DE152746T1 - Monoklonale antikoerper gegen faktor-viii-c. - Google Patents

Monoklonale antikoerper gegen faktor-viii-c.

Info

Publication number
DE152746T1
DE152746T1 DE198585100224T DE85100224T DE152746T1 DE 152746 T1 DE152746 T1 DE 152746T1 DE 198585100224 T DE198585100224 T DE 198585100224T DE 85100224 T DE85100224 T DE 85100224T DE 152746 T1 DE152746 T1 DE 152746T1
Authority
DE
Germany
Prior art keywords
monoclonal antibodies
cell lines
december
deposited
factor viiic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198585100224T
Other languages
English (en)
Inventor
Jennifer Carlton 3035 Victoria Favaloro
George San Francisco California 94122 Kuo
Frank R. San Francisco California 94131 Masiarz
Mirella Ezban Dk-2100 Copenhagen Rasmussen
Martha Oakland California 94611 Truett
Pablo San Francisco California 94117 Valenzuela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/570,062 external-priority patent/US5004804A/en
Priority claimed from US06/689,274 external-priority patent/US4716117A/en
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of DE152746T1 publication Critical patent/DE152746T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (4)

Chiron Corporation / 100 224.6 Patentansprüche
1. Hybridoma-Zellinie, ausgewählt aus der von den
Zellinien 42, 47, 56 und 1-28, hinterlegt bei der
National Collection of Annual Cell Cultures, Porton Down, Salisbury, Wilts, K.K., am 21. Dezember 1984, Nr. 84 12 21 03, 84 12 21 02, 84 12 21 04 bzw.
84 12 21 02, sowie den Zellinien 4E5, 5B1 und 2B6, hinterlegt bei der American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852, U.S.A., am 27. Dezember 1984, Nr. HB 8688, HB 8689 bzw. HB 8690, gebildeten Gruppe.
2. Monoklonale Antikörper, erhalten von einer Hybridoma-Zellinie nach Anspruch 1.
3. Hybridoma-Zellinien, die monoklonale Antikörper mit einer Reaktivität, welche im wesentlichen mit derjenigen der monoklonalen Antikörper nach Anspruch 2 identisch ist, bilden.
4. Monoklonale Antikörper, erhalten von einer Hybridoma-Zellinie nach Anspruch 3.
DE198585100224T 1984-01-12 1985-01-11 Monoklonale antikoerper gegen faktor-viii-c. Pending DE152746T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/570,062 US5004804A (en) 1984-01-12 1984-01-12 Method and composition for preparation of factor VIIIC
US66491984A 1984-10-26 1984-10-26
US06/689,274 US4716117A (en) 1984-10-26 1985-01-07 Monoclonal antibodies to factor VIIIC

Publications (1)

Publication Number Publication Date
DE152746T1 true DE152746T1 (de) 1986-04-10

Family

ID=27416093

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585100224T Expired - Lifetime DE3583750D1 (de) 1984-01-12 1985-01-11 Hybridom-zellinien und monoklonale antikoerper gegen faktor-viii-c.
DE198585100224T Pending DE152746T1 (de) 1984-01-12 1985-01-11 Monoklonale antikoerper gegen faktor-viii-c.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8585100224T Expired - Lifetime DE3583750D1 (de) 1984-01-12 1985-01-11 Hybridom-zellinien und monoklonale antikoerper gegen faktor-viii-c.

Country Status (5)

Country Link
EP (2) EP0152746B1 (de)
JP (2) JPH0764879B2 (de)
AT (1) ATE66249T1 (de)
DE (2) DE3583750D1 (de)
DK (1) DK13485A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
EP0491858A1 (de) * 1989-09-14 1992-07-01 Baxter International Inc. Vorrichtung und verfahren zur herstellung von arzneimittelzubereitungen
FR2662166A1 (fr) * 1990-05-18 1991-11-22 Fondation Nale Transfusion San Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption.
AT404429B (de) * 1995-06-09 1998-11-25 Immuno Ag Anti-plasma-antikörper-präparation
DE69939379D1 (de) * 1998-05-08 2008-10-02 Sanquin Bloedvoorziening Hemmstoff zur diagnose und behandlung von haemophilia a patienten
BR112013012213A2 (pt) 2010-11-17 2020-09-01 Chugai Seiyaku Kabushiki Kaisha moléculas de ligação a antígeno mul tlespecíficas tendo função alternativa à função dos fatores viii, ix e x de coagulação sanguínea, e anticorpo bies- 5 pecífico, seus usos na prevenção ou tratamento de hemorragia, ácido nucleico, vetor, célula, método para produzir as referidas moléculas de ligação, composição farmacêutica e kit
TWI701435B (zh) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
TWI700300B (zh) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
IE80638B1 (en) * 1983-03-31 1998-10-21 Scripps Research Inst Monoclonal antibodies to new factor VIII coagulant polypeptides

Also Published As

Publication number Publication date
JPH0817697B2 (ja) 1996-02-28
DE3583750D1 (de) 1991-09-19
DK13485D0 (da) 1985-01-11
JPH0764879B2 (ja) 1995-07-12
EP0152746B1 (de) 1991-08-14
JPH0678761A (ja) 1994-03-22
EP0152746A3 (en) 1987-05-27
DK13485A (da) 1985-07-13
ATE66249T1 (de) 1991-08-15
EP0432134A1 (de) 1991-06-12
EP0152746A2 (de) 1985-08-28
JPS60210981A (ja) 1985-10-23

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