ES2075244T3 - Analogos de la somatostatina. - Google Patents

Analogos de la somatostatina.

Info

Publication number
ES2075244T3
ES2075244T3 ES91104845T ES91104845T ES2075244T3 ES 2075244 T3 ES2075244 T3 ES 2075244T3 ES 91104845 T ES91104845 T ES 91104845T ES 91104845 T ES91104845 T ES 91104845T ES 2075244 T3 ES2075244 T3 ES 2075244T3
Authority
ES
Spain
Prior art keywords
mel
carbonyl
omega
formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91104845T
Other languages
English (en)
Inventor
Andrew V Schally
Tamas Janaky
Ren Zhi Cai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Application granted granted Critical
Publication of ES2075244T3 publication Critical patent/ES2075244T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTAN DOS GRUPOS DE COMPUESTOS CITOTOLICOS, ESTRECHAMENTE RELACIONADOS ESTRUCTURALMENTE, CUYOS COMPUESTOS TIENEN LA FORMULA: DONDE R ELEVADO 1 ES L O D-PHE, D-TRP, L O D-MEL, R ELEVADO 3 ES MEL, TYR O PHE, R ELEVADO 6 ES THR O VAL, R ELEVADO 8 ES THR, TRP O MEL, Q ES SELECCIONADO DEL GRUPO QUE CONSISTE EN HIDROGENO, L Y D-MEL, DIPEPTIDO DE MEL-MEL, CICLOPROPANOALCANOILO, AZIRIDINA-2-CARBONILO, METOTREXOILO, 1,4-NAFTOQUINONA-5-OXICARBONILETILO, EPOXIALQUILO Y LOS DERIVADOS DE OMEGA-CARBONIL-ALQUILAMINO DEL MISMO; Y LOS DERIVADOS DE OMEGA-CARBONIL-ALCANOILO DE 2-HIDROXIMETILO-ANTRAQUINONA-DOXORUBICINA, ESPERAMICINA Y MITOMICINA C; EN DONDE EL GRUPO OMEGA-CARBONIL-ALQUILAMINO TIENE LA FORMULA -CO-(CH SUB 2)SUB N-NH DONDE N ES 2-6, Y EL GRUPO OMEGA-CARBONIL-ALCANOILO TIENE LA FORMULA -CO-(CH SUB 2)SUB N-CO FORMULA EN DONDE R ELEVADO 1 ES L O D-PHE, L O D-TRP, R ELEVADO 3 ES PHE O TYR, R ELEVADO 6 ES VAL O THR, R ELEVADO 8 ES THR O TRP, A ES UN RESIDUO DIAMINOACILO QUE TIENE LA FORMULA -HNCH SUB 2-(CH SUB 2)SUB M-CH(NH)-(CH SUB 2)SUB N-COO 1 Y N ES 0 O 1, Q ELEVADO 1 ES UNA PORCION CITOTOXICA QUE TIENE LA FORMULA Q ELEVADO 2 O (B)SUB 2Q ELEVADO 3 O (Q ELEVADO 4)SUB 2 EN DONDE Q ELEVADO 2 ES PT(Y)SUB 2, DONDE Y ES UN ANION DE UN ACIDO FARMACEUTICAMENTE ACEPTABLE, Q ELEVADO 3 ES UN METAL DEL GRUPO NO PLATINO, SELECCIONADO DE UN GRUPO QUE CONTIENE TITANIO, VANADIO, HIERRO, COBRE, COBALTO, ORO, NIQUEL, CAOMIO Y ZINC, Q ELEVADO 4 ES SELECCIONADO DEL GRUPO QUE CONTIENE L O D-MEL, DIPEPTIDO DE MEL-MEL, CICLOPROPANOALCANOILO, AZIRIDINA-2-CARBONILO, EPOXIALQUIELO, 1,4 NAFTOQUINONA-5-OXICARBONILETILO O LOS DERIVADOS DE OMEGA-CARBONIL -ALQUILAMINO DEL MISMO; LOS DERIVADOS DE OMEGA-CARBONILALCANOILO DE 2-HIDROXIMETILO-ANTRAQUINONA, DOXORUBIOCINA, ESPERAMICINA Y MITOMICINA C, EN DONDE EL GRUPO DE OMEGA-CARBONIL-ALQUILAMINO TIENE LA FORMULA -CO-(CH SUB 2)SUB N-NHCANOILO TIENE LA FORMULA -CO-(CH SUB 2)SUB N-CO 6, B ES UN ARALQUILIDENO SUSTITUIDO O HETEROARALQUILIDENO SELECCIONADO DEL GRUPO QUE CONSISTE EN HALO Y ALQUILIDENOS INFERIORES DE NITROFENILO; HIDROXIMETILALQUILO INFERIOR O ALQUILIDENOS INFERIORES DE PIRIDILO DE FOSFOXIMETILO, EN DONDE ALK-INFERIOR SE REFIERE A 1-6 ATOMOS DE CARBONO Y LAS SALES DEL MISMO SON ACIDOS Y BASES FARMACEUTICAMENTE ACEPTABLES.
ES91104845T 1990-04-06 1991-03-27 Analogos de la somatostatina. Expired - Lifetime ES2075244T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50550190A 1990-04-06 1990-04-06

