DK1861405T3 - Fremgangsmåde til reduktion af alfa,beta-umættede ketoner i opioidsammensætninger - Google Patents
Fremgangsmåde til reduktion af alfa,beta-umættede ketoner i opioidsammensætningerInfo
- Publication number
- DK1861405T3 DK1861405T3 DK06707309T DK06707309T DK1861405T3 DK 1861405 T3 DK1861405 T3 DK 1861405T3 DK 06707309 T DK06707309 T DK 06707309T DK 06707309 T DK06707309 T DK 06707309T DK 1861405 T3 DK1861405 T3 DK 1861405T3
- Authority
- DK
- Denmark
- Prior art keywords
- beta
- unsaturated ketones
- reducing alpha
- opioid compositions
- reducing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65879105P | 2005-03-04 | 2005-03-04 | |
| PCT/EP2006/001798 WO2006094672A1 (en) | 2005-03-04 | 2006-02-27 | Method of reducing alpha, beta unsaturated ketones in opioid compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1861405T3 true DK1861405T3 (da) | 2009-07-20 |
Family
ID=36301669
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06707309T DK1861405T3 (da) | 2005-03-04 | 2006-02-27 | Fremgangsmåde til reduktion af alfa,beta-umættede ketoner i opioidsammensætninger |
| DK09158939.0T DK2112153T3 (da) | 2005-03-04 | 2006-02-27 | Fremgangsmåde til reduktion af alpha, beta-umættede ketoner i opioidsammensætninger |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09158939.0T DK2112153T3 (da) | 2005-03-04 | 2006-02-27 | Fremgangsmåde til reduktion af alpha, beta-umættede ketoner i opioidsammensætninger |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7939543B2 (sl) |
| EP (2) | EP1861405B1 (sl) |
| JP (1) | JP5314894B2 (sl) |
| KR (1) | KR100941761B1 (sl) |
| CN (1) | CN101133062B (sl) |
| AT (2) | ATE487722T1 (sl) |
| CA (1) | CA2598774C (sl) |
| CY (2) | CY1109262T1 (sl) |
| DE (2) | DE602006018208D1 (sl) |
| DK (2) | DK1861405T3 (sl) |
| ES (2) | ES2355870T3 (sl) |
| HK (2) | HK1111695A1 (sl) |
| HR (2) | HRP20090387T1 (sl) |
| ME (2) | ME01594B (sl) |
| PL (2) | PL1861405T3 (sl) |
| PT (2) | PT1861405E (sl) |
| RS (2) | RS51568B (sl) |
| SI (2) | SI1861405T1 (sl) |
| WO (1) | WO2006094672A1 (sl) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (de) * | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| WO2005016313A1 (de) * | 2003-08-06 | 2005-02-24 | Grünenthal GmbH | Gegen missbrauch gesicherte darreichungsform |
| TWI365880B (en) | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
| DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| WO2007103105A2 (en) | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
| AU2007329451B2 (en) | 2006-12-04 | 2012-08-30 | Noramco, Llc | Process for reducing impurities in oxycodone base |
| AU2007329453B2 (en) * | 2006-12-04 | 2013-04-04 | Noramco, Llc | Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| MX2009010931A (es) | 2007-04-16 | 2009-10-29 | Mallinckrodt Inc | Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno. |
| FR2923484B1 (fr) | 2007-11-09 | 2012-11-09 | Sanofi Aventis | Procede de preparation de composes morphiniques |
| TWI454288B (zh) | 2008-01-25 | 2014-10-01 | Gruenenthal Chemie | 藥物劑型 |
| AU2009223061B2 (en) * | 2008-03-11 | 2014-10-09 | Depomed Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| US8372432B2 (en) * | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| CA2723438C (en) | 2008-05-09 | 2016-10-11 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
| BR112012001244A2 (pt) * | 2009-07-22 | 2020-12-08 | Gruünenthal Gmbh | Forma de dosagem resitente à adulteração, seu processo de produção, e embalagem contendo tal forma |
| ES2534908T3 (es) * | 2009-07-22 | 2015-04-30 | Grünenthal GmbH | Forma de dosificación de liberación controlada extruida por fusión en caliente |
| PL399450A1 (pl) * | 2009-08-31 | 2013-01-21 | Depomed, Inc | Utrzymujace sie w zoladku kompozycje farmaceutyczne do natychmiastowego i przedluzonego uwalniania acetaminofenu |
| US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| EP2377866B1 (en) | 2010-03-23 | 2014-02-26 | Siegfried AG | Preparation of low impurity opiates in a continuous flow reactor |
| ES2666404T3 (es) | 2010-06-11 | 2018-05-04 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
| TWI471289B (zh) | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| JP5925779B2 (ja) | 2010-09-02 | 2016-05-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 無機塩を含む不正使用抵抗性剤形 |
