ES2049332T3 - Procedimiento para la reduccion de la heterogeneidad de los anticuerpos monoclonales. - Google Patents
Procedimiento para la reduccion de la heterogeneidad de los anticuerpos monoclonales.Info
- Publication number
- ES2049332T3 ES2049332T3 ES89309851T ES89309851T ES2049332T3 ES 2049332 T3 ES2049332 T3 ES 2049332T3 ES 89309851 T ES89309851 T ES 89309851T ES 89309851 T ES89309851 T ES 89309851T ES 2049332 T3 ES2049332 T3 ES 2049332T3
- Authority
- ES
- Spain
- Prior art keywords
- antibodies
- heterogeneity
- monoclonal antibodies
- procedure
- reduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE DESCUBREN NUEVOS METODOS PARA REDUCIR LA HETEROGENEIDAD DE ANTICUERPOS MONOCLONALES SEGREGADOS. EL PRIMER METODO COMPRENDE INCUBAR LOS ANTICUERPOS HETEROGENEOS A BAJO PH DURANTE UN PERIODO DE TIEMPO SUFICIENTE PARA CONVERTIR LAS FORMAS HETEROGENEAS DE ANTICUERPOS EN FORMAS SUBSTANCIALMENTE HOMOGENEAS. OTRO METODO PRODUCE EL MISMO RESULTADO USANDO ASCOCITOS LIQUIDO, MIENTRAS QUE TODAVIA OTRO METODO PRODUCE EL MISMO RESULTADO USANDO CARBOXIPEPTIDASA. LOS ANTICUERPOS HOMOGENEOS SE PUEDEN ENTONCES PURIFICAR CON GRAN RENDIMIENTO.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25078888A | 1988-09-28 | 1988-09-28 | |
| US25078788A | 1988-09-28 | 1988-09-28 | |
| US25078688A | 1988-09-28 | 1988-09-28 | |
| US07/364,056 US5126250A (en) | 1988-09-28 | 1989-06-09 | Method for the reduction of heterogeneity of monoclonal antibodies |
| CA000613379A CA1332367C (en) | 1988-09-28 | 1989-09-26 | Method for the reduction of heterogeneity of monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2049332T3 true ES2049332T3 (es) | 1994-04-16 |
Family
ID=27508376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89309851T Expired - Lifetime ES2049332T3 (es) | 1988-09-28 | 1989-09-27 | Procedimiento para la reduccion de la heterogeneidad de los anticuerpos monoclonales. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0361902B1 (es) |
| JP (1) | JP2925181B2 (es) |
| CN (1) | CN1041392A (es) |
| AR (1) | AR242986A1 (es) |
| AT (1) | ATE101876T1 (es) |
| AU (1) | AU615576B2 (es) |
| BG (1) | BG60017A3 (es) |
| CA (1) | CA1332367C (es) |
| DE (1) | DE68913251T2 (es) |
| DK (1) | DK475389A (es) |
| ES (1) | ES2049332T3 (es) |
| IE (1) | IE63562B1 (es) |
| IL (1) | IL91778A (es) |
| MX (1) | MX170441B (es) |
| NZ (1) | NZ230786A (es) |
| PL (1) | PL162260B1 (es) |
| RO (1) | RO105652B1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| EP2031064A1 (de) * | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| KR102467302B1 (ko) | 2007-09-26 | 2022-11-14 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| EP3521311A1 (en) | 2008-04-11 | 2019-08-07 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| US20120071634A1 (en) | 2009-03-19 | 2012-03-22 | Chugai Seiyaku Kabushiki Kaisha | Antibody Constant Region Variant |
| CA2819356C (en) | 2010-11-30 | 2023-01-24 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| KR101903208B1 (ko) * | 2010-12-28 | 2018-10-01 | 추가이 세이야쿠 가부시키가이샤 | 동물 세포의 배양 방법 |
