CY1121226T1 - Ενεσιμα παρασιτοκτονα σκευασματα μακρας δρασης - Google Patents
Ενεσιμα παρασιτοκτονα σκευασματα μακρας δρασηςInfo
- Publication number
- CY1121226T1 CY1121226T1 CY20191100165T CY191100165T CY1121226T1 CY 1121226 T1 CY1121226 T1 CY 1121226T1 CY 20191100165 T CY20191100165 T CY 20191100165T CY 191100165 T CY191100165 T CY 191100165T CY 1121226 T1 CY1121226 T1 CY 1121226T1
- Authority
- CY
- Cyprus
- Prior art keywords
- long
- endoparasites
- ectoparasites
- acting
- lai
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η δήλωση αφορά σε μακράς δράσης ενέσιμα (LAI) σκευάσματα για την καταπολέμηση των εκτοπαρασίτων και των ενδοπαρασίτων στα θηλαστικά. Ειδικότερα, αυτή η εφεύρεση προβλέπει ένα σκεύασμα LAI που περιλαμβάνει έναν υποδόρια πτητικό διαλύτη, ένα βιολογικά αποδεκτό πολυμερές, βιοδραστικούς παράγοντες και προαιρετικά ένα ή περισσότερα αντι-εκτοπαρασιτικά ή αντι-ενδοπαρασιτικά αποδεκτά πρόσθετα ή έκδοχα. Αναπάντεχα, τα υγρά, μακράς δράσης, ενέσιμα σκευάσματα της εφεύρεσης επιλύουν τα προβλήματα που σχετίζονται με τα προηγούμενα ενέσιμα σκευάσματα έχοντας μακροχρόνια σταθερότητα, όντας σε θέση να διαχειρίζονται βελόνες με μικρότερες διαμέτρους και επιτυγχάνοντας μακροχρόνια αποτελέσματα στον έλεγχο των παρασίτων σε ένα θηλαστικό. Τα μοναδικά σκευάσματα της εφεύρεσης επιτρέπουν επίσης την καταπολέμηση των εκτοπαρασίτων και των ενδοπαρασίτων που έχουν γίνει ανθεκτικά στα αντιβιοτικά μακρολιδίων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/207,980 US8362086B2 (en) | 2005-08-19 | 2005-08-19 | Long acting injectable formulations |
PCT/US2006/032407 WO2007024719A2 (en) | 2005-08-19 | 2006-08-18 | Long acting injectable parasiticidal formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121226T1 true CY1121226T1 (el) | 2020-05-29 |
Family
ID=37767566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100165T CY1121226T1 (el) | 2005-08-19 | 2019-02-07 | Ενεσιμα παρασιτοκτονα σκευασματα μακρας δρασης |
Country Status (20)
Country | Link |
---|---|
US (1) | US8362086B2 (el) |
EP (2) | EP1962794B1 (el) |
JP (1) | JP5132560B2 (el) |
KR (1) | KR101351644B1 (el) |
CN (1) | CN101312710A (el) |
BR (1) | BRPI0615355B8 (el) |
CA (1) | CA2619601C (el) |
CY (1) | CY1121226T1 (el) |
DK (1) | DK1962794T3 (el) |
ES (1) | ES2711233T3 (el) |
HR (1) | HRP20190084T1 (el) |
HU (1) | HUE042225T2 (el) |
LT (1) | LT1962794T (el) |
MX (1) | MX2008002345A (el) |
PL (1) | PL1962794T3 (el) |
PT (1) | PT1962794T (el) |
RS (1) | RS58385B1 (el) |
SI (1) | SI1962794T1 (el) |
TR (1) | TR201902039T4 (el) |
WO (1) | WO2007024719A2 (el) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2906466B1 (fr) * | 2006-09-28 | 2008-11-28 | Galderma Sa | Utilisation de composes de la famille des milbemycines pour le traitement de desordres dermatologiques chez l'homme |
BRPI0705822A2 (pt) * | 2007-10-25 | 2009-06-23 | Schering Plough Saude Animal Ltda | formulação injetável com ação prolongada e uso de um agente semi-sintético derivado do grupo das avermectinas, em combinação com um polìmero biodegradável |
WO2009070687A1 (en) * | 2007-11-26 | 2009-06-04 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
US20090281150A1 (en) * | 2008-04-09 | 2009-11-12 | Nicola Frances Bateman | Compound 249 |
RU2578036C2 (ru) * | 2010-06-29 | 2016-03-20 | Сева Санте Анимале Са | Новые инъекционные композиции эприномектина |
