DK174153B1 - N-Aralkyl-piperidenmethanolderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende sådanne derivater - Google Patents

N-Aralkyl-piperidenmethanolderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende sådanne derivater Download PDF

Info

Publication number
DK174153B1
DK174153B1 DK198603123A DK312386A DK174153B1 DK 174153 B1 DK174153 B1 DK 174153B1 DK 198603123 A DK198603123 A DK 198603123A DK 312386 A DK312386 A DK 312386A DK 174153 B1 DK174153 B1 DK 174153B1
Authority
DK
Denmark
Prior art keywords
compound according
formula
compound
hydrogen
compounds
Prior art date
Application number
DK198603123A
Other languages
Danish (da)
English (en)
Other versions
DK312386A (da
DK312386D0 (da
Inventor
Albert A Carr
Norbert L Wiech
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of DK312386D0 publication Critical patent/DK312386D0/da
Publication of DK312386A publication Critical patent/DK312386A/da
Application granted granted Critical
Publication of DK174153B1 publication Critical patent/DK174153B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK198603123A 1985-07-02 1986-07-01 N-Aralkyl-piperidenmethanolderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende sådanne derivater DK174153B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75141985A 1985-07-02 1985-07-02
US75141985 1985-07-02

Publications (3)

Publication Number Publication Date
DK312386D0 DK312386D0 (da) 1986-07-01
DK312386A DK312386A (da) 1987-01-03
DK174153B1 true DK174153B1 (da) 2002-07-29

Family

ID=25021900

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198603123A DK174153B1 (da) 1985-07-02 1986-07-01 N-Aralkyl-piperidenmethanolderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende sådanne derivater

Country Status (21)

Country Link
EP (1) EP0208235B1 (fr)
JP (1) JPH0655720B2 (fr)
KR (1) KR900001184B1 (fr)
CN (1) CN1023895C (fr)
AR (2) AR241904A1 (fr)
AT (1) ATE49403T1 (fr)
AU (1) AU590582B2 (fr)
CA (1) CA1280421C (fr)
DE (1) DE3668167D1 (fr)
DK (1) DK174153B1 (fr)
ES (1) ES2000299A6 (fr)
FI (1) FI84474C (fr)
GR (1) GR861699B (fr)
HU (1) HU196058B (fr)
IE (1) IE58460B1 (fr)
IL (1) IL79266A (fr)
NO (1) NO167384C (fr)
NZ (1) NZ216689A (fr)
PH (1) PH22141A (fr)
PT (1) PT82890B (fr)
ZA (1) ZA864772B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
ZA888572B (en) * 1987-11-23 1989-08-30 Merrell Dow Pharma Treatment of fibromyalgia
JPH02138214A (ja) * 1987-12-10 1990-05-28 Merrell Dow Pharmaceut Inc 不安を治療する方法
US5093341A (en) * 1987-12-17 1992-03-03 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine derivatives useful as antithrombolytic agents
DE3888340T2 (de) * 1988-01-21 1994-06-30 Merrell Dow Pharma Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit.
ZA891901B (en) * 1988-03-17 1989-11-29 Merrell Dow Pharma Method for the treatment of the extrapyramidal side effects associated with neuroleptic therapy
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
ZA9010081B (en) * 1989-12-20 1991-10-30 Merrell Dow Pharma Method for the treatment of glaucoma
JP2758050B2 (ja) * 1989-12-27 1998-05-25 株式会社トクヤマ 土質安定用薬液およびその注入工法
ATE114467T1 (de) * 1990-06-01 1994-12-15 Merrell Dow Pharma (+)-alpha-(2,3 dimethoxyphenyl)-1-(2- (fluorophenyl)ethyl>-4-piperidinmethanol.
US6004980A (en) * 1990-06-01 1999-12-21 Merrell Pharmaceuticals, Inc. (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
JPH07111050B2 (ja) * 1990-12-12 1995-11-29 株式会社親和テクノ セメントグラウトを用いた地盤注入工法
FR2672286B1 (fr) * 1991-01-31 1994-11-18 Synthelabo Derives de 1-(4-chlorophenyl)-2-[4-(phenylmethyl)piperidin-1-yl]ethanol, leur preparation et leur application en therapeutique.
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
AU4659793A (en) * 1992-06-30 1994-01-24 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Anorectic epinephrine derivatives
FR2696741B1 (fr) * 1992-10-12 1994-11-25 Synthelabo Dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl]piperidin-1-yl] éthanol, leur préparation et leur application en thérapeutique.
CA2108245A1 (fr) * 1992-11-04 1994-05-05 Gary J. Grover Methode de traitement de l'ischemie cardiaque a l'aide d'antagonistes des recepteurs a serotonine
EP0661266A1 (fr) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Composés cycliques aminés substitués comme 5HT2 antagonistes
DE19681115D2 (de) * 1995-12-20 1999-11-25 Eckhart Pein Neue 1-Phenylalkyl/Alkylen-4-(.Alpha.-Hydroxydiphenylmethyl)-Piperidin Derivative und ihre Verwendung als Serotonin Antagonisten
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
TWI249526B (en) * 1998-03-13 2006-02-21 Aventis Pharma Inc Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
US6713627B2 (en) 1998-03-13 2004-03-30 Aventis Pharmaceuticals Inc. Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
SE9801516D0 (sv) * 1998-04-30 1998-04-30 Maria Carlsson M100907/4-Piperidinemethanol derivatives for autism
DE19934432A1 (de) 1999-07-22 2001-02-01 Merck Patent Gmbh Indolderivate
DE19939756A1 (de) * 1999-08-21 2001-02-22 Merck Patent Gmbh Piperidinalkohole
US7345096B2 (en) 2002-10-15 2008-03-18 Wyeth Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
US7365076B2 (en) 2003-10-14 2008-04-29 Wyeth Substituted aryl cycloalkanol derivatives and methods of their use
US7550485B2 (en) 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
US7531543B2 (en) 2003-10-14 2009-05-12 Wyeth Phenylpiperazine cycloalkanol derivatives and methods of their use
US7419980B2 (en) 2003-10-14 2008-09-02 Wyeth Fused-aryl and heteroaryl derivatives and methods of their use
US7491723B2 (en) 2003-10-14 2009-02-17 Wyeth Alkanol and cycloalkanol-amine derivatives and methods of their use
US7402698B2 (en) 2003-10-14 2008-07-22 Wyeth Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use
US7524846B2 (en) 2003-10-14 2009-04-28 Wyeth Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use
AU2004305563C1 (en) 2003-12-11 2011-07-07 Sunovion Pharmaceuticals Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
DE102004010132A1 (de) 2004-02-27 2005-09-15 Merck Patent Gmbh Piperidinderivate
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en) 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
US20060069124A1 (en) * 2004-09-07 2006-03-30 Rao P S Use of MDL-100,907 for treatment of allergic and eosinophil mediated diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3100775A (en) * 1959-04-01 1963-08-13 Searle & Co alpha-phenyl(pyridyl or piperidyl)alkyl esters of (chloro or lower alkoxy)-benzoic acids and congeners
ZA717147B (en) * 1970-11-27 1972-07-26 Richardson Merrell Inc 4-(4-(alpha-hydroxybenzyl)piperidino)-4'-fluorobutyrophenone derivatives
SE7409245L (fr) * 1973-07-19 1975-01-20 Robins Co Inc A H
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체

