DK175316B1 - System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel - Google Patents

System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel Download PDF

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Publication number
DK175316B1
DK175316B1 DK198905837A DK583789A DK175316B1 DK 175316 B1 DK175316 B1 DK 175316B1 DK 198905837 A DK198905837 A DK 198905837A DK 583789 A DK583789 A DK 583789A DK 175316 B1 DK175316 B1 DK 175316B1
Authority
DK
Denmark
Prior art keywords
insulin
microspheres
administration
drug
nasal
Prior art date
Application number
DK198905837A
Other languages
Danish (da)
English (en)
Other versions
DK583789A (da
DK583789D0 (da
Inventor
Lisbeth Illum
Original Assignee
West Pharm Serv Drug Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharm Serv Drug Res Ltd filed Critical West Pharm Serv Drug Res Ltd
Publication of DK583789D0 publication Critical patent/DK583789D0/da
Publication of DK583789A publication Critical patent/DK583789A/da
Application granted granted Critical
Publication of DK175316B1 publication Critical patent/DK175316B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK198905837A 1987-05-22 1989-11-21 System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel DK175316B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878712176A GB8712176D0 (en) 1987-05-22 1987-05-22 Drug delivery system
GB8712176 1987-05-22
PCT/GB1988/000396 WO1988009163A1 (en) 1987-05-22 1988-05-20 Enhanced uptake drug delivery system
GB8800396 1988-05-20

Publications (3)

Publication Number Publication Date
DK583789D0 DK583789D0 (da) 1989-11-21
DK583789A DK583789A (da) 1990-01-18
DK175316B1 true DK175316B1 (da) 2004-08-16

Family

ID=10617794

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905837A DK175316B1 (da) 1987-05-22 1989-11-21 System til transmucosal indgivelse af den aktive bestanddel af et lægemiddel

Country Status (10)

Country Link
EP (1) EP0391896B1 (no)
JP (1) JP2914670B2 (no)
AU (1) AU614290B2 (no)
CA (1) CA1324079C (no)
DE (1) DE3888201T2 (no)
DK (1) DK175316B1 (no)
FI (1) FI97444C (no)
GB (2) GB8712176D0 (no)
NO (1) NO178564C (no)
WO (1) WO1988009163A1 (no)

Families Citing this family (53)

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US4865850A (en) * 1986-09-08 1989-09-12 See/Shell Biotechnology, Inc. Dietary fat reduction
US5811128A (en) * 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5298243A (en) * 1988-10-20 1994-03-29 Denki Kagaku Kogyo Kabushiki Kaisha Colony stimulating factor-gelatin conjugate
KR0157428B1 (ko) * 1989-02-17 1998-11-16 알렌 불룸 비 전달용 지질부형제와 그 사용법
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
JPH04504258A (ja) * 1989-03-29 1992-07-30 アルコン　ラボラトリーズ　インコーポレイテッド モノアシルホスホグリセリド類を使用して眼薬の角膜への浸透を増強する方法
US5725871A (en) * 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
GB8918879D0 (en) * 1989-08-18 1989-09-27 Danbiosyst Uk Pharmaceutical compositions
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5707644A (en) * 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
GB9012663D0 (en) * 1990-06-07 1990-08-01 Erba Carlo Spa Galenic formulations containing cyclodextrins
DK49791D0 (da) * 1991-03-20 1991-03-20 Novo Nordisk As Nasalt pulverpraeparat
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
CA2094217A1 (en) * 1992-04-17 1993-10-18 Yasutaka Igari Transmucosal therapeutic composition
DE69329295T2 (de) * 1992-12-02 2001-03-15 Alkermes Inc Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
US5549908A (en) * 1993-05-20 1996-08-27 The University Of Akron Hydrolytically labile microspheres of polysaccharide crosslinked with cyanogen halide and their application in wound dressings
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5506203C1 (en) * 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
US5830853A (en) 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
SE9303574D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method the manufacturing thereof
US6165976A (en) 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
KR100389080B1 (ko) 1994-12-22 2003-10-17 아스트라제네카 악티에볼라그 부갑상선호르몬(pth)을포함하는흡입용치료제제
GB9522351D0 (en) * 1995-11-01 1996-01-03 Medeva Holdings Bv Vaccine compositions
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
GB9700624D0 (en) 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
JP2000290184A (ja) * 1999-04-01 2000-10-17 Kyowa Hakko Kogyo Co Ltd 経鼻投与製剤
US7833549B2 (en) * 2000-01-19 2010-11-16 Mannkind Corporation Dry powder formulations of antihistamine for nasal administration
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
WO2003026699A1 (fr) * 2001-09-26 2003-04-03 Tanabe Seiyaku Co., Ltd. Compositions medicinales favorisant l'absorption de medicaments
EP1458360B1 (en) 2001-12-19 2011-05-11 Novartis AG Pulmonary delivery of aminoglycosides
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
NL1022442C2 (nl) * 2003-01-20 2004-07-22 Tno Toepassing van lipide ter verbetring van de opname van nutrienten en (farmaceutisch) actieve stoffen.
JP4493594B2 (ja) * 2003-03-04 2010-06-30 田辺三菱製薬株式会社 粉末経鼻投与製剤
JP2007500243A (ja) * 2003-06-09 2007-01-11 ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド 成長ホルモンの増進された経粘膜送達のための組成物および方法
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
WO2015111062A1 (en) 2014-01-27 2015-07-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nanoencapsulation of hydrophilic active compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681500A (en) * 1969-12-12 1972-08-01 Boehringer Sohn Ingelheim Spray compositions for treatment of obstructive disorders of the respiratory tract and methods therefor
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
GB8514090D0 (en) * 1985-06-04 1985-07-10 Sandoz Ltd Organic compounds
NZ221411A (en) * 1986-08-11 1989-10-27 Innovata Biomed Ltd Pharmaceutical compositions containing microcapsules and a surfactant

Also Published As

Publication number Publication date
GB2231495A (en) 1990-11-21
NO178564B (no) 1996-01-15
GB8924696D0 (en) 1990-09-05
EP0391896A1 (en) 1990-10-17
CA1324079C (en) 1993-11-09
WO1988009163A1 (en) 1988-12-01
AU614290B2 (en) 1991-08-29
JPH02503915A (ja) 1990-11-15
DE3888201T2 (de) 1994-07-14
GB8712176D0 (en) 1987-06-24
DK583789A (da) 1990-01-18
DK583789D0 (da) 1989-11-21
NO890283D0 (no) 1989-01-23
AU1793188A (en) 1988-12-21
GB2231495B (en) 1991-08-28
NO178564C (no) 1996-04-24
DE3888201D1 (de) 1994-04-07
FI895555A0 (fi) 1989-11-21
NO890283L (no) 1989-01-23
FI97444B (fi) 1996-09-13
FI97444C (fi) 1996-12-27
EP0391896B1 (en) 1994-03-02
JP2914670B2 (ja) 1999-07-05

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