DK196686A - Quinuclidinderivater - Google Patents

Quinuclidinderivater Download PDF

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Publication number
DK196686A
DK196686A DK196686A DK196686A DK196686A DK 196686 A DK196686 A DK 196686A DK 196686 A DK196686 A DK 196686A DK 196686 A DK196686 A DK 196686A DK 196686 A DK196686 A DK 196686A
Authority
DK
Denmark
Prior art keywords
quinuclidine derivatives
alkyl
aryl
hydrogen
diarylmethylol
Prior art date
Application number
DK196686A
Other languages
Danish (da)
English (en)
Other versions
DK196686D0 (da
DK173084B1 (da
Inventor
Abraham Fisher
Ishai Karton
Eliahu Heldman
Aharon Levy
Yona Grunfeld
Original Assignee
Israel State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL75166A external-priority patent/IL75166A/xx
Application filed by Israel State filed Critical Israel State
Publication of DK196686D0 publication Critical patent/DK196686D0/da
Publication of DK196686A publication Critical patent/DK196686A/da
Application granted granted Critical
Publication of DK173084B1 publication Critical patent/DK173084B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

Figure DK196686AD00021
DK198601966A 1985-05-10 1986-04-29 Quinuclidinderivater, fremgangsmåde til fremstilling heraf samt farmaceutisk præparat indeholdende disse DK173084B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL7516685 1985-05-10
IL75166A IL75166A (en) 1985-05-10 1985-05-10 2-substituted spiro(1,3-oxathiolane-5,3-quinuclidine)derivatives,their preparation and pharmaceutical compositions containing them and 3-hydroxy-3-mercaptomethylquinuclidine as intermidiate therefor
IL7756886 1986-01-10
IL7756886 1986-01-10

Publications (3)

Publication Number Publication Date
DK196686D0 DK196686D0 (da) 1986-04-29
DK196686A true DK196686A (da) 1986-11-11
DK173084B1 DK173084B1 (da) 1999-12-27

Family

ID=26321442

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198601966A DK173084B1 (da) 1985-05-10 1986-04-29 Quinuclidinderivater, fremgangsmåde til fremstilling heraf samt farmaceutisk præparat indeholdende disse

Country Status (9)

