DK2002258T3 - Anvendelse af gelsolin til behandling af multipel sklerose og diagnosticering af neurologiske sygdomme - Google Patents
Anvendelse af gelsolin til behandling af multipel sklerose og diagnosticering af neurologiske sygdomme Download PDFInfo
- Publication number
- DK2002258T3 DK2002258T3 DK07753226.5T DK07753226T DK2002258T3 DK 2002258 T3 DK2002258 T3 DK 2002258T3 DK 07753226 T DK07753226 T DK 07753226T DK 2002258 T3 DK2002258 T3 DK 2002258T3
- Authority
- DK
- Denmark
- Prior art keywords
- gelsolin
- subject
- multiple sclerosis
- level
- treating
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/285—Demyelinating diseases; Multipel sclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (10)
1. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, hvilken fremgangsmåde omfatter administration af gelsolin til individet flere gange.
2. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 1, hvor individet ellers er fri for indikationer, der nødvendiggør behandling med gelsolin.
3. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 1, hvor fremgangsmåden endvidere omfatter administration af et andet middel til behandling af multipel sklerose.
4. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 3, hvor det andet middel er interferon (IFN)^lb (Betaseron eller Betaferon), IFN-pia (Avonex, Rebif), glatirameracetat (Copaxone), mitoxantron (Novantrone), azathioprin, cyclosporin, methotrexat, cyclophosphamid, intravenøst immunglobulin, prednison, methylprednison, prednisolon, methylprednisolon, dexamethason, adrenocorticotropt hormon (ACTH), corticotropin, 2-chlordeoxyadenosin (2-CDA, cladribin), inosin, interleukin-2-antistof (Zenapax, daclizumab), leucovorin, teriflunomid, estroprogestiner, desogestrel, etinilestradiol, BHT-3009, ABT-874, (Bacille Calmette-Guérin)-vaccine (BCG-vaccine), T-cellevaccination, CNTO 1275, Rituximab, Tysabri (natalizumab), N-acetylcystein, minocyclin, R00506997 eller et statin.
5. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 1, hvor fremgangsmåden endvidere omfatter udvælgelse af et individ på det grundlag, at individet vides at have et niveau af gelsolin, som er mindst 10% mindre end det målte gennemsnitsniveau for en tilsyneladende rask population af individer; og administration af gelsolin til individet i en til behandling af individet, som har multipel sklerose, effektiv mængde.
6. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 5 i kombination med et andet middel til behandling af multipel sklerose.
7. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, hvilken fremgangsmåde omfatter: (i) behandling af individet med en første behandling til behandling af multipel sklerose, (ii) opnåelse af et niveau af gelsolin hos individet, (iii) sammenligning af det i (ii) opnåede niveau af gelsolin med en forudbestemt værdi svarende til et forudbestemt niveau af gelsolin hos en tilsyneladende rask kontrolpopulation, og, hvis det forudbestemte niveau af gelsolin ikke er nået, (iv) behandling af individet med et andet middel til behandling af multipel sklerose, og gentagelse af (ii) og (iii), indtil det forudbestemte niveau af gelsolin er nået.
8. Fremgangsmåde til evaluering af virkningen af en behandling til behandling af eller reduktion af risikoen for multipel sklerose hos et individ, hvilken fremgangsmåde omfatter: (i) opnåelse in vitro af et niveau af gelsolin i blod, plasma eller serum fra et individ, som gennemgår behandling med et middel til behandling af multipel sklerose, (ii) sammenligning af det i (i) opnåede niveau af gelsolin med en forudbestemt værdi svarende til et forudbestemt niveau af gelsolin hos en tilsyneladende rask kontrolpopulation og (iii) bestemmelse af, om niveauet af gelsolin i (i) er på eller over det forudbestemte niveau, hvilken bestemmelse er indikativ for, om behandlingen er virkningsfuld.
9. Fremgangsmåde ifølge krav 8, hvor trin (i) og trin (ii) og/eller trin (iii) gentages for at monitorere individets niveauer af gelsolin over tid.
10. Fremgangsmåde ifølge krav 8, hvor midlet er gelsolin, interferon (IFN)-pib (Betaseron eller Betaferon), IFN-pia (Avonex, Rebif), glatirameracetat (Copaxone), mitoxantron (Novantrone), azathioprin, cyclosporin, methotrexat, cyclophosphamid, intravenøst immunglobulin, prednison, methylprednison, prednisolon, methylprednisolon, dexamethason, adrenocorticotropt hormon (ACTH), corticotropin, 2-chlordeoxyadenosin (2-CDA, cladribin), inosin, interleukin-2-antistof (Zenapax, daclizumab), leucovorin, teriflunomid, estroprogestiner, desogestrel, etinilestradiol, BHT-3009, ABT-874, (Bacille Calmette-Guérin)-vaccine (BCG-vaccine), T-cellevaccination, CNTO 1275, Rituximab, Tysabri (natalizumab), N-acetylcystein, minocyclin, R00506997 eller et statin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78250906P | 2006-03-15 | 2006-03-15 | |
PCT/US2007/006581 WO2007106577A2 (en) | 2006-03-15 | 2007-03-14 | Gelsolin in the treatment and diagnosis of neurological disease |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2002258T3 true DK2002258T3 (da) | 2018-01-02 |
Family
ID=38510104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07753226.5T DK2002258T3 (da) | 2006-03-15 | 2007-03-14 | Anvendelse af gelsolin til behandling af multipel sklerose og diagnosticering af neurologiske sygdomme |
Country Status (11)
Country | Link |
---|---|
US (2) | US8440622B2 (da) |
EP (1) | EP2002258B1 (da) |
JP (2) | JP2009530613A (da) |
CN (1) | CN101460843B (da) |
CA (1) | CA2680333C (da) |
DK (1) | DK2002258T3 (da) |
ES (1) | ES2651619T3 (da) |
HU (1) | HUE035980T2 (da) |
PL (1) | PL2002258T3 (da) |
PT (1) | PT2002258T (da) |
WO (1) | WO2007106577A2 (da) |
Families Citing this family (17)
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PL1694342T3 (pl) * | 2003-11-12 | 2021-07-05 | Trustees Of The University Of Pennsylvania | Sposoby zastosowania gelsoliny do leczenia lub zapobiegania posocznicy bakteryjnej |
US9408891B2 (en) | 2003-11-12 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Methods of using gelsolin to treat or prevent bacterial sepsis |
PL1755661T3 (pl) | 2004-05-12 | 2014-10-31 | Brigham & Womens Hospital Inc | Gelsolina do stosowania w leczeniu infekcji |
JP4348631B2 (ja) * | 2005-03-29 | 2009-10-21 | セイコーエプソン株式会社 | 半導体素子の製造方法 |
PT3279663T (pt) | 2006-03-15 | 2021-09-24 | Brigham & Womens Hospital Inc | Utilização de gelsolina para o diagnóstico e tratamento de doenças inflamatórias |
ES2634263T3 (es) | 2008-01-25 | 2017-09-27 | The General Hospital Corporation | Usos de diagnóstico terapéuticos de gelsolina en insuficiencia renal |
WO2009124226A2 (en) * | 2008-04-03 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Gelsolin uses in neurological disorders |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
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EP3279668B1 (en) * | 2010-12-16 | 2019-05-15 | National Institute of Advanced Industrial Science and Technology | Method for enrichment and separation of spinal fluid glycoprotein, method for searching for marker for central nervous system diseases which utilizes the aforementioned method, and marker for central nervous system diseases |
KR101416954B1 (ko) | 2012-09-12 | 2014-07-16 | 한양대학교 산학협력단 | 조혈세포 분화 유도 방법 |
WO2015137738A1 (ko) * | 2014-03-11 | 2015-09-17 | 한양대학교 산학협력단 | 혈액질환 진단 |
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PL1694342T3 (pl) | 2003-11-12 | 2021-07-05 | Trustees Of The University Of Pennsylvania | Sposoby zastosowania gelsoliny do leczenia lub zapobiegania posocznicy bakteryjnej |
PL1755661T3 (pl) | 2004-05-12 | 2014-10-31 | Brigham & Womens Hospital Inc | Gelsolina do stosowania w leczeniu infekcji |
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2007
- 2007-03-14 WO PCT/US2007/006581 patent/WO2007106577A2/en active Application Filing
- 2007-03-14 ES ES07753226.5T patent/ES2651619T3/es active Active
- 2007-03-14 PT PT77532265T patent/PT2002258T/pt unknown
- 2007-03-14 PL PL07753226T patent/PL2002258T3/pl unknown
- 2007-03-14 HU HUE07753226A patent/HUE035980T2/hu unknown
- 2007-03-14 CA CA2680333A patent/CA2680333C/en active Active
- 2007-03-14 US US12/225,132 patent/US8440622B2/en active Active
- 2007-03-14 JP JP2009500495A patent/JP2009530613A/ja active Pending
- 2007-03-14 CN CN200780017675.5A patent/CN101460843B/zh active Active
- 2007-03-14 DK DK07753226.5T patent/DK2002258T3/da active
- 2007-03-14 EP EP07753226.5A patent/EP2002258B1/en active Active
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2011
- 2011-12-12 JP JP2011271607A patent/JP6203995B2/ja active Active
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2013
- 2013-04-12 US US13/861,578 patent/US20130230455A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2002258B1 (en) | 2017-09-27 |
EP2002258A2 (en) | 2008-12-17 |
ES2651619T3 (es) | 2018-01-29 |
WO2007106577A3 (en) | 2008-10-16 |
JP2009530613A (ja) | 2009-08-27 |
US8440622B2 (en) | 2013-05-14 |
EP2002258A4 (en) | 2009-03-18 |
CN101460843B (zh) | 2018-06-22 |
US20100021428A1 (en) | 2010-01-28 |
JP6203995B2 (ja) | 2017-09-27 |
PT2002258T (pt) | 2017-12-18 |
CA2680333C (en) | 2016-10-25 |
PL2002258T3 (pl) | 2018-06-29 |
HUE035980T2 (hu) | 2018-06-28 |
CN101460843A (zh) | 2009-06-17 |
WO2007106577A2 (en) | 2007-09-20 |
US20130230455A1 (en) | 2013-09-05 |
CA2680333A1 (en) | 2007-09-20 |
JP2012053071A (ja) | 2012-03-15 |
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