NZ594610A (en) * | 2011-08-16 | 2013-03-28 | Virbac New Zealand Ltd | Injectable Anthelmintic Formulations cotaining levamisole and one or more macrocyclic lactones for controlling internal parasites in ruminants |
CA2857958C (en) * | 2011-12-02 | 2020-08-25 | Merial Limited | Long-acting injectable moxidectin formulations and moxidectin crystal forms |
US10350196B2 (en) | 2013-09-30 | 2019-07-16 | Zoetis Services Llc | Long-acting spiro-isoxazoline formulations |
FI20136128L (fi) * | 2013-11-15 | 2015-05-16 | Filana Ltd Oy | Josamysiiniä sisältävät farmaseuttiset koostumukset ja menetelmä niiden valmistamiseksi |
BR102013031277B1 (pt) * | 2013-12-05 | 2018-10-02 | Ouro Fino Participacoes E Empreendimentos S A | processo para preparar uma suspensão anti-helmíntica e suspensão anti-helmíntica injetável |
CN103830170B (zh) * | 2013-12-17 | 2015-12-30 | 河南黑马动物药业有限公司 | 伊维菌素在体凝胶注射剂及其制备方法 |
EP3023092A1 (en) * | 2014-11-20 | 2016-05-25 | Ceva Sante Animale | Eprinomectin parenteral compositions |
CN104490769A (zh) * | 2014-12-08 | 2015-04-08 | 重庆综艺制药有限公司 | 长效兽用伊维菌素注射液及其制备方法 |
UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
KR102593069B1 (ko) * | 2015-04-08 | 2023-10-23 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 이속사졸린 활성제를 포함하는 서방형 주사 제형, 이의 방법 및 용도 |
EP3307275B1 (en) * | 2015-06-10 | 2021-05-26 | Piedmont Animal Health Inc. | Injectable antibiotic formulations and use thereof |
CN104984334B (zh) * | 2015-06-26 | 2018-06-26 | 金宇保灵生物药品有限公司 | 一种狂犬病弱毒苗-吡喹酮复合剂及其制备方法与应用 |
AU2017200250B2 (en) * | 2016-01-28 | 2020-08-27 | Anidea Limited | A Tick Treatment |
UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
CN113633609B (zh) * | 2016-09-09 | 2023-08-04 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | 抗寄生虫药物原位固化缓释注射剂及其制备方法 |
US11318156B2 (en) | 2017-04-13 | 2022-05-03 | Ceva Sante Animale | Solid injectable veterinary implants comprising monocyclic lactone |
KR102101969B1 (ko) | 2017-09-06 | 2020-04-22 | (주)인벤티지랩 | 목시덱틴을 포함하는 마이크로 입자 및 이의 제조 방법 |
WO2019050259A1 (ko) * | 2017-09-06 | 2019-03-14 | (주)인벤티지랩 | 목시덱틴을 포함하는 마이크로 입자 및 이의 제조 방법 |
CN111386112A (zh) * | 2017-11-23 | 2020-07-07 | 法国诗华大药厂 | 用于治疗寄生虫感染的含有莫昔克丁的组合物 |
CN108186658A (zh) * | 2018-01-30 | 2018-06-22 | 中国农业科学院兰州畜牧与兽药研究所 | 一种乙酰氨基阿维菌素缓释剂及其制备方法和应用 |
AR118215A1 (es) * | 2019-03-01 | 2021-09-22 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones inyectables de clorsulón, sus métodos y usos |
US11911499B2 (en) | 2019-11-07 | 2024-02-27 | Resurge Therapeutics, Inc. | System and method for prostate treatment |
CN111529698B (zh) * | 2020-04-16 | 2023-03-24 | 南京农业大学 | 一种捻转血矛线虫重组arf1蛋白纳米亚单位疫苗及其应用 |
MX2022014493A (es) * | 2020-05-20 | 2022-12-13 | Intervet Int Bv | Composiciones farmaceuticas inyectables y usos de las mismas. |
CN112006981B (zh) * | 2020-07-30 | 2023-01-10 | 瑞普(天津)生物药业有限公司 | 一种长效复方驱虫药物液体制剂及其制备方法与应用 |
US11957654B2 (en) | 2022-01-29 | 2024-04-16 | Resurge Therapeutics, Inc. | Treating benign prostatic hyperplasia |
US11602516B1 (en) | 2022-01-29 | 2023-03-14 | Resurge Therapeutics Inc. | Treating benign prostatic hyperplasia |
KR102464821B1 (ko) * | 2022-04-13 | 2022-11-09 | (주)인벤티지랩 | 목시덱틴을 포함하는 마이크로 입자 및 이를 포함하는 서방형 주사제 조성물 |
Family Cites Families (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US309229A (en) | 1884-12-16 | Car-coupling | ||
