DK175493B1 - Særlige kemoluminiscerende acridiniumderivater og deres anvendelse til luminiscensimmunassay - Google Patents

Særlige kemoluminiscerende acridiniumderivater og deres anvendelse til luminiscensimmunassay Download PDF

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Publication number
DK175493B1
DK175493B1 DK198900742A DK74289A DK175493B1 DK 175493 B1 DK175493 B1 DK 175493B1 DK 198900742 A DK198900742 A DK 198900742A DK 74289 A DK74289 A DK 74289A DK 175493 B1 DK175493 B1 DK 175493B1
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Denmark
Prior art keywords
group
conjugate
formula
carbon atoms
ppm
Prior art date
Application number
DK198900742A
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Danish (da)
English (en)
Other versions
DK74289D0 (da
DK74289A (da
Inventor
Tonio Kinkel
Peter Molz
Erwin Schmidt
Gerd Schnorr
Heinz Juergen Skrzipczyk
Original Assignee
Dade Behring Marburg Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19883805318 external-priority patent/DE3805318C2/de
Application filed by Dade Behring Marburg Gmbh filed Critical Dade Behring Marburg Gmbh
Publication of DK74289D0 publication Critical patent/DK74289D0/da
Publication of DK74289A publication Critical patent/DK74289A/da
Priority to DK199300307A priority Critical patent/DK173972B1/da
Application granted granted Critical
Publication of DK175493B1 publication Critical patent/DK175493B1/da

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyridine Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Paints Or Removers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK198900742A 1988-02-20 1989-02-17 Særlige kemoluminiscerende acridiniumderivater og deres anvendelse til luminiscensimmunassay DK175493B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK199300307A DK173972B1 (da) 1988-02-20 1993-03-18 Luminescensforbindelse indeholdende kemoluminescerende acridiniumderivat samt luminescensimmunbestemmelse ved anvendelse af forbindelsen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3805318 1988-02-20
DE19883805318 DE3805318C2 (de) 1988-02-20 1988-02-20 Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays

Publications (3)

Publication Number Publication Date
DK74289D0 DK74289D0 (da) 1989-02-17
DK74289A DK74289A (da) 1989-08-21
DK175493B1 true DK175493B1 (da) 2004-11-08

Family

ID=6347802

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198900742A DK175493B1 (da) 1988-02-20 1989-02-17 Særlige kemoluminiscerende acridiniumderivater og deres anvendelse til luminiscensimmunassay

Country Status (11)

Country Link
EP (1) EP0330050B1 (no)
JP (1) JP2602315B2 (no)
AT (1) ATE195757T1 (no)
CA (1) CA1339390C (no)
DE (2) DE3844954C2 (no)
DK (1) DK175493B1 (no)
ES (1) ES2151474T3 (no)
FI (1) FI90537C (no)
GR (1) GR3034888T3 (no)
NO (1) NO173237C (no)
PT (1) PT89759B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
ES2063735T3 (es) * 1986-10-22 1995-01-16 Abbott Lab Sales de acridinio quimioluminiscentes.
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
US5338847A (en) * 1987-12-31 1994-08-16 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation
US5281712A (en) * 1987-12-31 1994-01-25 London Diagnostics, Inc. Ammonium substituted chemiluminescent labels and their conjugates, and assays therefrom
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
WO1992009580A1 (en) * 1990-11-21 1992-06-11 Beckman Instruments, Inc. Chemiluminescent compounds
DE4041080A1 (de) 1990-12-21 1992-06-25 Behringwerke Ag Verfahren zur bestimmung eines analyten
DE69215983T2 (de) * 1991-07-10 1997-05-22 Tdk Corp Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz
DE4228839A1 (de) 1992-08-29 1994-03-03 Behringwerke Ag Verfahren zum Nachweis und zur Bestimmung von Mediatoren
JP3207933B2 (ja) * 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
BE1008216A4 (fr) * 1994-01-25 1996-02-20 Biocode Sa Derives chemoluminescents heterocycliques.
DE59510779D1 (de) * 1994-06-24 2003-10-02 Dade Behring Marburg Gmbh Verfahren zur Stabilisierung von hydrolyseempfindlichen Molekülen
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (en) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof
WO1999009012A1 (en) * 1997-08-21 1999-02-25 Maine Medical Center Peroxide-based chemiluminescent assays and chemiluminescent compounds used therein

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352791A (en) * 1965-01-22 1967-11-14 American Cyanamid Co Generation of light by the reaction of peroxide with heterocyclic derivatives
FR2043486B1 (no) * 1969-05-28 1973-07-13 Roussel Uclaf
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
IN142734B (no) * 1975-04-28 1977-08-20 Miles Lab
GB2008247B (en) * 1977-11-17 1982-12-15 Welsh Nat School Med Detecting or quantifying substances using labelling techniques
US4334069A (en) * 1978-07-24 1982-06-08 Miles Laboratories, Inc. Chemiluminescent phthalhydrazide-labeled hapten conjugates
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
ATE42317T1 (de) * 1983-07-29 1989-05-15 Henning Berlin Gmbh Voraktivierte kunststoffoberflaechen zur immobilisierung von organisch-chemischen und biologischen materialien, verfahren zur herstellung und verwendung derselben.
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
DE3645292C2 (de) * 1986-08-22 1997-12-11 Hoechst Ag Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung
ES2063735T3 (es) * 1986-10-22 1995-01-16 Abbott Lab Sales de acridinio quimioluminiscentes.
JPH0699401A (ja) * 1992-09-18 1994-04-12 I N R Kenkyusho:Kk 木工機械

Also Published As

Publication number Publication date
NO173237B (no) 1993-08-09
GR3034888T3 (en) 2001-02-28
FI90537B (fi) 1993-11-15
NO173237C (no) 1993-11-17
JPH01261461A (ja) 1989-10-18
PT89759B (pt) 1994-03-31
EP0330050A3 (de) 1991-11-06
CA1339390C (en) 1997-08-26
FI90537C (fi) 1994-02-25
DE58909877D1 (de) 2000-09-28
ATE195757T1 (de) 2000-09-15
FI890754A (fi) 1989-08-21
NO890689L (no) 1989-08-21
EP0330050B1 (de) 2000-08-23
FI890754A0 (fi) 1989-02-16
DE3844954C2 (de) 1998-07-16
ES2151474T3 (es) 2001-01-01
DK74289D0 (da) 1989-02-17
PT89759A (pt) 1989-10-04
EP0330050A2 (de) 1989-08-30
JP2602315B2 (ja) 1997-04-23
NO890689D0 (no) 1989-02-17
DK74289A (da) 1989-08-21

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