Publications (1)

Publication Number Publication Date
ES2075244T3 true ES2075244T3 (es) 1995-10-01

Family

ID=24010564

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91104845T Expired - Lifetime ES2075244T3 (es) 1990-04-06 1991-03-27 Analogos de la somatostatina.

Country Status (15)

Country Link
EP (1) EP0450480B1 (es)
JP (1) JPH0641194A (es)
AT (1) ATE124054T1 (es)
AU (1) AU638118B2 (es)
CA (1) CA2039880A1 (es)
DE (1) DE69110519T2 (es)
DK (1) DK0450480T3 (es)
ES (1) ES2075244T3 (es)
GR (1) GR3017298T3 (es)
HR (1) HRP921276A2 (es)
HU (2) HUT59165A (es)
IE (1) IE65825B1 (es)
MC (1) MC2266A1 (es)
NZ (1) NZ237704A (es)
YU (1) YU62091A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US5583104A (en) * 1993-12-06 1996-12-10 Mayo Foundation For Medical Research And Education Treatment of proliferation of bile duct epithelium
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
AU2002341792B2 (en) * 2001-09-21 2007-09-06 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
AU2004232314B2 (en) * 2003-04-22 2007-11-22 Ipsen Pharma S.A.S. Peptide vectors
KR101423898B1 (ko) * 2005-12-14 2014-07-28 암브룩스, 인코포레이티드 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
ZA895838B (en) * 1988-08-18 1991-03-27 Syntex Inc Pharmaceutical compounds

Also Published As

Publication number Publication date
HU911117D0 (en) 1991-10-28
HRP921276A2 (en) 1998-08-31
HUT59165A (en) 1992-04-28
EP0450480A2 (en) 1991-10-09
IE911133A1 (en) 1991-10-09
IE65825B1 (en) 1995-11-15
HU211612A9 (en) 1995-12-28
DE69110519T2 (de) 1995-11-30
YU62091A (sh) 1994-09-09
MC2266A1 (fr) 1993-04-26
CA2039880A1 (en) 1991-10-07
JPH0641194A (ja) 1994-02-15
AU7410591A (en) 1991-10-10
ATE124054T1 (de) 1995-07-15
DE69110519D1 (de) 1995-07-27
EP0450480B1 (en) 1995-06-21
EP0450480A3 (en) 1991-12-18
GR3017298T3 (en) 1995-12-31
AU638118B2 (en) 1993-06-17
DK0450480T3 (da) 1995-08-14
NZ237704A (en) 1992-12-23

Similar Documents

Publication Publication Date Title
DE3660010D1 (en) Peptide derivatives with a polycyclic nitrogen structure, process for their preparation and pharmaceutical compositions containing them
HK1045161A1 (en) Lhrh antagonist peptides lhrh
AU5211393A (en) Sustained-released preparation
ES2075244T3 (es) Analogos de la somatostatina.
EP0956033A4 (en) TOTAL SYNTHESIS OF DIDEMNINE A AMINO-HIP ANALOGS
IL106387A (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
ATE127476T1 (de) Lhrh-analoge.
CY2055B1 (en) N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
FR2632637B1 (fr) Ethers de la 2-amino-7-hydroxytetraline

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 450480

Country of ref document: ES