ECSP067074A - Derivados de 4-fenil-pirimidina-2-carbonitrilo - Google Patents

Derivados de 4-fenil-pirimidina-2-carbonitrilo

Info

Publication number
ECSP067074A
ECSP067074A EC2006007074A ECSP067074A ECSP067074A EC SP067074 A ECSP067074 A EC SP067074A EC 2006007074 A EC2006007074 A EC 2006007074A EC SP067074 A ECSP067074 A EC SP067074A EC SP067074 A ECSP067074 A EC SP067074A
Authority
EC
Ecuador
Prior art keywords
derivatives
pyrimidine
phenyl
carbonitrile
relates
Prior art date
Application number
EC2006007074A
Other languages
English (en)
Inventor
Jiaqiang Cai
Zoran Rankovic
Jennifer Helen Moir
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of ECSP067074A publication Critical patent/ECSP067074A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a derivados de 4-fenil-pirimidina-2-carbonitrilo que tienen la fórmula general (I) o a una sal farmacéuticamente aceptable de los mismos. La invención también se refiere a composiciones farmacéuticas que comprenden dichos derivados, así como a su uso en la preparación de un medicamento adecuado para el tratamiento de la osteoporosis, aterosclerosis, inflamación y enfermedades inmunológicas tales como artritis reumatoide y dolores crónicos tales como dolores neuropáticos.
EC2006007074A 2004-06-11 2006-12-11 Derivados de 4-fenil-pirimidina-2-carbonitrilo ECSP067074A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04253491 2004-06-11
EP04106949 2004-12-23

Publications (1)

Publication Number Publication Date
ECSP067074A true ECSP067074A (es) 2007-01-26

Family

ID=34972893

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006007074A ECSP067074A (es) 2004-06-11 2006-12-11 Derivados de 4-fenil-pirimidina-2-carbonitrilo

Country Status (27)

Country Link
US (1) US7589095B2 (es)
EP (1) EP1758870B1 (es)
JP (1) JP2008501764A (es)
KR (1) KR20070043779A (es)
CN (1) CN1980897A (es)
AR (1) AR053303A1 (es)
AT (1) ATE404542T1 (es)
AU (1) AU2005251923A1 (es)
BR (1) BRPI0511951A (es)
CA (1) CA2567845A1 (es)
DE (1) DE602005008960D1 (es)
DK (1) DK1758870T3 (es)
EC (1) ECSP067074A (es)
ES (1) ES2313380T3 (es)
HK (1) HK1100002A1 (es)
IL (1) IL179444A0 (es)
MX (1) MXPA06014423A (es)
MY (1) MY140123A (es)
NO (1) NO20070146L (es)
NZ (1) NZ551772A (es)
PE (1) PE20060432A1 (es)
PL (1) PL1758870T3 (es)
PT (1) PT1758870E (es)
RS (1) RS20060662A (es)
RU (1) RU2382773C2 (es)
TW (1) TW200614993A (es)
WO (1) WO2005121106A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008542219A (ja) * 2005-05-25 2008-11-27 インゲニウム ファーマシューティカルズ ジーエムビーエイチ 疼痛処置法
WO2007140263A2 (en) * 2006-05-26 2007-12-06 University Of Louisville Research Foundation, Inc. Macrophage migration inhibitory factor antagonists and methods of using same
JP5566880B2 (ja) 2007-04-24 2014-08-06 インゲニウム ファーマシューティカルズ ジーエムビーエイチ プロテインキナーゼの阻害剤としての４，６−二置換アミノピリミジン誘導体
KR100936278B1 (ko) * 2007-12-14 2010-01-13 한국생명공학연구원 단백질 포스파타제의 활성을 억제하는 피리미딘 유도체또는 이의 약학적으로 허용가능한 염을 유효성분으로함유하는 암 예방 및 치료용 조성물
RU2572616C2 (ru) * 2008-02-01 2016-01-20 Оркид Рисерч Лабораториз Лимитед Новые гетероциклы
WO2011038234A2 (en) 2009-09-24 2011-03-31 University Of Louisville Research Foundation, Inc. Novel iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (mif)-implicated diseases and conditions
US9155790B2 (en) 2010-05-20 2015-10-13 University of Lousiville Research Foundation, Inc. Methods and compositions for modulating ocular damage
UA114410C2 (uk) 2011-10-06 2017-06-12 Байєр Інтеллектуал Проперті Гмбх Гетероциклілпіри(mi)динілпіразол
CN104284895B (zh) * 2012-04-17 2016-08-31 安斯泰来制药株式会社 含氮双环式芳香族杂环化合物
CN104211645B (zh) * 2014-08-12 2016-08-24 武汉珈瑜科技有限公司 嘧啶类衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO890521L (no) 1988-02-25 1989-08-28 Bayer Ag Substituerte pyrimidiner.
JP2004518723A (ja) 2001-02-14 2004-06-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ピリミジンマトリックスメタロプロテイナーゼ阻害剤
AR036375A1 (es) 2001-08-30 2004-09-01 Novartis Ag Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
GB0121033D0 (en) 2001-08-30 2001-10-24 Novartis Ag Organic compounds
US20030144234A1 (en) 2001-08-30 2003-07-31 Buxton Francis Paul Methods for the treatment of chronic pain and compositions therefor
SE0201976D0 (sv) * 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
SE0201980D0 (sv) 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
GB0220187D0 (en) * 2002-08-30 2002-10-09 Novartis Ag Organic compounds
US7326715B2 (en) * 2005-09-23 2008-02-05 N.V. Organon 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives

Also Published As

Publication number Publication date
MY140123A (en) 2009-11-30
PT1758870E (pt) 2008-10-15
DE602005008960D1 (de) 2008-09-25
EP1758870B1 (en) 2008-08-13
RU2007101161A (ru) 2008-07-20
BRPI0511951A (pt) 2008-01-29
KR20070043779A (ko) 2007-04-25
HK1100002A1 (en) 2007-08-31
MXPA06014423A (es) 2007-02-19
PL1758870T3 (pl) 2009-01-30
RS20060662A (en) 2008-09-29
AR053303A1 (es) 2007-05-02
WO2005121106A1 (en) 2005-12-22
CN1980897A (zh) 2007-06-13
PE20060432A1 (es) 2006-06-23
AU2005251923A1 (en) 2005-12-22
DK1758870T3 (da) 2008-10-20
IL179444A0 (en) 2007-05-15
US20080090813A1 (en) 2008-04-17
TW200614993A (en) 2006-05-16
US7589095B2 (en) 2009-09-15
JP2008501764A (ja) 2008-01-24
ES2313380T3 (es) 2009-03-01
NO20070146L (no) 2007-02-02
ATE404542T1 (de) 2008-08-15
NZ551772A (en) 2009-05-31
CA2567845A1 (en) 2005-12-22
RU2382773C2 (ru) 2010-02-27
EP1758870A1 (en) 2007-03-07

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