DK174976B1 - Farmaceutiske sammensætning og fremgangsmåde til stabilisering af et ACE inhibitormedikament - Google Patents

Farmaceutiske sammensætning og fremgangsmåde til stabilisering af et ACE inhibitormedikament Download PDF

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Publication number
DK174976B1
DK174976B1 DK198705436A DK543687A DK174976B1 DK 174976 B1 DK174976 B1 DK 174976B1 DK 198705436 A DK198705436 A DK 198705436A DK 543687 A DK543687 A DK 543687A DK 174976 B1 DK174976 B1 DK 174976B1
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Prior art keywords
composition
ascorbic acid
drug
weight
lubricant
Prior art date
Application number
DK198705436A
Other languages
Danish (da)
English (en)
Other versions
DK543687A (da
DK543687D0 (da
Inventor
Kuchi Sury Murthy
Michael Ray Harris
Gerard Clifford Hokanson
Mahdi Bakir Fawzi
Frank Stanley Waldman
George Reisch Robert Jr
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25446206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK174976(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK543687D0 publication Critical patent/DK543687D0/da
Publication of DK543687A publication Critical patent/DK543687A/da
Application granted granted Critical
Publication of DK174976B1 publication Critical patent/DK174976B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Lubricants (AREA)
DK198705436A 1986-10-20 1987-10-16 Farmaceutiske sammensætning og fremgangsmåde til stabilisering af et ACE inhibitormedikament DK174976B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/921,931 US4793998A (en) 1986-10-20 1986-10-20 Stabilized drug compositions
US92193186 1986-10-20

Publications (3)

Publication Number Publication Date
DK543687D0 DK543687D0 (da) 1987-10-16
DK543687A DK543687A (da) 1988-04-21
DK174976B1 true DK174976B1 (da) 2004-04-05

Family

ID=25446206

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198705436A DK174976B1 (da) 1986-10-20 1987-10-16 Farmaceutiske sammensætning og fremgangsmåde til stabilisering af et ACE inhibitormedikament

Country Status (19)

