktion von polyhalosilanen mit alkylzinnhydriden.
DE3871461D1 (de) Verfahren zur selektiven monohydroesterifizierung von diolefinen.
DE3887124D1 (de) VERFAHREN ZUR BESTIMMUNG VON IgM-ANTIKÖRPERN.
DE59004279D1 (de) Verfahren zur C-terminalen Modifizierung von Proteinen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee