DK173138B1 - Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma - Google Patents

Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma Download PDF

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Publication number
DK173138B1
DK173138B1 DK199801526A DKPA199801526A DK173138B1 DK 173138 B1 DK173138 B1 DK 173138B1 DK 199801526 A DK199801526 A DK 199801526A DK PA199801526 A DKPA199801526 A DK PA199801526A DK 173138 B1 DK173138 B1 DK 173138B1
Authority
DK
Denmark
Prior art keywords
dextran
iron
molecular weight
solution
hydrogenation
Prior art date
Application number
DK199801526A
Other languages
Danish (da)
English (en)
Inventor
Lars Christensen
Hans Berg Andreasen
Original Assignee
Pharmacosmos Holding As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacosmos Holding As filed Critical Pharmacosmos Holding As
Priority to DK199801526A priority Critical patent/DK173138B1/da
Priority to ARP990103484A priority patent/AR019403A1/es
Priority to NZ508225A priority patent/NZ508225A/en
Priority to EA200001086A priority patent/EA003278B1/ru
Priority to CN99807988A priority patent/CN1308539A/zh
Priority to SK1943-2000A priority patent/SK19432000A3/sk
Priority to HU0101802A priority patent/HUP0101802A3/hu
Priority to EP99934521A priority patent/EP1123103B1/en
Priority to DE69903329T priority patent/DE69903329T2/de
Priority to AT99934521T priority patent/ATE225180T1/de
Priority to UA2000116538A priority patent/UA57140C2/uk
Priority to US09/509,681 priority patent/US6977249B1/en
Priority to DK99934521T priority patent/DK1123103T3/da
Priority to AU50273/99A priority patent/AU756555B2/en
Priority to IDW20010148A priority patent/ID26997A/id
Priority to CA002332882A priority patent/CA2332882A1/en
Priority to ES99934521T priority patent/ES2183582T3/es
Priority to TR2000/03648T priority patent/TR200003648T2/xx
Priority to PCT/DK1999/000425 priority patent/WO2000030657A1/en
Priority to PT99934521T priority patent/PT1123103E/pt
Priority to SI9930167T priority patent/SI1123103T1/xx
Priority to KR1020017000229A priority patent/KR20010071767A/ko
Priority to PL99345125A priority patent/PL345125A1/xx
Priority to BR9910834-8A priority patent/BR9910834A/pt
Priority to JP2000583540A priority patent/JP2002530345A/ja
Application granted granted Critical
Publication of DK173138B1 publication Critical patent/DK173138B1/da
Publication of DK199801526A publication Critical patent/DK199801526A/da
Priority to ZA200006878A priority patent/ZA200006878B/en
Priority to NO20006021A priority patent/NO20006021L/no
Priority to US10/300,032 priority patent/US20030083310A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK199801526A 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma DK173138B1 (da)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
ARP990103484A AR019403A1 (es) 1998-11-20 1999-07-15 Proceso para producir un compuesto de hierro-dextrano, el compuesto de hierro-dextrano producido de acuerdo con dicho proceso, composicion farmaceuticapara la profilaxis o el tratamiento de la deficiencia de hierro y uso de dicho compuesto para la preparacion de una composicion farmaceutica administ
TR2000/03648T TR200003648T2 (tr) 1998-11-20 1999-07-29 Bir demir-dekstran bileşiğinin üretilmesi için bir işlem.
ES99934521T ES2183582T3 (es) 1998-11-20 1999-07-29 Procedimiento para la produccion de un compuesto de hierro-dextrano.
SK1943-2000A SK19432000A3 (sk) 1998-11-20 1999-07-29 Spôsob výroby železo-dextránovej zlúčeniny, farmaceutický prostriedok s jej obsahom a jej použitie
EA200001086A EA003278B1 (ru) 1998-11-20 1999-07-29 Способ получения соединения железа с декстраном
EP99934521A EP1123103B1 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound
DE69903329T DE69903329T2 (de) 1998-11-20 1999-07-29 Verfahren zur herstellung einer eisen-dextran verbindung
AT99934521T ATE225180T1 (de) 1998-11-20 1999-07-29 Verfahren zur herstellung einer eisen-dextran verbindung
UA2000116538A UA57140C2 (uk) 1998-11-20 1999-07-29 Сполука залізо-декстран, спосіб її одержання, фармацевтична композиція, спосіб її одержання
US09/509,681 US6977249B1 (en) 1998-11-20 1999-07-29 Process for producing an iron-dextran compound, iron-dextran compound produced according to said process, pharmaceutical composition for prophylaxis or treatment of iron-deficiency and use of said compound for the preparation of parenterally administrable pharmaceutical composition
DK99934521T DK1123103T3 (da) 1998-11-20 1999-07-29 Fremgangsmåde til fremstilling af en jerndextranforbindelse
PCT/DK1999/000425 WO2000030657A1 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound
IDW20010148A ID26997A (id) 1998-11-20 1999-07-29 Proses pembuatan senyawa besi dekstran
NZ508225A NZ508225A (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound
CN99807988A CN1308539A (zh) 1998-11-20 1999-07-29 铁－葡聚糖化合物的制法
HU0101802A HUP0101802A3 (en) 1998-11-20 1999-07-29 A process for producing iron-dextran compounds
AU50273/99A AU756555B2 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound
PT99934521T PT1123103E (pt) 1998-11-20 1999-07-29 Processo para a producao de um composto de ferro-dextrano
SI9930167T SI1123103T1 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound
KR1020017000229A KR20010071767A (ko) 1998-11-20 1999-07-29 철-덱스트란 화합물을 생산하는 방법
PL99345125A PL345125A1 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound
BR9910834-8A BR9910834A (pt) 1998-11-20 1999-07-29 Processo para a produção de um composto de ferro-dextrano
JP2000583540A JP2002530345A (ja) 1998-11-20 1999-07-29 鉄−デキストラン化合物の製造法
CA002332882A CA2332882A1 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound
ZA200006878A ZA200006878B (en) 1998-11-20 2000-11-23 A process for producing an iron-dextran compound.
NO20006021A NO20006021L (no) 1998-11-20 2000-11-28 Fremgangsmåte for fremstilling av jern-dekstran forbindelse
US10/300,032 US20030083310A1 (en) 1998-11-20 2002-11-20 Process for producing an iron-dextran compound, iron-dextran compound produced according to said process, pharmaceutical composition for prophylaxis or treatment of iron-deficiency and use of said compound for the preparation of a parenterally administrable pharmaceutical composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
DK152698 1998-11-20

