ES460385A1 - Un procedimiento para preparar una 6a,10a-trans-hexahidrodi-benzo (b,d) piran-9-ona. - Google Patents

Un procedimiento para preparar una 6a,10a-trans-hexahidrodi-benzo (b,d) piran-9-ona.

Info

Publication number
ES460385A1
ES460385A1 ES460385A ES460385A ES460385A1 ES 460385 A1 ES460385 A1 ES 460385A1 ES 460385 A ES460385 A ES 460385A ES 460385 A ES460385 A ES 460385A ES 460385 A1 ES460385 A1 ES 460385A1
Authority
ES
Spain
Prior art keywords
pyran
ones
hexahydrodibenzo
trans
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES460385A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES460385A1 publication Critical patent/ES460385A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un procedimiento para preparar una 6ª, 10ª-trans-hexohidrodibenzo[b,d]piran-9-ona de la fórmula general **ver imagen (I)** en dónde R es alquilo de ci2c10, alquenilo de C5-C10, cicloalquilo de C5-C8, o cicloalquenilo de C5-C8, y en donde los átomos de hidrógeno unidos en las posiciones 6ª y 10 están orientados trans uno al otro, cuyo procedimiento está caracterizado por hacer reaccionar un a 6ª,10ª-cis-hexahidrodibenzopiranona que tiene la fórmula anterior, en donde los átomos de hidrógeno unidos en las posiciones 6ª y 10ª están unidos cis uno al otro, con bromuro de aluminio o cloruro de aluminio en un disolvente orgánico no reacctivo a una temperatura de -80ºC a 100ºC, durante de 10 minutos a 6 horas para producir la 6ª,10ª-trans 1-hidroxi-3-sustituido-6,6-dimetil-6,6ª,7,8,10,10ª-hexahidro-9H-dibenzo[b,d] piran-9-ona
ES460385A 1976-07-06 1977-07-04 Un procedimiento para preparar una 6a,10a-trans-hexahidrodi-benzo (b,d) piran-9-ona. Expired ES460385A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/702,807 US4054582A (en) 1976-07-06 1976-07-06 Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones

Publications (1)

Publication Number Publication Date
ES460385A1 true ES460385A1 (es) 1978-08-16

Family

ID=24822686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES460385A Expired ES460385A1 (es) 1976-07-06 1977-07-04 Un procedimiento para preparar una 6a,10a-trans-hexahidrodi-benzo (b,d) piran-9-ona.

Country Status (32)

