DK1968635T3 - Sammensætninger og fremgangsmåder med og anvendelser af ikke-naturlige aminosyrer og polypeptider - Google Patents

Sammensætninger og fremgangsmåder med og anvendelser af ikke-naturlige aminosyrer og polypeptider Download PDF

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DK1968635T3
DK1968635T3 DK06848566.3T DK06848566T DK1968635T3 DK 1968635 T3 DK1968635 T3 DK 1968635T3 DK 06848566 T DK06848566 T DK 06848566T DK 1968635 T3 DK1968635 T3 DK 1968635T3
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amino acid
natural amino
polypeptide
amino acids
alkylene
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Zhenwei Miao
Thea Norman
Junjie Liu
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Ambrx Inc
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
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    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
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    • C12N9/93—Ligases (6)
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Claims (11)

1. Polypeptid eller salt deraf, indeholdende mindst en forbindelse udvalgt fra gruppen bestående af:
hvor hvert Ra uafhængigt er udvalgt fra gruppen bestående af H, halogen, alkyl, -N02, - CN, substitueret alkyl, -N(R')2, -C(0)kR', -C(0)N(R')2, -OR' og -S(0)kR', hvor k er 1,2 eller 3; M er H eller -CH2R5; Ri er H, en aminobeskyttelsesgruppe, harpiks, aminosyre, polypeptid eller polynukleotid; R2 er OH, en esterbeskyttelsesgruppe, harpiks, aminosyre, polypeptid eller polynukleotid; R5 er L-X, hvor X er en polymer omfattende alkyl, alkenyl, alkynyl, alkoxy, alkylalkoxy, polyalkylenoxid, aryl, heteroaryl, alkaryl eller aralkyl; og L eventuelt, og når det er til stede, er en linker udvalgt fra gruppen bestående af alkylen, alkenylen, -O-, -0-(alkylen)-,-(alkylen)-0-, -C(O)-, -C(0)-(alkylen)-, -(alkylen)-C(O)-, -C(0)N(R')-, -C(0)N(R')-(alkylen)-, -(alkylen)-C(0)N(R'), -0C(0)N(R')-, -0C(0)N(R')-(alkylen)-, -(alkylen)-0C(0)N(R')-, -N(R')C(0)-, -NR’C(0)-(alkylen)-, -(alkylen)-NR’C(O)-, -S-, -S-(alkylen)-, -S(0)k- hvor k er 1, 2 eller 3, -S(0)k(alkylen)-, -C(S)-, -C(S)-(alkylen)-, - CSN(R')-, -CSN(R')-(alkylen)-, -N(R')CO-(alkylen)-, -N(R')C(0)0-, -(alkylen)-ON=CR'-, -(alkylen)-C(0)NR'-(alkylen)-, -(alkylen)-S(0)k-(alkylen eller substitueret alkylen)-S-, -(alkylen)-S-S-, -S(0)kN(R>, -N(R')C(0)N(R')-, -N(R')C(S)N(R')-, - N(R')S(0)kN(R')-, -N(R')-N=, -C(R')=N-, -C(R')=N-N(R')-, -C(R')=N-N=, -C(R')2-N=N- og -C(R')2-N(R')-N(R')-; og hvert R' uafhængigt er H, alkyl eller substitueret alkyl; hvor forbindelsen er udvalat fra aruDoen:
2. Forbindelse ifølge krav 1, hvor polymeren omfatter polyalkylenoxid.
3. Forbindelse ifølge krav 1, hvor polymeren omfatter -[(alkylen)-O-(hydrogen eller alkyl)]x, hvor x er fra 20-10.000.
4. Forbindelse ifølge krav 1, hvor polymeren er m-PEG med en molekylvægt, der ligger i området fra ca. 2 til ca. 40 KDa.
5. Fremgangsmåde til fremstilling af en forbindelse indeholdende mindst en ikke-naturlig aminosyre udvalgt fra gruppen bestående af:
hvor forbindelsen er dannet af en reduktiv alkylering af en aromatisk amino-enhed på mindst en ikke-naturlig aminosyre med mindst en reaktant omfat tende mindst en aldehydenhed, hvor R-ι, R2, R5, Ra og M er som defineret i krav 1; hvor den i det mindste ene ikke-naturliae aminosvre er udvalgt fra en gruppe:
6. Fremgangsmåde ifølge krav 5, hvorved polymeren omfatter polyalkylenox-id eller et substitueret polyalkylenoxid.
7. Fremgangsmåde ifølge krav 5, hvorved polymeren omfatter -[(alkylen eller substitueret alkyien)-0-(hydrogen, alkyl, eller substitueret alkyl)]x, hvor x er fra 20-10.000.
8. Fremgangsmåde ifølge krav 5, hvorved polymeren er m-PEG med en molekylvægt, der ligger i området fra ca. 2 til ca. 40 KDa.
9. Fremgangsmåde ifølge krav 5, hvorved den i det mindste ene aldehydenhed har strukturen, der svarer til :
hvor: R5 er som defineret i krav 1.
10. Fremgangsmåde ifølge krav 5, hvorved den ikke-naturlige aminosyre inkorporeres ved anvendelse af et translationssystem.
11. Fremgangsmåde ifølge krav 5, hvorved den ikke-naturlige aminosyre inkorporeres i polypeptidet ved anvendelse af et translationssystem og en post-translationsmodifikationssystem.
DK06848566.3T 2005-12-14 2006-12-13 Sammensætninger og fremgangsmåder med og anvendelser af ikke-naturlige aminosyrer og polypeptider DK1968635T3 (da)

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US74304005P 2005-12-14 2005-12-14
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US (6) US20080317670A1 (da)
EP (1) EP1968635B1 (da)
JP (1) JP2009519942A (da)
KR (2) KR101423898B1 (da)
CN (2) CN101448512B (da)
AU (1) AU2006326404B2 (da)
CA (2) CA2631491C (da)
DK (1) DK1968635T3 (da)
ES (1) ES2529065T3 (da)
HK (1) HK1123194A1 (da)
IL (1) IL209386A (da)
NZ (2) NZ595303A (da)
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