DK1853588T3 - Kemiske forbindelser - Google Patents
Kemiske forbindelserInfo
- Publication number
- DK1853588T3 DK1853588T3 DK06709750T DK06709750T DK1853588T3 DK 1853588 T3 DK1853588 T3 DK 1853588T3 DK 06709750 T DK06709750 T DK 06709750T DK 06709750 T DK06709750 T DK 06709750T DK 1853588 T3 DK1853588 T3 DK 1853588T3
- Authority
- DK
- Denmark
- Prior art keywords
- chemical compounds
- novel compounds
- cancer
- formula
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65357505P | 2005-02-16 | 2005-02-16 | |
US74213805P | 2005-12-01 | 2005-12-01 | |
PCT/GB2006/000513 WO2006087530A1 (en) | 2005-02-16 | 2006-02-15 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1853588T3 true DK1853588T3 (da) | 2008-09-15 |
Family
ID=36168456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06709750T DK1853588T3 (da) | 2005-02-16 | 2006-02-15 | Kemiske forbindelser |
Country Status (22)
Country | Link |
---|---|
US (2) | US8129403B2 (pl) |
EP (1) | EP1853588B1 (pl) |
JP (1) | JP5001179B2 (pl) |
KR (1) | KR101362621B1 (pl) |
AT (1) | ATE398613T1 (pl) |
AU (1) | AU2006215386B2 (pl) |
BR (1) | BRPI0607455A2 (pl) |
CA (1) | CA2597813C (pl) |
CY (1) | CY1108275T1 (pl) |
DE (1) | DE602006001515D1 (pl) |
DK (1) | DK1853588T3 (pl) |
ES (1) | ES2308731T3 (pl) |
HK (1) | HK1114375A1 (pl) |
IL (1) | IL185063A (pl) |
MX (1) | MX2007009843A (pl) |
NO (1) | NO20073788L (pl) |
NZ (1) | NZ561525A (pl) |
PL (1) | PL1853588T3 (pl) |
PT (1) | PT1853588E (pl) |
RU (1) | RU2405780C2 (pl) |
SI (1) | SI1853588T1 (pl) |
WO (1) | WO2006087530A1 (pl) |
Families Citing this family (51)
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SE0104140D0 (sv) * | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
ME02645B (me) | 2005-02-04 | 2012-04-30 | Astrazeneca Ab | Derivati pirazolil-aminopiridina korisni kao inhibitori kinaze |
MX2007009843A (es) | 2005-02-16 | 2007-08-23 | Astrazeneca Ab | Compuestos quimicos. |
JP2008540622A (ja) * | 2005-05-16 | 2008-11-20 | アストラゼネカ アクチボラグ | 化合物 |
DK1945631T3 (da) | 2005-10-28 | 2012-10-22 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer |
US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
WO2008051494A1 (en) * | 2006-10-19 | 2008-05-02 | Signal Pharmaceuticals, Llc | Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors |
EP2078019A2 (en) * | 2006-10-20 | 2009-07-15 | N.V. Organon | Purines as pkc-theta inhibitors |
JP2010524911A (ja) * | 2007-04-18 | 2010-07-22 | アストラゼネカ アクチボラグ | 5−アミノピラゾール−3−イル−3H−イミダゾ[4,5−b]ピリジン誘導体と癌の治療のためのその使用 |
UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
GB0725218D0 (en) * | 2007-12-24 | 2008-02-06 | Syngenta Ltd | Chemical compounds |
KR20110017445A (ko) * | 2008-06-11 | 2011-02-21 | 아스트라제네카 아베 | 암 및 골수증식성 장애의 치료에 유용한 트리시클릭 2,4-디아미노-l,3,5-트리아진 유도체 |
TW201018693A (en) * | 2008-09-30 | 2010-05-16 | Astrazeneca Ab | Chemical compounds 496-1p |
PA8851101A1 (es) | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
KR101903925B1 (ko) | 2009-10-26 | 2018-10-02 | 시그날 파마소티칼 엘엘씨 | 헤테로아릴 화합물의 합성 및 정제 방법 |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
WO2012097478A1 (en) * | 2011-01-21 | 2012-07-26 | Abbott Laboratories | Bicyclic carboxamide inhibitors of kinases |
MY183661A (en) | 2011-10-19 | 2021-03-05 | Signal Pharm Llc | Treatment of cancer with tor kinase inhibitors |
AU2012304276B2 (en) | 2011-12-02 | 2015-01-15 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use |
CA2864905A1 (en) | 2012-02-24 | 2013-08-29 | Signal Pharmaceuticals, Llc | Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy |
TW201341367A (zh) | 2012-03-16 | 2013-10-16 | Axikin Pharmaceuticals Inc | 3,5-二胺基吡唑激酶抑制劑 |
TWI585088B (zh) | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并[1,2-b]嗒衍生物 |
KR20150008907A (ko) | 2012-06-14 | 2015-01-23 | 일라이 릴리 앤드 캄파니 | Jak1 및 jak2의 억제제 |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
MX2015009209A (es) | 2013-01-16 | 2016-03-17 | Signal Pharm Llc | Compuestos sustituidos de pirrolopirimidina, composiciones de los mismos, y metodos de tratamiento con los mismos. |
JP6427115B2 (ja) * | 2013-03-05 | 2018-11-21 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 癌などの疾患の処置のためのトリアゾロ[4,5−d]ピリミジン誘導体 |
EP2964230A4 (en) | 2013-03-07 | 2016-10-26 | Califia Bio Inc | KINASEHEMMER WITH MIXED ABSTRACT AND TREATMENT PROCESS THEREWITH |
EP2986320A1 (en) | 2013-04-17 | 2016-02-24 | Signal Pharmaceuticals, LLC | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
TW201527300A (zh) | 2013-04-17 | 2015-07-16 | Signal Pharm Llc | 關於1-乙基-7-(2-甲基-6-(1H-1,2,4-三唑-3-基)吡啶-3-基)-3,4-二氫吡并[2,3-b]吡-2(1H)-酮之醫藥調配物、方法、固態型式及使用方法 |
US9630966B2 (en) | 2013-04-17 | 2017-04-25 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
US9358232B2 (en) | 2013-04-17 | 2016-06-07 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
TWI656875B (zh) | 2013-04-17 | 2019-04-21 | 美商標誌製藥公司 | 藉二氫吡并吡治療癌症 |
BR112015026297B1 (pt) | 2013-04-17 | 2022-08-23 | Signal Pharmaceuticals, Llc | Uso de um inibidor da quinase tor e quinazolinona 5-substituída, composição farmacêutica que os compreende, e kit |
AU2014254059B2 (en) | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Combination therapy comprising a TOR kinase inhibitor and a cytidine analog for treating cancer |
CN105407892B (zh) | 2013-05-29 | 2019-05-07 | 西格诺药品有限公司 | 一种化合物的药物组合物、其固体形式及它们的使用方法 |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
TWI731317B (zh) * | 2013-12-10 | 2021-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
US9737535B2 (en) | 2014-04-16 | 2017-08-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines |
US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
US9623028B2 (en) | 2014-07-14 | 2017-04-18 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
JP6606183B2 (ja) | 2014-12-18 | 2019-11-13 | ジェンザイム・コーポレーション | トロポミオシン関連キナーゼ(trk)阻害剤の医薬製剤 |
CN107250116B (zh) | 2014-12-23 | 2020-10-27 | 艾士盟医疗公司 | 3,5-二氨基吡唑激酶抑制剂 |
BR112019027402A2 (pt) | 2017-06-22 | 2020-07-07 | Celgene Corporation | tratamento de carcinoma hepatocelular caracterizado por infecção pelo vírus da hepatite b |
