TR200003648T2 - Bir demir-dekstran bileşiğinin üretilmesi için bir işlem. - Google Patents

Bir demir-dekstran bileşiğinin üretilmesi için bir işlem.

Info

Publication number
TR200003648T2
TR200003648T2 TR2000/03648T TR200003648T TR200003648T2 TR 200003648 T2 TR200003648 T2 TR 200003648T2 TR 2000/03648 T TR2000/03648 T TR 2000/03648T TR 200003648 T TR200003648 T TR 200003648T TR 200003648 T2 TR200003648 T2 TR 200003648T2
Authority
TR
Turkey
Prior art keywords
iron
producing
dextran
compound
groups
Prior art date
Application number
TR2000/03648T
Other languages
English (en)
Inventor
Berg Andreasen Hans
Christensen Lars
Original Assignee
Pharmacosmos Holding A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacosmos Holding A/S filed Critical Pharmacosmos Holding A/S
Publication of TR200003648T2 publication Critical patent/TR200003648T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

Insanlarda ve hayvanlarda demir eksikliginin parenteral yolla tedavisinde kullanilmak üzere bir demir-dekstran bilesiginin üretilmesi için bir islemde, istenen nispi düsük moleküler agirliga sahip dengeli bir bilesik, demirle reaksiyon öncesi dekstran moleküllerinin üzerinde bulunan uç gruplarin indirgenmesi için ilk olarak hidrojenleme ve daha sonra oksidasyon islemlerini kullanarak elde edilir. Hidrojenlenmis gruplarin, oksijenlenmis gruplara oraninin degistirilmesiyle, elde edilen demir-dekstran bilesiginin ortalama moleküler agirligi degistirilebilir.
TR2000/03648T 1998-11-20 1999-07-29 Bir demir-dekstran bileşiğinin üretilmesi için bir işlem. TR200003648T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma

Publications (1)

Publication Number Publication Date
TR200003648T2 true TR200003648T2 (tr) 2001-08-21

Family

ID=8105751

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03648T TR200003648T2 (tr) 1998-11-20 1999-07-29 Bir demir-dekstran bileşiğinin üretilmesi için bir işlem.

Country Status (26)

Country Link
US (2) US6977249B1 (tr)
EP (1) EP1123103B1 (tr)
JP (1) JP2002530345A (tr)
KR (1) KR20010071767A (tr)
CN (1) CN1308539A (tr)
AR (1) AR019403A1 (tr)
AT (1) ATE225180T1 (tr)
AU (1) AU756555B2 (tr)
BR (1) BR9910834A (tr)
CA (1) CA2332882A1 (tr)
DE (1) DE69903329T2 (tr)
DK (2) DK173138B1 (tr)
EA (1) EA003278B1 (tr)
ES (1) ES2183582T3 (tr)
HU (1) HUP0101802A3 (tr)
ID (1) ID26997A (tr)
NO (1) NO20006021D0 (tr)
NZ (1) NZ508225A (tr)
PL (1) PL345125A1 (tr)
PT (1) PT1123103E (tr)
SI (1) SI1123103T1 (tr)
SK (1) SK19432000A3 (tr)
TR (1) TR200003648T2 (tr)
UA (1) UA57140C2 (tr)
WO (1) WO2000030657A1 (tr)
ZA (1) ZA200006878B (tr)

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US6104802A (en) 1997-02-10 2000-08-15 Genesys Telecommunications Laboratories, Inc. In-band signaling for routing
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
US6599498B1 (en) * 1999-04-09 2003-07-29 Advanced Magnetics, Inc. Heat stable colloidal iron oxides coated with reduced carbohydrates and carbohdrate derivatives
EP1522318A3 (en) * 1999-04-09 2005-07-06 Advanced Magnetics Incorporated Heat stable coated colloidal iron oxides
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US7964568B2 (en) * 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
US20050191246A1 (en) * 2003-12-13 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powders comprising low molecular dextran and methods of producing those powders
ITMO20050056A1 (it) 2005-03-15 2006-09-16 Biofer Spa Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi.
PT1973549T (pt) 2006-01-06 2016-10-25 Luitpold Pharm Inc Métodos e composições para administração de ferro
DE102007054794A1 (de) * 2007-11-13 2009-05-14 Agilan Gmbh Wässrige Eisen-Dextran-Zubereitung mit ein oder mehreren Verbindungen der para-Hydroxy-Benzoesäureester und/oder deren Salzen
PL3156075T3 (pl) * 2009-03-25 2021-04-19 Pharmacosmos Holding A/S Oligosacharyd i sposób jego wytwarzania
EP2537866A1 (en) 2011-06-21 2012-12-26 Serumwerk Bernburg AG Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof
KR102196974B1 (ko) 2012-11-30 2020-12-31 파르마코스모스 에이/에스 동결 보호제, 동결 보호 및 동결 보존 조성물, 그 용도 및 동결 보존 방법
WO2015150394A1 (en) 2014-04-01 2015-10-08 Pharmacosmos A/S Cryoprotective agent, cryoprotective and cryopreserved compositions, uses thereof, and methods of cryopreservation
WO2015198304A1 (en) 2014-06-22 2015-12-30 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
EP3215543B1 (en) 2014-11-05 2020-01-08 DuPont Industrial Biosciences USA, LLC Enzymatically polymerized gelling dextrans
CN107404924B (zh) 2015-04-03 2022-07-19 营养与生物科学美国4公司 氧化的右旋糖酐
EP3277730B1 (en) 2015-04-03 2022-02-09 Nutrition & Biosciences USA 4, Inc. Gelling dextran ethers
WO2018198135A1 (en) 2017-04-26 2018-11-01 Mylan Laboratories Ltd. Improved process for the preparation of iron complex
EP3681539A1 (en) 2017-09-11 2020-07-22 Pharmacosmos Holding A/S Iron complex compounds for therapeutic use
CN109646454A (zh) * 2018-12-29 2019-04-19 博瑞生物医药（苏州）股份有限公司 异麦芽糖酐铁1000的制备方法
CN110183548B (zh) * 2019-06-28 2021-05-18 瑞普（天津）生物药业有限公司 一种低分子葡聚糖铁的制备方法及其应用
CN110551019A (zh) * 2019-09-12 2019-12-10 天津医科大学 一种亚铁糖(ⅱ)复合物、制备方法及其应用
CN110804107B (zh) * 2019-09-29 2021-08-31 山东金洋药业有限公司 一种使用右旋糖酐制备右旋糖酐铁水溶液的方法