| NZ711445A (en) | 2013-03-12 | 2018-06-29 | Biocon Ltd | Fusion immunomodulatory proteins and methods for making same |
| JP6442404B2 (ja) | 2013-06-11 | 2018-12-19 | 国立研究開発法人国立精神・神経医療研究センター | 再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法 |
| BR112017014067B1 (pt) | 2015-02-27 | 2021-01-12 | Chugai Seiyaku Kabushiki Kaisha | usos de um anticorpo receptor de il-6 para no tratamento de doenças relacionadas a il-6 |
| JP6875683B2 (ja) | 2015-05-19 | 2021-05-26 | 国立研究開発法人国立精神・神経医療研究センター | 多発性硬化症（ｍｓ）患者の新規治療適用判断方法 |
| EP3500586B1 (en) * | 2016-10-17 | 2021-02-24 | Enzene Biosciences Ltd. | Continuous process for reducing heterogeneity of therapeutic protein |
| WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| EP3698808A4 (en) | 2017-10-20 | 2021-07-14 | Hyogo College Of Medicine | MEDICAL COMPOSITION CONTAINING ANTI-IL-6 RECEPTOR ANTIBODIES FOR THE PREVENTION OF POSTOPERATIVE ADHESION |
-
1989
- 1989-09-26 BG BG89846A patent/BG60017A3/xx unknown
- 1989-09-26 AR AR89310004A patent/AR242986A1/es active
- 1989-09-26 NZ NZ230786A patent/NZ230786A/xx unknown
- 1989-09-26 RO RO141765A patent/RO105652B1/ro unknown
- 1989-09-26 IL IL9177889A patent/IL91778A/en not_active IP Right Cessation
- 1989-09-26 CA CA000613379A patent/CA1332367C/en not_active Expired - Fee Related
- 1989-09-27 AU AU42343/89A patent/AU615576B2/en not_active Ceased
- 1989-09-27 PL PL89281598A patent/PL162260B1/pl unknown
- 1989-09-27 IE IE309489A patent/IE63562B1/en not_active IP Right Cessation
- 1989-09-27 ES ES89309851T patent/ES2049332T3/es not_active Expired - Lifetime
- 1989-09-27 MX MX017721A patent/MX170441B/es unknown
- 1989-09-27 DE DE68913251T patent/DE68913251T2/de not_active Expired - Fee Related
- 1989-09-27 DK DK475389A patent/DK475389A/da not_active Application Discontinuation
- 1989-09-27 EP EP89309851A patent/EP0361902B1/en not_active Expired - Lifetime
- 1989-09-27 AT AT89309851T patent/ATE101876T1/de not_active IP Right Cessation
- 1989-09-28 CN CN89107508.9A patent/CN1041392A/zh active Pending
- 1989-09-28 JP JP1256890A patent/JP2925181B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AR242986A1 (es) | 1993-06-30 |
| BG60017A3 (en) | 1993-06-15 |
| PL162260B1 (pl) | 1993-09-30 |
| EP0361902A2 (en) | 1990-04-04 |
| JPH02163096A (ja) | 1990-06-22 |
| RO105652B1 (ro) | 1992-11-30 |
| ATE101876T1 (de) | 1994-03-15 |
| EP0361902A3 (en) | 1990-08-16 |
| DE68913251D1 (de) | 1994-03-31 |
| NZ230786A (en) | 1991-11-26 |
| DE68913251T2 (de) | 1994-06-23 |
| AU615576B2 (en) | 1991-10-03 |
| IE893094L (en) | 1990-03-28 |
| EP0361902B1 (en) | 1994-02-23 |
| CN1041392A (zh) | 1990-04-18 |
| DK475389A (da) | 1990-03-29 |
| CA1332367C (en) | 1994-10-11 |
| IL91778A (en) | 1994-10-07 |
| MX170441B (es) | 1993-08-23 |
| AU4234389A (en) | 1990-04-05 |
| IE63562B1 (en) | 1995-05-17 |
| JP2925181B2 (ja) | 1999-07-28 |
| DK475389D0 (da) | 1989-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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