US2562830A (en) | 1951-07-31 | Derivatives | ||
US3337570A (en) | 1965-10-23 | 1967-08-22 | Schering Corp | Substituted nicotinic acids and method for the manufacture thereof |
US4009197A (en) | 1967-01-13 | 1977-02-22 | Syntex Corporation | 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof |
US3904682A (en) | 1967-01-13 | 1975-09-09 | Syntex Corp | 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid |
NL160809C (nl) | 1970-05-15 | 1979-12-17 | Duphar Int Res | Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen. |
US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
JPS4914624A (el) | 1972-06-08 | 1974-02-08 | ||
US3896145A (en) | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
US3818047A (en) | 1972-08-07 | 1974-06-18 | C Henrick | Substituted pyrones |
US4150108A (en) | 1975-12-29 | 1979-04-17 | Graham Neil B | Injectable medicinal compositions |
SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
CH604517A5 (el) | 1976-08-19 | 1978-09-15 | Ciba Geigy Ag | |
US5089490A (en) | 1977-04-02 | 1992-02-18 | Hoechst Aktiengesellschaft | Cephem derivatives |
GB2006492B (en) | 1977-08-12 | 1982-01-20 | English Electric Co Ltd | Input circuits |
US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
US4489055A (en) | 1978-07-19 | 1984-12-18 | N.V. Sopar S.A. | Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use |
EP0007895B1 (fr) | 1978-07-19 | 1983-06-22 | Patrick Couvreur | Nanoparticules biodégradables, compositions pharmaceutiques les contenant et procédé pour leur préparation |
US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
DE2841668A1 (de) | 1978-09-25 | 1980-04-10 | Bayer Ag | Medikiertes tierfutter auf basis lebermehl |
US4331652A (en) | 1979-09-12 | 1982-05-25 | Eli Lilly And Company | Controlled release parasitic formulations and method |
US4333919A (en) | 1979-09-12 | 1982-06-08 | Eli Lilly And Company | Growth promotant controlled release formulations and method of treatment |
US4761471A (en) | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
US4455256A (en) | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4619989A (en) | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
US4294753A (en) | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4789732A (en) | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
DE3378250D1 (en) | 1982-04-22 | 1988-11-24 | Ici Plc | Continuous release formulations |
US4542025A (en) | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
NZ207655A (en) * | 1983-04-07 | 1986-09-10 | Merck & Co Inc | Synergistic veterinary compositions containing an avermectin compound and clorsulon |
JPS59199673A (ja) | 1983-04-25 | 1984-11-12 | Sumitomo Chem Co Ltd | 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤 |
US4904478A (en) | 1983-08-11 | 1990-02-27 | Mission Pharmacal Company | Slow-release sodium fluoride tablet and method for treatment of osteoporosis |
US4795804A (en) | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
US4526909A (en) | 1984-01-09 | 1985-07-02 | Regents Of The University Of California | Polymethylmethacrylate delivery system for bone morphogenetic protein |
US4563489A (en) | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
US4686092A (en) | 1984-04-13 | 1987-08-11 | Union Carbide Corporation | Manganese-aluminum-phosphorus-silicon-oxide molecular sieves |