Family Cites Families (20)

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Publication number Priority date Publication date Assignee Title
USRE24642E (en) 1959-04-28 Therapeutic preparations of iron
DK117730A (tr)
US2885393A (en) 1956-02-24 1959-05-05 R K Laros Company Dextran-iron complex and process for making same
US3093545A (en) 1960-08-29 1963-06-11 Armour Pharma Therapeutic iron-dextran preparations
US3234209A (en) * 1963-09-13 1966-02-08 Chemicals Inc Process for making iron hydrogenated dextran
GB1200902A (en) 1967-05-13 1970-08-05 Fisons Pharmaceuticals Ltd Iron-dextran complexes
US3549614A (en) * 1967-07-13 1970-12-22 Jan Zbigniew Mioduszewski Method of manufacture of mixed complex compounds of ferric iron with hydrogenated dextran and citric acid or sodium citrate
SU364625A1 (ru) * 1968-07-12 1972-12-28 Способ получения комплексных соединений
US3697502A (en) 1969-11-03 1972-10-10 Christensen Henry M Method of making iron dextran-preparations
HU176073B (hu) 1978-03-08 1980-12-28 Chinoin Gyogyszer Es Vegyeszet Eljárás nagy vastartalmú vasdextrán előállítására
US4370476A (en) * 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
US4788281A (en) 1984-01-04 1988-11-29 Tosoni Anthony L Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof
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US5075885A (en) * 1988-12-21 1991-12-24 National Semiconductor Corporation Ecl eprom with cmos programming
SU1797196A1 (ru) * 1991-03-29 1996-02-10 Научно-исследовательский ветеринарный институт Нечерноземной зоны РСФСР Препарат для профилактики алиментарной анемии поросят
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DE69627171T2 (de) * 1995-11-09 2004-02-12 Abbott Laboratories, Abbott Park Verfahren zur herstellung eines kristallinen eisendextrans
DK172860B1 (da) * 1998-03-25 1999-08-16 Pharmacosmos Holding As Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman

Also Published As

Publication number Publication date
HUP0101802A2 (hu) 2001-10-28
SI1123103T1 (en) 2003-04-30
CN1308539A (zh) 2001-08-15
ATE225180T1 (de) 2002-10-15
EA003278B1 (ru) 2003-04-24
DK1123103T3 (da) 2002-11-25
DE69903329T2 (de) 2003-07-10
PL345125A1 (en) 2001-12-03
ID26997A (id) 2001-02-22
US20030083310A1 (en) 2003-05-01
JP2002530345A (ja) 2002-09-17
DE69903329D1 (de) 2002-11-07
EP1123103B1 (en) 2002-10-02
UA57140C2 (uk) 2003-06-16
DK173138B1 (da) 2000-02-07
US6977249B1 (en) 2005-12-20
ZA200006878B (en) 2001-05-10
NO20006021L (no) 2000-11-28
BR9910834A (pt) 2001-02-13
EP1123103A1 (en) 2001-08-16
NO20006021D0 (no) 2000-11-28
WO2000030657A1 (en) 2000-06-02
PT1123103E (pt) 2003-02-28
HUP0101802A3 (en) 2003-07-28
NZ508225A (en) 2003-10-31
AU756555B2 (en) 2003-01-16
DK199801526A (da) 2000-02-07
SK19432000A3 (sk) 2001-06-11
CA2332882A1 (en) 2000-06-02
ES2183582T3 (es) 2003-03-16
KR20010071767A (ko) 2001-07-31
AU5027399A (en) 2000-06-13
EA200001086A1 (ru) 2001-06-25
AR019403A1 (es) 2002-02-20

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