DK1861493T3 - Muterede allerer af zwf-genet (g6pdh) fra coryneforme bakterier til øget produktion af lysin - Google Patents
Muterede allerer af zwf-genet (g6pdh) fra coryneforme bakterier til øget produktion af lysinInfo
- Publication number
- DK1861493T3 DK1861493T3 DK06725146.2T DK06725146T DK1861493T3 DK 1861493 T3 DK1861493 T3 DK 1861493T3 DK 06725146 T DK06725146 T DK 06725146T DK 1861493 T3 DK1861493 T3 DK 1861493T3
- Authority
- DK
- Denmark
- Prior art keywords
- coryne
- g6pdh
- lysine production
- shaped bacteria
- zwf gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/227—Tryptophan
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005013676A DE102005013676A1 (de) | 2005-03-24 | 2005-03-24 | Allele des zwf-Gens aus coryneformen Bakterien |
PCT/EP2006/060519 WO2006100177A1 (de) | 2005-03-24 | 2006-03-07 | Mutierte allele des zwg-gens (g6pdh) aus coryneformen bakterien zur gesteigerten lysin produktion |
PCT/EP2006/060851 WO2006100211A1 (de) | 2005-03-24 | 2006-03-17 | Mutierte allele des zwg-gens (g6pdh) aus coryneformen bakterien zur gesteigerten lysin produktion |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1861493T3 true DK1861493T3 (da) | 2013-01-02 |
Family
ID=36370857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06725146.2T DK1861493T3 (da) | 2005-03-24 | 2006-03-17 | Muterede allerer af zwf-genet (g6pdh) fra coryneforme bakterier til øget produktion af lysin |
Country Status (4)
Country | Link |
---|---|
DE (1) | DE102005013676A1 (es) |
DK (1) | DK1861493T3 (es) |
ES (1) | ES2394918T3 (es) |
WO (2) | WO2006100177A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006026328A1 (de) * | 2006-06-02 | 2008-01-03 | Evonik Degussa Gmbh | Verfahren zur Herstellung eines L-Lysin enthaltenden Futtermitteladditivs |
DE102006032634A1 (de) | 2006-07-13 | 2008-01-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
WO2008092956A1 (en) * | 2007-02-02 | 2008-08-07 | Evonik Degussa Gmbh | Production of l-lysine and l-lysine-containing feed additives |
DE102008001874A1 (de) | 2008-05-20 | 2009-11-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
DE102009030342A1 (de) | 2009-06-25 | 2010-12-30 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen |
DE102010003419B4 (de) | 2010-03-30 | 2019-09-12 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von L-Ornithin |
DE102011006716A1 (de) | 2011-04-04 | 2012-10-04 | Evonik Degussa Gmbh | Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung |
EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
CN112646767B (zh) * | 2020-12-30 | 2022-08-09 | 宁夏伊品生物科技股份有限公司 | 具有增强的l-谷氨酸生产力的菌株及其构建方法与应用 |
Family Cites Families (43)
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SU507634A1 (ru) | 1973-09-24 | 1976-03-25 | Институт Микробиологии Имени А.Кирхенштейна Ан Латвийской Сср | Способ получени -лизина |
JPS54105293A (en) | 1978-02-01 | 1979-08-18 | Ajinomoto Co Inc | Preparation of l-proline by fermentation |
JPS559783A (en) | 1978-07-10 | 1980-01-23 | Ajinomoto Co Inc | Preparation of l-lysine by fermentation |
US4601983A (en) | 1983-06-15 | 1986-07-22 | Ajinomoto Co., Inc. | Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine |
JPH0655149B2 (ja) | 1985-03-12 | 1994-07-27 | 協和醗酵工業株式会社 | L―リジンの製造法 |
US5250434A (en) | 1987-03-27 | 1993-10-05 | Ajinomoto Co., Inc. | Microorganisms for production of glutamic acid |
JP2656300B2 (ja) | 1988-04-18 | 1997-09-24 | 協和醗酵工業株式会社 | L−トリプトファンの製造法 |
GB2223754B (en) | 1988-09-12 | 1992-07-22 | Degussa | Dna encoding phosphoenolpyruvate carboxylase |
JP2990735B2 (ja) | 1990-04-20 | 1999-12-13 | 味の素株式会社 | L―リジンの発酵的製造法 |
JP3023615B2 (ja) | 1990-08-30 | 2000-03-21 | 協和醗酵工業株式会社 | 発酵法によるl―トリプトファンの製造法 |
DE4100920A1 (de) | 1991-01-15 | 1992-07-16 | Degussa | Wirkstoffzubereitung zur oralen verabreichung an wiederkaeuer |
FR2679569B1 (fr) | 1991-07-26 | 1995-05-19 | Eurolysine | Procede de separation de la lysine sous la forme de solutions aqueuses et utilisation de ces solutions pour l'alimentation animale. |
DE4130867A1 (de) | 1991-09-17 | 1993-03-18 | Degussa | Verfahren zur fermentativen herstellung von aminosaeuren |
