DK1758870T3 - 4-phenyl-pyrimidin-2-carbonnitrilderivater - Google Patents

4-phenyl-pyrimidin-2-carbonnitrilderivater

Info

Publication number
DK1758870T3
DK1758870T3 DK05763140T DK05763140T DK1758870T3 DK 1758870 T3 DK1758870 T3 DK 1758870T3 DK 05763140 T DK05763140 T DK 05763140T DK 05763140 T DK05763140 T DK 05763140T DK 1758870 T3 DK1758870 T3 DK 1758870T3
Authority
DK
Denmark
Prior art keywords
carbonnitrilderivater
pyrimidine
phenyl
Prior art date
Application number
DK05763140T
Other languages
English (en)
Inventor
Jiaqiang Cai
Zoran Rankovic
Jennifer Helen Moir
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of DK1758870T3 publication Critical patent/DK1758870T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK05763140T 2004-06-11 2005-06-09 4-phenyl-pyrimidin-2-carbonnitrilderivater DK1758870T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04253491 2004-06-11
EP04106949 2004-12-23
PCT/EP2005/006266 WO2005121106A1 (en) 2004-06-11 2005-06-09 4-phenyl-pyrimidine-2-carbonitrile derivatives

Publications (1)

Publication Number Publication Date
DK1758870T3 true DK1758870T3 (da) 2008-10-20

Family

ID=34972893

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05763140T DK1758870T3 (da) 2004-06-11 2005-06-09 4-phenyl-pyrimidin-2-carbonnitrilderivater

Country Status (27)

Country Link
US (1) US7589095B2 (da)
EP (1) EP1758870B1 (da)
JP (1) JP2008501764A (da)
KR (1) KR20070043779A (da)
CN (1) CN1980897A (da)
AR (1) AR053303A1 (da)
AT (1) ATE404542T1 (da)
AU (1) AU2005251923A1 (da)
BR (1) BRPI0511951A (da)
CA (1) CA2567845A1 (da)
DE (1) DE602005008960D1 (da)
DK (1) DK1758870T3 (da)
EC (1) ECSP067074A (da)
ES (1) ES2313380T3 (da)
HK (1) HK1100002A1 (da)
IL (1) IL179444A0 (da)
MX (1) MXPA06014423A (da)
MY (1) MY140123A (da)
NO (1) NO20070146L (da)
NZ (1) NZ551772A (da)
PE (1) PE20060432A1 (da)
PL (1) PL1758870T3 (da)
PT (1) PT1758870E (da)
RS (1) RS20060662A (da)
RU (1) RU2382773C2 (da)
TW (1) TW200614993A (da)
WO (1) WO2005121106A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008542219A (ja) * 2005-05-25 2008-11-27 インゲニウム ファーマシューティカルズ ジーエムビーエイチ 疼痛処置法
CA2653733A1 (en) * 2006-05-26 2007-12-06 University Of Louisville Research Foundation, Inc. Macrophage migration inhibitory factor antagonists and methods of using same
EP2137166B1 (en) 2007-04-24 2012-05-30 Ingenium Pharmaceuticals GmbH 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
KR100936278B1 (ko) * 2007-12-14 2010-01-13 한국생명공학연구원 단백질 포스파타제의 활성을 억제하는 피리미딘 유도체또는 이의 약학적으로 허용가능한 염을 유효성분으로함유하는 암 예방 및 치료용 조성물
BRPI0912029A2 (pt) * 2008-02-01 2020-06-30 Orchid Research Laboratories Limited novos heterociclos
US9162987B2 (en) 2009-09-24 2015-10-20 University Of Louisville Research Foundation, Inc. Iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (MIF)-implicated diseases and conditions
WO2011146824A1 (en) 2010-05-20 2011-11-24 University Of Louisville Research Foundation, Inc. Methods and compositions for modulating ocular damage
EP2763993B1 (en) 2011-10-06 2017-04-19 Bayer Intellectual Property GmbH Heterocyclylpyri(mi)dinylpyrazole
EP2840083B1 (en) * 2012-04-17 2017-09-13 Astellas Pharma Inc. Nitrogenated bicyclic aromatic heterocyclic compound
CN104211645B (zh) * 2014-08-12 2016-08-24 武汉珈瑜科技有限公司 嘧啶类衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO890521L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte pyrimidiner.
EP1368323B1 (en) * 2001-02-14 2010-06-30 Warner-Lambert Company LLC Pyrimidine matrix metalloproteinase inhibitors
AR036375A1 (es) 2001-08-30 2004-09-01 Novartis Ag Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
US20030144234A1 (en) 2001-08-30 2003-07-31 Buxton Francis Paul Methods for the treatment of chronic pain and compositions therefor
GB0121033D0 (en) 2001-08-30 2001-10-24 Novartis Ag Organic compounds
SE0201976D0 (sv) * 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
SE0201980D0 (sv) 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
GB0220187D0 (en) * 2002-08-30 2002-10-09 Novartis Ag Organic compounds
US7326715B2 (en) * 2005-09-23 2008-02-05 N.V. Organon 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives

Also Published As

Publication number Publication date
MY140123A (en) 2009-11-30
CN1980897A (zh) 2007-06-13
TW200614993A (en) 2006-05-16
NO20070146L (no) 2007-02-02
EP1758870A1 (en) 2007-03-07
RU2382773C2 (ru) 2010-02-27
MXPA06014423A (es) 2007-02-19
US20080090813A1 (en) 2008-04-17
RS20060662A (en) 2008-09-29
PE20060432A1 (es) 2006-06-23
ECSP067074A (es) 2007-01-26
PT1758870E (pt) 2008-10-15
AR053303A1 (es) 2007-05-02
JP2008501764A (ja) 2008-01-24
ATE404542T1 (de) 2008-08-15
WO2005121106A1 (en) 2005-12-22
CA2567845A1 (en) 2005-12-22
BRPI0511951A (pt) 2008-01-29
KR20070043779A (ko) 2007-04-25
NZ551772A (en) 2009-05-31
US7589095B2 (en) 2009-09-15
IL179444A0 (en) 2007-05-15
EP1758870B1 (en) 2008-08-13
PL1758870T3 (pl) 2009-01-30
ES2313380T3 (es) 2009-03-01
DE602005008960D1 (de) 2008-09-25
RU2007101161A (ru) 2008-07-20
HK1100002A1 (en) 2007-08-31
AU2005251923A1 (en) 2005-12-22

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