Also Published As

Publication number Publication date
NZ216689A (en) 1989-07-27
CN1023895C (zh) 1994-03-02
DE3668167D1 (de) 1990-02-15
FI862801A (fi) 1987-01-03
CA1280421C (fr) 1991-02-19
EP0208235A1 (fr) 1987-01-14
CN86104408A (zh) 1987-05-20
IE58460B1 (en) 1993-09-22
NO167384C (no) 1991-10-30
FI84474C (fi) 1991-12-10
GR861699B (en) 1986-10-31
AU5931886A (en) 1987-01-08
KR900001184B1 (ko) 1990-02-27
DK312386A (da) 1987-01-03
PT82890A (en) 1986-08-01
NO167384B (no) 1991-07-22
AR242184A1 (es) 1993-03-31
FI862801A0 (fi) 1986-07-01
ZA864772B (en) 1987-02-25
JPH0655720B2 (ja) 1994-07-27
PT82890B (pt) 1988-05-27
DK312386D0 (da) 1986-07-01
ATE49403T1 (de) 1990-01-15
IL79266A (en) 1990-04-29
AU590582B2 (en) 1989-11-09
PH22141A (en) 1988-06-01
FI84474B (fi) 1991-08-30
HU196058B (en) 1988-09-28
JPS625955A (ja) 1987-01-12
IE861771L (en) 1987-01-02
NO862661D0 (no) 1986-07-01
ES2000299A6 (es) 1988-02-16
HUT41387A (en) 1987-04-28
KR870001164A (ko) 1987-03-11
EP0208235B1 (fr) 1990-01-10
NO862661L (no) 1987-01-05
AR241904A1 (es) 1993-01-29

Similar Documents

Publication Publication Date Title
DK174153B1 (da) N-Aralkyl-piperidenmethanolderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende sådanne derivater
US4783471A (en) N-aralkyl piperidine methanol derivatives and the uses thereof
US5021428A (en) Novel chemical compounds for the prophylactic treatment of migraine
US5116846A (en) N-aralkyl piperidine derivatives as psychotropic drugs
US5169096A (en) N-aralkyl-piperidine-methanol derivatives
EP1077940B1 (fr) Nouvelles 4-phenylpiperidines destinees au traitement de dermatoses prurigineuses
US3080372A (en) 1-aroylalkyl-4-arylpiperidine derivatives
US5071859A (en) N-substituted azaheterocyclic carboxylic acids and pharmaceutical uses
HU196370B (en) Process for producing piperidine derivatives and pharmaceutical compositions comprising such compounds
US4912117A (en) Novel chemical compounds
EP0861832A1 (fr) Dérivés de Tétrahydropyridine
MX2007002308A (es) Derivados arilsulfonilestilbeno para el tratamiento del insomnio y afecciones relacionadas.
US5929072A (en) 1H-2,1,3-benzothiadiazine-2,2-dioxide compounds or derivatives thereof
PT98375B (pt) Processo de preparacao de compostos de piperidina e de composicoes farmaceuticas
US5486527A (en) Anticholinergic agents
US4076821A (en) 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
IE53738B1 (en) 1-phenylindazol-3-one compounds, a method of preparing them, intermediates used in the preparation of said compounds and pharmaceutical compositions containing these compounds
WO1991010651A1 (fr) Agents anticholinergiques
US4902799A (en) Bicyclic alkoxy- and alkylthio-substituted aminoalcohols
SK2192002A3 (en) Piperidine alcohol derivative, process for the preparation and use thereof and pharmaceutical composition comprising same
HU186655B (en) Process for producing new piperidine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them
US4518713A (en) Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines
MXPA05002366A (es) Compuestos benzoil piperidina novedosos.
JPH0588222B2 (fr)
HU186656B (en) Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired