DK174984A - Faktor viii polypeptidkoaguleringsmiddel og monoklone antistoffer over for disse - Google Patents

Faktor viii polypeptidkoaguleringsmiddel og monoklone antistoffer over for disse Download PDF

Info

Publication number
DK174984A
DK174984A DK174984A DK174984A DK174984A DK 174984 A DK174984 A DK 174984A DK 174984 A DK174984 A DK 174984A DK 174984 A DK174984 A DK 174984A DK 174984 A DK174984 A DK 174984A
Authority
DK
Denmark
Prior art keywords
polypeptides
reacts
factor viii
those
react
Prior art date
Application number
DK174984A
Other languages
English (en)
Other versions
DK174984D0 (da
DK172036B1 (da
Inventor
Theodore S Zimmerman
Carol A Fulcher
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27046849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK174984(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of DK174984D0 publication Critical patent/DK174984D0/da
Publication of DK174984A publication Critical patent/DK174984A/da
Application granted granted Critical
Publication of DK172036B1 publication Critical patent/DK172036B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)

Description

(iv) koaguleringsmidlet udviser human faktor VIII:C-anti-stof-bindingskapacitet.
Hertil kommer biologiske præparater indeholdende koagulerings-midlet samt fremgangsmåde til fremstilling af koaguleringsmidlet ved digestion af human faktor VIII:C i en digestionsblanding med en effektiv mængde af en protease, afbrydelse af digestionen, medens koaguleringsmidlet stadig er til stede i digestionsblandingen, og udvinding af det resulterende koaguleringsmiddel, desuden en fremgangsmåde til udvinding af VIII:C-polypeptider uden tab af koagulerende aktivitet fra en immu-noadsorbent indeholdende monoklone antistoffer over for faktor VIII:C samt et monoklont antistof af klassen IgG.
DK174984A 1983-03-31 1984-03-30 Faktor VIII:C-koaguleringsmiddel, fremgangsmåde til fremstilling heraf samt fremgangsmåde til udvinding heraf DK172036B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48110583A 1983-03-31 1983-03-31
US48110583 1983-03-31
US55650883A 1983-11-30 1983-11-30
US55650883 1983-11-30

Publications (3)

Publication Number Publication Date
DK174984D0 DK174984D0 (da) 1984-03-30
DK174984A true DK174984A (da) 1984-10-01
DK172036B1 DK172036B1 (da) 1997-09-22

Family

ID=27046849

Family Applications (2)

Application Number Title Priority Date Filing Date
DK174984A DK172036B1 (da) 1983-03-31 1984-03-30 Faktor VIII:C-koaguleringsmiddel, fremgangsmåde til fremstilling heraf samt fremgangsmåde til udvinding heraf
DK050497A DK50497A (da) 1983-03-31 1997-05-02 Monoklonale antistoffer over for nye faktor VIII-koaguleringspolypeptider

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK050497A DK50497A (da) 1983-03-31 1997-05-02 Monoklonale antistoffer over for nye faktor VIII-koaguleringspolypeptider

Country Status (12)

Country Link
EP (3) EP0770396A3 (da)
JP (2) JPH0829089B2 (da)
AT (2) ATE155490T1 (da)
AU (1) AU572128B2 (da)
CA (1) CA1341506C (da)
DE (2) DE3486453T2 (da)
DK (2) DK172036B1 (da)
FI (1) FI841281A (da)
IE (2) IE80858B1 (da)
NO (1) NO167533C (da)
SG (2) SG49675A1 (da)
ZA (1) ZA842418B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
US4716117A (en) * 1984-10-26 1987-12-29 Chiron Corporation Monoclonal antibodies to factor VIIIC
DK13485A (da) * 1984-01-12 1985-07-13 Chiron Corp Hybridomacellelinie og monoklonalt antistof opnaaet ved hjaelp af en saadan cellelinie
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
US5004804A (en) * 1984-01-12 1991-04-02 Nordisk Gentofte Method and composition for preparation of factor VIIIC
DE3586402T3 (de) * 1984-01-12 2004-12-23 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Proteinzusammensetzung mit Koagulations-wirkung und Verfahren zu ihrer Herstellung.
US5045455A (en) * 1984-01-12 1991-09-03 Chiron Corporation Factor VIII:C cDNA cloning and expression
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
EP0272304B1 (en) * 1986-06-24 1994-01-26 Novo Nordisk A/S A process for producing a coagulation active complex of factor viii fragments
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
EP0294910B1 (en) 1987-06-12 1996-09-11 Immuno Ag Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
IL88309A0 (en) * 1987-11-17 1989-06-30 Scripps Clinic Res Peptides for use in the purification of factor viii
FR2662166A1 (fr) * 1990-05-18 1991-11-22 Fondation Nale Transfusion San Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption.
WO1995003332A1 (en) * 1993-07-23 1995-02-02 Baxter International Inc. Activated human factor viii and method of preparation
US5576291A (en) * 1993-09-13 1996-11-19 Baxter International Inc. Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
JP5149470B2 (ja) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
EP1418810A4 (en) 2001-08-03 2006-08-02 Us Gov Health & Human Serv TREATMENT OF HEMOPHILIA ORAL
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364937A (en) * 1980-01-08 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human T cell antigen and methods of preparing same
US4364936A (en) * 1980-01-08 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human monocyte antigen and methods of preparing same
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C