Country Link
US (1) US4793998A (ja)
EP (1) EP0264888B1 (ja)
JP (1) JP2852043B2 (ja)
KR (1) KR960000431B1 (ja)
AT (1) ATE65915T1 (ja)
AU (1) AU614710B2 (ja)
CA (1) CA1297023C (ja)
DE (1) DE3772001D1 (ja)
DK (1) DK174976B1 (ja)
ES (1) ES2040231T3 (ja)
FI (1) FI94092C (ja)
GR (1) GR3002454T3 (ja)
HK (1) HK85394A (ja)
IE (1) IE61436B1 (ja)
NO (1) NO174765C (ja)
PH (1) PH25502A (ja)
PT (1) PT85941B (ja)
SG (1) SG90194G (ja)
ZA (1) ZA877131B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1322957C (en) * 1988-03-30 1993-10-12 Hitoshi Yamauchi Cyclic amp derivative ointments
US5006344A (en) * 1989-07-10 1991-04-09 E. R. Squibb & Sons, Inc. Fosinopril tablet formulations
CA2019324C (en) * 1989-07-10 1996-08-20 Robert L. Jerzewski Fosinopril tablet formulations
US5292521A (en) * 1990-04-06 1994-03-08 Eisai Co., Ltd. Solid oral preparation containing a pyrrolidine derivative with a catechol group
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
HU222489B1 (hu) * 1990-07-25 2003-07-28 Novartis Ag. Stabilizált gyógyszerkészítmények és eljárás az előállításukra
HU222497B1 (hu) * 1996-12-18 2003-07-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Enalapril-maleátot tartalmazó stabilizált gyógyszerkészítmény és eljárás előállítására
US6296871B1 (en) * 1998-04-12 2001-10-02 Ranbaxy Laboratories Limited Stable solid pharmaceutical compositions containing enalapril maleate
HUP0102260A3 (en) * 1998-06-05 2002-12-28 Warner Lambert Co Stabilization of compositions containing ace inhibitors using magnesium oxide
US6555551B1 (en) 1999-08-31 2003-04-29 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
US20040157911A1 (en) * 1999-08-31 2004-08-12 Spiridon Spireas Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
AU7580000A (en) * 1999-09-17 2001-04-17 Mylan Pharmaceuticals, Inc. Stabilization of enalapril maleate with maleic acid
CA2469940A1 (en) * 2001-12-19 2003-06-26 Takeda Chemical Industries, Ltd. Solid compositions comprising compounds unstable to oxygen and method for stabilizing them
US20050202081A1 (en) * 2002-01-15 2005-09-15 Deepak Bahl Stable pharmaceutical compositions comprising ace inhibitor(s)
CA2530788C (en) * 2003-06-26 2010-02-09 Teva Pharmaceutical Industries Ltd Stable pharmaceutical compositions of 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivatives
US6869963B2 (en) * 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
GR1006875B (el) * 2005-06-30 2010-07-12 "Φαρματεν" Φαρμακευτικη Βιομηχανικη Εμπορικη Α.Ε., Βελτιωμενες φαρμακευτικες συνθεσεις περιεχουσες αναστολεις του μετατρεπτικου ενζυμου αγγειοτενσινης και μεθοδοι παρασκευης αυτων.
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
US20070232680A1 (en) * 2006-04-04 2007-10-04 Vijayabhaskar Bolugoddu Preparation of ramipril and stable pharmaceutical compositions
MX2008013374A (es) * 2006-04-19 2008-11-12 Teva Pharma Composiciones farmaceuticas estables de derivados del acido 2-aza-biciclo[3.3.0]-octano-3-carboxilico.
US20080008694A1 (en) 2006-07-05 2008-01-10 Elgebaly Salwa A Methods to prevent and treat diseases
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
US8568747B1 (en) 2012-10-05 2013-10-29 Silvergate Pharmaceuticals, Inc. Enalapril compositions
US9463183B1 (en) 2015-10-30 2016-10-11 Silvergate Pharmaceuticals, Inc. Lisinopril formulations
US9669008B1 (en) 2016-03-18 2017-06-06 Silvergate Pharmaceuticals, Inc. Enalapril formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE569430A (ja) * 1957-07-17
US3697641A (en) * 1970-01-02 1972-10-10 Gerhard W Ahrens Nonhygroscopic non-sugarbase noncariogenic-vitamin c releasable base material for use in the preparation of suckable tablets,lozenges and chocolate
DE3175410D1 (en) * 1980-07-29 1986-11-06 Sanofi Sa Acid stabilized compositions of thieno-pyridine derived compounds and process for preventing degradation of such compounds
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4442089A (en) * 1982-07-06 1984-04-10 E. R. Squibb & Sons, Inc. Method for treating glaucoma with topical or systemic ACE inhibitor compositions
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4666705A (en) * 1985-06-03 1987-05-19 E. R. Squibb & Sons, Inc. Controlled release formulation
US4656188A (en) * 1985-10-09 1987-04-07 Merck & Co., Inc. Ace inhibitors in macular degeneration

Also Published As

Publication number Publication date
FI874593A0 (fi) 1987-10-19
HK85394A (en) 1994-08-26
FI94092C (fi) 1995-07-25
NO174765B (no) 1994-03-28
JP2852043B2 (ja) 1999-01-27
CA1297023C (en) 1992-03-10
AU614710B2 (en) 1991-09-05
DK543687A (da) 1988-04-21
KR880004812A (ko) 1988-06-27
IE872549L (en) 1988-04-20
FI94092B (fi) 1995-04-13
NO174765C (no) 1994-07-06
PT85941A (en) 1987-11-01
US4793998A (en) 1988-12-27
ES2040231T3 (es) 1993-10-16
FI874593A (fi) 1988-04-21
ATE65915T1 (de) 1991-08-15
NO874351L (no) 1988-04-21
SG90194G (en) 1994-10-14
DE3772001D1 (de) 1991-09-12
PH25502A (ja) 1991-07-24
IE61436B1 (en) 1994-11-02
PT85941B (pt) 1990-07-31
ZA877131B (en) 1989-04-26
KR960000431B1 (ko) 1996-01-06
NO874351D0 (no) 1987-10-19
DK543687D0 (da) 1987-10-16
AU7927487A (en) 1988-04-28
GR3002454T3 (en) 1992-12-30
EP0264888B1 (en) 1991-08-07
JPS63104930A (ja) 1988-05-10
EP0264888A1 (en) 1988-04-27

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