DE4130868C2 (de) | 1991-09-17 | 1994-10-13 | Degussa | Tierfuttermittelsupplement auf der Basis einer Aminosäure und Verfahren zu dessen Herstellung |
JPH05195736A (ja) | 1992-01-20 | 1993-08-03 | Mazda Motor Corp | エンジンのバルブ駆動装置 |
DE4232468A1 (de) | 1992-09-28 | 1994-03-31 | Consortium Elektrochem Ind | Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung |
JP3369231B2 (ja) | 1992-12-03 | 2003-01-20 | 協和醗酵工業株式会社 | 芳香族アミノ酸の製造法 |
AU706285B2 (en) | 1995-05-16 | 1999-06-10 | Ajinomoto Co., Inc. | Feed additive |
DE19547361A1 (de) | 1995-12-19 | 1997-06-26 | Degussa | Verfahren zur Herstellung von L-Aminosäuren durch Fermentation |
DE19548222A1 (de) | 1995-12-22 | 1997-06-26 | Forschungszentrum Juelich Gmbh | Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern |
JPH09224661A (ja) | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | グルコース−6−リン酸デヒドロゲナーゼおよびそれをコードするdna |
JP4075087B2 (ja) | 1996-12-05 | 2008-04-16 | 味の素株式会社 | L−リジンの製造法 |
DE19831609B4 (de) | 1997-10-04 | 2009-11-12 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Aminosäuren der Aspartat- und/oder Glutamatfamilie und im Verfahren einsetzbare Mittel |
JP2000262288A (ja) | 1999-03-16 | 2000-09-26 | Ajinomoto Co Inc | コリネ型細菌の温度感受性プラスミド |
CN1236690C (zh) | 1999-06-23 | 2006-01-18 | 德古萨股份公司 | 含有赖氨酸的含水动物饲料添加剂及其生产方法 |
MXPA01013123A (es) | 1999-06-25 | 2002-06-21 | Basf Ag | Genes de corynebacterium glutamicum que codifican proteinas de via metabolica. |
KR20070087088A (ko) | 1999-06-25 | 2007-08-27 | 바스프 악티엔게젤샤프트 | 탄소 대사 및 에너지 생산과 관련된 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 |
KR100575403B1 (ko) | 1999-07-23 | 2006-05-03 | 아처 다니엘 미드랜드 캄파니 | 세포 nadph를 증가시켜 l-아미노산을 생산하는 방법 |
US6586214B1 (en) | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
DE19959328A1 (de) | 1999-12-09 | 2001-06-13 | Degussa | Neue für das zwa1-Gen codierende Nukleotidsequenzen |
JP4623825B2 (ja) | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
US20030175911A1 (en) * | 2000-03-20 | 2003-09-18 | Stephen Hans | Process for the preparation of L-amino acids with amplification of the zwf gene |
ATE351908T1 (de) | 2000-03-20 | 2007-02-15 | Degussa | Verfahren zur fermentativen herstellung von l- aminosäuren durch verstärkung des zwf-gens |
ES2341432T3 (es) | 2000-06-21 | 2010-06-21 | Kyowa Hakko Bio Co., Ltd. | Nueva glucosa-6-fosfato deshidrogenasa. |
WO2002031158A2 (en) | 2000-10-13 | 2002-04-18 | Archer-Daniels-Midland Company | Feedback-resistant pyruvate carboxylase gene from corynebacterium |
DE10109996A1 (de) | 2001-03-01 | 2002-09-05 | Basf Ag | Verfahren zur Veränderung des Genoms von gram-positiven Bakterien mit einem neuen konditional negativ dominanten Markergen |
WO2003040373A2 (en) | 2001-08-06 | 2003-05-15 | Degussa Ag | Production of l-lysine by genetically modified corynebacterium glutamicum strains |
WO2003014330A2 (en) | 2001-08-06 | 2003-02-20 | Degussa Ag | Coryneform bacteria which produce chemical compounds ii |
DE10137815A1 (de) | 2001-08-06 | 2003-02-27 | Basf Ag | Verfahren zur Herstellung eines marker-freien mutierten Zielorganismus sowie dafür geeignete Plasmidvektoren |
US7160711B2 (en) | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
DE10155505A1 (de) * | 2001-11-13 | 2003-05-22 | Basf Ag | Gene die für Glucose-6-Phosphat-Dehydrogenase Proteine codieren |
JP2003219807A (ja) | 2002-01-25 | 2003-08-05 | Ajinomoto Co Inc | L−リジンを主成分とする造粒乾燥物 |
US20040115304A1 (en) | 2002-12-16 | 2004-06-17 | Frank Dubner | Feesdstuffs additives containing L-lysine with improved abrasion resistance, and process for their production |
-
2005
- 2005-03-24 DE DE102005013676A patent/DE102005013676A1/de not_active Ceased
-
2006
- 2006-03-07 WO PCT/EP2006/060519 patent/WO2006100177A1/de not_active Application Discontinuation
- 2006-03-17 ES ES06725146T patent/ES2394918T3/es active Active
- 2006-03-17 DK DK06725146.2T patent/DK1861493T3/da active
- 2006-03-17 WO PCT/EP2006/060851 patent/WO2006100211A1/de not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2006100211A1 (de) | 2006-09-28 |
WO2006100177A1 (de) | 2006-09-28 |
DE102005013676A1 (de) | 2006-09-28 |
ES2394918T3 (es) | 2013-02-06 |
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