Publications (2)

Publication Number Publication Date
DK173138B1 true DK173138B1 (da) 2000-02-07
DK199801526A DK199801526A (da) 2000-02-07

Family

ID=8105751

Family Applications (2)

Application Number Title Priority Date Filing Date
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
DK99934521T DK1123103T3 (da) 1998-11-20 1999-07-29 Fremgangsmåde til fremstilling af en jerndextranforbindelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99934521T DK1123103T3 (da) 1998-11-20 1999-07-29 Fremgangsmåde til fremstilling af en jerndextranforbindelse

Country Status (26)

Country Link
US (2) US6977249B1 (no)
EP (1) EP1123103B1 (no)
JP (1) JP2002530345A (no)
KR (1) KR20010071767A (no)
CN (1) CN1308539A (no)
AR (1) AR019403A1 (no)
AT (1) ATE225180T1 (no)
AU (1) AU756555B2 (no)
BR (1) BR9910834A (no)
CA (1) CA2332882A1 (no)
DE (1) DE69903329T2 (no)
DK (2) DK173138B1 (no)
EA (1) EA003278B1 (no)
ES (1) ES2183582T3 (no)
HU (1) HUP0101802A3 (no)
ID (1) ID26997A (no)
NO (1) NO20006021L (no)
NZ (1) NZ508225A (no)
PL (1) PL345125A1 (no)
PT (1) PT1123103E (no)
SI (1) SI1123103T1 (no)
SK (1) SK19432000A3 (no)
TR (1) TR200003648T2 (no)
UA (1) UA57140C2 (no)
WO (1) WO2000030657A1 (no)
ZA (1) ZA200006878B (no)