Also Published As

Publication number Publication date
ATE155490T1 (de) 1997-08-15
IE840788L (en) 1984-09-30
IE960783L (en) 1984-09-30
DK174984D0 (da) 1984-03-30
DE3486453D1 (de) 1997-08-21
DE3486453T2 (de) 1998-02-26
SG49675A1 (en) 1998-06-15
EP0770396A2 (en) 1997-05-02
ATE135400T1 (de) 1996-03-15
EP0561427A1 (en) 1993-09-22
AU572128B2 (en) 1988-05-05
NO167533C (no) 1991-11-13
DE3486423T3 (de) 2001-02-08
AU2627284A (en) 1984-10-04
CA1341506C (en) 2006-06-06
FI841281A0 (fi) 1984-03-30
NO167533B (no) 1991-08-05
IE80638B1 (en) 1998-10-21
JPH0829089B2 (ja) 1996-03-27
IE80858B1 (en) 1999-04-21
ZA842418B (en) 1984-11-28
FI841281A (fi) 1984-10-01
EP0123945B2 (en) 2000-04-19
DK50497A (da) 1997-05-02
SG48229A1 (en) 1998-04-17
JPS59184130A (ja) 1984-10-19
EP0123945A1 (en) 1984-11-07
DK172036B1 (da) 1997-09-22
DE3486423T2 (de) 1996-09-19
DE3486423D1 (de) 1996-04-18
JPH0638790A (ja) 1994-02-15
EP0561427B1 (en) 1997-07-16
NO841277L (no) 1984-10-01
EP0770396A3 (en) 1997-07-23
EP0123945B1 (en) 1996-03-13

Similar Documents

Publication Publication Date Title
DK174984A (da) Faktor viii polypeptidkoaguleringsmiddel og monoklone antistoffer over for disse
Lamoyi et al. Preparation of F (ab′) 2 fragments from mouse IgG of various subclasses
Miyamoto et al. Demonstration of high molecular weight forms of inhibin in bovine follicular fluid (bFF) by using monoclonal antibodies to bFF 32K inhibin
Makiya et al. Placental alkaline phosphatase has a binding site for the human immunoglobulin‐G Fc portion
EP0699755A3 (en) Process for obtaining modified immunoglobulins with reduced immunogenicity of the variable domains of a murine antibody, compositions containing them
EP0175360A3 (en) Peptide antibodies and their use in detecting oncogene products
NO964863L (no) Kloning av ikke-IgA-Fc-bindende former av <beta>-antigenene fra streptokokker i gruppe B
KR870004137A (ko) 항인간 인터로이킨 1항체(Anti Hunam Interleukin 1 Antibody)와 그의 제법 및 그의 사용법
Quackenbush et al. Identification of three antigens in human brain associated with similar antigens on human leukaemic cells
Fellah et al. Characterization of an IgY-like low molecular weight immunoglobulin class in the Mexican axolotl
KR870010192A (ko) 융합단백질 및 항체의 제조방법
DE152746T1 (de) Monoklonale antikoerper gegen faktor-viii-c.
DE68917797T2 (de) Gegen menschliches Fibrinopepid A spezifische monoklonale Antikörper.
ATE62709T1 (de) Monoklonale antikoerper.
Hønberg Probing barley mutants with a monoclonal antibody to a polypeptide involved in photosynthetic oxygen evolution
DE3650570D1 (de) Verfahren und Reagenz zur Bestimmung des Follikel stimulierenden Hormons sowie hierzu geeignete monoklonale Antikörper
Rubin et al. Rabbit antisera with specificity for isolated mouse T‐lymphocyte receptors
Høyer-Hansen Monoclonal Antibodies to Chlorophyll α-protein 1 in Barley
CHARDIN et al. Characterization of axolotl heavy and light immunoglobulin chains by monoclonal antibodies
Nolan et al. A monoclonal antibody to dopamine β-monooxygenase: detection of biosynthetic intermediates
Thorpe et al. Detection and affinity purification of β‐endorphin precursors using a monoclonal antibody
US5171663A (en) Monoclonal antibody against regulatory protein, sgp 120
Clezardin et al. Characterization of Monoclonal Antibodies Specific for a High Molecular Weight Glycoprotein Secreted from Activated Human Blood Platelets
Kasturi et al. A monoclonal antibody against erythrocyte spectrin reacts with both α-and β-subunits and detects spectrin-like molecules in non-erythroid cells
Kishida Preparation of anti-Gm antibodies and their application to enzyme-linked immunosorbent assay (ELISA) and immunoblotting for Gm typing

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired