DK1962794T3 - Langtidsvirkende injicerbare parasiticide formuleringer - Google Patents
Langtidsvirkende injicerbare parasiticide formuleringer Download PDFInfo
- Publication number
- DK1962794T3 DK1962794T3 DK06801888.6T DK06801888T DK1962794T3 DK 1962794 T3 DK1962794 T3 DK 1962794T3 DK 06801888 T DK06801888 T DK 06801888T DK 1962794 T3 DK1962794 T3 DK 1962794T3
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- DK
- Denmark
- Prior art keywords
- optionally substituted
- alkyl
- group
- formulation
- acting injectable
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (13)
1. Flydende langtidsvirkende injicerbar formulering til bekæmpelse af ektoparasitter og/eller endoparasitter hos et pattedyr omfattende: (a) en terapeutisk effektiv mængde af et bioaktivt middel der omfatter en kombination af et første bioaktivt middel valgt fra emamectin, eprinomectin, ivermectin og moxidectin og blandinger deraf, og et andet bioaktivt middel som er clorsulon; (b) subkutant flygtigt opløsningsmiddel valgt fra glycerol formal, N-methylpyrrolidon (NMP), triacetin, dimethylacetamid, ethylacetamid, ethyl acetate, solketal, propylencarbonat, ethyllactat og blandinger deraf; (c) en biologisk acceptabel polymer som er poly(mælke-co-glycol)-syre-copolymer (PLGA); (d) eventuelt, mindst ét anti-ectoparasitisk eller anti-endoparasitisk acceptabelt additiv, excipiens eller blandinger deraf; og (e) eventuelt, en antioxidant.
2. Flydende langtidsvirkende injicerbar formulering ifølge krav 1, hvor det første bioaktive middel er valgt fra eprinomectin, ivermectin, og moxidectin.
3. Flydende langtidsvirkende injicerbar formulering ifølge krav 1, hvor det første bioaktive middel er eprinomectin.
4. Flydende langtidsvirkende injicerbar formulering ifølge krav 1, hvor det subkutane flygtige opløsningsmiddel er valgt fra gruppen bestående af N-meth-ylpyrrolidon (NMP), triacetin, dimethylacetamid, ethylacetamid, ethylacetat og blandinger deraf.
5. Formuleringen ifølge krav 1, hvor formuleringen har en terapeutisk virkning i en tidsperiode valgt fra gruppen bestående af mindst fire måneder til ca. et år, mindst fire måneder til omkring seks måneder og mindst ca. tre måneder til ca. fem måneder.
6. Fremgangsmåde til fremstilling af den flydende langtidsvirkende injicerbare formulering ifølge krav 1 som omfatter: (i) opløse den biologisk acceptable polymer i et subkutant flygtigt opløsningsmiddel for at danne en opløsning; (ii) tilsætte en terapeutisk effektiv mængde af et bioaktivt middel til opløsningen for danne formuleringen.
7. Fremgangsmåden ifølge krav 6, hvor den flydende langtidsvirkende injicerbare formulering er fri for partikler der stopper nålen anvendt til injektion hvor nåletykkelsen er valgt fra gruppen bestående af ca. 16 til ca. 30, ca. 18 til ca. 24 og ca. 24 til ca. 30.
8. Flydende langtidsvirkende injicerbar formulering ifølge krav 1 til anvendelse i bekæmpelse af ektoparasitter og/eller endoparasitter hos et pattedyr hvor formuleringen er til parenteral administration.
9. Flydende langtidsvirkende injicerbar formulering til anvendelse ifølge krav 8, hvor endoparasitten er en helminth valgt fra gruppen bestående af Ancylostoma, Anecator, Ascaris, Capillaria, Cooperia, Dirofilaria, Dictyocaulus, Echinococcus, Fasciola, Haemonchus, Oesophagostomum, Ostertagia, Toxocara, Strongyloides, Toxascaris, Trichinella, Trichuris, Trichostrongylus og blandinger deraf.
10. Flydende langtidsvirkende injicerbar formulering til anvendelse ifølge krav 8, hvor ektoparasitten er valgt fra gruppen bestående af Ctenocephalides, Rhipicephalus, Dermacentor, Ixodes, Boophilus, Ambylomma, Hyalomma, Sarcoptes, Psoroptes, Otodectes, Chorioptes, Hypoderma, Damalinia, Linognathus, Hematopinus, Solenoptes og blandinger deraf.
11. Flydende langtidsvirkende injicerbar formulering til anvendelse ifølge krav 8, hvor injektionsstedet på pattedyret er subkutant og er valgt fra gruppen bestående aføret; base aføret mellem skulderen, i halsen; og skulderen.