KR20210142154A (ko) | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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-
2006
- 2006-02-15 MX MX2007009843A patent/MX2007009843A/es active IP Right Grant
- 2006-02-15 WO PCT/GB2006/000513 patent/WO2006087530A1/en active IP Right Grant
- 2006-02-15 DK DK06709750T patent/DK1853588T3/da active
- 2006-02-15 JP JP2007555688A patent/JP5001179B2/ja not_active Expired - Fee Related
- 2006-02-15 SI SI200630060T patent/SI1853588T1/sl unknown
- 2006-02-15 AT AT06709750T patent/ATE398613T1/de active
- 2006-02-15 PT PT06709750T patent/PT1853588E/pt unknown
- 2006-02-15 RU RU2007134396/04A patent/RU2405780C2/ru not_active IP Right Cessation
- 2006-02-15 CA CA2597813A patent/CA2597813C/en not_active Expired - Fee Related
- 2006-02-15 US US11/816,374 patent/US8129403B2/en not_active Expired - Fee Related
- 2006-02-15 BR BRPI0607455-3A patent/BRPI0607455A2/pt not_active IP Right Cessation
- 2006-02-15 NZ NZ561525A patent/NZ561525A/en not_active IP Right Cessation
- 2006-02-15 EP EP06709750A patent/EP1853588B1/en not_active Not-in-force
- 2006-02-15 AU AU2006215386A patent/AU2006215386B2/en not_active Ceased
- 2006-02-15 DE DE602006001515T patent/DE602006001515D1/de active Active
- 2006-02-15 KR KR1020077020887A patent/KR101362621B1/ko not_active IP Right Cessation
- 2006-02-15 ES ES06709750T patent/ES2308731T3/es active Active
- 2006-02-15 PL PL06709750T patent/PL1853588T3/pl unknown
-
2007
- 2007-07-20 NO NO20073788A patent/NO20073788L/no not_active Application Discontinuation
- 2007-08-06 IL IL185063A patent/IL185063A/en not_active IP Right Cessation
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2008
- 2008-03-07 HK HK08102715.2A patent/HK1114375A1/xx not_active IP Right Cessation
- 2008-08-21 CY CY20081100887T patent/CY1108275T1/el unknown
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2012
- 2012-01-25 US US13/357,848 patent/US20120122892A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2007009843A (es) | 2007-08-23 |
NZ561525A (en) | 2010-11-26 |
DE602006001515D1 (de) | 2008-07-31 |
AU2006215386A1 (en) | 2006-08-24 |
RU2405780C2 (ru) | 2010-12-10 |
PL1853588T3 (pl) | 2008-11-28 |
CA2597813C (en) | 2014-04-22 |
AU2006215386B2 (en) | 2009-06-11 |
IL185063A0 (en) | 2007-12-03 |
KR101362621B1 (ko) | 2014-02-13 |
KR20070103773A (ko) | 2007-10-24 |
RU2007134396A (ru) | 2009-03-27 |
HK1114375A1 (en) | 2008-10-31 |
SI1853588T1 (sl) | 2008-10-31 |
CA2597813A1 (en) | 2006-08-24 |
US8129403B2 (en) | 2012-03-06 |
PT1853588E (pt) | 2008-08-25 |
JP2008530190A (ja) | 2008-08-07 |
ATE398613T1 (de) | 2008-07-15 |
NO20073788L (no) | 2007-09-03 |
US20080176872A1 (en) | 2008-07-24 |
ES2308731T3 (es) | 2008-12-01 |
CY1108275T1 (el) | 2014-02-12 |
EP1853588B1 (en) | 2008-06-18 |
WO2006087530A1 (en) | 2006-08-24 |
JP5001179B2 (ja) | 2012-08-15 |
BRPI0607455A2 (pt) | 2009-09-01 |
EP1853588A1 (en) | 2007-11-14 |
IL185063A (en) | 2012-01-31 |
US20120122892A1 (en) | 2012-05-17 |
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