Country Link
US (1) US4054582A (es)
JP (1) JPS5943467B2 (es)
AR (1) AR213965A1 (es)
AT (1) AT351532B (es)
AU (1) AU511626B2 (es)
BE (1) BE856411A (es)
BG (1) BG28060A3 (es)
CA (1) CA1088082A (es)
CH (1) CH633787A5 (es)
CS (1) CS193581B2 (es)
DD (1) DD131648A5 (es)
DE (1) DE2729818C2 (es)
DK (1) DK143401C (es)
ES (1) ES460385A1 (es)
FR (1) FR2357556A1 (es)
GB (1) GB1582566A (es)
GR (1) GR66429B (es)
HU (1) HU176774B (es)
IE (1) IE45245B1 (es)
IL (1) IL52422A (es)
MX (1) MX4952E (es)
MY (1) MY8500786A (es)
NL (1) NL7707460A (es)
NZ (1) NZ184527A (es)
PH (1) PH13925A (es)
PL (1) PL104312B1 (es)
PT (1) PT66745B (es)
RO (1) RO72581A (es)
SE (1) SE428019B (es)
SU (1) SU778711A3 (es)
YU (1) YU163577A (es)
ZA (1) ZA773959B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1096390A (en) * 1976-07-06 1981-02-24 Edward R. Lavagnino PROCESS FOR PREPARING DL-CIS-1-HYDROXY-3-SUBSTITUTED- 6,6-DIMETHYL-6,6.alpha.,7,8,10,10.alpha.-HEXAHYDRO-9H- DIBENZO(B,D,)PYRAN-9-ONES
US4395560A (en) * 1982-05-24 1983-07-26 Eli Lilly And Company Preparation of 6a,10a-trans-hexahydrodibenzopyranones
JPS6067906U (ja) * 1983-10-14 1985-05-14 株式会社　日立工機原町 自動鉋盤における送材速度可変機構
US4861886A (en) * 1987-07-10 1989-08-29 Ishahara Sangyo Kaisha Ltd Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3')q
US5498419A (en) * 1994-06-03 1996-03-12 Pars; Harry G. Fumarate salt of 4-(diethyl-3-(1-methyloctyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, 4-(diethyl-amino) butyric
DE69910373T2 (de) * 1998-05-04 2004-04-01 The University Of Connecticut, Farmington Analgetische und immunomodulierende cannabinoiden
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
DE60033834T2 (de) 1999-10-18 2007-11-15 The University Of Connecticut, Farmington Für periphäre cannabinoid-rezeptoren selektive liganden
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7119108B1 (en) * 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
JP2004532185A (ja) * 2001-01-26 2004-10-21 ユニバーシティ オブ コネチカット 新規なカンナビミメティックリガンド
DE60237431D1 (de) 2001-01-29 2010-10-07 Univ Connecticut Rezeptor-selektive cannabimimetische aminoalkylindole
JP4312594B2 (ja) * 2001-07-13 2009-08-12 ユニバーシティ オブ コネチカット 新規な二環式及び三環式カンナビノイド
WO2003035005A2 (en) * 2001-10-26 2003-05-01 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
CN1678303A (zh) 2002-08-23 2005-10-05 康涅狄格大学 具有治疗作用的酮类大麻类
US7674922B2 (en) * 2005-09-29 2010-03-09 Albany Molecular Research, Inc. Process for production of delta-9-tetrahydrocannabinol
CA2638940C (en) * 2008-08-28 2009-09-15 Dalton Chemical Laboratories Inc. Improved synthesis of hexahydrodibenzopyranones
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol

Also Published As

Publication number Publication date
AR213965A1 (es) 1979-04-11
PT66745A (en) 1977-06-30
FR2357556A1 (fr) 1978-02-03
US4054582A (en) 1977-10-18
IL52422A0 (en) 1977-08-31
NL7707460A (nl) 1978-01-10
SU778711A3 (ru) 1980-11-07
DE2729818C2 (de) 1982-08-05
DE2729818A1 (de) 1978-01-12
PL199363A1 (pl) 1978-04-10
DK143401C (da) 1981-12-21
ATA483577A (de) 1979-01-15
AU2667977A (en) 1979-01-04
CS193581B2 (en) 1979-10-31
JPS537679A (en) 1978-01-24
DK143401B (da) 1981-08-17
AU511626B2 (en) 1980-08-28
PT66745B (en) 1978-11-27
FR2357556B1 (es) 1980-12-26
GR66429B (es) 1981-03-23
MY8500786A (en) 1985-12-31
IE45245B1 (en) 1982-07-14
JPS5943467B2 (ja) 1984-10-22
BE856411A (fr) 1978-01-04
AT351532B (de) 1979-07-25
GB1582566A (en) 1981-01-14
PL104312B1 (pl) 1979-08-31
MX4952E (es) 1983-01-12
BG28060A3 (en) 1980-02-25
IE45245L (en) 1978-01-06
DK301077A (da) 1978-01-07
RO72581A (ro) 1981-04-30
DD131648A5 (de) 1978-07-12
CH633787A5 (de) 1982-12-31
ZA773959B (en) 1979-02-28
HU176774B (en) 1981-05-28
CA1088082A (en) 1980-10-21
NZ184527A (en) 1978-09-20
IL52422A (en) 1980-09-16
PH13925A (en) 1980-11-04
SE428019B (sv) 1983-05-30
YU163577A (en) 1982-06-30
SE7707632L (sv) 1978-01-07

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