DK175504B1 - Farmaceutisk præparat indeholdende 3alfa-hydroxy-5beta-pregnan-20-on og fremstilling deraf - Google Patents

Farmaceutisk præparat indeholdende 3alfa-hydroxy-5beta-pregnan-20-on og fremstilling deraf Download PDF

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Publication number
DK175504B1
DK175504B1 DK198700621A DK62187A DK175504B1 DK 175504 B1 DK175504 B1 DK 175504B1 DK 198700621 A DK198700621 A DK 198700621A DK 62187 A DK62187 A DK 62187A DK 175504 B1 DK175504 B1 DK 175504B1
Authority
DK
Denmark
Prior art keywords
oil
pregnanolone
amount
water
final preparation
Prior art date
Application number
DK198700621A
Other languages
Danish (da)
English (en)
Other versions
DK62187A (da
DK62187D0 (da
Inventor
Roland Ingolf Jeppsson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of DK62187D0 publication Critical patent/DK62187D0/da
Publication of DK62187A publication Critical patent/DK62187A/da
Application granted granted Critical
Publication of DK175504B1 publication Critical patent/DK175504B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK198700621A 1986-02-13 1987-02-06 Farmaceutisk præparat indeholdende 3alfa-hydroxy-5beta-pregnan-20-on og fremstilling deraf DK175504B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8600632A SE8600632D0 (sv) 1986-02-13 1986-02-13 Novel pharmaceutical composition
SE8600632 1986-02-13

Publications (3)

Publication Number Publication Date
DK62187D0 DK62187D0 (da) 1987-02-06
DK62187A DK62187A (da) 1987-08-14
DK175504B1 true DK175504B1 (da) 2004-11-15

Family

ID=20363448

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700621A DK175504B1 (da) 1986-02-13 1987-02-06 Farmaceutisk præparat indeholdende 3alfa-hydroxy-5beta-pregnan-20-on og fremstilling deraf

Country Status (14)

Country Link
US (1) US5028600A (xx)
EP (1) EP0233849B1 (xx)
JP (1) JPH0788305B2 (xx)
AT (1) ATE64526T1 (xx)
CA (1) CA1301651C (xx)
DE (1) DE3770830D1 (xx)
DK (1) DK175504B1 (xx)
ES (1) ES2037742T3 (xx)
FI (1) FI88676C (xx)
GR (1) GR3002299T3 (xx)
HK (1) HK83293A (xx)
NO (1) NO175040B (xx)
SE (1) SE8600632D0 (xx)
SG (1) SG102892G (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9302295D0 (sv) * 1993-07-02 1993-07-02 Kabi Pharmacia Ab New pharmaceutical composition
US5616330A (en) * 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
WO1999007381A1 (en) * 1997-08-11 1999-02-18 Weider Nutrition International, Inc. Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors
AU2002241738A1 (en) * 2000-12-29 2002-07-16 The Trustees Of Columbia University In The City Of New York Use of iv emulsions with different triglyceride composition, particle size and apolipoprotein e for targeted tissue delivery of hydrophobic compounds
US8182824B2 (en) * 2002-07-02 2012-05-22 Nycomed Gmbh Ciclesonide-containing sterile aqueous suspension
PE20050941A1 (es) * 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
KR20070058608A (ko) * 2004-09-13 2007-06-08 바라트 쎄럼스 앤드 백신스 리미티드 항미생물 방부 효능을 갖는 정맥 내 투여를 위한 안정한에멀젼 조성물
CN103491976B (zh) * 2011-01-14 2015-04-01 卡思伯特·O·辛普金斯 用于处理与缺乏血液供给、休克和神经损伤相关的疾病的方法和组合物
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
RS59734B1 (sr) 2012-01-23 2020-02-28 Sage Therapeutics Inc Formulacije neuroaktivnog steroida koje uključuju kompleks alopregnanolona i sulfobutil etar beta-ciklodekstrina
WO2014028398A2 (en) 2012-08-13 2014-02-20 The Regents Of The University Of California Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
US20140057885A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
US20150313915A1 (en) 2012-11-30 2015-11-05 The Regents Of The University Of California Anticonvulsant activity of steroids
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
RU2766155C2 (ru) 2016-03-08 2022-02-08 Сейдж Терапьютикс, Инк. Нейроактивные стероиды, их композиции и применения
JP2022514991A (ja) * 2018-12-10 2022-02-16 ハロー・サイエンス・エル・エル・シー 安定な麻酔薬製剤および関連する剤形
CA3151334C (en) * 2019-08-19 2024-04-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Topical neurosteroid formulations
CN114344309B (zh) * 2021-12-30 2024-02-06 南京迈诺威医药科技有限公司 一种别孕烷醇酮衍生物自乳化制剂及其制备方法
US11969434B1 (en) 2022-08-29 2024-04-30 Lipocine Inc. Oral allopregnanolone compositions and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1215702B (de) * 1962-07-03 1966-05-05 Merck Ag E Verfahren zur Herstellung von 1alpha-Alkylthio-3-keto-androstanen
CA895860A (en) * 1969-11-05 1972-03-21 Kruger Gunther PROCESS FOR THE PREPARATION OF 3.alpha.-HYDROXY-5.beta.-PREGNAN-20-ONE
US3900561A (en) * 1970-12-17 1975-08-19 Glaxo Lab Ltd Pharmaceutical compositions
US3917830A (en) * 1970-12-17 1975-11-04 Glaxo Lab Ltd Steroidal anaesthetic composition for intraveneous injection
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
JPS609726B2 (ja) * 1980-05-15 1985-03-12 株式会社 ミドリ十字 ステロイド製剤
JPS5716818A (en) * 1981-04-25 1982-01-28 Green Cross Corp:The Steroid fatty emulsion
JPS60258110A (ja) * 1984-06-05 1985-12-20 Daigo Eiyou Kagaku Kk 静脈注射可能なプロゲステロン乳化注射液

Also Published As

Publication number Publication date
FI88676C (fi) 1993-06-28
JPH0788305B2 (ja) 1995-09-27
ATE64526T1 (de) 1991-07-15
NO870560D0 (no) 1987-02-12
NO870560L (no) 1987-08-14
SG102892G (en) 1992-12-04
EP0233849A1 (en) 1987-08-26
EP0233849B1 (en) 1991-06-19
US5028600A (en) 1991-07-02
FI870589A0 (fi) 1987-02-12
DK62187A (da) 1987-08-14
HK83293A (en) 1993-08-20
CA1301651C (en) 1992-05-26
JPS62192322A (ja) 1987-08-22
DK62187D0 (da) 1987-02-06
SE8600632D0 (sv) 1986-02-13
NO175040C (xx) 1994-08-24
DE3770830D1 (de) 1991-07-25
NO175040B (no) 1994-05-16
ES2037742T3 (es) 1993-07-01
FI88676B (fi) 1993-03-15
GR3002299T3 (en) 1992-12-30
FI870589A (fi) 1987-08-14

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