US4596574A (en) | 1984-05-14 | 1986-06-24 | The Regents Of The University Of California | Biodegradable porous ceramic delivery system for bone morphogenetic protein |
CA1256638A (en) | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
US4729999A (en) | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
DE3580444D1 (en) | 1984-10-18 | 1990-12-13 | Ciba Geigy Ag | Benzoylphenylharnstoffe. |
US4687768A (en) | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
ATE67493T1 (de) | 1985-02-04 | 1991-10-15 | Bayer Agrochem Kk | Heterocyclische verbindungen. |
US4857456A (en) | 1985-04-30 | 1989-08-15 | The Regents Of The University Of California | Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders |
DE3519361A1 (de) | 1985-05-30 | 1986-12-04 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | (gamma)-ifn als wirkstoff zur hemmung (verhinderung) von abbauprozessen im knochen |
US4633372A (en) | 1985-08-26 | 1986-12-30 | The Standard Oil Company | Polyoxometalate-modified carbon electrodes and uses therefor in capacitors |
GB8713768D0 (en) | 1987-06-12 | 1987-07-15 | May & Baker Ltd | Compositions of matter |
US5232940A (en) | 1985-12-20 | 1993-08-03 | Hatton Leslie R | Derivatives of N-phenylpyrazoles |
EP0237482A1 (de) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
BR8701302A (pt) | 1986-03-25 | 1987-12-22 | Sankyo Co | Compostos macrolideos,sua preparacao e seu uso |
EP0252879B1 (de) | 1986-07-02 | 1992-05-06 | Ciba-Geigy Ag | Pestizide |
DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
US4758435A (en) | 1986-08-11 | 1988-07-19 | American Cyanamid Company | Estradiol implant composition and method for preparation |
US4902296A (en) | 1986-10-29 | 1990-02-20 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
US4871719A (en) | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
US4857335A (en) | 1987-03-27 | 1989-08-15 | Lim Technology Laboratories, Inc. | Liquid controlled release formulations and method of producing same via multiple emulsion process |
US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
US4911931A (en) | 1987-08-03 | 1990-03-27 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
DE3888936T2 (de) | 1987-11-03 | 1994-07-21 | Beecham Group Plc | Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung. |
US4916241A (en) | 1988-06-06 | 1990-04-10 | American Home Products Corporation | Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones |
US4931287A (en) | 1988-06-14 | 1990-06-05 | University Of Utah | Heterogeneous interpenetrating polymer networks for the controlled release of drugs |
US5725491A (en) | 1988-10-03 | 1998-03-10 | Atrix Laboratories, Inc. | Method of forming a biodegradable film dressing on tissue |
US5632727A (en) | 1988-10-03 | 1997-05-27 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5215890A (en) | 1988-11-03 | 1993-06-01 | Spyros Theodoropulos | Chromogenic substrate to peroxidase enzymes |
US5324520A (en) | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
NZ232422A (en) | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5077049A (en) | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
US5487897A (en) | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
NZ234802A (en) | 1989-08-14 | 1992-11-25 | Merck & Co Inc | Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals |
AU641944B2 (en) | 1989-11-10 | 1993-10-07 | Sumitomo Chemical Company, Limited | Improved pesticidal composition |
US5478564A (en) | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
US5733566A (en) * | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
US5288496A (en) | 1990-05-15 | 1994-02-22 | Stolle Research & Development Corporation | Growth promoters for animals |
CA2036147A1 (en) | 1990-06-29 | 1991-12-30 | Hiroki Tomioka | A 1-pyridylimidazole derivative and its production and use |
US5252701A (en) | 1990-07-06 | 1993-10-12 | American Cyanamid Company | Segmented absorbable copolymer |
SI9011409A (en) | 1990-07-18 | 1995-10-31 | Pliva Pharm & Chem Works | O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them |
US5072716A (en) | 1990-07-30 | 1991-12-17 | Toxoric, Inc. | Archery bow sighting device |
US5275820A (en) | 1990-12-27 | 1994-01-04 | Allergan, Inc. | Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles |
NZ247278A (en) | 1991-02-12 | 1995-03-28 | Ancare Distributors | Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier |
CA2064634C (en) | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
WO1993005907A1 (en) | 1991-09-25 | 1993-04-01 | Kawasaki Steel Corporation | Method of continuously casting steel slabs by use of electromagnetic field |
ATE180671T1 (de) | 1991-09-30 | 1999-06-15 | Merck & Co Inc | Hydrierte rizinusöl-enthaltende injizierbare formulierungen mit verlängerter wirkstoffabgabe |
AU2605592A (en) | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US5288469A (en) | 1992-03-16 | 1994-02-22 | Envirosurgical, Inc. | Surgery plume filter device |
US5540912A (en) | 1992-03-30 | 1996-07-30 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
US5711968A (en) | 1994-07-25 | 1998-01-27 | Alkermes Controlled Therapeutics, Inc. | Composition and method for the controlled release of metal cation-stabilized interferon |
US5210235A (en) | 1992-08-26 | 1993-05-11 | Merck & Co., Inc. | Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics |
US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
US5345377A (en) | 1992-10-30 | 1994-09-06 | Electric Power Research Institute, Inc. | Harmonic controller for an active power line conditioner |
US5686092A (en) | 1992-11-24 | 1997-11-11 | Alkermes Controlled Therapeutics Inc. Ii | Growth promoters for animals |
DE69329295T2 (de) | 1992-12-02 | 2001-03-15 | Alkermes Controlled Therapeutics, Inc. | Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung |
HRP930014A2 (en) | 1993-01-08 | 1994-08-31 | Pliva Pharm & Chem Works | 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates |
US5332807A (en) | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
US5447725A (en) | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
JP3220331B2 (ja) | 1993-07-20 | 2001-10-22 | エチコン・インコーポレーテツド | 非経口投与用の吸収性液体コポリマー類 |
NZ248486A (en) | 1993-08-24 | 1996-07-26 | Ashmont Holdings Limited Subst | Stable anthelmintic formulation containing closantel and one or more avermectins or milbemycins in a glycol based solvent |
US5399582A (en) | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
HRP931480B1 (en) | 1993-12-08 | 1997-08-31 | Sour Pliva | 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A |
JP3715994B2 (ja) | 1993-12-21 | 2005-11-16 | 住友化学株式会社 | 害虫防除剤 |