| MX2013002293A (es) | 2010-09-02 | 2013-05-09 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico. |
| US8658631B1 (en) | 2011-05-17 | 2014-02-25 | Mallinckrodt Llc | Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia |
| US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
| US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
| JP6063462B2 (ja) | 2011-07-29 | 2017-01-18 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| JP2014524925A (ja) | 2011-07-29 | 2014-09-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
| MX362357B (es) | 2012-04-18 | 2019-01-14 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis. |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| WO2014140899A2 (en) | 2013-03-15 | 2014-09-18 | Johnson Matthey Public Limited Company | Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain |
| MX2015016254A (es) | 2013-05-29 | 2016-04-20 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal. |
| CN105682643B (zh) | 2013-07-12 | 2019-12-13 | 格吕伦塔尔有限公司 | 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型 |
| CA2931553C (en) | 2013-11-26 | 2022-01-18 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| CA2947786A1 (en) | 2014-05-12 | 2015-11-19 | Grunenthal Gmbh | Tamper resistant immediate release capsule formulation comprising tapentadol |
| MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
| MA40332A (fr) | 2014-07-09 | 2021-04-28 | Rhodes Tech | Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane |
| CA2983642A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
| EP3346991A1 (en) | 2015-09-10 | 2018-07-18 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3812312A (en) | 1971-11-15 | 1974-05-21 | Chrysler Corp | Impact velocity sensor switch with linearly movable controller |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| GB9713703D0 (en) | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
| US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
| TWI365880B (en) * | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
-
2006
- 2006-02-27 ES ES09158939T patent/ES2355870T3/es active Active
- 2006-02-27 RS RS20110031A patent/RS51568B/en unknown
- 2006-02-27 PT PT06707309T patent/PT1861405E/pt unknown
- 2006-02-27 ME MEP-2011-17A patent/ME01594B/me unknown
- 2006-02-27 DK DK06707309T patent/DK1861405T3/da active
- 2006-02-27 AT AT09158939T patent/ATE487722T1/de active
- 2006-02-27 KR KR1020077022566A patent/KR100941761B1/ko active IP Right Grant
- 2006-02-27 CN CN200680006690.5A patent/CN101133062B/zh active Active
- 2006-02-27 PT PT09158939T patent/PT2112153E/pt unknown
- 2006-02-27 SI SI200630344T patent/SI1861405T1/sl unknown
- 2006-02-27 DE DE602006018208T patent/DE602006018208D1/de active Active
- 2006-02-27 WO PCT/EP2006/001798 patent/WO2006094672A1/en active Application Filing
- 2006-02-27 SI SI200630885T patent/SI2112153T1/sl unknown
- 2006-02-27 RS RSP-2009/0347A patent/RS51131B/sr unknown
- 2006-02-27 CA CA2598774A patent/CA2598774C/en active Active
- 2006-02-27 JP JP2007557403A patent/JP5314894B2/ja active Active
- 2006-02-27 ES ES06707309T patent/ES2326491T3/es active Active
- 2006-02-27 US US11/885,402 patent/US7939543B2/en active Active
- 2006-02-27 EP EP06707309A patent/EP1861405B1/en active Active
- 2006-02-27 PL PL06707309T patent/PL1861405T3/pl unknown
- 2006-02-27 EP EP09158939A patent/EP2112153B1/en active Active
- 2006-02-27 AT AT06707309T patent/ATE430153T1/de active
- 2006-02-27 DK DK09158939.0T patent/DK2112153T3/da active
- 2006-02-27 PL PL09158939T patent/PL2112153T3/pl unknown
- 2006-02-27 ME MEP-2009-248A patent/ME01184B/me unknown
- 2006-02-27 DE DE602006006558T patent/DE602006006558D1/de active Active
-
2008
- 2008-03-06 HK HK08102671.4A patent/HK1111695A1/xx unknown
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2009
- 2009-07-07 HR HR20090387T patent/HRP20090387T1/xx unknown
- 2009-07-23 CY CY20091100790T patent/CY1109262T1/el unknown
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2010
- 2010-04-13 HK HK10103566.6A patent/HK1135107A1/xx unknown
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2011
- 2011-02-01 HR HR20110078T patent/HRP20110078T1/hr unknown
- 2011-02-03 CY CY20111100129T patent/CY1111241T1/el unknown
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