DK173464B1 - BU-3608 serinanaloger, mellemprodukt og mikroorganismekultur til brug ved deres fremstilling, fremgangsmåde hertil og farma - Google Patents

BU-3608 serinanaloger, mellemprodukt og mikroorganismekultur til brug ved deres fremstilling, fremgangsmåde hertil og farma Download PDF

Info

Publication number
DK173464B1
DK173464B1 DK198905612A DK561289A DK173464B1 DK 173464 B1 DK173464 B1 DK 173464B1 DK 198905612 A DK198905612 A DK 198905612A DK 561289 A DK561289 A DK 561289A DK 173464 B1 DK173464 B1 DK 173464B1
Authority
DK
Denmark
Prior art keywords
pharmaceutically acceptable
formula
acceptable salts
compound according
hydrogen
Prior art date
Application number
DK198905612A
Other languages
Danish (da)
English (en)
Other versions
DK561289A (da
DK561289D0 (da
Inventor
Masatoshi Kakushima
Toshikazu Oki
Yosuke Sawada
Takeo Miyaki
Maki Nishio
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of DK561289D0 publication Critical patent/DK561289D0/da
Publication of DK561289A publication Critical patent/DK561289A/da
Application granted granted Critical
Publication of DK173464B1 publication Critical patent/DK173464B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK198905612A 1988-11-10 1989-11-09 BU-3608 serinanaloger, mellemprodukt og mikroorganismekultur til brug ved deres fremstilling, fremgangsmåde hertil og farma DK173464B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/269,821 US4973673A (en) 1988-11-10 1988-11-10 Serine analogs of BU-3608 antibiotics
US26982188 1988-11-10

Publications (3)

Publication Number Publication Date
DK561289D0 DK561289D0 (da) 1989-11-09
DK561289A DK561289A (da) 1990-05-11
DK173464B1 true DK173464B1 (da) 2000-11-27

Family

ID=23028793

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905612A DK173464B1 (da) 1988-11-10 1989-11-09 BU-3608 serinanaloger, mellemprodukt og mikroorganismekultur til brug ved deres fremstilling, fremgangsmåde hertil og farma

Country Status (23)

Country Link
US (1) US4973673A (no)
EP (1) EP0368349B1 (no)
JP (1) JP2817064B2 (no)
KR (1) KR930006995B1 (no)
CN (1) CN1044299A (no)
AT (1) ATE94556T1 (no)
AU (1) AU628418B2 (no)
CA (1) CA2001714C (no)
CY (1) CY1884A (no)
DE (1) DE68909170T2 (no)
DK (1) DK173464B1 (no)
EG (1) EG19153A (no)
ES (1) ES2059681T3 (no)
FI (1) FI98147C (no)
HK (1) HK151595A (no)
IE (1) IE63305B1 (no)
IL (1) IL92240A (no)
MY (1) MY110238A (no)
NO (1) NO172393C (no)
OA (1) OA09246A (no)
PL (2) PL161779B1 (no)
PT (1) PT92263B (no)
ZA (1) ZA898566B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109122A (en) * 1987-11-02 1992-04-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antibiotics, dexylosylbenanomicin B
US5183808A (en) * 1988-11-10 1993-02-02 Bristol-Myers Squibb Company Method for treating fungal infections with serine analogs of BU-3608 antibiotics
US5114857A (en) * 1988-11-10 1992-05-19 Bristol-Myers Company Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics
US5061624A (en) * 1988-11-10 1991-10-29 Bristol-Myers Company Serine analogs of BU-3608 antibiotics
JP2643404B2 (ja) * 1989-01-13 1997-08-20 財団法人微生物化学研究会 新抗生物質ｎ―アセチルベナノマイシンｂならびにその製造法
US5227370A (en) * 1989-11-14 1993-07-13 Bristol-Myers Squibb Company Pradimicin derivatives
FI92207C (fi) * 1989-11-14 1994-10-10 Squibb Bristol Myers Co Menetelmä terapeuttisesti käyttökelpoisten pradimisiinijohdannaisten valmistamiseksi
CA2162186C (en) * 1989-11-22 1998-12-15 Shimpei Aburaki Pradimicin derivatives
JP3035313B2 (ja) * 1990-03-14 2000-04-24 財団法人微生物化学研究会 ベナノマイシンａ４▲′′′▼‐ｏ‐硫酸エステルの塩類およびそれらの製造法
US5696096A (en) * 1990-09-28 1997-12-09 Bristol-Myers Squibb Company Pradimicin derivatives
US5217877A (en) * 1990-09-28 1993-06-08 Bristol-Myers Squibb Company Process for the preparation of α-glucosidase inhibitor, pradimicin Q
US5843908A (en) * 1990-09-28 1998-12-01 Bristol-Myers Squibb Company Pradimicins l and fl, and derivatives thereof
CA2068484A1 (en) * 1991-05-29 1992-11-30 Osamu Tenmyo Pradimicin s antibiotics
US5194371A (en) * 1991-07-31 1993-03-16 Bristol-Myers Squibb Company Production of pradimicin antibiotics
JP3134010B2 (ja) * 1991-11-26 2001-02-13 財団法人微生物化学研究会 デスアラニンベナノマイシンａ誘導体およびそれらの製造法
US5837828A (en) * 1992-04-08 1998-11-17 Bristol-Myers Squibb Co. Pradimicin derivatives
US5420261A (en) * 1992-05-29 1995-05-30 Schering Corporation Glycosides of 3'-deoxyaquayamycin antibiotics
US5326867A (en) * 1992-07-16 1994-07-05 Bristol-Myers Squibb Company Pradimic acids, amides, and pradimicin derivatives
US5338728A (en) * 1992-08-14 1994-08-16 Bristol-Myers Squibb Pradimicin compounds
ZA938725B (en) * 1992-11-30 1994-05-23 Bristol Myers Squibb Co C-11 Modified pradimicin derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US4870165A (en) * 1987-02-02 1989-09-26 Bristol-Myers Company Antifungal antibiotics

Also Published As

Publication number Publication date
CA2001714C (en) 1999-01-26
KR930006995B1 (ko) 1993-07-26
FI98147C (fi) 1997-04-25
HK151595A (en) 1995-09-29
NO894417L (no) 1990-05-11
ATE94556T1 (de) 1993-10-15
KR900008049A (ko) 1990-06-02
NO172393B (no) 1993-04-05
EP0368349A2 (en) 1990-05-16
NO894417D0 (no) 1989-11-07
NO172393C (no) 1993-07-14
DE68909170T2 (de) 1994-03-10
CA2001714A1 (en) 1990-05-10
PL161784B1 (pl) 1993-07-30
CN1044299A (zh) 1990-08-01
ES2059681T3 (es) 1994-11-16
EG19153A (en) 1994-07-30
DK561289A (da) 1990-05-11
IE893617L (en) 1990-05-10
JP2817064B2 (ja) 1998-10-27
IE63305B1 (en) 1995-04-05
DK561289D0 (da) 1989-11-09
PL161779B1 (pl) 1993-07-30
FI98147B (fi) 1997-01-15
ZA898566B (en) 1990-10-31
MY110238A (en) 1998-03-31
PT92263B (pt) 1995-07-06
EP0368349B1 (en) 1993-09-15
IL92240A0 (en) 1990-07-26
OA09246A (fr) 1992-06-30
AU628418B2 (en) 1992-09-17
DE68909170D1 (de) 1993-10-21
JPH02188596A (ja) 1990-07-24
IL92240A (en) 1994-02-27
US4973673A (en) 1990-11-27
PT92263A (pt) 1990-05-31
CY1884A (en) 1996-04-05
FI895281A0 (fi) 1989-11-07
AU4461589A (en) 1990-05-17
EP0368349A3 (en) 1991-04-24

Similar Documents

Publication Publication Date Title
DK173464B1 (da) BU-3608 serinanaloger, mellemprodukt og mikroorganismekultur til brug ved deres fremstilling, fremgangsmåde hertil og farma
EP0238011A2 (en) Polycyclic condensed amino sugar derivatives with anti-tumor and anti-bacterial activity, produced by streptomyces
DK160429B (da) N-heterocyclisk glycosid med antitumorvirkning, fremstilling deraf samt farmaceutisk praeparat indeholdende glycosidet
CA1337907C (en) Antifungal antibiotic bu-3608 complex
FI86892B (fi) Foerfarande foer framstaellning av antitumoer ll-e33288-antibioter och mikroorganismer, som producerar dessa.
US5114857A (en) Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics
US5061624A (en) Serine analogs of BU-3608 antibiotics
US5183808A (en) Method for treating fungal infections with serine analogs of BU-3608 antibiotics
JP2593495B2 (ja) 化合物ｔａｎ−９９９、その製造法および用途
US5843908A (en) Pradimicins l and fl, and derivatives thereof
IL107367A (en) Aglycone of d-serine intermediate for the synthesis of bu-3608 antibiotics
NZ231319A (en) Serine analogs of bu-3608 antibiotics, production by culture and the pure culture of the microorganism actinomadura hibisca
US5096817A (en) Process for producing antibiotics BU-3608 D and BU-3608 E
US4340725A (en) Novel compound DC-38-V and process for production thereof
JPH05310766A (ja) 新規抗生物質ｍｉ４８１−４２ｆ４−ａ及びその製造方法
JP3067322B2 (ja) 抗かび性抗生物質３′−ヒドロキシベナノマイシンａの製造法
SASSE et al. Antibiotics from gliding bacteria. No. 61. Gephyronic Acid, a Novel Inhibitor of Eukaryotic Protein Synthesis from Archangium gephyra (Myxobacteria). Production, Isolation, Physico-chemical and Biological Properties, and Mechanism of Action.
IL106806A (en) History of amino and N-alkyl of the antibiotic compounds from the complex of UB-8063 and their preparation
EP0399505A1 (en) Physiologically active compounds SN-198C and method and bacteria for their production
WO1995018142A1 (en) Wf15604 substances
WO2001029182A1 (en) Novel compound, wf217

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK