DK2002258T3 - Anvendelse af gelsolin til behandling af multipel sklerose og diagnosticering af neurologiske sygdomme - Google Patents

Anvendelse af gelsolin til behandling af multipel sklerose og diagnosticering af neurologiske sygdomme Download PDF

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Publication number
DK2002258T3
DK2002258T3 DK07753226.5T DK07753226T DK2002258T3 DK 2002258 T3 DK2002258 T3 DK 2002258T3 DK 07753226 T DK07753226 T DK 07753226T DK 2002258 T3 DK2002258 T3 DK 2002258T3
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gelsolin
subject
multiple sclerosis
level
treating
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DK07753226.5T
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English (en)
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Thomas P Stossel
Bonnie Dittel
Katarzyna Maresz
Po-Shun Lee
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Brigham & Womens Hospital Inc
Bloodcenter Res Foundation Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/35—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicinal Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
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Claims (10)

1. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, hvilken fremgangsmåde omfatter administration af gelsolin til individet flere gange.
2. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 1, hvor individet ellers er fri for indikationer, der nødvendiggør behandling med gelsolin.
3. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 1, hvor fremgangsmåden endvidere omfatter administration af et andet middel til behandling af multipel sklerose.
4. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 3, hvor det andet middel er interferon (IFN)^lb (Betaseron eller Betaferon), IFN-pia (Avonex, Rebif), glatirameracetat (Copaxone), mitoxantron (Novantrone), azathioprin, cyclosporin, methotrexat, cyclophosphamid, intravenøst immunglobulin, prednison, methylprednison, prednisolon, methylprednisolon, dexamethason, adrenocorticotropt hormon (ACTH), corticotropin, 2-chlordeoxyadenosin (2-CDA, cladribin), inosin, interleukin-2-antistof (Zenapax, daclizumab), leucovorin, teriflunomid, estroprogestiner, desogestrel, etinilestradiol, BHT-3009, ABT-874, (Bacille Calmette-Guérin)-vaccine (BCG-vaccine), T-cellevaccination, CNTO 1275, Rituximab, Tysabri (natalizumab), N-acetylcystein, minocyclin, R00506997 eller et statin.
5. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 1, hvor fremgangsmåden endvidere omfatter udvælgelse af et individ på det grundlag, at individet vides at have et niveau af gelsolin, som er mindst 10% mindre end det målte gennemsnitsniveau for en tilsyneladende rask population af individer; og administration af gelsolin til individet i en til behandling af individet, som har multipel sklerose, effektiv mængde.
6. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, ifølge krav 5 i kombination med et andet middel til behandling af multipel sklerose.
7. Gelsolin til anvendelse ved en fremgangsmåde til behandling af et individ, som har multipel sklerose, hvilken fremgangsmåde omfatter: (i) behandling af individet med en første behandling til behandling af multipel sklerose, (ii) opnåelse af et niveau af gelsolin hos individet, (iii) sammenligning af det i (ii) opnåede niveau af gelsolin med en forudbestemt værdi svarende til et forudbestemt niveau af gelsolin hos en tilsyneladende rask kontrolpopulation, og, hvis det forudbestemte niveau af gelsolin ikke er nået, (iv) behandling af individet med et andet middel til behandling af multipel sklerose, og gentagelse af (ii) og (iii), indtil det forudbestemte niveau af gelsolin er nået.
8. Fremgangsmåde til evaluering af virkningen af en behandling til behandling af eller reduktion af risikoen for multipel sklerose hos et individ, hvilken fremgangsmåde omfatter: (i) opnåelse in vitro af et niveau af gelsolin i blod, plasma eller serum fra et individ, som gennemgår behandling med et middel til behandling af multipel sklerose, (ii) sammenligning af det i (i) opnåede niveau af gelsolin med en forudbestemt værdi svarende til et forudbestemt niveau af gelsolin hos en tilsyneladende rask kontrolpopulation og (iii) bestemmelse af, om niveauet af gelsolin i (i) er på eller over det forudbestemte niveau, hvilken bestemmelse er indikativ for, om behandlingen er virkningsfuld.
9. Fremgangsmåde ifølge krav 8, hvor trin (i) og trin (ii) og/eller trin (iii) gentages for at monitorere individets niveauer af gelsolin over tid.
10. Fremgangsmåde ifølge krav 8, hvor midlet er gelsolin, interferon (IFN)-pib (Betaseron eller Betaferon), IFN-pia (Avonex, Rebif), glatirameracetat (Copaxone), mitoxantron (Novantrone), azathioprin, cyclosporin, methotrexat, cyclophosphamid, intravenøst immunglobulin, prednison, methylprednison, prednisolon, methylprednisolon, dexamethason, adrenocorticotropt hormon (ACTH), corticotropin, 2-chlordeoxyadenosin (2-CDA, cladribin), inosin, interleukin-2-antistof (Zenapax, daclizumab), leucovorin, teriflunomid, estroprogestiner, desogestrel, etinilestradiol, BHT-3009, ABT-874, (Bacille Calmette-Guérin)-vaccine (BCG-vaccine), T-cellevaccination, CNTO 1275, Rituximab, Tysabri (natalizumab), N-acetylcystein, minocyclin, R00506997 eller et statin.
DK07753226.5T 2006-03-15 2007-03-14 Anvendelse af gelsolin til behandling af multipel sklerose og diagnosticering af neurologiske sygdomme DK2002258T3 (da)

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US78250906P 2006-03-15 2006-03-15
PCT/US2007/006581 WO2007106577A2 (en) 2006-03-15 2007-03-14 Gelsolin in the treatment and diagnosis of neurological disease

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US (2) US8440622B2 (da)
EP (1) EP2002258B1 (da)
JP (2) JP2009530613A (da)
CN (1) CN101460843B (da)
CA (1) CA2680333C (da)
DK (1) DK2002258T3 (da)
ES (1) ES2651619T3 (da)
HU (1) HUE035980T2 (da)
PL (1) PL2002258T3 (da)
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JP2012053071A (ja) 2012-03-15
CA2680333C (en) 2016-10-25
US8440622B2 (en) 2013-05-14
WO2007106577A3 (en) 2008-10-16
PL2002258T3 (pl) 2018-06-29
US20130230455A1 (en) 2013-09-05
CN101460843A (zh) 2009-06-17
PT2002258T (pt) 2017-12-18
EP2002258B1 (en) 2017-09-27
ES2651619T3 (es) 2018-01-29
CA2680333A1 (en) 2007-09-20
JP2009530613A (ja) 2009-08-27
EP2002258A4 (en) 2009-03-18
HUE035980T2 (hu) 2018-06-28
US20100021428A1 (en) 2010-01-28
JP6203995B2 (ja) 2017-09-27
EP2002258A2 (en) 2008-12-17
CN101460843B (zh) 2018-06-22

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