ATE66249T1 - Hybridom-zellinien und monoklonale antikoerper gegen faktor-viii-c. - Google Patents

Hybridom-zellinien und monoklonale antikoerper gegen faktor-viii-c.

Info

Publication number
ATE66249T1
ATE66249T1 AT85100224T AT85100224T ATE66249T1 AT E66249 T1 ATE66249 T1 AT E66249T1 AT 85100224 T AT85100224 T AT 85100224T AT 85100224 T AT85100224 T AT 85100224T AT E66249 T1 ATE66249 T1 AT E66249T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
cell lines
factor viiic
december
deposited
Prior art date
Application number
AT85100224T
Other languages
English (en)
Inventor
George Kuo
Frank R Masiarz
Martha Truett
Pablo Valenzuela
Mirella Ezban Rasmussen
Jennifer Favaloro
Original Assignee
Chiron Corp
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/570,062 external-priority patent/US5004804A/en
Priority claimed from US06/689,274 external-priority patent/US4716117A/en
Application filed by Chiron Corp, Novo Nordisk As filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE66249T1 publication Critical patent/ATE66249T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT85100224T 1984-01-12 1985-01-11 Hybridom-zellinien und monoklonale antikoerper gegen faktor-viii-c. ATE66249T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/570,062 US5004804A (en) 1984-01-12 1984-01-12 Method and composition for preparation of factor VIIIC
US66491984A 1984-10-26 1984-10-26
US06/689,274 US4716117A (en) 1984-10-26 1985-01-07 Monoclonal antibodies to factor VIIIC
EP85100224A EP0152746B1 (de) 1984-01-12 1985-01-11 Hybridom-Zellinien und monoklonale Antikörper gegen Faktor-VIII-C

Publications (1)

Publication Number Publication Date
ATE66249T1 true ATE66249T1 (de) 1991-08-15

Family

ID=27416093

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85100224T ATE66249T1 (de) 1984-01-12 1985-01-11 Hybridom-zellinien und monoklonale antikoerper gegen faktor-viii-c.

Country Status (5)

Country Link
EP (2) EP0152746B1 (de)
JP (2) JPH0764879B2 (de)
AT (1) ATE66249T1 (de)
DE (2) DE152746T1 (de)
DK (1) DK13485A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
WO1991004059A2 (en) * 1989-09-14 1991-04-04 Baxter International Inc. Method and useful apparatus for preparing pharmaceutical compositions
FR2662166A1 (fr) * 1990-05-18 1991-11-22 Fondation Nale Transfusion San Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption.
AT404429B (de) * 1995-06-09 1998-11-25 Immuno Ag Anti-plasma-antikörper-präparation
US7364735B1 (en) 1998-05-08 2008-04-29 Stichting Sanquin Bloedvoorziening Method for diagnosis and treatment of haemophilia A patients with an inhibitor
KR101398363B1 (ko) 2010-11-17 2014-05-22 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
TWI701435B (zh) * 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
TWI700300B (zh) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
CA1341506C (en) * 1983-03-31 2006-06-06 Theodore S. Zimmerman Factor viii coagulant polypeptides and monoclonal antibodies to them

Also Published As

Publication number Publication date
DE3583750D1 (de) 1991-09-19
DK13485D0 (da) 1985-01-11
DK13485A (da) 1985-07-13
EP0152746A3 (en) 1987-05-27
EP0432134A1 (de) 1991-06-12
JPS60210981A (ja) 1985-10-23
EP0152746B1 (de) 1991-08-14
DE152746T1 (de) 1986-04-10
JPH0678761A (ja) 1994-03-22
JPH0817697B2 (ja) 1996-02-28
EP0152746A2 (de) 1985-08-28
JPH0764879B2 (ja) 1995-07-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time