12. Flydende langtidsvirkende injicerbar formulering til anvendelse ifølge krav 8, hvor bekæmpelsen af ektoparasitter og/eller endoparasitter har en terapeutisk virkning i en tidsperiode valgt fra gruppen bestående af mindst fire måneder til ca. et år, mindst fire måneder til omkring seks måneder og mindst ca. tre måneder til ca. fem måneder.
13. Flydende langtidsvirkende injicerbar formulering til anvendelse ifølge krav 8, hvor endoparasitten er en helminth valgt fra gruppen bestående af Ostertagia, Haemonchus, og blandinger deraf hvor denne helminth er resistent for macrolidantibiotika når den ikke administreres ifølge krav 8.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/207,980 US8362086B2 (en) | 2005-08-19 | 2005-08-19 | Long acting injectable formulations |
PCT/US2006/032407 WO2007024719A2 (en) | 2005-08-19 | 2006-08-18 | Long acting injectable parasiticidal formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1962794T3 true DK1962794T3 (da) | 2019-02-25 |
Family
ID=37767566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06801888.6T DK1962794T3 (da) | 2005-08-19 | 2006-08-18 | Langtidsvirkende injicerbare parasiticide formuleringer |
Country Status (20)
Country | Link |
---|---|
US (1) | US8362086B2 (da) |
EP (2) | EP3479818A1 (da) |
JP (1) | JP5132560B2 (da) |
KR (1) | KR101351644B1 (da) |
CN (1) | CN101312710A (da) |
BR (1) | BRPI0615355B8 (da) |
CA (1) | CA2619601C (da) |
CY (1) | CY1121226T1 (da) |
DK (1) | DK1962794T3 (da) |
ES (1) | ES2711233T3 (da) |
HR (1) | HRP20190084T1 (da) |
HU (1) | HUE042225T2 (da) |
LT (1) | LT1962794T (da) |
MX (1) | MX2008002345A (da) |
PL (1) | PL1962794T3 (da) |
PT (1) | PT1962794T (da) |
RS (1) | RS58385B1 (da) |
SI (1) | SI1962794T1 (da) |
TR (1) | TR201902039T4 (da) |
WO (1) | WO2007024719A2 (da) |
Families Citing this family (34)
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FR2906466B1 (fr) * | 2006-09-28 | 2008-11-28 | Galderma Sa | Utilisation de composes de la famille des milbemycines pour le traitement de desordres dermatologiques chez l'homme |
BRPI0705822A2 (pt) * | 2007-10-25 | 2009-06-23 | Schering Plough Saude Animal Ltda | formulação injetável com ação prolongada e uso de um agente semi-sintético derivado do grupo das avermectinas, em combinação com um polìmero biodegradável |
DK2222168T3 (da) * | 2007-11-26 | 2018-12-03 | Merial Inc | Opløsningsmiddelsystemer til pour-on formuleringer til bekæmpelse af parasitter |
US20090281150A1 (en) * | 2008-04-09 | 2009-11-12 | Nicola Frances Bateman | Compound 249 |
RU2578036C2 (ru) * | 2010-06-29 | 2016-03-20 | Сева Санте Анимале Са | Новые инъекционные композиции эприномектина |
NZ594610A (en) * | 2011-08-16 | 2013-03-28 | Virbac New Zealand Ltd | Injectable Anthelmintic Formulations cotaining levamisole and one or more macrocyclic lactones for controlling internal parasites in ruminants |
ES2659159T3 (es) * | 2011-12-02 | 2018-03-14 | Merial, Inc. | Formulaciones de moxidectina inyectable de acción prolongada y nuevas formas cristalinas de moxidectina |
MX2016004035A (es) | 2013-09-30 | 2016-06-02 | Zoetis Services Llc | Formulaciones de espiro-isoxazolina de accion prolongada. |
FI20136128L (fi) * | 2013-11-15 | 2015-05-16 | Filana Ltd Oy | Josamysiiniä sisältävät farmaseuttiset koostumukset ja menetelmä niiden valmistamiseksi |
BR102013031277B1 (pt) * | 2013-12-05 | 2018-10-02 | Ouro Fino Participacoes E Empreendimentos S A | processo para preparar uma suspensão anti-helmíntica e suspensão anti-helmíntica injetável |
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EP3023092A1 (en) * | 2014-11-20 | 2016-05-25 | Ceva Sante Animale | Eprinomectin parenteral compositions |
CN104490769A (zh) * | 2014-12-08 | 2015-04-08 | 重庆综艺制药有限公司 | 长效兽用伊维菌素注射液及其制备方法 |
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MX2017012848A (es) * | 2015-04-08 | 2018-01-15 | Merial Inc | Formulaciones inyectables de liberacion extendida que comprenden un agente activo de isoxazolina, metodos y usos de las mismas. |
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UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
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CN107811967B (zh) * | 2016-09-09 | 2021-08-24 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | 抗寄生虫药物原位固化缓释注射剂及其制备方法 |
WO2018189314A1 (en) | 2017-04-13 | 2018-10-18 | Ceva Sante Animale | Composition for treating worms infestations |
KR102101969B1 (ko) * | 2017-09-06 | 2020-04-22 | (주)인벤티지랩 | 목시덱틴을 포함하는 마이크로 입자 및 이의 제조 방법 |
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CN108186658A (zh) * | 2018-01-30 | 2018-06-22 | 中国农业科学院兰州畜牧与兽药研究所 | 一种乙酰氨基阿维菌素缓释剂及其制备方法和应用 |
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-
2005
- 2005-08-19 US US11/207,980 patent/US8362086B2/en active Active
-
2006
- 2006-08-18 TR TR2019/02039T patent/TR201902039T4/tr unknown
- 2006-08-18 PT PT06801888T patent/PT1962794T/pt unknown
- 2006-08-18 HU HUE06801888A patent/HUE042225T2/hu unknown
- 2006-08-18 PL PL06801888T patent/PL1962794T3/pl unknown
- 2006-08-18 WO PCT/US2006/032407 patent/WO2007024719A2/en active Application Filing
- 2006-08-18 MX MX2008002345A patent/MX2008002345A/es active IP Right Grant
- 2006-08-18 SI SI200632314T patent/SI1962794T1/sl unknown
- 2006-08-18 EP EP18195458.7A patent/EP3479818A1/en not_active Withdrawn
- 2006-08-18 KR KR1020087006713A patent/KR101351644B1/ko active IP Right Grant
- 2006-08-18 EP EP06801888.6A patent/EP1962794B1/en active Active
- 2006-08-18 ES ES06801888T patent/ES2711233T3/es active Active
- 2006-08-18 DK DK06801888.6T patent/DK1962794T3/da active
- 2006-08-18 JP JP2008527182A patent/JP5132560B2/ja not_active Expired - Fee Related
- 2006-08-18 LT LTEP06801888.6T patent/LT1962794T/lt unknown
- 2006-08-18 CA CA2619601A patent/CA2619601C/en not_active Expired - Fee Related
- 2006-08-18 RS RS20190113A patent/RS58385B1/sr unknown
- 2006-08-18 CN CNA2006800388650A patent/CN101312710A/zh active Pending
- 2006-08-18 BR BRPI0615355A patent/BRPI0615355B8/pt active IP Right Grant
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Also Published As
Publication number | Publication date |
---|---|
ES2711233T3 (es) | 2019-04-30 |
CA2619601A1 (en) | 2007-03-01 |
JP5132560B2 (ja) | 2013-01-30 |
KR20080038235A (ko) | 2008-05-02 |
CY1121226T1 (el) | 2020-05-29 |
EP3479818A1 (en) | 2019-05-08 |
LT1962794T (lt) | 2019-02-25 |
HUE042225T2 (hu) | 2019-06-28 |
HRP20190084T1 (hr) | 2019-03-08 |
PT1962794T (pt) | 2019-02-25 |
RS58385B1 (sr) | 2019-04-30 |
BRPI0615355A2 (pt) | 2011-05-17 |
EP1962794A2 (en) | 2008-09-03 |
BRPI0615355B1 (pt) | 2020-04-07 |
TR201902039T4 (tr) | 2019-03-21 |
BRPI0615355B8 (pt) | 2022-09-20 |
WO2007024719A3 (en) | 2007-08-09 |
US8362086B2 (en) | 2013-01-29 |
WO2007024719A2 (en) | 2007-03-01 |
JP2009504778A (ja) | 2009-02-05 |
CA2619601C (en) | 2014-05-20 |
SI1962794T1 (sl) | 2019-02-28 |
PL1962794T3 (pl) | 2019-05-31 |
US20070042013A1 (en) | 2007-02-22 |
CN101312710A (zh) | 2008-11-26 |
KR101351644B1 (ko) | 2014-01-14 |
MX2008002345A (es) | 2008-04-29 |
EP1962794B1 (en) | 2018-11-14 |
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