Country Link
US (1) US4855290A (af)
EP (1) EP0205247B1 (af)
JP (2) JPH0725767B2 (af)
AT (1) ATE83485T1 (af)
CA (1) CA1311479C (af)
DE (1) DE3687288T2 (af)
DK (1) DK173084B1 (af)
ES (1) ES8703461A1 (af)
NO (1) NO173785C (af)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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US4861886A (en) * 1987-07-10 1989-08-29 Ishahara Sangyo Kaisha Ltd Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3')q
US4981858A (en) * 1987-08-13 1991-01-01 State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research Optical isomers
US5106831A (en) * 1987-08-13 1992-04-21 State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research Pharmaceutical composition comprising a spiro oxathiolon/quinuclidine and method of treating senile dementia
IL87234A (en) * 1987-08-13 1992-02-16 Israel Inst Biolog Res Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them
ES2074441T3 (es) * 1987-10-05 1995-09-16 Yamanouchi Pharma Co Ltd Compuestos espiro heterociclicos y su preparacion.
US4900830A (en) * 1987-10-28 1990-02-13 Israel Institute For Biological Research Process for labelling sulfur-containing compounds
US4876260A (en) * 1987-10-28 1989-10-24 State Of Israel, Israel Institute Of Biological Research Oxathiolanes
GB8816299D0 (en) * 1988-07-08 1988-08-10 Merck Sharp & Dohme Therapeutic agents
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5268687A (en) * 1990-07-30 1993-12-07 Spectrum Sciences B.V. Laser scanning apparatus
JP2761973B2 (ja) * 1990-08-28 1998-06-04 雪印乳業株式会社 粉砕容易なシス‐２‐メチルスピロ（１，３‐オキサチオラン‐５，３′）キヌクリジン塩酸塩１／２水和物の製造方法
JP2683783B2 (ja) * 1992-07-10 1997-12-03 雪印乳業株式会社 シェーグレン症候群治療剤
JPH06239861A (ja) * 1993-02-17 1994-08-30 Kanegafuchi Chem Ind Co Ltd 二環式含チッ素化合物
JP2983141B2 (ja) * 1993-10-06 1999-11-29 株式会社三和化学研究所 新規化合物及び該化合物を有効成分とする脳機能改善剤
US5571918A (en) 1994-05-19 1996-11-05 Ishihara Sangyo Kaisha Ltd. Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine
JP2852608B2 (ja) * 1994-06-27 1999-02-03 雪印乳業株式会社 口腔乾燥症治療剤
US5605701A (en) * 1995-02-17 1997-02-25 Eli Lilly And Company Transdermal formulation
WO1998030243A1 (en) * 1997-01-08 1998-07-16 Warner-Lambert Company Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
WO2000047210A1 (en) * 1999-02-09 2000-08-17 Uab Research Foundation Use of 4-amino pyridine for treatment of peripheral neuropathies
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US6433168B1 (en) 1999-07-26 2002-08-13 Sumika Fine Chemicals Co., Ltd. Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
KR100998804B1 (ko) * 2002-05-03 2010-12-06 이스라엘 인스티튜트 포 바이올로지컬 리서치 중추 및 말초 신경계 장애의 치료를 위한 방법 및 조성물,및 그에 유용한 신규 화합물
WO2005005435A1 (en) * 2003-07-08 2005-01-20 Astrazeneca Ab Spiro ′1-azabicyclo ′2.2.2!octan-3,5′-oxazolidin -2′-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor
US20050192321A1 (en) * 2003-09-15 2005-09-01 Meythaler Jay M. Treatment of neuropathy with rapid release aminopyridine
WO2006013914A1 (ja) * 2004-08-06 2006-02-09 Daiichi Pharmaceutical Co., Ltd. 口腔粘膜投与剤
BRPI0518949A2 (pt) * 2004-12-15 2008-12-16 Astrazeneca Ab composto, uso de um composto, mÉtodo para induÇço da interrupÇço do hÁbito de fumar, composiÇço farmacÊutica, e, uso de uma composiÇço farmacÊutica
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
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EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
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WO2008157288A2 (en) 2007-06-13 2008-12-24 Wayne State University Board Of Governors A baclofen solution for low-volume therapeutic delivery
WO2008157308A2 (en) * 2007-06-13 2008-12-24 Wayne State University Board Of Governors A zwitterion solution for low-volume therapeutic delivery
US8143400B2 (en) * 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
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RU2506266C2 (ru) * 2009-01-26 2014-02-10 Израэл Инститьют Фо Байолоджикал Рисерч Бициклические гетероциклические спиросоединения
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
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JP5452165B2 (ja) * 2009-10-23 2014-03-26 第一ファインケミカル株式会社 キヌクリジン類の製造法
US8450487B2 (en) * 2010-06-08 2013-05-28 Apicore, Llc Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine
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CN104892619A (zh) * 2015-06-26 2015-09-09 大道隆达（北京）医药科技发展有限公司 一种药物中间体的制备方法
EP3347011A4 (en) 2015-09-11 2019-06-19 Chase Pharmaceuticals Corporation MUSCARIN COMBINATION AND ITS USE FOR COMBATING HYPOCHOLINERGEN DISORDERS OF THE CENTRAL NERVOUS SYSTEM
JP2019052093A (ja) * 2016-02-01 2019-04-04 宇部興産株式会社 ２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン硫酸塩の製造方法
ES2924432T3 (es) 2016-10-05 2022-10-06 Nsc Therapeutics Gmbh Polimorfos cristalinos de un agonista del receptor de la acetilcolina muscarínica
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GB1301254A (af) * 1971-07-08 1972-12-29
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IL48453A (en) 1975-11-11 1980-06-30 Purdue Frederick Co Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
IL48452A (en) * 1975-11-11 1979-07-25 Purdue Frederick Co Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
IL72684A (en) 1984-08-14 1989-02-28 Israel State Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs
IL75166A (en) 1985-05-10 1989-05-15 Israel Inst Biolog Res 2-substituted spiro(1,3-oxathiolane-5,3-quinuclidine)derivatives,their preparation and pharmaceutical compositions containing them and 3-hydroxy-3-mercaptomethylquinuclidine as intermidiate therefor

Also Published As

Publication number Publication date
ATE83485T1 (de) 1993-01-15
EP0205247A2 (en) 1986-12-17
JPH0725767B2 (ja) 1995-03-22
NO861682L (no) 1986-11-11
ES554280A0 (es) 1987-03-01
DE3687288T2 (de) 1993-04-15
CA1311479C (en) 1992-12-15
DK196686D0 (da) 1986-04-29
DK173084B1 (da) 1999-12-27
ES8703461A1 (es) 1987-03-01
US4855290A (en) 1989-08-08
JPH07223953A (ja) 1995-08-22
DE3687288D1 (de) 1993-01-28
JPS61280497A (ja) 1986-12-11
EP0205247B1 (en) 1992-12-16
EP0205247A3 (en) 1988-02-03
NO173785B (no) 1993-10-25
NO173785C (no) 1994-02-02

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