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US6599498B1 (en) 1999-04-09 2003-07-29 Advanced Magnetics, Inc. Heat stable colloidal iron oxides coated with reduced carbohydrates and carbohdrate derivatives
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
EP1522318A3 (en) * 1999-04-09 2005-07-06 Advanced Magnetics Incorporated Heat stable coated colloidal iron oxides
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US7964568B2 (en) * 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
US20050191246A1 (en) * 2003-12-13 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powders comprising low molecular dextran and methods of producing those powders
ITMO20050056A1 (it) * 2005-03-15 2006-09-16 Biofer Spa Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi.
KR20080082674A (ko) 2006-01-06 2008-09-11 루이트폴드 파머수티컬스, 인코퍼레이티드 철을 투여하기 위한 방법 및 조성물
DE102007054794A1 (de) * 2007-11-13 2009-05-14 Agilan Gmbh Wässrige Eisen-Dextran-Zubereitung mit ein oder mehreren Verbindungen der para-Hydroxy-Benzoesäureester und/oder deren Salzen
AU2009342799B2 (en) 2009-03-25 2014-12-18 Pharmacosmos Holding A/S A stable iron oligosaccharide compound
EP2537866A1 (en) * 2011-06-21 2012-12-26 Serumwerk Bernburg AG Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof
BR112015012161B1 (pt) 2012-11-30 2020-05-05 Pharmacosmos As agente de crioproteção e seu uso, composições de crioproteção e método para criopreservar amostra".
WO2015150394A1 (en) 2014-04-01 2015-10-08 Pharmacosmos A/S Cryoprotective agent, cryoprotective and cryopreserved compositions, uses thereof, and methods of cryopreservation
EP3157516A4 (en) 2014-06-22 2017-12-13 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
MX2017005784A (es) 2014-11-05 2017-07-28 Du Pont Dextranos gelificantes enzimaticamente polimerizados.
WO2016160737A1 (en) 2015-04-03 2016-10-06 E I Du Pont De Nemours And Company Oxidized dextran
AU2016243411B2 (en) 2015-04-03 2020-10-22 Nutrition & Biosciences USA 4, Inc. Gelling dextran ethers
WO2018198135A1 (en) 2017-04-26 2018-11-01 Mylan Laboratories Ltd. Improved process for the preparation of iron complex
AU2018328052B2 (en) 2017-09-11 2024-02-29 Pharmacosmos Holding A/S Iron complex compounds for therapeutic use
CN109646454A (zh) * 2018-12-29 2019-04-19 博瑞生物医药（苏州）股份有限公司 异麦芽糖酐铁1000的制备方法
CN110183548B (zh) * 2019-06-28 2021-05-18 瑞普（天津）生物药业有限公司 一种低分子葡聚糖铁的制备方法及其应用
CN110551019A (zh) * 2019-09-12 2019-12-10 天津医科大学 一种亚铁糖(ⅱ)复合物、制备方法及其应用
CN110804107B (zh) * 2019-09-29 2021-08-31 山东金洋药业有限公司 一种使用右旋糖酐制备右旋糖酐铁水溶液的方法

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Also Published As

Publication number Publication date
EA003278B1 (ru) 2003-04-24
ATE225180T1 (de) 2002-10-15
EA200001086A1 (ru) 2001-06-25
CN1308539A (zh) 2001-08-15
ES2183582T3 (es) 2003-03-16
AR019403A1 (es) 2002-02-20
JP2002530345A (ja) 2002-09-17
US6977249B1 (en) 2005-12-20
KR20010071767A (ko) 2001-07-31
PT1123103E (pt) 2003-02-28
AU756555B2 (en) 2003-01-16
SK19432000A3 (sk) 2001-06-11
HUP0101802A2 (hu) 2001-10-28
NO20006021D0 (no) 2000-11-28
EP1123103A1 (en) 2001-08-16
WO2000030657A1 (en) 2000-06-02
BR9910834A (pt) 2001-02-13
HUP0101802A3 (en) 2003-07-28
SI1123103T1 (en) 2003-04-30
UA57140C2 (uk) 2003-06-16
DE69903329T2 (de) 2003-07-10
NZ508225A (en) 2003-10-31
PL345125A1 (en) 2001-12-03
TR200003648T2 (tr) 2001-08-21
CA2332882A1 (en) 2000-06-02
US20030083310A1 (en) 2003-05-01
AU5027399A (en) 2000-06-13
ID26997A (id) 2001-02-22
NO20006021L (no) 2000-11-28
DK199801526A (da) 2000-02-07
DK1123103T3 (da) 2002-11-25
ZA200006878B (en) 2001-05-10
EP1123103B1 (en) 2002-10-02
DE69903329D1 (de) 2002-11-07

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