ATE241394T1 (de) | 1994-04-08 | 2003-06-15 | Atrix Lab Inc | Beigeordnetes polymersystem zur verwendung mit einer medizinischen vorrichtung |
JP4259610B2 (ja) | 1994-04-08 | 2009-04-30 | キューエルティー・ユーエスエイ・インコーポレーテッド | 液体デリバリー組成物 |
US5599852A (en) | 1994-10-18 | 1997-02-04 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
US5607686A (en) | 1994-11-22 | 1997-03-04 | United States Surgical Corporation | Polymeric composition |
AUPM969994A0 (en) | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
ATE435648T1 (de) | 1995-03-20 | 2009-07-15 | Merck & Co Inc | Derivaten von nodulisporen säure |
US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
US5773422A (en) * | 1996-01-29 | 1998-06-30 | Komer; Gene | Avermectin formulation |
ES2122905B1 (es) | 1996-07-11 | 1999-11-16 | Astur Pharma Sa | Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). |
GB9625045D0 (en) | 1996-11-30 | 1997-01-22 | Pfizer Ltd | Parasiticidal compounds |
US6207647B1 (en) | 1997-07-18 | 2001-03-27 | Smithkline Beecham Corporation | RatA |
ATE269676T1 (de) * | 1998-03-19 | 2004-07-15 | Merck & Co Inc | Flüssige polymerlosung zur kontrollierten freisetzung von bioaktiven substanzen |
DE69925255T2 (de) * | 1998-03-19 | 2006-02-23 | Merck & Co., Inc. | Schwefelpentafluorophenylpyrazole zur kontrolle von ektoparasitenbefall |
GB9815801D0 (en) * | 1998-07-21 | 1998-09-16 | Merck & Co Inc | Liquid polymeric compositions for controlled released bioactive substances |
US6733767B2 (en) * | 1998-03-19 | 2004-05-11 | Merck & Co., Inc. | Liquid polymeric compositions for controlled release of bioactive substances |
GB2386067A (en) | 2002-02-28 | 2003-09-10 | Norbrook Lab Ltd | Long-acting parasiticidal composition with improved bioavailability comprising an avermectin or milbemycin, plus a salicylanilide & a polymeric species |
US6653288B1 (en) | 2002-09-30 | 2003-11-25 | Virbac S.A. | Injectable anthelmintic compositions and methods for using same |
-
2005
- 2005-08-19 US US11/207,980 patent/US8362086B2/en active Active
-
2006
- 2006-08-18 TR TR2019/02039T patent/TR201902039T4/tr unknown
- 2006-08-18 RS RS20190113A patent/RS58385B1/sr unknown
- 2006-08-18 HU HUE06801888A patent/HUE042225T2/hu unknown
- 2006-08-18 LT LTEP06801888.6T patent/LT1962794T/lt unknown
- 2006-08-18 CA CA2619601A patent/CA2619601C/en not_active Expired - Fee Related
- 2006-08-18 EP EP06801888.6A patent/EP1962794B1/en active Active
- 2006-08-18 KR KR1020087006713A patent/KR101351644B1/ko active IP Right Grant
- 2006-08-18 DK DK06801888.6T patent/DK1962794T3/en active
- 2006-08-18 PT PT06801888T patent/PT1962794T/pt unknown
- 2006-08-18 BR BRPI0615355A patent/BRPI0615355B8/pt active IP Right Grant
- 2006-08-18 MX MX2008002345A patent/MX2008002345A/es active IP Right Grant
- 2006-08-18 PL PL06801888T patent/PL1962794T3/pl unknown
- 2006-08-18 WO PCT/US2006/032407 patent/WO2007024719A2/en active Application Filing
- 2006-08-18 ES ES06801888T patent/ES2711233T3/es active Active
- 2006-08-18 EP EP18195458.7A patent/EP3479818A1/en not_active Withdrawn
- 2006-08-18 CN CNA2006800388650A patent/CN101312710A/zh active Pending
- 2006-08-18 JP JP2008527182A patent/JP5132560B2/ja not_active Expired - Fee Related
- 2006-08-18 SI SI200632314T patent/SI1962794T1/sl unknown
-
2019
- 2019-01-15 HR HRP20190084TT patent/HRP20190084T1/hr unknown
- 2019-02-07 CY CY20191100165T patent/CY1121226T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20070042013A1 (en) | 2007-02-22 |
EP3479818A1 (en) | 2019-05-08 |
HUE042225T2 (hu) | 2019-06-28 |
ES2711233T3 (es) | 2019-04-30 |
BRPI0615355B1 (pt) | 2020-04-07 |
LT1962794T (lt) | 2019-02-25 |
BRPI0615355A2 (pt) | 2011-05-17 |
BRPI0615355B8 (pt) | 2022-09-20 |
DK1962794T3 (en) | 2019-02-25 |
JP5132560B2 (ja) | 2013-01-30 |
CA2619601A1 (en) | 2007-03-01 |
TR201902039T4 (tr) | 2019-03-21 |
EP1962794A2 (en) | 2008-09-03 |
JP2009504778A (ja) | 2009-02-05 |
PL1962794T3 (pl) | 2019-05-31 |
MX2008002345A (es) | 2008-04-29 |
KR101351644B1 (ko) | 2014-01-14 |
KR20080038235A (ko) | 2008-05-02 |
WO2007024719A2 (en) | 2007-03-01 |
SI1962794T1 (sl) | 2019-02-28 |
CN101312710A (zh) | 2008-11-26 |
HRP20190084T1 (hr) | 2019-03-08 |
PT1962794T (pt) | 2019-02-25 |
EP1962794B1 (en) | 2018-11-14 |
CA2619601C (en) | 2014-05-20 |
US8362086B2 (en) | 2013-01-29 |
RS58385B1 (sr) | 2019-04-30 |
WO2007024719A3 (en) | 2007-08-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1121226T1 (el) | Ενεσιμα παρασιτοκτονα σκευασματα μακρας δρασης | |
SMT201300093B (it) | Formulazioni di vwf ricombinante liofilizzate | |
CL2010001346A1 (es) | Polipeptido mutante del factor de crecimiento de fibroblastos (fgf); multimero que comprende dos o mas copias del polipeptido de fusion antes mencionado; composicion farmaceutica que comprende el polipeptido. | |
CR9591A (es) | Inhibidores de proteina cinasa derivados de pirrol (2,3-b) piridina | |
CY1124157T1 (el) | Προσδετες δικυκλικου πεπτιδιου ειδικοι για μτ1-mmρ | |
CY1120137T1 (el) | Ενεσιμα σκευασματα βοτουλινικης τοξινης | |
DOP2006000025A (es) | Agonistas de pyy y sus usos | |
EA202090868A1 (ru) | Составы | |
CL2017003436A1 (es) | Compuestos de benzoxacepina oxazolidinona y métodos de uso | |
CY1118731T1 (el) | Φαρμακευτικες συνθεσεις αλβιγλουτιδης | |
BRPI0515118A (pt) | conjugados de hormÈnio do crescimento humano com polietileno glicol | |
ECSP056167A (es) | Fenil quinolinas y su uso como agentes estrogénicos | |
ECSP077336A (es) | Control de parásitos en animales mediante el uso de nuevos derivados de trifluorometansulfonanilida oxima éter | |
BRPI0618479A2 (pt) | pirrolpiridinas composição farmacêutica que as contém | |
UY29198A1 (es) | Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones | |
CY1122168T1 (el) | Φαρμακοτεχνικες μορφες παραγωγων δεσιταβινης | |
ATE433961T1 (de) | Ansamycine mit verbesserten pharmakologischen und biologischen eigenschaften | |
BR112018017265A2 (pt) | compostos antiparasíticos de isoxazolina, formulações injetáveis de ação prolongada que os compreendem, métodos e utilizações dos mesmos | |
GT200600114A (es) | Derivados de ciclopropanocarboxamida | |
BRPI0607649B8 (pt) | uso de uma formulação subcutânea ou intramuscular compreendendo uma quantidade eficaz de tmc278 e um veículo | |
WO2008153933A3 (en) | Soluble her2 and her3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease | |
AR056606A1 (es) | Agentes fitosanitarios solidos con contenido de polialcoxilato procedimiento para su preparacion y su uso | |
DE602004025151D1 (de) | Stabile injizierbare Diclofenac- Zubereitungen | |
EA202190650A1 (ru) | Замедленная доставка ангиопоэтин-подобных полипептидов 3 | |
CO2019013342A2 (es) | Formulaciones de medicamentos de moleculas pequeñas resistentes a la precipitación |